36 results about "Senile deafness" patented technology

The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.

The invention relates to the treatment and/or prevention of age-related hearing loss (presbycusis) with a modulator of a metabotropic glutamate receptor 7 (mGluR7).

The present invention relates to a health care wine, in particular to a health care wire which contains the traditional Chinese medicine for nourishing yin, the existing health care wines are mostly the wines for strengthening yang, which can cause the imbalance between yin and yang by excessive drinking; China has a word that yang mainly controls the organs and yin mainly controls body fluids, the excess of yang often causes qi stagnation and blood stasis, so as to cause cardiovascular diseases, hearing loss, memory impairment and alopecia. The components of the present invention include: beverage wine, each 1000 parts by weight of the beverage wine is added with 30 parts of radix rehmanniae glutinosae, 30 parts of radix rehmanniae preparata, 20 parts of common yam rhizome, 20 parts of common macrocarpium fruit, 20 parts of barbary wolfberry fruit, 15 parts of glossy privet fruit, 15 parts of tree peony bark, 20 parts of hawthorn fruit, 30 parts of tuber fleeceflower root, 30 parts of salvia, 30 parts of membranous milkvetch root, 20 parts of Chinese magnoliavine fruit, 15 parts of oriental waterplantain rhizome, 15 parts of Indian buead and 15 parts of kudzuvine root, and all the components are soaked for 25 to 40 days and then the wastes are removed. The product can be used as the health care wine for the treatment of age related hearing loss, alopecia, bad memory and the improvement of the cardiovascular adverse states.

Electronics for altering the audio frequency response of a micro-speaker without modifying the micro-speaker itself are used to provide a selected frequency response of the micro-speaker. The micro-speaker has a resonant peak region, from which the response declines for both higher and lower frequencies. In one embodiment the electronics includes a first circuit for modifying the frequency response curve up to the resonant peak region, and a second circuit for modifying the frequency response curve for audio frequencies higher than this region. Each filter yields an integer multiple of 6 dB per octave slope. In the described embodiment, for approximately correcting presbyacusis (age related hearing loss), a set of high pass filters, low pass filters, and/or high order filters are connected to the micro-speaker to progressively attenuate the frequency response curve as the frequency decreases from 10000 Hz to 100 Hz.

The present invention relates to a traditional Chinese medicine for treating deafness, in particular to a Chinese traditional patent medicine which is prepared by taking the Chinese herbal medicines as the pharmaceutical raw materials and is suitable for both internal application and external application. The present invention includes the pharmaceutical raw materials with the following parts by weight: 3 to 7 parts of Szechuan lovage rhizome, 3 to 7 parts of earthworm and 2 to 7 parts of grassleaf sweelflag rhizome. The pharmaceutical raw materials can be added with 0.05 to 0.5 part of musk, 0.05 to 0.5 part of borneol, the externally applied medicine can also be added with 2 to 7 parts of common monkshood mother root and 0.5 to 1.5 parts of magnetite. Ointment prepared by using the scallion juice is the best form for external administration. The traditional Chinese medicine of the present invention has the effects of activating qi, activating blood circulation and dredging channel blockage, and the total effective rate for the chronic deafness, sudden deafness, traumatic deafness, explosive deafness and age related hearing loss is more than 93 percent.

The present invention relates to a Chinese medicine preparation with the functions of promoting blood circulation, removing stasis, supplementing blood, nourishing blood, clearing away heat and removing toxic material, etc. for curing deefness, including senile deafness, nerve deafness, ischemic deafness, deafness due to drug intoxication, sudden deafness and other deafness due to various diseases. The Chinese medicine preparation is made up by using 24 Chinese medicinal materials of saffron, red peony root, peach kernel, Chinese angelica root, ligusticum root and others.

The invention discloses a traditional Chinese medicine for treating presbycusis, which is characterized by comprising the following medicinal materials by weight: 12-15 parts of radix rehmanniae praeparata, 12-15 parts of Chinese yam rhizome, 8-10 parts of fructus corni, 8-10 parts of the root bark of the peony tree, 8-10 parts of poria cocos, 8-10 parts of rhizoma alismatis, 8-10 parts of the fruit of Chinese magnoliavine, 12-15 parts of magnetite, 8-10 parts of rhizoma acori graminei, 12-15 parts of abutilon indicum, 8-10 parts of fructus psoraleae, 0-6 parts of Chinese knotweed root and 0-8 parts of glabrous gardneria stem. The preparation method comprises the following steps: weighing the medicinal materials, putting the medicinal materials in the container, adding 8 times amount of water, decocting for 1.5 h, and filtering; adding 6 times amount of water in the filter residue, decocting for 1 h, and filtering; mixing the filtrates, concentrating, drying, and arranging in capsule shells. Clinical experiments prove that the remarkable effect of treating the presbycusis is achieved through selecting appropriate medicinal materials and the ratio thereof, and the traditional Chinese medicine is safe, and has no toxic or side effects.

