96 results about "Anti glycation" patented technology

Compositions and methods for administering ketone bodies to a subject include beta-hydroxybutyrate complexed with or coupled to at least one amino acid. The compositions and methods cause one or more of: weight loss, weight maintenance, reduced blood glucose level, maintenance of blood glucose level, increased muscle and physical performance, enhanced metabolic and cellular repair, improved detoxification and gut health, targeted bioavailability, sustained release and controlled absorption, increased metabolic efficiency, enhanced cellular uptake, minimized side effects, multifunctional therapeutics, improved focus, improved energy, improved cognitive function, improved mental acuity, treatment of traumatic brain injury, treatment of diabetes, treatment of neurological disorder, treatment of cancer, treatment of inflammatory condition, appetite suppression, anti-aging effects, anti-glycation effects, treatment of epilepsy, treatment of depression, improved performance, improved muscle mass, improved motor function, increased strength, increased metabolism, increased fat loss, increased fat oxidation, improved body composition, and improved mood.

The invention discloses Kluffa yeast and application of the Kluffa yeast in preparation of red camellia fermentation liquor with anti-aging and repairing functions, the Kluffa yeast is used for repairing PR-LQX002, the Latin name of the Kluffa yeast is Lachancea kluyveri, and the preservation number of the Kluffa yeast is CCTCC NO: M 20241723. The invention also provides a red camellia fermentation broth, a composition containing the fermentation broth and application of the red camellia fermentation broth in preparation of products with anti-oxidation, anti-saccharification, anti-wrinkle or repair effects. The fermentation broth is prepared from the following raw materials: red camellia flowers, red camellia leaves and Kluffa yeast PR-LQX002. The Kluffa yeast can greatly promote fermentation of flowers and leaves of the red camellia, and the obtained red camellia fermentation liquor not only contains active substances such as flavone, polyphenol and free amino acid, but also contains lipid substances such as ceramide, and has multiple effects such as saccharification resistance, repair, wrinkle resistance and oxidation resistance.

The invention belongs to the technical field of cosmetics, and particularly discloses a natural anti-saccharification composition with plant extracts as main components, application, emulsion and a preparation method. The natural anti-saccharification composition with the plant extracts as the main raw materials comprises walnut seed extracts, sea-buckthorn extracts, aesculus hippocastanum extracts, fructus evodiae extracts, ormosia henryi bark extracts and capryloyl hydroximic acid. According to the formula system, multi-stage intervention in the whole saccharification reaction process is achieved through the multi-target-point and multi-channel synergistic effect, the comprehensive effects of aging resistance and tissue function protection are achieved, meanwhile, all the components have the synergistic effect in the aspects of oxidation resistance, saccharification resistance and repairing, abnormal combination of carbohydrates and protein / lipid is inhibited or hindered, and the anti-aging and anti-saccharification effects are achieved. According to the composition, the whole saccharification reaction process is inhibited, the effect stronger than that of a single component can be achieved, then generation of end-of-saccharification products is delayed, and the anti-aging capacity of skin is improved.

The invention relates to a green preparation method and application of an anti-saccharification tea extract, and belongs to the technical field of biology. The preparation method of the tea extract comprises the following steps: extracting tea by using a deep eutectic solvent to obtain the tea extract, and carrying out deproteinization and decoloration to obtain the tea extract. The hydrogen bond acceptor of the deep eutectic solvent comprises proline or betaine, and the hydrogen bond donor of the deep eutectic solvent comprises xylitol or glycerol. By utilizing the NaDES extraction technology, effective components can flow out by efficiently breaking cell walls, so that the extraction efficiency of tea active components represented by tea polyphenol is effectively improved; the selected NaDES solvent is natural, green and easy to obtain; the tea extract disclosed by the invention has an anti-saccharification effect, blocks glycosylation reaction, reduces and inhibits generation of AGEs, improves the problems of dark skin, skin laxity and aging caused by saccharification, reduces collagen loss, keeps skin elasticity and delays skin aging.

