A kind of preparation method of dendrobium and sealwort ointment

Abstract

The invention discloses a caulis dendrobii and rhizoma polygonati soft extract preparation method. The method includes that fresh dendrobium stems serving as a raw material are subjected to enzymolysis, alkali and hydroboron treatment, nanofiltration membrane impurity removal, alcohol precipitation, dissolution promotion and the like to obtain dendrobium polysaccharide liquid extract; rhizoma polygonati powder serving as a raw material is subjected to extraction, styrene macroporous resin adsorption, activated carbon treatment, alcohol precipitation and the like to obtain polygonatum total polysaccharides; the two types of polysaccharides are mixed to obtain caulis dendrobii and rhizoma polygonati soft extract. The method is simple and easy in operation and suitable for industrial production and market promotion and application.

Description

technical field [0001] The invention relates to a preparation method of dendrobium and sealwort ointment. Background technique [0002] Dendrobium and Rhizoma Polygonatum have a long history of medicinal use in my country. Traditional medicine believes that Dendrobium has the effects of nourishing the five viscera, strengthening yin, and thickening the stomach after long-term use; Polygonatum has the effects of nourishing yin and moistening the lungs; nourishing the spleen and Qi, nourishing the kidneys and replenishing essence. Both medicines are yin-nourishing medicines, but they have different emphases in treating diseases, and the combined use can synergistically enhance the efficacy of medicines. Modern medical research has shown that the medicinal components of Dendrobium polysaccharides and Polygonatum polysaccharides isolated from Dendrobium and Rhizoma Polygonatum have a wide range of pharmacological activities, and have preventive effects on various diseases such ...

AI Technical Summary

Problems solved by technology

Many reports of high-purity and high-activity Dendrobium polysaccharides are mainly obtained by deproteinization with organic solvents, which are difficult to use in actual production

There are many technical bottlenecks in the actual production of high-purity polysaccharides: the strong viscosity of Dendrobium makes it difficult to dissolve the active ingredients; the polysaccharides of Dendrobium are mainly alkali-soluble polysaccharides, which dissolve slowly in water with a large molecular weight; the crude product of Dendrobium polysaccharides has a large ash content of heavy metals and is difficult to remove , acid treatment can easily destroy the polysaccharide structure while removing part of the heavy metals in the salt; conventional organic solvents such as chloroform and n-butanol are difficult to use in industrialization, and are prone to residual organic solvents. A single protein precipitant, ion exchange, etc. are very difficult It is difficult to achieve the purpose of completely removing protein; Dendrobium polysaccharides are difficult to dry in the traditional drying and vacuum drying process, and molecular polymerization is prone to occur, resulting in changes in drug properties and greatly reduced water solubility

In the process of preparing high-purity Polygonatum Polysaccharides, the traditional water extraction and alcohol precipitation method will precipitate some steroidal saponins and most gum polysaccharides, resulting in low polysaccharide purity and more invalid impurities or invalid physiologically active polysaccharides.