115 results about "Anti glycation" patented technology

Compositions and methods for administering ketone bodies to a subject include beta-hydroxybutyrate complexed with or coupled to at least one amino acid. The compositions and methods cause one or more of: weight loss, weight maintenance, reduced blood glucose level, maintenance of blood glucose level, increased muscle and physical performance, enhanced metabolic and cellular repair, improved detoxification and gut health, targeted bioavailability, sustained release and controlled absorption, increased metabolic efficiency, enhanced cellular uptake, minimized side effects, multifunctional therapeutics, improved focus, improved energy, improved cognitive function, improved mental acuity, treatment of traumatic brain injury, treatment of diabetes, treatment of neurological disorder, treatment of cancer, treatment of inflammatory condition, appetite suppression, anti-aging effects, anti-glycation effects, treatment of epilepsy, treatment of depression, improved performance, improved muscle mass, improved motor function, increased strength, increased metabolism, increased fat loss, increased fat oxidation, improved body composition, and improved mood.

The invention discloses application of a compound shown as a formula I or salt or deuterated substance thereof in preparation of an anti-saccharification agent, in which ring A is a benzene ring or a five-membered ring containing O or S; the ring A may be substituted by m Ra, m being 0, 1, 2, 3 or 4; ra is hydroxyl, methyl, methoxyl, nitro or dimethylamino, and the deuterated substance is a partial deuterated substance and / or a perdeuterated substance. In the experiment of inhibiting generation of AGEs, compared with an Amino guanidine AG (Amino guanidine, AG), the anti-saccharification effect is obvious: under the low concentration, the anti-saccharification inhibition rate (the final administration concentration is 33 mu M) of the aromatic methylene acetone active small molecule compound protected by the invention is between 10% and 58%, and is far higher than the anti-saccharification inhibition rate (8.4%) of the Amino guanidine AG under the same final administration concentration (33 mu M), and the anti-saccharification inhibition rate (8.4%) of the Amino guanidine AG is far higher than the anti-saccharification inhibition rate (8.4%) of the Amino guanidine AG under the same final administration concentration (33 mu M) of the Amino guanidine AG. And the anti-saccharification inhibition rate of the radix codonopsis AG approaches to the final administration concentration (1mM) and is 57%. # imgabs0 #

The invention belongs to the technical field of functional foods and health foods, and particularly relates to an anti-saccharification and anti-aging aronia melanocarpa fruit composition and a preparation method thereof. The composition is prepared from the following raw materials in parts by weight: 150 to 400 parts of aronia melanocarpa fruit fermentation liquor, 10 to 80 parts of lycium ruthenicum, 10 to 80 parts of ginseng, 0.5 to 2.5 parts of grape seed extract, 10 to 70 parts of collagen peptide, 0.5 to 4 parts of sodium hyaluronate, 0.1 to 0.8 part of resveratrol and 0.03 to 0.3 part of yeast extract. The content of type I collagen peptide in the skin is increased, the generation of in-vitro anti-glycation end products is inhibited, and the anti-glycation and anti-aging effects are achieved.

The invention discloses Kluffa yeast and application of the Kluffa yeast in preparation of red camellia fermentation liquor with anti-aging and repairing functions, the Kluffa yeast is used for repairing PR-LQX002, the Latin name of the Kluffa yeast is Lachancea kluyveri, and the preservation number of the Kluffa yeast is CCTCC NO: M 20241723. The invention also provides a red camellia fermentation broth, a composition containing the fermentation broth and application of the red camellia fermentation broth in preparation of products with anti-oxidation, anti-saccharification, anti-wrinkle or repair effects. The fermentation broth is prepared from the following raw materials: red camellia flowers, red camellia leaves and Kluffa yeast PR-LQX002. The Kluffa yeast can greatly promote fermentation of flowers and leaves of the red camellia, and the obtained red camellia fermentation liquor not only contains active substances such as flavone, polyphenol and free amino acid, but also contains lipid substances such as ceramide, and has multiple effects such as saccharification resistance, repair, wrinkle resistance and oxidation resistance.