The present invention relates to a decarboxylated carnosine derivative, a preparation method thereof and an application. The structural formula of the decarboxylated carnosine derivative of the present invention is shown in formula (I), wherein R is selected from: C5-C 21 alkyl group, C5-C 21 unsaturated hydrocarbon group. The decarboxylated carnosine derivative of the present invention has a more excellent anti-glycation effect compared with decarboxylated carnosine; meanwhile, it has good antioxidant effect; and, the decarboxylated carnosine derivative of the present invention has certain lipophilicity, is relatively easy to penetrate through the skin cutin layer, has good skin penetration performance, and has good stability at the same time. It can be used for preparing cosmetics with anti-glycation, antioxidant, anti-skin aging and other functions, and has important market value#imgabs0#(I).

The invention provides an in-vitro anti-saccharification effect evaluation method and application thereof, and belongs to the technical field of skin saccharification resistance. A photoaging fibroblast model is adopted, after induction of an inducer, anti-saccharification evaluation is carried out by detecting the contents of collagen and waveform protein after application of a substance to be detected, and it is proved that the anti-saccharification effect of the anti-saccharification substance in the cell model is consistent with the result in human body effect evaluation; the evaluation method can be applied to screening and evaluation of anti-skin saccharification substances.

The invention provides a cosmetic application of nervonic acid. The cosmetic application is selected from the group consisting of anti-saccharification, energy metabolism, DNA damage repair, soothing and / or repair efficacy. The invention also relates to application of nervonic acid in preparation of an external skin preparation with anti-saccharification, energy metabolism, DNA damage repair, soothing and / or repair effects.

The invention belongs to the technical field of protein beverage processing and utilization, and particularly relates to soybean milk powder based on a white kidney bean extract and a preparation method of the soybean milk powder. The soybean milk powder is prepared by taking soybeans as a main raw material, the soybeans are subjected to peeling treatment, mechanical impurities, dust and soybean germs in the soybeans as well as purine, alkali and other components which are contained in peels and are harmful to a human body are removed, the content of bacteria is reduced, and the flavor of the soybean milk powder is optimized; the white kidney bean extract is added, and the white kidney bean extract contains an alpha-amylase inhibitor which can inhibit the activity of alpha-amylase, so that absorption of carbohydrates is delayed and partially blocked, the blood sugar level is favorably controlled, rapid increase of postprandial blood sugar is reduced, and the anti-saccharification effect is indirectly achieved; meanwhile, the white kidney bean extract is rich in high-quality protein, various amino acids, mineral substances, vitamins B1 and B2 and the like, so that the health level of a human body can be further improved.

The invention relates to the technical field of anti-aging preparations, and particularly discloses an anti-aging preparation of a human exosome combined with a plant exosome as well as a preparation method and application of the anti-aging preparation. The invention provides an anti-aging preparation combining a human exosome and a plant exosome. The anti-aging preparation specifically comprises the following components in parts by weight: 8-12 parts of the human exosome, 3-7 parts of the plant exosome and 0.5-1.5 parts of collagen, the preparation method of the plant exosome comprises the following steps: taking beet root tubers and mesembryanthemum crystallinum in a weight ratio of (0.5-3): (7-11) as raw materials, crushing the raw materials, adding a buffer solution, and then sequentially carrying out wall breaking treatment, gradient centrifugation to take supernate, dilution, deep filtration, concentration and purification to obtain the plant exosome. According to the technical scheme provided by the invention, the prepared anti-aging preparation has relatively strong oxidation resistance, saccharification resistance and stability, and has a relatively strong anti-aging effect when being used in skin care products.

