Antimicrobial composition having efficacy against endospores

一种组合物、孢子的技术，应用在洗涤剂组合物、pH调节组合物、洗涤组合物溶剂等方向，能够解决能力有限、不足以破坏等问题

Inactive Publication Date: 2018-04-17
NEXT SCI IP HLDG PTY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this composition has not been found to be particularly effective against spores, possibly due to a limited ability to destroy and then penetrate the spore outer shell and inner spore shell

Method used

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  • Antimicrobial composition having efficacy against endospores
  • Antimicrobial composition having efficacy against endospores
  • Antimicrobial composition having efficacy against endospores

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-2

[0127] Embodiment 1-2 contrast and comparison

[0128] A 0.01 M phosphate-buffered saline solution was prepared by adding one phosphate-buffered saline tablet (Sigma-Aldrich Corp.; St. Louis, Missouri) to 200 mL of distilled water. The solution was covered and stored at room temperature.

[0129] VIRASEPT TM Disinfectant (Ecolab USA; St. Paul, Minnesota) was kept at room temperature as purchased and used without modification.

Embodiment 3-6

[0131] Four compositions were prepared by adding each of the following ingredients (quantities in grams) to a 100 mL glass container:

[0132]

[0133] The composition also includes an electrolyte oxidizing agent (KHSO 5 ), glycosidase (lysozyme) and sodium hydroxide, the consumption (in grams) of its change is shown in the table below. Sodium hydroxide solution (50% w / v in water) was added dropwise to adjust the pH of the composition upwards to the values ​​shown in the table below.

[0134] table 5

[0135]

Example 3

Example 4

Example 5

Example 6

KHSO 5

0.8

0.8

1.0

1.0

Lysozyme

0.015

0.03

0.03

0.03

NaOH

3.75

3.75

3.75

8.33

pH

6

6

6

5

[0136] After the above pH adjustment, enough distilled water was added to bring each composition to 100 ml.

[0137] Using the procedure of ASTM E2197-11, the comparative and inventive compositions were allowed to come into contact...

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PUM

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Abstract

A sporicidal composition has a moderately low pH and includes a glycosidase and the dissocia-tion product of at least one inorganic oxidizing agent. High effective solute concentrations can enhance the efficacy of the composition. The composition can be applied to a surface and allowed to absorb into an endospore, ultimately killing at least some of those bacteria in mature endospore form. Surfaces to be treated include inanimate (hard) surfaces via cleaning and medical devices such as endoscopes, typically via immersion.

Description

[0001] Related Application Cross Reference [0002] This international application claims the benefit of U.S. Provisional Patent Application Nos. 62 / 202,644 and 62 / 212,552, filed August 7, 2015, and August 31, 2015, respectively, the disclosures of which are incorporated herein by reference. Background technique [0003] Unlike true spores, endospores are not the offspring of another organism. However, the terms "spore" and "endospore" are used interchangeably throughout this document. [0004] Vegetative bacteria are bacteria that can grow, feed and reproduce. When nutrients become scarce, certain vegetative bacteria begin a process called "spore formation," in which they adopt a reduced, dormant form that allows them to survive without nutrients and gives them resistance to ultraviolet radiation , dryness, elevated temperatures, extreme cold and resistance to chemical disinfectants. Shortly after environmental conditions return to favor vegetative growth, the bacteria are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11D3/02
CPCA01N37/46A01N59/00C11D1/02C11D1/83C11D1/835C11D1/94C11D3/0047C11D3/046C11D3/2068C11D3/2075C11D3/38618C11D3/38636C11D3/38645C11D3/43C11D3/48A01N25/30A01N37/02
Inventor 马修·F·米恩笛
Owner NEXT SCI IP HLDG PTY LTD
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