Application of acidoglycoprotein ORM in preparing drugs for treating cardiac failure
A technology of acid glycoprotein and heart failure, which is applied in the field of medicine to achieve high safety effects
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Embodiment 1
[0025] Example 1: Effect of ORM administration on cardiac function in mice with ischemic heart failure
[0026] 1. Method:
[0027] 1. Construction of ischemic heart failure model
[0028] After isoflurane anesthesia, the endotracheal tube was connected to a ventilator to control breathing. Clean surgery was performed under a binocular microscope, and the left fourth intercostal space was opened to expose the left atrial appendage and left ventricle. Under the microscope, the left coronary artery can be seen running downward from the middle of the left atrial appendage edge to the front wall of the left ventricle, and the coronary artery is sutured at a high position about 1mm below the left atrial appendage. After ligation, the myocardium gradually changes from red to pale. ST-segment arched and elevated. The chest was closed layer by layer. After the spontaneous breathing of the mice recovered, the endotracheal tubes were pulled out, caged, fed in a day and night cycle, a...
Embodiment 2
[0033] Example 2: Effect of ORM Administration on Cardiac Function of Isoproterenol-Induced Heart Failure Mice
[0034] 1. Method:
[0035] 1. Construction of isoproterenol drug-induced heart failure mouse model
[0036] Isoproterenol 5 mg / kg / d mice were injected intraperitoneally for 15 days to prepare the isoproterenol-induced heart failure model, and the experiments were carried out after 4 weeks of feeding.
[0037] 2. Cardiac ultrasound
[0038] The method is the same as above.
[0039] 2. Results:
[0040] Such as Figure 2A-Figure 2D As shown, after ORM administration, the ejection fraction EF, short-axis shortening rate FS and stroke volume SV of heart failure mice increased gradually compared with those before administration, and the most significant was at 60 minutes. Cedilan significantly increased EF and FS at 30 minutes, but returned to the level before administration at 60 minutes. * indicates that there is a significant statistical difference compared with...
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