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Evaluation of multimodal pharmacological diagnostics for brain health

A multi-modal, diagnostic agent technology, applied in the direction of diagnosis, diagnostic recording/measurement, instruments for radiological diagnosis, etc.

Inactive Publication Date: 2019-11-19
CERORA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This will be followed by a second post-dose multimodal diagnostic scan

Method used

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  • Evaluation of multimodal pharmacological diagnostics for brain health
  • Evaluation of multimodal pharmacological diagnostics for brain health
  • Evaluation of multimodal pharmacological diagnostics for brain health

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] Example 1. Using Sinemet to help diagnose Parkinson's disease

[0143] As previously described, a physician may scan a patient's brain using a multimodal system with subsequent analysis of the type described above. Subjects were scanned prior to dosing to collect baseline assessments. Subjects were then administered a single diagnostic dose of Sinemet and asked to wait in the waiting room for 30, 60 or 90 minutes or until the T_max of the drug was known from the drug label and pharmacokinetic studies. The patient is then scanned a second time in the same manner. The patient can also scan the third, fourth and / or fifth times earlier or later than T_max, so as to obtain a time series observation of the action of Xinningmei. Parkinson's patients with pre-motor deficits or patients already diagnosed with Parkinson's disease can be predicted to show abnormal responses to Xinningmei because their dopamine levels are abnormal due to the neurodegenerative process associated w...

Embodiment 2

[0145] Example 2. Use of ice or other cooling objects to aid in pain identification and return-to-work (RtW) decisions

[0146] As mentioned earlier, physicians can scan a patient's brain using a multimodal system with subsequent analysis of the type described above. Whenever possible, subjects were scanned prior to injury to collect baseline assessments. Then, if a claim is made for soft tissue related pain, the method of the present invention can be used. As a non-limiting example, it is known that in the resting closed state of the eyes, the alpha rhythm is dominant, producing a peak typically around 10 Hz. Observations were recorded on a 45-year-old male subject via a single-lead EEG headband at 128 samples / sec and a 10-bit (10-bit) markerless ADC (MindSet Pro from NeuroSky). As a surrogate for lower back pain or soft tissue injury and pain, the subject places an ice cube in the left hand and holds for 60 seconds while the headgear is recording. Although a major alpha p...

Embodiment 3

[0147] Example 3. Use of Heat Roasts to Aid in Pain Identification and Return to Work Decisions

[0148]As mentioned earlier, physicians can scan a patient's brain using a multimodal system with subsequent analysis of the type described above. Whenever possible, subjects were scanned prior to injury to collect baseline assessments. Then, if a soft tissue related pain claim is made, the method of the present invention can be used. As a non-limiting example, it is known that in the resting closed state of the eyes, the alpha rhythm is dominant, producing a peak typically around 10 Hz. This was recorded on a 45-year-old male subject via a single-lead EEG headband at 128 samples / sec and a 10-bit markerless ADC (MindSet Pro from NeuroSky). As a surrogate for lower back pain or soft tissue injury and pain, subjects place their hands on a thermal roaster, consisting of two separate pieces of metal with interlaced fingers exposed to various temperatures. Pain circuits are known to ...

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Abstract

Patients are provided between brain scans with a single diagnostic dose of a chemical agent that can bind specifically through the molecule or provide a well-characterized molecular effect on mammalian hosts, including humans. The method generally includes at least one pre-dose scan of the subject, followed by a waiting period of time before a second post-dose diagnostic scan. Diagnostic scans can be routine in themselves or can be of multimodal variety. The comparison (in difference or ratio form) between the data or the extracted features before and after the diagnostic dose represents the level of the subject's brain by molecular specificity. The resulting data can be used to evaluate cases of medical fraud and to make return-to-work decisions for brain and soft tissue injuries, for which decisions have traditionally been somewhat subjective in nature.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 61 / 794,143, filed March 15, 2013, and US Provisional Application No. 61 / 864,864, filed August 12, 2013. The contents of these patent applications are incorporated by reference in their entirety into this application. technical field [0003] The present invention relates to the diagnosis and analysis of brain health information by using activation tasks and stimuli in a system combined with single doses of approved drugs, biological agents and biochemical CNS active agents to dynamically assess brain health, function and brain activity. Background technique [0004] The proper functioning of the brain and central nervous system is essential for a healthy, happy and productive life. Disorders of the brain and central nervous system are among the most dreadful diseases. Many neurological disorders, such as Alzheimer's disease and Parkinson's disease,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00
CPCA61B5/055A61B5/224A61B5/4064A61B5/4082A61B5/4088A61B5/4094A61B5/4824A61B5/483A61B5/4833A61B5/4848A61B6/037A61B6/481A61B6/486A61B6/501A61B6/5235A61B6/5247A61B2503/10A61B2576/026A61B90/37A61B5/369G16H30/40A61B2503/22
Inventor 亚当·J·西蒙史蒂芬·J·马蒂诺
Owner CERORA
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