Nuclear magnetic resonance multi-spectral method for measuring hydrogen-hydrogen coupling constant of plurality of coupling networks

A technology of nuclear magnetic resonance and coupling constant, which is used in the analysis, measurement of magnetic variables, measurement devices, etc. using nuclear magnetic resonance

Inactive Publication Date: 2017-05-24
XIAMEN UNIV
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Problems solved by technology

However, this method can only measure the coupling constants in the coupled network of one selected core at a time

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  • Nuclear magnetic resonance multi-spectral method for measuring hydrogen-hydrogen coupling constant of plurality of coupling networks
  • Nuclear magnetic resonance multi-spectral method for measuring hydrogen-hydrogen coupling constant of plurality of coupling networks
  • Nuclear magnetic resonance multi-spectral method for measuring hydrogen-hydrogen coupling constant of plurality of coupling networks

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Embodiment Construction

[0029] Below in conjunction with accompanying drawing and embodiment, the present invention will be further described:

[0030] A nuclear magnetic resonance multidimensional spectroscopy method for simultaneously measuring hydrogen-hydrogen coupling constants of multiple coupling networks, the main steps of which are:

[0031] 1) collecting the NMR one-dimensional spectrum of the sample;

[0032] 2) Measure the pulse width of the 90-degree hard pulse of the sample;

[0033] 3) Determine the scope of the hydrogen spectrum that needs to be analyzed;

[0034] 4) take the central frequency of the range of the hydrogen spectrum to be analyzed as the excitation center of the soft pulse, determine the soft pulse width according to the peak interval of the hydrogen spectrum to be analyzed, and measure the power of the 180-degree soft pulse of the sample;

[0035] 5) Determine the spatial encoding gradient G 1 , to satisfy γ*G 1 *L>SW1D, where γ is the gyromagnetic ratio of the hyd...

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Abstract

The invention provides a nuclear magnetic resonance multi-spectral method for measuring the hydrogen-hydrogen coupling constant of a plurality of coupling networks. The method comprises the following steps: applying a 90 DEG hard pulse to make a magnetization vector rotate to the XY plane from the Z direction; applying a selective 180 DEG soft pulse and a magnetic field gradient in the Z direction t1 / 2 time later in order to excite different nuclei in different space positions; applying a PSYCHE module; applying gradients with the same intensity and the same direction to two sides of the PSYCHE module to disperse unwanted signals; adopting an EPSI sampling module t1 / 2 time later to obtain chemical displacement information and space position information; coupling other nuclei obtained at different layers and the nuclei excited by he 180 DEG soft pulse in the same layer to make the couplings have split peaks in indirect dimension; and measuring a corresponding J coupling constant from the split peaks.

Description

technical field [0001] The invention relates to a nuclear magnetic resonance multidimensional spectrum method, in particular to a nuclear magnetic resonance multidimensional spectrum method capable of accurately measuring hydrogen-hydrogen J coupling constants of multiple coupling networks in molecules. Background technique [0002] The interaction between spin nuclei and spin nuclei is a main information in NMR spectra, which plays an important role in molecular structure analysis. Among them, the triple bond J coupling between hydrogen and hydrogen is widely used in the study of molecular conformation because its coupling constant is related to the dihedral angle formed by the triple bond. However, the coupling constants between hydrogen and hydrogen are often submerged in one-dimensional NMR spectra due to narrow chemical shift distributions, complex split peak modes, and large spectral peak linewidths. Davy Sinnaeve from the UK proposed a PSYCHEDELIC method (Sinnaeve D,...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N24/08
CPCG01N24/08G01R33/4633G01R33/4608G01R33/4616G01R33/4625
Inventor 林雁勤曾庆陈金永陈忠
Owner XIAMEN UNIV
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