The invention belongs to the technical field of cosmetics, and particularly discloses a natural anti-saccharification composition with plant extracts as main components, application, emulsion and a preparation method. The natural anti-saccharification composition with the plant extracts as the main raw materials comprises walnut seed extracts, sea-buckthorn extracts, aesculus hippocastanum extracts, fructus evodiae extracts, ormosia henryi bark extracts and capryloyl hydroximic acid. According to the formula system, multi-stage intervention in the whole saccharification reaction process is achieved through the multi-target-point and multi-channel synergistic effect, the comprehensive effects of aging resistance and tissue function protection are achieved, meanwhile, all the components have the synergistic effect in the aspects of oxidation resistance, saccharification resistance and repairing, abnormal combination of carbohydrates and protein / lipid is inhibited or hindered, and the anti-aging and anti-saccharification effects are achieved. According to the composition, the whole saccharification reaction process is inhibited, the effect stronger than that of a single component can be achieved, then generation of end-of-saccharification products is delayed, and the anti-aging capacity of skin is improved.

The invention relates to a green preparation method and application of an anti-saccharification tea extract, and belongs to the technical field of biology. The preparation method of the tea extract comprises the following steps: extracting tea by using a deep eutectic solvent to obtain the tea extract, and carrying out deproteinization and decoloration to obtain the tea extract. The hydrogen bond acceptor of the deep eutectic solvent comprises proline or betaine, and the hydrogen bond donor of the deep eutectic solvent comprises xylitol or glycerol. By utilizing the NaDES extraction technology, effective components can flow out by efficiently breaking cell walls, so that the extraction efficiency of tea active components represented by tea polyphenol is effectively improved; the selected NaDES solvent is natural, green and easy to obtain; the tea extract disclosed by the invention has an anti-saccharification effect, blocks glycosylation reaction, reduces and inhibits generation of AGEs, improves the problems of dark skin, skin laxity and aging caused by saccharification, reduces collagen loss, keeps skin elasticity and delays skin aging.

The invention discloses application of carboline compounds in preparation of products for reducing accumulation of advanced glycosylation end products, and belongs to the technical field of preparation of anti-saccharification products. The carboline compound not only can reduce the generation of AGEs in a BSA-MGO pure in-vitro AGEs generation model, but also can effectively reduce the level of AGEs in a glucose-induced intracellular AGEs generation model, has a remarkable AGEs inhibition effect, has no toxic effect on cells, has good safety, and can meet the application requirements of anti-saccharification products.

The present invention relates to a decarboxylated carnosine derivative, a preparation method thereof and an application. The structural formula of the decarboxylated carnosine derivative of the present invention is shown in formula (I), wherein R is selected from: C5-C 21 alkyl group, C5-C 21 unsaturated hydrocarbon group. The decarboxylated carnosine derivative of the present invention has a more excellent anti-glycation effect compared with decarboxylated carnosine; meanwhile, it has good antioxidant effect; and, the decarboxylated carnosine derivative of the present invention has certain lipophilicity, is relatively easy to penetrate through the skin cutin layer, has good skin penetration performance, and has good stability at the same time. It can be used for preparing cosmetics with anti-glycation, antioxidant, anti-skin aging and other functions, and has important market value#imgabs0#(I).

The invention provides an in-vitro anti-saccharification effect evaluation method and application thereof, and belongs to the technical field of skin saccharification resistance. A photoaging fibroblast model is adopted, after induction of an inducer, anti-saccharification evaluation is carried out by detecting the contents of collagen and waveform protein after application of a substance to be detected, and it is proved that the anti-saccharification effect of the anti-saccharification substance in the cell model is consistent with the result in human body effect evaluation; the evaluation method can be applied to screening and evaluation of anti-skin saccharification substances.

