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Whitening, freckle and anti-glycation fermented product cosmetics

A whitening, freckle-removing and anti-glycation technology, which is applied to cosmetics, cosmetic preparations, cosmetic preparations, etc., to achieve the effects of wide application, obvious anti-glycation and whitening effects, and convenient use.

Active Publication Date: 2021-01-29
广州市千邦化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Whitening products in the prior art are often only researched on the activity of inhibiting tyrosinase. The present invention aims to provide a whitening, freckle, and anti-glycation plant fermentation composition and its application in cosmetics

Method used

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  • Whitening, freckle and anti-glycation fermented product cosmetics
  • Whitening, freckle and anti-glycation fermented product cosmetics
  • Whitening, freckle and anti-glycation fermented product cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A whitening, freckle-removing, and anti-glycation plant fermented composition is characterized in that its preparation method is as follows:

[0024] (1) Under sterile conditions, inoculate 1v / v% of preserved Lactobacillus crispatus CGMCC No.6364 in MRS medium, and cultivate it at 35°C and 200rpm for 12 hours, and the resulting culture is used as the seed liquid for fermentation culture , the final concentration is 6*10 7 cfu / ml;

[0025] (2) (2) The Lactobacillus crispatus CGMCC No.6364 seed solution was inoculated in the liquid medium according to the inoculum size 10v / v%, and cultured on a shaking table at 30°C for 24 hours at 200rpm;

[0026] The liquid medium preparation method: the curcumin of 0.3g, the Cortex Morus alba extract of 50ml, the glucose of 25g, the peptone of 8g, the yeast extract of 7g, the beef extract of 8g, the sodium acetate of 5g, the citric acid of 2g Ammonium, 2 mL of Tween-80, 0.6 g of MgSO 4 ·7H 2 O, 0.3g of MnSO 4 4H 2 O, 2g of K 2 H...

Embodiment 2

[0028] Embodiment 2 comparative example

[0029] The R&D team found that curcumin and Morus alba can synergistically increase the antioxidant, whitening and anti-glycation properties of fermented extracts.

Embodiment 3

[0039] Cytotoxicity test:

[0040]The plant fermentation composition obtained in Example 1 was dissolved in serum-free DMEM culture fluid, and 4 samples were prepared respectively, with mass fractions of 0.25%, 0.5%, 1%, and 2%, respectively, and serum-free DMEM culture fluid was used as a negative MTT test was carried out in the same group to evaluate the cytotoxicity of the whitening, freckle-removing and anti-glycation plant fermentation composition.

[0041] Inoculate L929 cells into a 96-well plate at 100 μL / well, and adjust the concentration to 1×10 5 cells / mL, at 37°C, 5% CO 2 After culturing for 24 hours in serum-free DMEM culture solution for adherence, the culture solution was discarded, and 100 μL of sample solutions with different mass fractions were added to each well. The negative control group continued to culture in serum-free DMEM for 48 hours. Add 20 μL of 5 mg / mL MTT solution and incubate for 4 h in an incubator protected from light. Discard the supernata...

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Abstract

The invention relates to a whitening and freckle removing anti-glycation fermentation product cosmetic. A preparation method for the cosmetic is shown as follows: (1) under the aseptic condition, preserved lactobacillus crispatus CGMCC No.6364 is inoculated for fermentation culture to obtain a seed solution; (2) the seed solution of the lactobacillus crispatus CGMCC No.6364 is inoculated by 10v / v%into a liquid culture medium containing cortex mori extract and curcumin for fermentation culture; and (3) fermentation liquid obtained in the step (2) is centrifuged at the centrifugal rotational speed of 8000r / min for 30min, and a supernate is collected to obtain a fermentation filtrate, and the fermentation filtrate is filtered through a 0.22um sterilizing filter. The cosmetic can be further made into forms of a mask, essence, lotion, skin milk and face cream for application.

Description

technical field [0001] The invention relates to the technical field of cosmetic formulations, in particular to a whitening, freckle-removing and anti-glycation plant fermentation composition and its application in whitening, freckle-removing and anti-glycation fermented product cosmetics. Background technique [0002] The reason why the color of human skin can show different colors does not depend on the number of melanocytes, but on the amount of various melanin produced, on the number, size, distribution of melanosomes and melanin degree of transformation. The formation and deposition of normal melanin in melanocytes not only protect the skin, resist ultraviolet radiation and prevent internal tissues from overheating, but also have important significance for the health and beauty of the skin. When the skin undergoes abnormal changes such as hyperpigmentation, too little or lack thereof, it will lead to different types of pigmented disordered skin diseases such as vitiligo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/99A61K8/9789A61K8/35A61Q19/02A61Q19/08
CPCA61K8/35A61K8/99A61K2800/592A61K2800/782A61K2800/85A61Q19/02A61Q19/08A61K8/9789
Inventor 罗春梅
Owner 广州市千邦化妆品有限公司
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