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Application of cucurbit[7]uril

A seven-membered melon ring, blood anticoagulant technology, applied in medical preparations containing active ingredients, blood diseases, extracellular fluid diseases, etc.

Active Publication Date: 2019-03-08
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pharmacological effects of melon ring itself have not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0012] Example: Anticoagulant activity test of the seven-membered melon ring

[0013] (1) Sample preparation

[0014] Weigh 1 mg of the seven-membered melon ring and dissolve it in 200 μL of normal saline to prepare a solution with a concentration of 5 mg / mL, and accurately weigh 8 mg of scutellarin and dissolve it in 600 μL of normal saline to prepare a solution with a concentration of 13.33 mg / mL. Accurately weigh 1 mg of Yunnan Baiyao and dissolve it in 200 μL of normal saline to obtain a solution with a concentration of 5 mg / mL, and prepare a blank solvent control group at the same time. Rabbits were used as experimental animals, and then the PT detection kits, APPT detection kits, TT detection kits, and FIB content detection kits were used for determination.

[0015] Take 3.6 mL of blood from the ear vein of male rex rabbits, place it in a centrifuge tube containing 400 μL (0.109 mol / L) of sodium citrate, mix gently, centrifuge at 3000 rpm for 15 min, and take the supern...

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PUM

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Abstract

The invention discloses application of cucurbit[7]uril in a blood anticoagulation medicine.

Description

technical field [0001] The invention relates to the application of a seven-membered melon ring, in particular to the application of the seven-membered melon ring in anticoagulation. Background technique [0002] Seven-membered melon rings (Cucurbit[7]urils), also known as cucurbit[7]urils, are macrocyclic cages with special hydrophobic cages and hydrophilic ports connected by glycoside urea units through methylene bridges. compound. Cucurbit rings can form stable host-guest inclusion complexes with a variety of inorganic or organic molecules through weak non-covalent interactions such as cage interactions, hydrogen bonds, van der Waals forces, and ionic dipoles. Domestic and foreign studies have shown that cucurbit rings are It is non-toxic and can be used as a safe drug carrier. However, the pharmacological effects of melon ring itself have not been reported. [0003] Cardiovascular and cerebrovascular diseases are collectively referred to as cardiovascular diseases and ...

Claims

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Application Information

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IPC IPC(8): A61K31/4188A61P7/02
CPCA61K31/4188A61P7/02
Inventor 张前军陶朱黄净净谢军曾智书
Owner GUIZHOU UNIV
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