38 results about "Senile deafness" patented technology

The invention relates to methods for the prevention and / or treatment of tinnitus induced by cochlear excitotoxicity. In these methods, a pharmaceutical composition comprising an NMDA receptor antagonist is administered to an individual in need of such treatment by appropriate devices and / or formulations for local administration to the inner ear. The tinnitus to be prevented and / or treated may be provoked by acoustic trauma, presbycusis, ischemia, anoxia, sudden deafness, or other cochlear excitotoxic-inducing occurrence.

The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.

The invention relates to methods for the prevention and / or treatment of tinnitus induced by cochlear excitotoxicity. In these methods, a pharmaceutical composition comprising an NMDA receptor antagonist is administered to an individual in need of such treatment by appropriate devices and / or formulations for local administration to the inner ear. The tinnitus to be prevented and / or treated may be provoked by acoustic trauma, presbycusis, ischemia, anoxia, treatment with one or more ototoxic medications, sudden deafness, or other cochlear excitotoxic-inducing occurrence. The invention also relates to method for the identification of compounds effective in the treatment and prevention of tinnitus by a novel screening method incorporating an electrophysiological test method.

The invention relates to methods for the prevention and / or treatment of tinnitus induced by cochlear excitotoxicity. In these methods, a pharmaceutical composition comprising an NMDA receptor antagonist is administered to an individual in need of such treatment by appropriate devices and / or formulations for local administration to the inner ear. The tinnitus to be prevented and / or treated may be provoked by acoustic trauma, presbycusis, ischemia, anoxia, treatment with one or more ototoxic medications, sudden deafness, or other cochlear excitotoxic-inducing occurrence. The invention also relates to method for the identification of compounds effective in the treatment and prevention of tinnitus by a novel screening method incorporating an electrophysiological test method.

The present invention relates to compositions and methods for treating neurodegenerative diseases. In some embodiments, the present invention provides compositions for treating and preventing presbycusis.

The invention relates to a Chinese medicament for curing sudden deafness and tinnitus, which adopts the following technical scheme that: the Chinese medicament is prepared from the following raw material medicaments in part by weight: 15 to 25 parts of rehmannia glutinosa, 10 to 20 parts of root of rehmannia, 5 to 15 parts of common yam rhizome, 5 to 15 parts of common macrocarpium fruit, 10 to 20 parts of siberian solomonseal rhizome, 10 to 20 parts of himalayan teasel root, 5 to 15 parts of cortex moutan, 5 to 15 parts of oriental waterplantain rhizome, 10 to 15 parts of Indian buead, 5 to 15 parts of golden thread, 15 to 25 parts of spiny jujube kernel, 15 to 25 parts of magnetite, 10 to 20 parts of dragon's bone, 10 to 20 parts of oyster, 5 to 15 parts of akebia stem and 5 to 15 parts of thinleaf milkwort root-bark. The Chinese medicament can relieve and eliminate the pain caused by the sudden deafness for patients and has good curative effect and no side effect.

Electronics for altering the audio frequency response of a micro-speaker without modifying the micro-speaker itself are used to provide a selected frequency response of the micro-speaker. The micro-speaker has a resonant peak region, from which the response declines for both higher and lower frequencies. In one embodiment the electronics includes a first circuit for modifying the frequency response curve up to the resonant peak region, and a second circuit for modifying the frequency response curve for audio frequencies higher than this region. Each filter yields an integer multiple of 6 dB per octave slope. In the described embodiment, for approximately correcting presbyacusis (age related hearing loss), a set of high pass filters, low pass filters, and / or high order filters are connected to the micro-speaker to progressively attenuate the frequency response curve as the frequency decreases from 10000 Hz to 100 Hz.

The present invention concerns peptides and nucleic acids encoding the peptides, and their use for modulating large conductance Ca2+ activated K+ (BK) channel activity in cells; for treating conditions such as presbycusis (age-related hearing loss), audiogenic seizures, alcohol addiction, cancer, and neurodegenerative disease; and for delivering a cargo moiety to the brain of a subject through the blood-brain barrier.

The present invention relates to a traditional Chinese medicine for treating deafness, in particular to a Chinese traditional patent medicine which is prepared by taking the Chinese herbal medicines as the pharmaceutical raw materials and is suitable for both internal application and external application. The present invention includes the pharmaceutical raw materials with the following parts by weight: 3 to 7 parts of Szechuan lovage rhizome, 3 to 7 parts of earthworm and 2 to 7 parts of grassleaf sweelflag rhizome. The pharmaceutical raw materials can be added with 0.05 to 0.5 part of musk, 0.05 to 0.5 part of borneol, the externally applied medicine can also be added with 2 to 7 parts of common monkshood mother root and 0.5 to 1.5 parts of magnetite. Ointment prepared by using the scallion juice is the best form for external administration. The traditional Chinese medicine of the present invention has the effects of activating qi, activating blood circulation and dredging channel blockage, and the total effective rate for the chronic deafness, sudden deafness, traumatic deafness, explosive deafness and age related hearing loss is more than 93 percent.

The present invention relates to compositions and methods for treating neurodegenerative diseases. In some embodiments, the present invention provides compositions for treating and preventing presbycusis.

The invention relates to a traditional Chinese medicine preparation for presbycusis and a preparation method. The raw materials of the active ingredients of the traditional Chinese medicine preparation are composed of: Mutong, Kudingcha, sunflower receptacle, Gong Laozi, Abutilon, quinoa, Qingniangzi, mountain Piaoercao, rock broom, Baichang, Mopancao, wild goose fat, rosin, Zhemu white bark, Tian Nanxing and Bamboo leaf ginseng; the traditional Chinese medicine preparation of the present invention has the functions of invigorating the kidney, protecting the liver, nourishing the heart and strengthening the brain, clearing the meridians and opening the orifices, dispelling wind, clearing heat and detoxifying It can reduce the pressure of blood vessels in the ear and promote the blood circulation in the ear, so as to achieve a unique therapeutic effect, and achieve the purpose of treating both the symptoms and the root causes of deafness; the traditional Chinese medicine preparation of the present invention is used for the treatment of presbycusis, which conforms to the theory of traditional Chinese medicine and modern pharmacological research. The selected medicinal materials are suitable for compatibility, obvious curative effect, high safety performance, no side effects and low price, and are worthy of widespread application.

The present invention provides compositions and methods for preventing and treating presbycusis. In particular, the present invention provides compositions and methods for preventing and treating presbycusis by inhibiting Bak.