The invention provides a cosmetic application of nervonic acid. The cosmetic application is selected from the group consisting of anti-saccharification, energy metabolism, DNA damage repair, soothing and / or repair efficacy. The invention also relates to application of nervonic acid in preparation of an external skin preparation with anti-saccharification, energy metabolism, DNA damage repair, soothing and / or repair effects.

The invention belongs to the technical field of protein beverage processing and utilization, and particularly relates to soybean milk powder based on a white kidney bean extract and a preparation method of the soybean milk powder. The soybean milk powder is prepared by taking soybeans as a main raw material, the soybeans are subjected to peeling treatment, mechanical impurities, dust and soybean germs in the soybeans as well as purine, alkali and other components which are contained in peels and are harmful to a human body are removed, the content of bacteria is reduced, and the flavor of the soybean milk powder is optimized; the white kidney bean extract is added, and the white kidney bean extract contains an alpha-amylase inhibitor which can inhibit the activity of alpha-amylase, so that absorption of carbohydrates is delayed and partially blocked, the blood sugar level is favorably controlled, rapid increase of postprandial blood sugar is reduced, and the anti-saccharification effect is indirectly achieved; meanwhile, the white kidney bean extract is rich in high-quality protein, various amino acids, mineral substances, vitamins B1 and B2 and the like, so that the health level of a human body can be further improved.

The invention relates to the technical field of anti-aging preparations, and particularly discloses an anti-aging preparation of a human exosome combined with a plant exosome as well as a preparation method and application of the anti-aging preparation. The invention provides an anti-aging preparation combining a human exosome and a plant exosome. The anti-aging preparation specifically comprises the following components in parts by weight: 8-12 parts of the human exosome, 3-7 parts of the plant exosome and 0.5-1.5 parts of collagen, the preparation method of the plant exosome comprises the following steps: taking beet root tubers and mesembryanthemum crystallinum in a weight ratio of (0.5-3): (7-11) as raw materials, crushing the raw materials, adding a buffer solution, and then sequentially carrying out wall breaking treatment, gradient centrifugation to take supernate, dilution, deep filtration, concentration and purification to obtain the plant exosome. According to the technical scheme provided by the invention, the prepared anti-aging preparation has relatively strong oxidation resistance, saccharification resistance and stability, and has a relatively strong anti-aging effect when being used in skin care products.

The invention discloses an anti-glycation beverage containing a white kidney bean and cherry blossom compound extract and a preparation method thereof, which specifically belongs to the field of biotechnology extracts; the beverage comprises components: a white kidney bean and cherry blossom compound extract, fish collagen peptides, erythritol, fish skin collagen peptides, Haematococcus pluvialis, L-arabinose, sodium hyaluronate and a solvent; the white kidney bean and cherry blossom compound extract is obtained by fermenting white kidney beans and cherry blossoms with mulberry igniarius; the white kidney bean and cherry blossom compound extract provided by the invention has excellent anti-glycation effect and antioxidant effect; the anti-glycation beverage containing the white kidney bean and cherry blossom compound extract provided by the invention has the effects of brightening, removing spots, whitening and tightening.

The invention discloses a collagen peptide composition with a skin saccharification resisting effect and a preparation method of the collagen peptide composition, and belongs to the technical field of health care products. The composition is prepared from the following raw materials in parts by mass: 50-60 parts of collagen peptide, 9-15 parts of decarboxylated carnosine, 5-8 parts of peony peptide, 2-4 parts of fucoxanthol, 5-8 parts of tricholoma lobayense heim polysaccharide, 1-2 parts of sesamin and 3-7 parts of cyclodextrin. The collagen peptide composition is prepared through a reasonable material compounding agent inclusion technology, the anti-saccharification activity of the collagen peptide composition is remarkably improved, and a better scheme is provided for resisting skin saccharification.

