80 results about "Anti glycation" patented technology

The invention provides methods, compositions, and dietary formulations useful for managing blood glucose, preventing or treating insulin resistance, and improving insulin sensitivity. The methods comprise administering to an animal a therapeutically effective amount of a combination of at least two of one or more antioxidants; one or more anti-glycation agents; one or more body fat reducing agents; one or more insulin sensitivity enhancing agents; and one or more anti-inflammatory agents.

The invention provides new inhibitors of protein glycation, identified from compound libraries by a high throughput screening assay. The anti-glycation agents so identified are characterized by a variety of chemical structures and are useful for the prevention or treatment of age-, diabetes-, and smoking-related complications, including neuropathy, nephropathy, ocular pathologies, or the loss of mechanical properties of collagenous tissues. Among compounds identified as having the anti-glycation activity, of special interest are epinephrine and its analogs, in particular D-epinephrine and its analogs, which are particularly useful for the prevention or treatment of age-, diabetes-, and smoking-related ocular pathologies.

The invention provides methods and compositions useful for ameliorating age related maladies, enhancing and maintaining immune function, enhancing and maintaining cognitive function, enhancing and maintaining muscle strength, enhancing and maintaining balance, and reducing and mitigating oxidative stress in an animal. The compositions comprise a combination of at least two of one or more unsaturated fatty acids (UFA); one or more nitric oxide releasing compounds (NORC); one or more anti-glycation agents; and colostrum, and the methods comprise administering to an animal a therapeutically effective amount of the compositions.

The invention relates to the field of cosmetics and provides a co-conveying nano composition of phenylethyl resorcinol. The co-conveying nano composition comprises phenylethyl resorcinol, other skin whitening active components, a nano medicine carrier as well as solvent complex lipid and water, wherein the phenylethyl resorcinol accounts for 0.1-10% of the total mass of the co-conveying nano composition; the other skin whitening active components comprise at least one of an antioxidant, a cutin peeling type active substance, a melanosome transferring inhibition active substance, an anti-glycation active substance and an anti-allergic agent; the nano medicine carrier comprises raw materials of an emulsifier, a Anti-allergic agent and polyhydric alcohols. Due to compounding of different skinwhitening components and carrying of the nano medicine carrier, a remarkable synergetic effect can be achieved, irritation of high-concentration phenylethyl resorcinol can be remarkably reduced, andthe co-conveying nano composition is good in stability, excellent in skin whitening effect, good in water solubility, good in skin permeability and widely applicable to cosmetics.

The invention relates to the field of cosmetics and provides an alpha-arbutin co-conveying nanometer composition. The alpha-arbutin co-conveying nanometer composition comprises alpha-arbutin, other skin-whitening active components and a nanometer medicine carrier; the alpha-arbutin accounts for 0.05 to 20.0 percent of the total mass of the co-conveying nanometer composition; other skin-whitening active components comprise at least one of a tyrosinase inhibitor outside the alpha-arbutin, a melanosomal migration inhibitor, an antioxidant, an anti-glycation active substance and an anti-inflammatory agent; the raw materials of the nanometer medicine carrier comprise an emulsifier and a co-emulsifier; and the alpha-arbutin co-conveying nanometer compositionl also comprises grease and water. Remarkable synergistic effect is achieved through compounding of different skin-whitening mechanisms and loading of the nanometer medicine carrier; the melanin content of skin is obviously reduced through multi-target-point effect; and the co-conveying nanometer composition can realize sustained release and controlled release of medicines, has large medicine carrying quantity, high stability, high water solubility, high skin permeability and excellent skin-whitening effect, and can be widely applied to cosmetics.

The invention discloses a composition with an anti-glycosylation effect and an application thereof. The anti-glycosylation composition consists of the following components in parts by mass: 0.1 to 5 parts of an osmanthus fragrans flower extract, 0.1 to 5 parts of a pomegranate extract and 0.01 to 0.1 part of a canarium album fruit extract, wherein the mass content of polyphenol in the osmanthus fragrans flower extract is greater than or equal to 10 percent, the mass content of verbascoside in the osmanthus fragrans flower extract is greater than or equal to 10 percent, the mass content of polyphenol in the pomegranate extract is greater than or equal to 30%, the mass content of punicalagin in the pomegranate extract is greater than or equal to 8%, wherein the mass content of polyphenol inthe canarium album fruit extract is greater than or equal to 10%, and the mass content of hydroxytyrosol in the canarium album fruit extract is greater than or equal to 3%. Through the synergistic effect of the osmanthus fragrans flower extract, the pomegranate extract and thecanarium album fruit extract which have a specific proportion and specific quality, anti-glycation capacity of skins is improved in three aspects that generation of a fibroblast glycosylation reaction end product CML is remarkably reduced, generation of AGEs is reduced, and SOD expression is increased.

