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An interferon-related kit for evaluating prognosis and predicting chemotherapy efficacy in gliomas

A glioma and interferon technology, applied in the professional field of biomedicine, has achieved strong clinical transformation value, stable prediction ability, and improved prognosis accuracy

Active Publication Date: 2019-01-11
THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the kit used for the interferon prognosis evaluation model in glioma

Method used

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  • An interferon-related kit for evaluating prognosis and predicting chemotherapy efficacy in gliomas
  • An interferon-related kit for evaluating prognosis and predicting chemotherapy efficacy in gliomas
  • An interferon-related kit for evaluating prognosis and predicting chemotherapy efficacy in gliomas

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Embodiment Construction

[0030] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0031] Example.

[0032] 1. Description of interferon status in glioma and establishment of interferon-related models in GBM.

[0033] In order to explore the difference of interferon response between LGG and GBM, the inventors performed gene set variation analysis (GSVA) ​​analysis based on a series of interferon-related reactions. The results showed that interferon-related pathways were significantly enriched in GBM, suggesting that the interferon state was more active in GBM ( figure 1 A). In order to explore the prognostic value of interferon-related genes in GBM patients, the present invention selected 132 genes directly related to interferon. Through univariate COX regression analysis, the present invention screened five potential prognostic genes (SOCS3, ISG20, IFIT5, NLRC5 and IRF9). Among them, SOCS3 and ISG20 are risk genes (HR>1), while...

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Abstract

The invention relates to the biomedical professional field, in particular to an interferon-related kit for evaluating prognosis and predicting chemotherapy effect in gliomas. The present invention describes for the first time the state of interferon in gliomas, the first interferon-related model in glioma is established, The model is transformed into a kit to distinguish the status of interferon,to guide the diagnosis of glioma, to predict the poor prognosis and chemosensitivity, and to explain the instability of interferon therapy in glioma, and to provide constructive guidance strategy forfinding the best subset of patients suitable for interferon therapy.

Description

technical field [0001] The invention belongs to the professional field of biomedicine, and in particular relates to an interferon-related kit used for prognosis evaluation and chemotherapy effect prediction in glioma. Background technique [0002] Glioblastoma (GBM) is the most common and malignant tumor of the central nervous system. Even with standardized treatment, the median survival time of GBM patients is only 14 months. Recent studies have confirmed that aberrant immune response is an important driving force for the malignant progression of glioma. The inventors found that overactivated immune response and abnormal immune microenvironment can promote the malignant progression and treatment resistance of glioma. As an important component of regulating immune response, interferon mainly depends on the cytotoxic effect of activating antigen-producing cells and immune effector cells. Although interferon therapy is widely used in clinical research in tumors including gli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/166
Inventor 吴安华程文朱晨邹存义管格非
Owner THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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