The present invention belongs to the field of biomedicine technology and discloses an anti-glycation amino acid derivative having a structure of general formula I or an isomer of general formula I: #imgabs0# wherein R 1 is selected from the group consisting of alanine, threonine, proline, asparagine, glutamine, leucine, tryptophan, serine, valine, methionine, tyrosine, histidine, L-aspartic acid-4-tert-butyl ester, L-aspartic acid-1-tert-butyl ester, glycine, isoleucine, phenylalanine, lysine, arginine, cysteine, L-glutamic acid-5-tert-butyl ester, and the residue after condensation of L-glutamic acid-1-tert-butyl ester, R 2 Select one of the following structures: -C 15 H 29 ,‑C 15 H 31 ,‑C 15 H 27 , ‑CHOHC 14 H 27 , ‑CHOHC 14 H 29 The present invention also discloses a synthesis method and application of anti-glycation amino acid derivatives. Such compounds improve the fat solubility of amino acid compounds, which is conducive to penetration into the skin, and show excellent effects in anti-oxidation, anti-glycation, skin barrier repair, tissue healing and the like.

To provide food compositions and the like for inhibiting protein glycation that exhibit excellent anti-glycation properties, particularly, protein glycation inhibitors that exhibit anti-glycation properties against a wide range of advanced glycation end products, have antioxidant properties, and are resistant to coloring when used in cosmetics and the like, and are highly safe and biocompatible.SOLUTION: Provided is a protein glycation inhibitor characterized in that the constituent amino acids are selected from the group consisting of acidic amino acids, basic amino acids, hydroxy amino acids, branched-chain amino acids, and antioxidant amino acids, and that the constituent amino acid on the C-terminus side contains a dipeptide or a salt thereof, which is an antioxidant amino acid, as an active ingredient.SELECTED DRAWING: None

This invention relates to an anti-wrinkle repair composition containing red camellia extract and its application. The anti-wrinkle repair composition of this invention comprises the following components in weight percentages: polyol 1: 1-25%; red camellia extract: 0.1-15%; creatine: 0.1-2%; carnosine: 0.01-0.5%; recombinant collagen: 0.01-5%; tetrahydrocurcumin inclusions: 1-20%; ergothioneine: 0.0001-1%; water: balance. This invention combats aging through multiple pathways and approaches, providing multi-dimensional skin anti-oxidation and anti-glycation, scavenging free radicals, promoting the production of type I collagen in the skin's extracellular matrix, and strengthening the skin barrier. This composition can be used as an active ingredient in various types of cosmetics, including aqueous solutions, lotions, creams, and shampoos.

The invention relates to an anti-saccharification composition applicable to sensitive skin and application, and belongs to the technical field of cosmetics. The anti-saccharification composition suitable for sensitive skin is prepared from the following components in parts by mass: 0.01 to 0.5 part of ascorbic acid polypeptide, 0.5 to 2 parts of ginseng root extract, 0.1 to 2 parts of acetyl tetrapeptide-2 and 0.1 to 5 parts of herba andrographitis leaf extract. The anti-saccharification composition suitable for the sensitive skin, provided by the invention, has a remarkable anti-saccharification effect, can remarkably improve skin elasticity, has a certain repairing effect and is suitable for the sensitive skin.

The present invention relates to an obesity inhibitor, an anti-dementia agent, a deodorant agent, an anti-aging agent, an anti-saccharification agent, an anti-type I allergy agent, an anti-hypertensive agent, a flavor-improving agent, a muscle-enhancing agent, and a bone metabolism-improving agent. One aspect of the present invention provides an obesity inhibitor, an anti-dementia agent, a deodorant agent, an anti-aging agent, an anti-saccharification agent, an anti-type I allergy agent, an anti-hypertension agent, a flavor-improving agent, a muscle-enhancing agent, and a bone metabolism-improving agent containing a decomposed extract of bagasse as an active ingredient.

