39 results about "Senile deafness" patented technology

The invention belongs to the technical field of biological medicines, and particularly relates to application of butyric acid-producing enteromonas in prevention and treatment of senile deafness. It is found for the first time that the butyric acid producing enteromonas sp. Has a remarkable hearing protection effect in a senile deafness model; the action mechanism is mainly embodied in that by improving hearing threshold rise caused by aging, the structural integrity of cochlea hair cells is partially protected to relieve arrangement disorder and deletion of outer hair cells, and the number of inner ear spiral neuron ganglions and vascular stripe aging cells is effectively reduced; meanwhile, the high expression of Pvalb key genes and Parvalbumin in neurons and hair cells of spiral ganglions is up-regulated, so that the synergistic effect is achieved by enhancing the sound transmission muscle efficiency of the middle ear, improving the blood vessel microcirculation of the inner ear, stabilizing the hair cytoskeleton and protecting nerves. The invention provides a new candidate strain resource and an intervention target for preventing and treating senile deafness, and has important clinical application prospect and social value.