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Medical application of imperatorin against enteritis

A technology of imperatorin and enteritis, applied in the field of medicine, to achieve the effect of exact curative effect, improvement of inflammatory bowel disease, and clear target

Inactive Publication Date: 2018-02-23
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether imperatorin has anti-inflammatory bowel disease efficacy is unknown

Method used

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  • Medical application of imperatorin against enteritis
  • Medical application of imperatorin against enteritis
  • Medical application of imperatorin against enteritis

Examples

Experimental program
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Effect test

Embodiment Construction

[0021] Examples, see Figure 1 to Figure 7 , the present embodiment provides a medical use of imperatorin for anti-enteritis, specifically, the present invention provides an application of imperatorin in the preparation of medicine or food for preventing and treating enteritis.

[0022] The enteritis is inflammation and diarrhea caused by ulcerative colitis, chronic colitis or Crohn's disease.

[0023] 1. hPXR trans-transcriptional activation research

[0024] HCT116 colon cancer cells were planted in 10cm culture dish at 3×106 cells / ml, and after adhering to the wall, Lipofectamine 2000 reagent was used to co-transfect Flag-pCDNA3.1, Flag-pCDNA3.1-hPXR, Flag-pCDNA3.1 at the same time - After 48 hours of mPXR, pGL-CYP3A4-luc and TK-Renilla-luc, the cells were harvested, and 50 μl of cell fluid (1×104 cells) containing high, medium and low concentrations of imperatorin (6.25, 12.5 and 25 μM) of 50 μl culture solution, rifampicin (10 μM) and ketoconazole (5 μM) with or without...

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Abstract

The invention relates to the field of medicine and pharmacology, in particular to medical application of an imperatorin against enteritis. The imperatorin disclosed by the invention is used as a PXR (Pregnane X Receptor) receptor stimulant for preventing and treating inflammation, diarrhea and the like caused by ulcerative colitis, chronic colitis and crohn disease.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medical application of imperatorin. The imperatorin for treating inflammatory bowel disease of the present invention is used as a PXR receptor agonist to prevent and treat inflammation and diarrhea caused by ulcerative colitis, chronic colitis and Crohn's disease. Background technique [0002] Inflammatory bowel disease (IBD, enteritis) is quite common in western countries, and its incidence has also increased in my country in the past decade. IBD is a chronic non-specific intestinal inflammatory disease of unknown etiology, including ulcerative colitis (UC) and Crohn's disease (CD). This disease is one of the high-risk pathogenic factors inducing intestinal cancer, and has gradually developed into one of the five major epidemic diseases in the world. According to the World Health Organization, about 15% of enteritis patients eventually lead to cancer occurrence and metastasis, serious...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61P1/00A61P1/04A61P1/12A23L33/105
CPCA61K31/366A23L33/105
Inventor 刘昌辉张郭慧蔡佳仲刘美静黄小桃邹元平
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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