The invention discloses an application of a coumarin compound in preparation of a product for reducing accumulation of advanced glycosylation end products, and belongs to the technical field of preparation of anti-saccharification products. The coumarin compound Apiravin can significantly inhibit generation of AGEs, has an efficient AGEs inhibition effect, can be used for treatment of diseases related to accumulation of AGEs, and can meet the application requirements of anti-saccharification food or health care products.

The invention discloses an antibody for resisting glycosylated hemoglobin HbA1c and application of the antibody, and relates to the field of antibodies. The anti-glycosylated hemoglobin HbA1c antibody disclosed by the invention comprises a heavy chain complementarity determining region and a light chain complementarity determining region, provides an important raw material source for detection of glycosylated hemoglobin HbA1c, and has good affinity or activity.

The application belongs to the technical field of cosmetics and skin care, and provides a polypeptide compound combination for strengthening the resistance to free radicals for skin anti-aging and tightening. The application constructs a multi-pathway efficacy system with five active polypeptides as the core, which respectively covers free radical scavenging, stress resistance, anti-glycation / anti-carbonylation, collagen promotion and repair promotion nodes. In the obtained in-vitro and 3D full-thickness skin model data, the product shows multiple synergistic effects such as antioxidant, anti-carbonylation, anti-glycation, collagen promotion, elastin promotion and repair promotion, and can be used in various types and functions of cosmetics.

This invention relates to the technical field of deep processing of rye pollen, and particularly to a rye pollen peptide with antioxidant, anti-glycation, and α-amylase inhibitory activities, its preparation method, and functional products. The preparation method includes the following steps: mixing rye pollen with water, then sequentially adding cellulase and pectinase for pretreatment; after enzyme inactivation in the pretreatment solution, sequentially adding Bacillus licheniformis alkaline protease, papain, and Bacillus subtilis neutral protease for three hydrolysis cycles; and obtaining powdered rye pollen peptides after solid-liquid separation, filtration, and drying. The rye pollen peptides prepared by the method of this invention possess antioxidant, α-amylase inhibitory, and anti-glycation activities, and also have prebiotic effects that promote the proliferation of *Lactobacillus plantarum* and *Lactobacillus fermentum*.

The present invention belongs to the technical field of daily-use cosmetics, and discloses an anti-glycation and antioxidant composition, an anti-aging cream and a preparation method thereof. The anti-glycation and antioxidant composition of the present invention comprises the following components in parts by weight: 0.1-1.5 parts of carnosine hydrochloride, 0.2-10.4 parts of algal extract, and 0.1-12.5 parts of yeast / rice fermentation product filtrate. Compared with the prior art, the anti-aging cream containing the anti-glycation and antioxidant composition of the present invention has excellent anti-glycation and antioxidant effects and good absorbability at the same time, can reduce oxidative and glycation damage, inhibit the degradation of matrix metalloproteinase, thereby improving wrinkles, brightening the skin and promoting the generation of collagen. At the same time, the present invention also has the functions of moisturizing, supplementing filaggrin or underlying fibers of the skin, and exhibits excellent skin conditioning effects.

An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.

A cosmetic composition to combat skin aging, particularly on the neck, includes a blend of skin actives comprising vitamin C, a vitamin C derivative, or a combination thereof; dandelion root extract; and at least one additional active selected from the group consisting of caffeine, vitamin E, lavender oil, and combinations thereof; and an aqueous carrier system comprising water, wherein the cosmetic composition inhibits peptide and protein glycation. The skin actives are provided in an aqueous carrier in a single phase, biphase or emulsion wherein the cosmetic composition is a leave on treatment in the form of a cream, gel, lotion, toner, or serum.

