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Application of a kind of indole diketopiperazine compound in preparation of biological pesticide
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A technology of bio-pesticides and compounds, applied in the field of agriculture and biology, to achieve the effect of strong anti-plant pathogenic bacteria
Inactive Publication Date: 2018-07-17
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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But so far, there are no reports about 1,2,3,4-tetrahydro-2-methyl-3-methylene-1,4-dioxopyrazino[1,2-a]indole against plant pathogens in domestic and foreign literature
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Embodiment 1
[0016] The effect of the compound 1,2,3,4-tetrahydro-2-methyl-3-methylene-1,4-dioxopyrazino[1,2-a]indole on Curvularia crescenae, Gleospora anthracnose, Inhibitory effect of Gemini sp.
[0017] The compound 1,2,3,4-tetrahydro-2-methyl-3-methylene-1,4-dioxopyrazino[1,2-a]indole was dissolved in DMSO and diluted to a concentration of 2 mg / mL.
[0018] In the center of the plate containing the PDA medium, respectively insert the phytopathogenic bacterial cake with a diameter of 4mm for testing, place 4 pieces of filter paper evenly around the bacterial cake, and drop 5 μL of the extract on the filter paper, and replace the sample extract with DMSO as a blank control. Place in an incubator at 28°C for 3 to 5 days, record the growth diameter of the bacteria cake with the cross measurement method, and calculate the inhibition rate according to the following formula.
[0019]
[0020] The experimental results are shown in Table 1:
[0021] Table 1: Inhibitory effect of compound...
Embodiment 2
[0025] Determination of compound 1,2,3,4-tetrahydro-2-methyl-3-methylene-1,4-dioxopyrazino[1,2-a]i ndole on plant pathogen Curvularia lunene and Gleospora anthracnose by filter paper method EC 50 value.
[0026]Compound 1,2,3,4-tetrahydro-2-methyl-3-methylene-1,4-dioxopyrazino[1,2-a]indole was diluted to 800, 400, 200, 100, 50, 25, 12.5 with DMSO μg / mL. In the center of the plate containing the PDA medium, respectively insert the phytopathogenic bacterial cake with a diameter of 4mm for testing, place 4 pieces of filter paper evenly around the bacterial cake, and drop 5 μL of the extract on the filter paper, and replace the sample extract with DMSO as a blank control. Place in a constant temperature box at 28°C for 3 to 5 days, record the growth diameter of the bacteria cake with the cross measurement method, calculate the inhibition rate, and use SigmaPlot 10.0 software to calculate the EC 50 value. The experimental results are shown in Table 2: Table 2: Compound 1,2,3,4...
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Abstract
The invention discloses an application of an indolyl diketopiperazine compound in preparation of biological pesticides. According to the application, the discovered compound, i.e., 1,2,3,4-tetrahydro-2-methyl-3-methylene-1,4-dioxopyrazino[1,2-a]indole has a very high inhibiting effect on phytopathogens, i.e., Curvularia lunata, Colletotrichum gloeosporioides, Alternaria alternata and Cylindrocladium scoparium, so that the compound, i.e., 1,2,3,4-tetrahydro-2-methyl-3-methylene-1,4-dioxopyrazino[1,2-a]indole has a very good phytopathogen inhibiting effect and has a good application development prospect. Therefore, the invention provides candidate biopesticides for researching and developing novel antiphytopathogen pesticides and provides a scientific basis for developing and utilizing marine fungus derived natural active substances.
Description
technical field [0001] The invention belongs to the field of agriculture and biotechnology, in particular to compound 1,2,3,4-tetrahydro-2-methyl-3-methylene-1,4-dioxopyrazino[1,2-a]indole in the preparation of biological pesticides and as pesticides application of active ingredients. Background technique: [0002] Plant diseases are mainly caused by pathogenic microorganisms, which are a major factor threatening the survival of plants and bring huge losses to agricultural and forestry production every year. For example, anthracnose is a worldwide plant disease that poses a serious threat to many crops, especially in tropical and subtropical regions. There are many anthracnose bacteria that can cause crop anthracnose, of which G. anthracnose is the largest species in the genus Anthracnose. It is widely distributed and endangers a wide variety of hosts, and is an important class of plant pathogens; Alternaria can cause diseases of dozens of crops including corn, wheat, tobac...
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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/90A01P3/00A01P1/00
CPCA01N43/90
Inventor 李浩华范震章卫民
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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