Medicine composition for preventing and treating presbycusis
A composition and senile technology, applied in the field of medicine, can solve the problems of long course of disease, difficult observation and follow-up in clinical research, etc., achieve good therapeutic effect and eliminate the effect of mast cell activation
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[0012] The above description is only an overview of the technical solution of the present invention. In order to understand the technical means of the present invention more clearly and implement it according to the content of the description and conventional technical means in the field, the animal test examples of the present invention will be further described in detail below .
[0013] The preparation method of the compound Trefolane A involved in the present invention can be found in the literature (Trefolanes A–D with aDiterpene-Sesquiterpene Skeleton from Supercritical Fluid Extracts of Helianthus annuus L.var.AriannaOrg.Lett., 2015, 17(19), 4730–4733).
[0014] Antitide, CAS: 112568-12-4, is available in the market.
[0015] Modeling: newborn clean-grade mice, male, the ambient temperature of the animal room is 27°C-30°C, and the humidity is 35%-45%. 210 mice were randomly divided into 21 groups, 10 in each group, divided into 20 groups of drug administration and one ...
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