The invention discloses a skincare product having five-dimensional anti-wrinkle and anti-aging functions and a preparation method thereof. Through addition of a variety of components such as nicotinamide, a saccharomycopsis ferment filtrate, a hydrocotyle asiatica extract, [belta]-glucan, a punica granatum fruit extract, a rice extract, ceramide 3, N2-(1-Oxohexadecyl)-L-lysyl-L-valyl-L-lysine 2,2,2-trifluoroacetate (1:2), argireline, and dimethylsilanol hyaluronate in a formula, effects of increasing degree of adhesion of epidermis and dermis, promoting collagen synthesis, relieving nerves, reducing expression lines, supplementing silicon, improving skin elasticity, being resistant to glycation, and improving skin to achieve anti-wrinkle and anti-aging effects in five dimensions can be achieved; and at the same time, because combination of the components is water-soluble, the components are not limited by a product dosage form and can be added to a water agent, emulsion, cream, the essence, and the like; and the product completely compensates for obvious defects of single function of a commercially available product.

The invention discloses a preparation method of a composition with anti-glycation and anti-skin-aging effects in the technical field of skin care product composition preparation. The composition withthe anti-glycation and anti-skin-aging effects comprises a phase A and a phase B, wherein the phase A is prepared from 0.1 part of sclerotium rolfssii gum, 2 parts of 1,3butanediol, 1 part of glyceroland 87.75 parts of water, the phase B is prepared from 5 parts of malus domestica fruit cell culture extracts, 2 parts of glycosylglycerol, 5 parts of water, 5 parts of nicotinamide, 5 parts of glycerol, 5 parts of caprylyl glycol, 5 parts of xanthan gum and 5 parts of salvia miltiorrhiza extracts. the skin effectively recovers the young state; the glycated protein is eliminated; the formed crosslinking Maillard reaction collagen is broken; the skin color unevenness and yellow color phenomena can be reduced; the composition can be used for mask essence liquid, and can also be used for essenceliquid and emulsion cream.

The invention discloses an anti-glycation facial mask which comprises a mask base fabric (1) and a mask essence (2), wherein the mask essence comprises a water-soluble thickener (a), 0.1-20 wt% of a moisturizer (b), 0.1-10 wt% of an anti-glycation composition (c) and a water-bearing carrier (d); by using the water-soluble thickener, the mask essence has the viscosity of 1-10000 mPa.s; the moisturizer comprises polylol and sodium hyaluronate; and the anti-glycation composition comprises a pea extract and an Argania spinosa leaf extract. The anti-glycation facial mask can effectively inhibit the activities of metal proteinase and collagenase, promotes the synthesis of collagen, glycosaminoglycans (GAGs) and elastin, enables the skin to be tight and elastic and have fewer wrinkles, and thus, has favorable antiaging effects.

An anti-glycation agent includes a Garcinia kola extract or fraction. The compositions including the extract or the fraction are used to inhibit the glycation of proteins, in particular the glycation of skin proteins involved in cutaneous aging. A method for determining the activity of compounds for inhibiting the glycation of cutaneous proteins, in particular for inhibiting the glycation of collagen is also described.

The invention discloses an anti-glycation facial mask containing Poria extract, comprising mask base cloth (1), and mask essential liquid (2); the mask essential liquid comprises a water-soluble thickener (a) enabling the mask essential liquid to be 1-5000 mPa.s; 0.1-20% by weight of a wetting agent comprising a polyol and sodium hyaluronate; and 0.1-10% by weight of an anti-glycation composition that includes pea extract and Poria extract; and a water-bearing carrier (d). The rich effective ingredient in the anti-glycation facial mask cooperate with one another to effectively inhibiting the activity of metal proteinase and collagenase, the synthesis of collagen and elastin is accelerated, tight elastic skin with reduced winkles is achieved effectively, and the anti-glycation facial mask has good anti-aging effect.

