Method and system for early risk assessment of preterm delivery outcome

A risky and microbial technology, applied in the direction of biochemical equipment and methods, applications, pharmaceutical formulations, etc., can solve problems such as inapplicability and inconvenience

Active Publication Date: 2018-11-09
TATA CONSULTANCY SERVICES LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, reliance on the indicators discussed above makes this diagnostic technique inappropriate for first-time pregnancies or for preterm outcomes not driven by known risk factors (i.e., vaginal infection and/or "fetal/uterine" abnormalities)
Additionally, some existing diagnostic methods require sampling techniques that are invasive in nature,

Method used

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  • Method and system for early risk assessment of preterm delivery outcome
  • Method and system for early risk assessment of preterm delivery outcome
  • Method and system for early risk assessment of preterm delivery outcome

Examples

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Embodiment Construction

[0026] Embodiments herein and their various features and advantageous details are explained more fully with reference to the non-limiting embodiments illustrated in the drawings and detailed in the following description. The examples used herein are intended merely to facilitate an understanding of ways in which the embodiments herein may be practiced and to further enable those skilled in the art to practice the embodiments herein. Therefore, these examples should not be construed as limiting the scope of the embodiments herein.

[0027] According to one embodiment, a system and method for assessing a pregnant subject's risk of preterm delivery (PTD) is disclosed. In one aspect, systems and methods for qualitative and quantitative assessment of a pregnant woman's risk of preterm delivery (PTD) are disclosed. More specifically, systems and methods for assessing PTD risk by analyzing microbiome samples obtained from pregnant subjects within the first 15 weeks of pregnancy or w...

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Abstract

System and method for assessing preterm delivery risk for pregnant subject is disclosed. Existing preterm delivery risk assessment methods provide results in late second or third trimester of pregnancy, so little time is available for medical advice. Presently disclosed method and system predict preterm delivery risk within 15 weeks of pregnancy. Microbiome characterization data obtained from microbiome sample from pregnant subject. 'Microbial taxonomic abundance profile' generated from microbiome characterization data, contains abundance values of microbes present in the microbiome sample. 'Taxonomic Composition Skew' value, and distribution characteristic value for 'microbial taxonomic abundance profile', quantifying biases in abundance values of microbes from the microbial taxonomic abundance profile, is computed. Risk of preterm delivery is determined based on the distribution characteristic value or 'taxonomic composition skew' value of the set DSR, wherein the set DSR comprises values quantifying biases in the abundance values of microbes from the microbiome sample.

Description

[0001] Cross References to Related Applications [0002] This application claims priority from Indian Provisional Patent Application No. 201621005426 filed on February 16, 2016, the entirety of which is hereby incorporated by reference. technical field [0003] Embodiments described herein relate generally to methods and systems for risk assessment of preterm birth outcomes in pregnant subjects, and more specifically to microbiome-based methods for early risk assessment of preterm birth outcomes in pregnant subjects. Background technique [0004] According to recent estimates by the World Health Organization (WHO), preterm birth (ie, birth before the 37th full week of gestation) is the leading cause of neonatal death worldwide. More children die from complications related to preterm birth than from diarrhea, malaria or AIDS. Preterm birth (PTD) cases are observed in 5%-18% of total pregnancies (www.who.int / mediacentre / factsheets / fs363 / en / ). Prenatal and / or postnatal costs ...

Claims

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Application Information

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IPC IPC(8): A61K31/702C12Q1/6883G01N33/53G01N33/68A61B34/10G16B25/10G16B30/00G16B40/20
CPCC12Q1/6883C12Q1/689C12Q2600/158G16B25/10A61B5/4343G16B40/00Y02A90/10G16B30/00G16B40/20G16H50/30
Inventor 沙尔米拉·谢卡尔·曼德穆罕默德·蒙佐尔·哈克阿尼班·杜塔尼什尔·库马尔·平纳米塔利·麦钱特
Owner TATA CONSULTANCY SERVICES LTD
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