Aggregation-inducing luminophores for cancer cell imaging

A technology of aggregation-induced luminescence and luminescence, applied in the field of luminescence, which can solve problems such as interference with binding affinity

Active Publication Date: 2021-07-23
THE HONG KONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this high labeling ratio may interfere with binding affinity

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  • Aggregation-inducing luminophores for cancer cell imaging
  • Aggregation-inducing luminophores for cancer cell imaging
  • Aggregation-inducing luminophores for cancer cell imaging

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[0066] definition

[0067] The following definitions are provided to aid in the understanding of this application and the appended claims.

[0068] It should be noted that, as used in this specification and the appended claims, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.

[0069] "Aggregation-induced emission", or AIE, refers to the activation of fluorescence / phosphorescence upon formation of aggregates or solid states. The material is non-luminescent when the molecules are dissolved, but luminescent when the intramolecular rotation is restricted.

[0070] "Emission intensity" refers to the intensity of fluorescence / phosphorescence usually measured by a fluorescence spectrometer or a fluorescence microscope; "fluorophore" or "fluorophore" refers to a molecule that exhibits fluorescence; Molecules; "AIEgen" refers to molecules with AIE properties.

[0071] Unless otherwise defined, all technical and scientifi...

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Abstract

The present application relates to emitters exhibiting aggregation-induced luminescence, wherein T1, T2 and T3 comprise one or more polyynes as conjugate bridges. The present application also relates to an AIEgen comprising: a hydrophilic pyridyl group as a strong electron-withdrawing group; a piperazine group and an α-cyano-stilbene as an electron-donating group; wherein the AIEgen exhibits aggregation induced luminescence. The present application also relates to a method for synthesizing AIEgen, and further relates to a labeling method, the method comprising: incubating an object having cells with a conjugate formed by conjugating AIEgen with an antibody; and selecting by light-up imaging Target cells are selectively stained by AIEgen's fluorescence emission based on antibody degradation following cellular internalization of the conjugate through endocytosis.

Description

[0001] Instructions for application [0002] This patent application claims priority to Provisional U.S. Patent Application No. 62 / 493,902, filed July 21, 2016, and Provisional U.S. Patent Application No. 62 / 495,029, filed August 31, 2016, which were filed by the present inventors and which The entire content of is incorporated herein by reference. technical field [0003] The present application relates to water-soluble aggregation-induced luminescent (AIEgens) for cancer cell imaging, especially AIEgens for antibody labeling. This application relates to strategies for designing red-emitting or near-infrared (NIR) emitting AIEgens, and the application of AIEgens in targeted imaging of cancer cells. Background technique [0004] Organic dyes with red emission are advantageous in many fields, such as organic light-emitting diodes (OLEDs), fluorescence imaging, and anti-counterfeiting technology, among others. For example, fluorescence imaging, as a biocompatible imaging tec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64G01N33/53C09K11/06C12Q1/04
CPCC09K11/06G01N33/533G01N33/582A61N5/06C07D221/14C07D213/57C07C211/43C07D401/12C07D285/14C09K2211/1007C09K2211/1018
Inventor 唐本忠石秀娟余义勇郭子健赵征张鹏飞苏会芳
Owner THE HONG KONG UNIV OF SCI & TECH
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