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A kind of composition for replacing Xanthium japonica to prepare prostate cancer treatment medicine and determination method thereof

A technology for treating prostate cancer and drugs, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc.

Active Publication Date: 2018-12-25
徐州馨予康建材有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, it is not known which combination of these ingredients can basically replace the medicinal effect of Xanthium

Method used

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  • A kind of composition for replacing Xanthium japonica to prepare prostate cancer treatment medicine and determination method thereof
  • A kind of composition for replacing Xanthium japonica to prepare prostate cancer treatment medicine and determination method thereof
  • A kind of composition for replacing Xanthium japonica to prepare prostate cancer treatment medicine and determination method thereof

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Embodiment Construction

[0046] The substantive content of the present invention will be described in detail below in conjunction with the accompanying drawings and embodiments, but the protection scope of the present invention is not limited thereto.

[0047] 1. Experimental materials

[0048] The cocklebur medicinal material was purchased from Bozhou medicinal material market, and its origin was Benxi, Liaoning. After being pulverized, it was dried at 55°C overnight, and dried and stored for later use.

[0049] Agilent 1100 liquid chromatograph; Sartorius BS210S electronic balance, Beijing Sartorius Instrument System Co., Ltd.; Sartorius CP225D electronic balance, Beijing Sartorius Instrument System Co., Ltd.; acetonitrile (chromatographically pure) and methanol (chromatographically pure) were purchased from TEDIA; the water is Wahaha purified water.

[0050] RNAiso plus reagent, SYBRGreen PCRMaster Mix and PrimeScript RT kit were purchased from TaKaRa.

[0051] 2. Experimental method

[0052] 1....

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Abstract

The invention discloses a composition for preparing a medicine for treating prostate cancer instead of Siberian cocklebur fruits and a measuring method thereof. The composition prepared from neochlorogenic acid, cryptochlorogenic acid, thiazine diketoside, 1,5-dicaffeoylquinic acid and 4,5-dicaffeoylquinic acid basically can equivalently replace the Siberian cocklebur fruits in the inhibiting effect on AMPK gene expression, and the composition and the Siberian cocklebur fruits have the equivalent strength. The composition can equivalently replace the Siberian cocklebur fruits to prepare an AMPK gene expression inhibitor. Technicians in the field know that proliferation of prostate cancer cells can be effectively inhibited by inhibiting AMPK gene expression (influence of AMPK silencing by RNA interference in biological behavior of prostate cancer cells, Chinese Journal of Cancer Prevention and Treatment, Volume 25, Issue 2, January 2018), so that the composition can equivalently replacethe Siberian cocklebur fruits to prepare the medicine for treating prostate cancer.

Description

technical field [0001] The invention relates to a composition used to replace cocklebur seeds to prepare tumor therapeutic drugs and a determination method thereof. Background technique [0002] Fructus Xanthii (Fructus Xanthii) is the dry and mature fruit with seed coat of Xanthium sibiricum Patr. et Widd., which has the effects of dispelling wind and dehumidification, clearing the nose and resuscitation. Modern studies have shown that it has a therapeutic effect on tumors. [0003] The use of fruit as medicine has the disadvantages of complex components, unclear medicinal components, and difficult quality control. If a composition that can replace the Xanthium as medicine can be found, the chemically blended product can be used instead of the Xanthium as medicine, and the composition is clear and the quality is controllable. [0004] Xanthium mainly contains neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, thiazidediketone glycoside, 1,5-dicaffeoylquinic ac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/216A61K31/7042A61P35/00G01N30/02
CPCA61K31/216A61K31/7042A61P35/00G01N30/02A61K2300/00
Inventor 杨真慧
Owner 徐州馨予康建材有限公司
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