The invention discloses a collagen peptide composition with a skin saccharification resisting effect and a preparation method of the collagen peptide composition, and belongs to the technical field of health care products. The composition is prepared from the following raw materials in parts by mass: 50-60 parts of collagen peptide, 9-15 parts of decarboxylated carnosine, 5-8 parts of peony peptide, 2-4 parts of fucoxanthol, 5-8 parts of tricholoma lobayense heim polysaccharide, 1-2 parts of sesamin and 3-7 parts of cyclodextrin. The collagen peptide composition is prepared through a reasonable material compounding agent inclusion technology, the anti-saccharification activity of the collagen peptide composition is remarkably improved, and a better scheme is provided for resisting skin saccharification.

This invention relates to an anti-wrinkle repair composition containing red camellia extract and its application. The anti-wrinkle repair composition of this invention comprises the following components in weight percentages: polyol 1: 1-25%; red camellia extract: 0.1-15%; creatine: 0.1-2%; carnosine: 0.01-0.5%; recombinant collagen: 0.01-5%; tetrahydrocurcumin inclusions: 1-20%; ergothioneine: 0.0001-1%; water: balance. This invention combats aging through multiple pathways and approaches, providing multi-dimensional skin anti-oxidation and anti-glycation, scavenging free radicals, promoting the production of type I collagen in the skin's extracellular matrix, and strengthening the skin barrier. This composition can be used as an active ingredient in various types of cosmetics, including aqueous solutions, lotions, creams, and shampoos.

The invention relates to an anti-saccharification composition applicable to sensitive skin and application, and belongs to the technical field of cosmetics. The anti-saccharification composition suitable for sensitive skin is prepared from the following components in parts by mass: 0.01 to 0.5 part of ascorbic acid polypeptide, 0.5 to 2 parts of ginseng root extract, 0.1 to 2 parts of acetyl tetrapeptide-2 and 0.1 to 5 parts of herba andrographitis leaf extract. The anti-saccharification composition suitable for the sensitive skin, provided by the invention, has a remarkable anti-saccharification effect, can remarkably improve skin elasticity, has a certain repairing effect and is suitable for the sensitive skin.

The present invention relates to an obesity inhibitor, an anti-dementia agent, a deodorant agent, an anti-aging agent, an anti-saccharification agent, an anti-type I allergy agent, an anti-hypertensive agent, a flavor-improving agent, a muscle-enhancing agent, and a bone metabolism-improving agent. One aspect of the present invention provides an obesity inhibitor, an anti-dementia agent, a deodorant agent, an anti-aging agent, an anti-saccharification agent, an anti-type I allergy agent, an anti-hypertension agent, a flavor-improving agent, a muscle-enhancing agent, and a bone metabolism-improving agent containing a decomposed extract of bagasse as an active ingredient.

The invention discloses an antibody for resisting glycosylated hemoglobin HbA1c and application of the antibody, and relates to the field of antibodies. The anti-glycosylated hemoglobin HbA1c antibody disclosed by the invention comprises a heavy chain complementarity determining region and a light chain complementarity determining region, provides an important raw material source for detection of glycosylated hemoglobin HbA1c, and has good affinity or activity.

The application belongs to the technical field of cosmetics and skin care, and provides a polypeptide compound combination for strengthening the resistance to free radicals for skin anti-aging and tightening. The application constructs a multi-pathway efficacy system with five active polypeptides as the core, which respectively covers free radical scavenging, stress resistance, anti-glycation / anti-carbonylation, collagen promotion and repair promotion nodes. In the obtained in-vitro and 3D full-thickness skin model data, the product shows multiple synergistic effects such as antioxidant, anti-carbonylation, anti-glycation, collagen promotion, elastin promotion and repair promotion, and can be used in various types and functions of cosmetics.

This invention relates to the technical field of deep processing of rye pollen, and particularly to a rye pollen peptide with antioxidant, anti-glycation, and α-amylase inhibitory activities, its preparation method, and functional products. The preparation method includes the following steps: mixing rye pollen with water, then sequentially adding cellulase and pectinase for pretreatment; after enzyme inactivation in the pretreatment solution, sequentially adding Bacillus licheniformis alkaline protease, papain, and Bacillus subtilis neutral protease for three hydrolysis cycles; and obtaining powdered rye pollen peptides after solid-liquid separation, filtration, and drying. The rye pollen peptides prepared by the method of this invention possess antioxidant, α-amylase inhibitory, and anti-glycation activities, and also have prebiotic effects that promote the proliferation of *Lactobacillus plantarum* and *Lactobacillus fermentum*.