The present invention relates to compositions and methods for treating neurodegenerative diseases. In some embodiments, the present invention provides compositions for treating and preventing presbycusis.

The invention relates to a Chinese herbal preparation for presbycusis and a preparation method of the preparation. The Chinese herbal preparation comprises the following active ingredient materials: akebiaquinata, broadleaf holly leaf, sunflower disc, mahonia bealei carr, piemarker, chandali fruit, lytta caraganae, scarlet swertia herb, yichang meadow rue, rhizoma calami, honewort, duck fat, rosin, tricuspid cudrania bark, rhizoma arisaematis and bamboo leaf flavones. The Chinese herbal preparation disclosed by the invention has the effects of nourishing kidneys and protecting liver, nourishing heart and improving brain fitness, restoring menstrual flow for resuscitation, clearing away heat and toxic materials and the like, can be used for effectively relieving ear blood vessel pressure and promoting ear blood circulation, so that a special treatment effect is achieved for treating both symptoms and root causes of the presbycusis. The Chinese herbal preparation is used for treating presbycusis and conforms to the traditional Chinese medicine and modern pharmacological research theory. Besides, the Chinese herbal preparation is appropriate in selected material compatibility, remarkable in treatment effect, high in safety performance, free of side effect, low in price and worthy of wide popularization and application.

The invention relates to a traditional Chinese medicinal composition for treating presbycusis. The traditional Chinese medicinal composition is composed of the following components: by weight, 20-30 parts of eucommia, 20-30 parts of teasel root, 20-30 parts of cibotium barometz, 10-20 parts of keel, 10-20 parts of oyster, 10-20 parts of abalone shell, 10-20 parts of rhizoma Gastrodiae, 5-10 parts of cynanchum paniculatum, 5-10 parts of mulberry leaf and 5-10 parts of Bungarus Parvus. The traditional Chinese medicinal composition has a reasonable pharmaceutical formulation, is safe, has no side effect, requires low treatment cost, has a function of simultaneously treating principal and subordinate symptoms, and can be used to effectively treat presbycusis of the deficiency type of liver-yin and kidney-yin.

The invention discloses a healthcare wine for senile deafness. The healthcare wine comprises a potable spirit and is characterized in that 30 parts of prepared rehmannia root, 20 parts of hawthorn, 15 parts of the fruit of Chinese wolfberry, 30 parts of Chinese magnoliavine fruit, 20 parts of liquorice, 30 parts of polygonum multiflorum, 20 parts of dogwood, 15 parts of glossy privet fruit, 15 parts of rhizoma alismatis, 15 parts of tuckahoe, 20 parts of almond and 30 parts of walnut are added to every 1000 parts of portable spirit in parts by weight, the mixture is soaked for 30-40 days, dregs are removed from mixture, and a liquid supernatant is obtained. The healthcare wine for senile deafness is reasonable in formula and low in cost and has an adjuvant therapy effect on senile deafness and efficacies of tonifying kidney, protecting liver, nourishing heart and invigorating brain.

The invention discloses a medicine for treating presbycusis and a preparation method and belongs to the field of traditional Chinese medicines. The medicine is prepared from effective components including herb of Indian abutilon, all-grass of fourfinger rattanpalm, pink plumepoppy herb, flowers of cherokee rose, leaves of betel pepper, radix angelicae, roots of common bombax, herb of common corydalis, amur barberry roots, herba cistanches, herb of Indian kalimeris, leaves of broadleaf holly, lygodium microphyllum (Cav.) R.Br., semen sinapis, Indian stringbush roots and lucid ganoderma. The selected medicinal materials are compatible, and the medicine conforms to the traditional Chinese medicine and pharmacy and modern medicine and pharmacology theories, has effects of dispelling wind, clearing heat, tonifying qi, opening apertures, promoting the circulation of qi and reducing phlegm and has a unique curative effect of treating presbycusis; the treatment effect is remarkable, relapse does not occur after curing, the medicine is safe and has no toxic or side effect, the cost is low, a person can normally work and live in the medicine taking period, and the medicine is effective, practical and worth wide application and popularization clinically.