The invention provides a method for synergistically extracting an anti-saccharification composition from morchella esculenta and ramulus mori, which comprises the following steps: S1, crushing morchella esculenta, performing water extraction, performing ethanol precipitation, performing enzyme treatment, and performing ultrafiltration concentration to obtain an extract rich in polysaccharide and small molecule peptide; s2, crushing the mulberry twigs, carrying out ultrasonic extraction by adopting an ethanol-water mixed solvent, and carrying out separation and purification by combining with macroporous adsorption resin, so as to obtain an extract rich in flavonoids components such as mulberroside, quercetin and the like; s3, compounding the two extracts according to a mass ratio, performing spray drying or freeze drying, and combining a cyclodextrin inclusion or nano emulsification process to prepare a stable anti-saccharification composition; s4, through a BSA-glucose model, an MGO induction model and animal experiments, it is verified that the morchella esculenta polysaccharide has remarkable activity in the aspects of carbonyl capture in the early stage, cross-linking inhibition in the middle stage and AGEs removal in the late stage in the saccharification reaction, oxidative inactivation of flavonoid substances is reduced, the structural integrity of morchella esculenta polysaccharide is protected, and the anti-saccharification efficiency is improved.

The invention discloses an anti-sugar moisturizing brightening mask composition without irritation to eyes. The anti-sugar moisturizing brightening mask composition comprises the following raw materials in percentage by weight: 92.99% of water; 2% of glycerin; 0.2% of Giga Moist PM-II hydrolyzed sclerotium gum, and 0.2% of Giga Moist PM-II hydrolyzed sclerotium gum; 0.03% of beta-glucan; 3% of 1, 2-propylene glycol; 0.1% of cosmetic grade sodium hyaluronate; 1% of PPG-24-glyceryl polyether-24; 0.1% of Xinhaidew acetyl chitosamine; 0.6% of Kesen K708; 0.05% of essence; according to the composition disclosed by the invention, the irritation test is carried out by using a cosmetic eye irritation-chick embryo chorioallantoic membrane vascular test method CAMVA method, and the detection method not only shortens the component irritation screening detection period of the composition, but also reduces the cost; meanwhile, a chick embryo chorioallantoic membrane blood vessel test method meets animal protection ethical requirements, the prepared composition finished product contains components capable of resisting saccharification and brightening skin, can be used by various skin types, can effectively reduce fine wrinkles and wrinkles and brighten the skin color, and finally has the effects of resisting wrinkles, preserving moisture and reducing dull skin for sensitive skin consumers.

The invention provides a composition with moisturizing and anti-saccharification effects, and the composition comprises the following components: 70-85 parts of water, 8-12 parts of butanediol, 0.2-0.3 part of a tremella sporocarp extract, 1-3 parts of a Japanese yam root extract, 1-3 parts of a lotus root extract, 1-3 parts of an abelmoschus esculentus fruit extract, and 1-3 parts of 1, 2-hexanediol. The composition with the moisturizing and anti-saccharification effects shows remarkable advantages in core performance such as moisturizing, anti-saccharification, stability and transdermal absorption, selection of technological parameters directly influences the final effect, and innovativeness of collaborative optimization of the formula and the technology is verified.

The present invention relates to a medicine-food homologous composition with anti-aging and whitening effects and its application. The composition includes raspberry extract, guava extract, rose extract and licorice extract. The composition utilizes the active ingredients of natural plants to achieve anti-aging effects by inhibiting the activities of collagenase and elastase and promoting the generation of collagen and elastin; prevents aging caused by skin glycation by inhibiting the activity of α-glucosidase and directly inhibiting the generation of AGEs; achieves whitening effects by scavenging DPPH free radicals, inhibiting the activity of tyrosinase and reducing melanin production; the composition is formulated in a specific ratio to achieve synergistic effects, and further improves the whitening and anti-glycation effects while anti-aging, improving skin problems from multiple dimensions. The four natural ingredients used in the composition are all derived from medicine-food homology, and the extraction process does not contain organic reagents, which is green, environmentally friendly, safe and reliable.