Multilayer tablet drug controlled release system optimization method and system

Abstract

The invention discloses a multilayer tablet drug controlled release system optimization method and system. The method comprises the following steps: acquiring a multilayer tablet drug controlled release system; establishing a mathematical model according to the multilayer tablet drug controlled release system; transforming an optimization problem of a drug release behavior into inverse problem solving on the basis of a mathematical physics inverse problem framework according to the mathematical model so as to obtain a first type of Fredholm integral equations; performing discrete processing onthe integral equations so as to obtain a system of linear algebraic equations; solving by a regularization method to obtain a solution according to the system of linear algebraic equations; determining the multilayer tablet drug controlled release system optimization scheme according to the solution. According to the method or system disclosed by the invention, parameters can be accurately predicted.

Description

technical field [0001] The invention relates to the field of optimization control of drug release behavior, in particular to an optimization method and system for a multilayer flat drug release system. Background technique [0002] The controllable release system can regulate the release of active substances according to needs, and then maintain the target concentration of active substances at different times. In recent years, this technology has been widely used in many fields such as medicine, food and cosmetics because of its safe and effective characteristics. Especially in the field of medicine, the controllable release system has become a hot research direction. The drug release behavior usually presents the phenomenon of "burst release" first and then diffusion according to first-order kinetics. The so-called "burst release" means that the release rate is very high at the initial stage of release, and then the release rate decreases rapidly. The "burst release" effe...

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Problems solved by technology

[0005] Obviously, in the existing technical solutions, researchers only regard it as a simple optimization problem. Using traditional optimization methods to solve it, not only the solution effect is unsatisfactory, but also cannot give a complete mathematical proof theoretically.

For the optimization of parameters in the multi-layer flat drug controlled release system, the previous methods are often unable to accurately predict the parameters, and the complexity is high and the randomness is relatively large

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