The present invention belongs to the technical field of daily-use cosmetics, and discloses an anti-glycation and antioxidant composition, an anti-aging cream and a preparation method thereof. The anti-glycation and antioxidant composition of the present invention comprises the following components in parts by weight: 0.1-1.5 parts of carnosine hydrochloride, 0.2-10.4 parts of algal extract, and 0.1-12.5 parts of yeast / rice fermentation product filtrate. Compared with the prior art, the anti-aging cream containing the anti-glycation and antioxidant composition of the present invention has excellent anti-glycation and antioxidant effects and good absorbability at the same time, can reduce oxidative and glycation damage, inhibit the degradation of matrix metalloproteinase, thereby improving wrinkles, brightening the skin and promoting the generation of collagen. At the same time, the present invention also has the functions of moisturizing, supplementing filaggrin or underlying fibers of the skin, and exhibits excellent skin conditioning effects.

A cosmetic composition to combat skin aging, particularly on the neck, includes a blend of skin actives comprising vitamin C, a vitamin C derivative, or a combination thereof; dandelion root extract; and at least one additional active selected from the group consisting of caffeine, vitamin E, lavender oil, and combinations thereof; and an aqueous carrier system comprising water, wherein the cosmetic composition inhibits peptide and protein glycation. The skin actives are provided in an aqueous carrier in a single phase, biphase or emulsion wherein the cosmetic composition is a leave on treatment in the form of a cream, gel, lotion, toner, or serum.

The invention provides a method for synergistically extracting an anti-saccharification composition from morchella esculenta and ramulus mori, which comprises the following steps: S1, crushing morchella esculenta, performing water extraction, performing ethanol precipitation, performing enzyme treatment, and performing ultrafiltration concentration to obtain an extract rich in polysaccharide and small molecule peptide; s2, crushing the mulberry twigs, carrying out ultrasonic extraction by adopting an ethanol-water mixed solvent, and carrying out separation and purification by combining with macroporous adsorption resin, so as to obtain an extract rich in flavonoids components such as mulberroside, quercetin and the like; s3, compounding the two extracts according to a mass ratio, performing spray drying or freeze drying, and combining a cyclodextrin inclusion or nano emulsification process to prepare a stable anti-saccharification composition; s4, through a BSA-glucose model, an MGO induction model and animal experiments, it is verified that the morchella esculenta polysaccharide has remarkable activity in the aspects of carbonyl capture in the early stage, cross-linking inhibition in the middle stage and AGEs removal in the late stage in the saccharification reaction, oxidative inactivation of flavonoid substances is reduced, the structural integrity of morchella esculenta polysaccharide is protected, and the anti-saccharification efficiency is improved.

The invention provides a composition with moisturizing and anti-saccharification effects, and the composition comprises the following components: 70-85 parts of water, 8-12 parts of butanediol, 0.2-0.3 part of a tremella sporocarp extract, 1-3 parts of a Japanese yam root extract, 1-3 parts of a lotus root extract, 1-3 parts of an abelmoschus esculentus fruit extract, and 1-3 parts of 1, 2-hexanediol. The composition with the moisturizing and anti-saccharification effects shows remarkable advantages in core performance such as moisturizing, anti-saccharification, stability and transdermal absorption, selection of technological parameters directly influences the final effect, and innovativeness of collaborative optimization of the formula and the technology is verified.