The invention discloses a traditional Chinese medicine composition for treating presbycusis, and belongs to the technical field of traditional Chinese medicines. Traditional Chinese medicines including roots of Schoepfia jasminodora Sieb,et Zucc., leaves, bark and roots of Viburnum odoratissimum Ker, Melochia corchorifolia L., Cardamine hirsuta L., all grass of Oxalis acetosella L., rhizome of Humata repens (L. f.) Diels, Themeda triandra Forsk. Var. Japonica (Willd. )Makino, all grass of Panzeria alashanica Kupr, Fructus Alpinae Oxyphyllae, roots of Aralia melanocarpa(Levl.)Lauener, all grass of Geum urbanum L. and raspberries which have the functions of tonifying kidneys, invigorating blood circulation, tonifying qi, replenishing essence, clearing heat and promoting diuresis are selected for pathogenesis of presbycusis according to the syndrome differentiation depending treatment theory and decocted with water into decoction, and it is proved through clinical tests that the total effective rate reaches 95.2%.

The invention discloses a medicine composition for preventing and treating presbycusis. The effective components comprise Trefolane A and antide acetate. By weight, the ratio of the Trefolane A to the antide acetate is 1:1-20:1. The medicine composition for preventing and treating the presbycusis has a good effect on prevention and treatment of the presbycusis.

The invention discloses composition for relieving presbycusis and tinnitus and a preparation method of the composition. The composition is mainly prepared from raw materials in parts by weight as follows: 3-9 parts of Chinese angelica, 3-9 parts of yine abrus, 6-10 parts of honeysuckle, 2-8 parts of kudzuvine roots, 6-10 parts of benzoin, 3-6 parts of golden thread, 4-9 parts of common dysosmatis rhizomes and roots, 10-18 parts of glossy privet fruits, 3-9 parts of herbs of tropic ageratum, 3-9 parts of Chinese yams, 6-12 parts of apples, 4-10 parts of unibract fritillary bulb, 3-6 parts of moutan bark and 12-17 parts of cassia bark. The composition completely accords with traditional Chinese medicine principles and physical and psychological characteristics of patients suffering from presbycusis, tinnitus and palpitation, different kinds of composition with different functions can be prepared according to different people on the premise that the composition abides by the general principle, and the composition mainly has the efficacy of clearing heat, facilitating sleeping and soothing nerves.

The present invention provides compositions and methods for preventing and treating presbycusis. In particular, the present invention provides compositions and methods for preventing and treating presbycusis by inhibiting Bak.

Permanent hearing loss or deafness affects about 15% of people worldwide, about 40 million in the US alone. There are currently no FDA-approved drugs on the market in the US, or anywhere in the world that prevent, treat or reverse permanent hearing loss or deafness. Age-related hearing loss (ARHL) is one of the most common forms of permanent hearing loss and deafness. ARHL is the #1 neurodegenerative disorder, #1 communication disorder, and 1 of the top 3 chronic medical conditions (along with arthritis & cardiovascular diseases) of our aged population. The incidence of ARHL is increasing due to the “Baby Boomers” reaching old age, and cumulative effects of lifetime noise exposure, and widespread use of chemotherapeutic and antibiotic drugs, which are ototoxic, or have ototoxic side effects. A new drug is disclosed to prevent or slow the progression of ARHL, based upon natural, existing FDA-approved compounds that are on the market to treat other non-ARHL biomedical problems. When given in the proper dosage the compounds have few, if any side effects, and initial evidence supports the effectiveness of the drug from in vitro experiments, and in vivo studies of aging mice, indicating is usefulness in preventing/treating one of the most pervasive forms of permanent hearing loss.

The invention discloses compound tiarella composition for presbycusis and a preparation method of the compound tiarella composition. The compound tiarella composition for the presbycusis is mainly prepared from components as follows: tiarella, phytolacca flowers, Dipterocarpus turbinatus, Sarcopyramis nepalensis, franchet peashrub flowers, sida seeds, Crotalaria ferruginea, Tofieldia divergens, Oxygraphis glacialis, wild soybeans, sweetflag nano-powder, caragana flower nano-powder, longan shell nano-powder, bayberry root nano-powder, a black sesame seed extract, a cabbage extract and a feather cockscomb seed extract. According to the traditional Chinese medicine concept, for the presbycusis, various Chinese herbal medicine raw materials or Chinese herbal medicine extracts are selected to be reasonably matched, and the prepared composition can have functions of nourishing the liver and the kidney, promoting blood circulation, promoting qi circulation, regulating qi, eliminating stagnation, inducing resuscitation and dredging collaterals, has the exact curative effect on the presbycusis, can regulate blood pressure and blood fat of old people, can perform nursing while treating the disease, protects the body health of the old people and is free of side effects and high in safety through clinical verification.