A kind of hydrogel transdermal patch containing multiple pure plant extract oils and preparation method thereof

A hydrogel transdermal patch and oil extraction technology, which is applied in the field of traditional Chinese medicine patches, can solve the problems of low content of drug ingredients, insufficient cross-linking reaction, poor blood circulation effect, etc., to increase heat and blood circulation, effectively Good for absorption and strong affinity

Active Publication Date: 2021-05-11
张文涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the existing gel patches in the market use PVPK30 or Carbomer 930 single-molecule low-density material as the cross-linked body of the gel layer molecules. Because of the small molecular weight, the cross-linking reaction is insufficient and the stability is not good. The drug is single and the amount of addition is low, which may easily cause the finished patch to contain low drug ingredients, the effect of promoting blood circulation is not good, the adhesion is low, and it is easy to fall off

Method used

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  • A kind of hydrogel transdermal patch containing multiple pure plant extract oils and preparation method thereof
  • A kind of hydrogel transdermal patch containing multiple pure plant extract oils and preparation method thereof
  • A kind of hydrogel transdermal patch containing multiple pure plant extract oils and preparation method thereof

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Effect test

Embodiment 1

[0070] A hydrogel transdermal patch containing a variety of pure plant extract oils, comprising a gel layer, an isolation film on the surface of the gel layer and a backing cloth on the back of the gel layer, the gel layer is prepared from the following raw materials in parts by weight Obtained: pure plant extract oil: 100g; Carbomer 940: 25g; NP800: 25g; Glycerol: 225g; ; Pure water: 475g. The pure plant extract oil includes the following components in grams by weight: white mustard seed extract oil: 22.5g; cinnamon extract oil: 10g; ginger extract oil: 11g; saffron extract oil: 15g; mint extract oil: 14g; yellow mustard seed extract Oil: 27.5 g.

[0071] The preparation method of the above-mentioned hydrogel transdermal patch containing various pure plant extract oils comprises the following steps:

[0072] S1: Take pure water, add tartaric acid and stir evenly, then add PVPK90 for stirring, and stir again to obtain mixture A;

[0073] S2: Take glycerin and add NP800 to s...

Embodiment 2

[0078] A hydrogel transdermal patch containing a variety of pure plant extract oils, comprising a gel layer, an isolation film on the surface of the gel layer and a backing cloth on the back of the gel layer, the gel layer is prepared from the following raw materials in parts by weight Obtained: pure plant extract oil: 90g; Carbomer 940: 10g; NP800: 25g; Glycerin: 160g; ; Pure water: 400g. The pure plant extract oil includes the following components by weight: white mustard seed extract oil: 20g; cinnamon extract oil: 10g; ginger extract oil: 10g; saffron extract oil: 15g; peppermint extract oil: 10g; yellow mustard seed extract oil : 25g.

[0079] The preparation method of the above-mentioned hydrogel transdermal patch containing various pure plant extract oils comprises the following steps:

[0080] S1: Take pure water, add tartaric acid and stir evenly, then add PVPK90 for stirring, and stir again to obtain mixture A;

[0081] S2: Take glycerin and add NP800 to stir, aft...

Embodiment 3

[0086] A hydrogel transdermal patch containing a variety of pure plant extract oils, comprising a gel layer, an isolation film on the surface of the gel layer and a backing cloth on the back of the gel layer, the gel layer is prepared from the following raw materials in parts by weight Obtained: pure plant extract oil: 70g; Carbomer 940: 10g; NP800: 20g; Glycerol: 150g; g; pure water: 400g. The pure plant extract oil includes the following components in grams by weight: white mustard seed extract oil: 20g; cinnamon extract oil: 5g; ginger extract oil: 5g; saffron extract oil: 10g; peppermint extract oil: 5g; yellow mustard seed extract oil : 25g.

[0087] The preparation method of the above-mentioned hydrogel transdermal patch containing various pure plant extract oils comprises the following steps:

[0088] S1: Take pure water, add tartaric acid and stir evenly, then add PVPK90 for stirring, and stir again to obtain mixture A;

[0089] S2: Take glycerin and add NP800 to st...

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Abstract

The invention provides a hydrogel transdermal patch containing various pure plant extract oils and a preparation method thereof, comprising a gel layer, an isolation film on the surface of the gel layer and a backing cloth on the back of the gel layer, and the gel layer is composed of Prepared from raw materials including the following parts by weight: pure plant extract oil: 14-30 parts; Carbomer 940: 2-5 parts; NP800: 4-7 parts; glycerol: 30-50 parts; : 4‑9 parts; PVPK90: 10‑30 parts; tartaric acid: 2‑9 parts; ethanol: 20‑30 parts; EDTA‑2Na: 6‑16 parts; pure water: 80‑100 parts. The hydrogel transdermal patch of the present invention improves the sticking degree of the hydrogel transdermal patch, the paste is firm, the colloid stability is high, and the product is more delicate, and the hydrogel transdermal patch also increases the plant components while increasing the viscosity of loading. By adding a variety of plants for promoting blood circulation, reducing swelling and relieving pain into the raw materials of the gel layer, the heat-activating and blood-activating properties of the product are increased, and the application effect and application time of the product of the present invention are improved.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine patches, in particular to a hydrogel transdermal patch containing various pure plant extract oils and a preparation method thereof. Background technique [0002] Hydrogel patch is a new type of external application agent with high technological content, wide application range and convenient use in the world today. In the early 1970s, countries such as Japan and Europe began to develop medical hydrogel patches. With the continuous development of the pharmaceutical industry, this new dosage form has developed in my country in recent years. The hydrogel patch matrix has a large amount of drug loading, strong moisture retention, good compatibility with the skin, and is resistant to aging. It can be peeled off repeatedly, and the administration can be terminated at any time. The dosage is accurate, and the blood drug concentration is balanced without peaks and valleys, which can reduce toxic...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K9/70A61K47/32A61K36/9068A61P29/00
CPCA61K9/7023A61K36/31A61K36/534A61K36/54A61K36/88A61K36/9068A61K47/32A61P29/00A61K2300/00
Inventor张文涛万楠楠
Owner张文涛