The present invention relates to a medicine-food homologous composition with anti-aging and whitening effects and its application. The composition includes raspberry extract, guava extract, rose extract and licorice extract. The composition utilizes the active ingredients of natural plants to achieve anti-aging effects by inhibiting the activities of collagenase and elastase and promoting the generation of collagen and elastin; prevents aging caused by skin glycation by inhibiting the activity of α-glucosidase and directly inhibiting the generation of AGEs; achieves whitening effects by scavenging DPPH free radicals, inhibiting the activity of tyrosinase and reducing melanin production; the composition is formulated in a specific ratio to achieve synergistic effects, and further improves the whitening and anti-glycation effects while anti-aging, improving skin problems from multiple dimensions. The four natural ingredients used in the composition are all derived from medicine-food homology, and the extraction process does not contain organic reagents, which is green, environmentally friendly, safe and reliable.

This invention provides a composition containing DNA extracted from camellia flowers that has anti-aging and antioxidant properties. [Solution] The present invention relates to a composition containing DNA (PDRN) extracted from camellia. The camellia PDRN improves and activates the state of mitochondria and enhances anti-glycation efficacy. It also expresses various cell-stimulating factors or skin-improving factors that restore aged or damaged cells to a youthful state. For this reason, the camellia PDRN of the present invention can be widely applied as a cosmetic composition or pharmaceutical composition for anti-aging or skin condition improvement.

The invention belongs to the technical field of microorganisms, and particularly discloses a composition with anti-aging and anti-saccharification functions and application of the composition. The composition is prepared from the following components: lactobacillus paracasei BL-22 and stachyose, wherein the lactobacillus paracasei BL-22 is prepared from lactobacillus paracasei BL-22 and stachyose; the preservation number of the lactobacillus paracasei BL-22 is CGMCC (China General Microbiological Culture Collection Center) NO. 33475. Through animal experiments and research on interaction of the two substances, the invention reveals that the lactobacillus paracasei BL-22 and the stachyose have a synergistic effect mechanism for the first time, and confirms that the lactobacillus paracasei BL-22 and the stachyose are combined to generate a remarkable synergistic effect in the aspects of relieving aging and skin saccharification. The invention provides a safe and convenient new scheme for solving the problems of skin aging and saccharification, and also provides a new research direction and technical support for development of aging health related products.

The application discloses a glycation-resistant composition suitable for sensitive skin and application thereof and belongs to the technical field of cosmetics. The glycation-resistant composition is prepared by compounding schisandra chinensis extract, oxidized white resveratrol, ascorbic acid polypeptide, recombinant humanized collagen and recombinant elastin, can effectively realize multi-target synergistic effect of the glycation-resistant composition, can inhibit the generation of glycosylation end product AGEs, reduce glycation stress inflammatory damage, supplement skin structure protein loss caused by protein glycation, form a mild and systematic anti-glycation network, has remarkable yellow-removing, lightening, elastic and firming effects on the skin, is mild and non-irritating, and is suitable for long-term use of people with sensitive skin.

The application belongs to the field of new daily chemical materials, and discloses a composition with skin efficacy improving function, application and cosmetic, the composition comprising acetyl hydroxyproline and white nymphaea alba extract; in addition, the application also discloses a whitening composition comprising ergothioneine, superoxide dismutase, acetyl hydroxyproline, white nymphaea alba extract and malt extract. The whitening composition realizes the whitening performance through double anti-glycation, double anti-oxidation, inhibition of the pathways of melanin and tyrosinase, and the composition also has potential anti-wrinkle and firming efficacy.

The invention relates to the field of cosmetics, in particular to a sialic acid composition with whitening, brightening and anti-saccharification functions, a preparation method of the sialic acid composition and cosmetics. The sialic acid composition is prepared from the following components in parts by mass: 4 to 10 parts of sialic acid, 8 to 15 parts of carnosine and 15 to 25 parts of nicotinamide. According to the sialic acid composition with the whitening, brightening and anti-saccharification functions, sialic acid, nicotinamide and carnosine are matched and synergistically exert effects, and the sialic acid composition can enhance the epidermal barrier function, promote permeation of active ingredients, remove AGEs, block generation of saccharification end products, inhibit melanin transport and regulate cell metabolism, so that the skin whitening, brightening and anti-saccharification functions are achieved. Finally, the three components form a synergistic pathway of blocking saccharification, inhibiting melanin and transdermal permeation promotion; therefore, the problems of uneven skin color and darkness of the skin are fundamentally solved.

