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Compositions and methods for treating neurodegenerative diseases

A technology for neurodegenerative diseases and compositions, applied in neurological diseases, sensory diseases, drug combinations, etc., can solve problems such as the development of preventive or therapeutic interventions for presbycusis

Inactive Publication Date: 2011-03-23
MARINE BIO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, no preventive or therapeutic interventions for presbycusis have been developed

Method used

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  • Compositions and methods for treating neurodegenerative diseases
  • Compositions and methods for treating neurodegenerative diseases
  • Compositions and methods for treating neurodegenerative diseases

Examples

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Embodiment 1

[0058] A. Materials and methods

[0059] 1.1. Preparation of water

[0060] Coral-treated water and control water were prepared as follows: 100 g of coral pellets were immersed in 2 L of distilled water for 24 hr, and then the pH of the water was adjusted to 8.0±0.5 using NaOH or HCl. Control water was prepared using distilled water. The pH of the control water was adjusted to 3.0 ± 0.5 using NaOH or HCl, since standard drinking water for laboratory mice is acidified water with a pH of about 3.0.

[0061] 1.2. Water composition

[0062] Calcium and magnesium contents were determined using an inductively coupled plasma optical emission spectrometer (n=3). Sodium content and potassium content were determined using an atomic absorption spectrometer (n=3). Data were examined using a two-tailed standard t-test. All data are reported as mean ± S.E.M.

[0063] 1.3. Animal and diet handling

[0064] Details of methods used to store and maintain male inbred C57BL / 6 (B6) ...

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Abstract

The present invention relates to compositions and methods for treating neurodegenerative diseases. In some embodiments, the present invention provides compositions for treating and preventing presbycusis.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application Serial No. 61 / 043,557, filed April 9, 2008, the entire contents of which are incorporated herein by reference. field of invention [0003] The present invention relates to compositions and methods for treating neurodegenerative diseases. In some embodiments, the present invention provides compositions for treating and preventing presbycusis. Background of the invention [0004] Age-related hearing loss or presbycusis poses enormous humanitarian and economic challenges to society. In the United States, it is estimated that 23% of people between the ages of 65 and 75 and 40% of people over the age of 75 have presbycusis, and the number of people with this condition is expected to increase gradually with the growth of the elderly population ( Someya et al., Neurobiol. Aging 20:1613 [2007]). [0005] Presbycusis is hearing loss that occurs gradually in most...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61P25/28A61K33/06A61K33/00
CPCA61K33/00A61K33/06A61P9/00A61P25/00A61P25/02A61P25/28A61P27/16A61K2300/00
Inventor 梁谷慎一
Owner MARINE BIO CO LTD
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