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Medicine composition for preventing and treating presbycusis

A composition and senile technology, applied in the field of medicine, can solve the problems of long course of disease, difficult observation and follow-up in clinical research, etc., achieve good therapeutic effect and eliminate the effect of mast cell activation

Inactive Publication Date: 2017-03-29
徐州诺克非医药科技有限公司
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AI Technical Summary

Problems solved by technology

Due to the gradual development of the disease and the long course of the disease, it is difficult to observe and follow up in clinical research, and most patients have not paid attention to it in the early stage. When the hearing impairment is obvious and goes to the doctor, it is already a relatively severe sensorineural hearing loss.

Method used

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  • Medicine composition for preventing and treating presbycusis
  • Medicine composition for preventing and treating presbycusis

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Embodiment Construction

[0012] The above description is only an overview of the technical solution of the present invention. In order to understand the technical means of the present invention more clearly and implement it according to the content of the description and conventional technical means in the field, the animal test examples of the present invention will be further described in detail below .

[0013] The preparation method of the compound Trefolane A involved in the present invention can be found in the literature (Trefolanes A–D with aDiterpene-Sesquiterpene Skeleton from Supercritical Fluid Extracts of Helianthus annuus L.var.AriannaOrg.Lett., 2015, 17(19), 4730–4733).

[0014] Antitide, CAS: 112568-12-4, is available in the market.

[0015] Modeling: newborn clean-grade mice, male, the ambient temperature of the animal room is 27°C-30°C, and the humidity is 35%-45%. 210 mice were randomly divided into 21 groups, 10 in each group, divided into 20 groups of drug administration and one ...

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Abstract

The invention discloses a medicine composition for preventing and treating presbycusis. The effective components comprise Trefolane A and antide acetate. By weight, the ratio of the Trefolane A to the antide acetate is 1:1-20:1. The medicine composition for preventing and treating the presbycusis has a good effect on prevention and treatment of the presbycusis.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating presbycusis, belonging to the technical field of medicine. Background technique [0002] Presbycusis is a common sensorineural deafness. Due to the gradual development of the disease and the long course of the disease, it is not easy to observe and follow up in clinical research, and most patients do not pay attention to it in the early stage. When the hearing impairment is obvious and goes to the doctor, it belongs to relatively severe sensorineural deafness. Therefore, it is very important to implement early drug intervention and focus on prevention. Presbycusis is a process of aging and degeneration of auditory organs, but the degeneration process varies in speed and individual differences are large. Genetic factors, environmental noise, blood changes and vascular reactions, metabolic disorders, diet and nutrition, living conditions, labor intensity, climate change, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K31/047A61P27/16
CPCA61K38/08A61K31/047
Inventor 庄焕迪王伟峰
Owner 徐州诺克非医药科技有限公司
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