The invention discloses health wine capable of delaying senescence as well as a preparation method and application of the health wine, and belongs to the technical field of health food. According to the health-preserving wine, mulberries and sea-buckthorn are used as monarch materials, rhizoma polygonati and radix puerariae are used as ministerial materials, lophatherum gracile, fructus lycii and Chinese yam are used as assistants and guides, and all the raw materials are medicinal and edible substances. According to the invention, through an optimized'warm soaking-cold soaking 'two-step extraction process, synergistic interaction is realized, and active ingredients such as anthocyanin, flavone, polysaccharide and puerarin are extracted to the greatest extent. The health-preserving wine disclosed by the invention not only has good antioxidant capacity, but also can be used for remarkably removing free radicals such as DPPH (1, 1-diphenyl-2-picrylhydrazyl) and hydroxyl, improving the activity of serum SOD (superoxide dismutase) and GSH-Px (glutathione The formation of advanced glycosylation end products can be effectively inhibited, and the obvious anti-aging and anti-saccharification dual effects are achieved. The health-preserving wine disclosed by the invention is simple in preparation process, mellow in taste and suitable for daily health-preserving drinking.

The present application relates to a cosmetic composition for combating skin aging, particularly neck skin aging, comprising a mixture of skin active ingredients comprising Vitamin C, Vitamin C derivatives, or combinations thereof; dandelion root extract; and at least one other active ingredient selected from the group consisting of caffeine, Vitamin E, lavender oil, and combinations thereof; and an aqueous carrier system comprising water, wherein the cosmetic composition inhibits peptide and protein glycation. The skin active ingredients are provided in a single phase, bi-phase, or emulsion state in the aqueous carrier, wherein the cosmetic composition is a leave-on care product in the form of a cream, serum, emulsion, toner, or essence.

The invention relates to the technical field of anti-saccharification and anti-aging, in particular to anti-saccharification and anti-aging nanoparticles, a preparation method of the anti-saccharification and anti-aging nanoparticles and an anti-saccharification and anti-aging composition. The preparation method comprises the following steps: under the protection of inert gas, hyaluronic acid and L-carnosine are subjected to an acid-amine condensation reaction under the catalytic action of a carboxyl activator to obtain a hyaluronic acid-carnosine derivative; and performing a coordination self-assembly reaction on the digallocatechin a, Zn < 2 + > and the hyaluronic acid-carnosine derivative in deionized water to form the nanoparticles as shown in a formula II. In the nano-particle structure, the HA-CAN component mainly aims at an AGEs / RAGE pathway; the TSA-Zn component mainly aims at an HMGB1 / RAGE pathway, and the TSA-Zn component and the HMGB1 / RAGE pathway cooperatively inhibit dual pathways; the introduction of HA greatly improves the transdermal performance, CAN, TSA and HA are integrated in a nano entity through chemical bonds / coordinate bonds, the stability of the nano structure is improved, and the activity of each component is enhanced.

A cerium-doped mesoporous bioactive glass nanoparticle, its preparation method, hydrogel and application. The Ce-MBG@L-Car composite nanoparticle is synthesized by the surfactant template method to obtain MBG with a uniform mesoporous structure and good particle size distribution, providing ideal drug carrier properties. By doping cerium element through ion replacement, the antioxidant performance of the material is significantly improved, and the stability and loading capacity of L-carnosine are enhanced through coordination chelation. All the characterization and in vitro and in vivo experimental results show that the Ce-MBG@L-Car composite nanoparticle not only has a high drug loading capacity, but also has potential dual anti-glycation and antioxidant effects in the diabetic microenvironment, providing a solid material basis for subsequent bone defect treatment.