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Composition marker for ovarian cancer detection and application of composition marker for ovarian cancer detection

A marker and ovarian cancer technology, applied in the field of biomedicine, can solve problems such as threats to women's lives

Inactive Publication Date: 2018-05-15
上海阿趣生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the mortality rate of ovarian epithelial cancer ranks first in all kinds of gynecological tumors, posing a serious threat to women's lives

Method used

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  • Composition marker for ovarian cancer detection and application of composition marker for ovarian cancer detection

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Embodiment

[0015] see figure 1 , the present invention is based at least in part on the discovery of markers associated with the development of ovarian cancer and the response to treatment in subjects with ovarian cancer. Accordingly, the present invention provides methods and kits for predicting whether a subject has or will develop ovarian cancer by measuring and identifying specific marker combinations.

[0016] Accordingly, the present invention provides the combined markers guanosine-5-phosphate, histamine, phenyllactic acid, 3-oxo-methylguanosine for use in determining whether a subject has or will develop ovarian cancer.

[0017] In another aspect, the invention provides methods for inhibiting the development of ovarian cancer in a subject. The method includes administering to the subject an effective amount of an agent that modulates the expression and / or activity of various markers of the invention, thereby inhibiting the development of ovarian cancer in the subject.

[0018] ...

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Abstract

The invention provides a composition marker for determining whether subjects have ovarian cancers or potential ovarian cancers or not. The composition marker comprises 5-guanosine phosphate, histamine, phenyllactic acid and 3-oxo-methylguanosine, and diagnosis sensitivity reaches 86.36%.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a combination marker of ovarian cancer. Background technique [0002] A biomarker is an indicator that can objectively measure and evaluate normal biological processes, pathological processes, or responses to drug interventions. It is also an important early warning indicator when organisms are damaged. Changes, abnormal performance of physiological activities, abnormal changes of individuals, groups or the entire ecosystem, etc. [0003] Ovarian cancer is one of the common malignant tumors of female reproductive organs, and its incidence ranks third after cervical cancer and uterine body cancer. However, the mortality rate of epithelial ovarian cancer ranks first in all types of gynecological tumors, posing a serious threat to women's lives. Due to the complex embryonic development, tissue anatomy and endocrine function of the ovary, and the atypical early symptoms, it is quite diff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/57449
Inventor 吴洪强邓军亮楼格尔
Owner 上海阿趣生物科技有限公司