Acanthopanax trifoliatus polysaccharide, preparation method thereof, and application of Acanthopanax trifoliatus polysaccharide in preparation of antitumor drugs

Abstract

The invention discloses an Acanthopanax trifoliatus polysaccharide, a preparation method thereof, and an application of the Acanthopanax trifoliatus polysaccharide in the preparation of antitumor drugs. The Acanthopanax trifoliatus polysaccharide has a high total sugar content (90% or above), and is a precipitate formed by precipitating a water extract, obtained by removing a 66% ethanol precipitate from Acanthopanax trifoliatus stems, with 80% ethanol. In-vitro antitumor activity test results show that the Acanthopanax trifoliatus polysaccharide has extremely strong proliferation inhibition activity on human esophageal cancer cells and human ovarian cancer cells, so that the Acanthopanax trifoliatus polysaccharide has a prospect of being developed into anti-human esophageal cancer and anti-human ovarian cancer drugs.

Description

technical field [0001] The invention relates to bougainvillea polysaccharides, in particular to a bougainvillea polysaccharide, a preparation method and an application for preparing antitumor drugs. Background technique [0002] Ovarian cancer is the second most common female reproductive malignancy, and its mortality rate ranks first among gynecological tumors. Worldwide, approximately 200,000 people are diagnosed with ovarian cancer each year and 125,000 people die from the disease. Due to the relatively hidden incidence of ovarian cancer and the lack of effective screening and early diagnosis methods, 70% to 80% of patients are already at an advanced stage when they see a doctor. The treatment effect and prognosis are extremely poor, and the 5-year survival rate is less than 20%. [0003] Esophageal cancer is a malignant tumor that occurs on the esophagus. The etiology is unknown so far. It is generally believed that it is related to factors such as poor food, alcohol co...

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Problems solved by technology

[0005] Studies have found that a variety of small molecular compounds in Bougainvillea have antican

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