The invention discloses an anti-glycation whitening cosmetic composition and an anti-glycation whitening cosmetic containing the same. A formula of the anti-glycation whitening cosmetic composition comprises 0.001-15 parts of an anti-glycation agent; the whitening cosmetic containing the anti-glycation whitening cosmetic composition comprises the anti-glycation whitening cosmetic composition, a cosmetic matrix and water, wherein the weight part of the cosmetic matrix is 0.0001 to 70 parts; wherein the anti-glycation agent A is prepared from one or more of a sunflower seed extract, nicotinamide, acetylchitosan amine, and a paper mulberry bark extract, a mulberry bark extract, an apple fruit extract, a camellia extract, a tea extract, a rhus chinensis extract, madecassoside, ethylhexylglycerin and a tricholoma matsutake extract; according to the invention, the anti-glycation effect can be effectively improved, the problems of dark yellow skin, uneven skin color and the like caused by glycation and oxidation can be prevented, inhibited or improved, the skin color can be brightened, the skin wrinkles can be reduced, the skin texture can be improved, and the skin elasticity can be recovered.

The invention belongs to the technical field of beautifying, and mainly relates to a stem cell composition containing an adipose derived stem cell exogenous protein extract, a preparation method of the extract and application thereof. The composition includes the components of adipose derived stem cell exogenous protein extract, milk thistle extract, tea polyphenol, L-carnosine and evening primrose extract. The preparation method of the composition comprises the following steps: a) collecting an adipose derived stem cell culture supernatant and conducting ultra high speed centrifuging to collect a stem cell exogenous protein; b) mixing the milk thistle extract, the tea polyphenol, the L-carnosine, the evening primrose extract and the adipose derived stem cell exogenous protein extract. Thecomposition is simple in component, the stem cell protein used is derived from auto adipose derived stem cells, the material is not limited, no rejection reaction exists, and the anti-glycation effect has broad application prospects in anti-aging cosmetics.

The invention discloses a brightening and anti-glycation composition containing carnosine and ergothioneine. The brightening and anti-glycation composition is prepared from the following components inpercentage by weight: 0.0001-20% of the carnosine, 0.0001-5% of the ergothioneine, 0.0001-2% of inositol and the balance of water. In the brightening and anti-glycation composition, the ergothioneinehas good synergistic and anti-oxidation effects, not only can play a strong anti-oxidation effect, but also can cooperate with other antioxidants to take effect, so that the composition can fully play the effects. The carnosine and the ergothioneine are combined to make skin have stronganti-glycation, anti-oxidantion, repairing and brightening functions. And the brightening and anti-glycation composition is mild and non-irritant, can be used as a brightening and anti-glycation skin active component to be applied to various cosmetics.

The invention relates to anti-glycation particles used for powder-type cosmetics. The anti-glycation particles are characterized by being prepared from natural coral powder loaded anti-glycation composition, and the anti-glycation composition is prepared from prolinamidoethyl imidazole, sweet osmanthus extract, asparagus officinalis extract, hydrolyzed rice protein and Jania decussato-dichotoma Yendo extract. The average particle size of natural coral powder is 5-50 micrometers. The anti-glycation particles used for powder-type cosmetics has the advantages of being safe, stable and capable of acting on skin and having a remarkable anti-glycation function and further have the advantages that hand feeling is soft and smooth, using feeling is good, stability is high, and the particles are convenient to add into the powder-type cosmetics.

The invention discloses an anti-glycation black tea extract and a preparation method thereof. The preparation method comprises the following steps: (1) withering; (2) rolling; (3) fermenting; (4) drying; and (5) extracting. By adopting the anti-glycation black tea extract and the preparation method thereof, the anti-glycation black tea extract has rich nutrient substances and rich fragrance, has remarkable anti-glycation effect and anti-oxidation effect, and has a wide application group since caffeine is removed, and can be used for preparing health-protecting foods or used as cosmetic raw materials.

The invention discloses essence with anti-sugar and anti-oxidation functions and a preparation method thereof. The essence comprises an antioxidant and an anti-saccharifying agent; the antioxidant is a mixture of carnosine, inositol, a saccharomycetes lysate extract, a haematococcus pluvialis extract, astaxanthin, oryzanol and tocopherol; the anti-saccharifying agent is decarboxylated carnosine HCl, and other functional active components are carefully selected; multiple functional components are compounded, and by eliminating skin oxygen free radicals, inhibiting glycosylation and treating glycosylated protein to resist oxidation and saccharification, release of inflammatory factors is inhibited, expression of barrier repair related genes is promoted, skin barriers are repaired, senescence is delayed, damage is repaired, and the activity of fibroblasts is activated. By reasonably compounding the anti-saccharification component, the anti-oxidation component and the other active components, the activity of each component is improved, so that the essence has good anti-saccharification and anti-oxidation effects at the same time.

The invention discloses a preparation method of a composition with anti-glycation and anti-skin aging functions. Characterized in that it is characterized in that it comprises, the feed additive is prepared from the following raw materials in parts by weight. 4-8 parts of astragalus membranaceus, 4-6 parts of radix ophiopogonis, 2-4 parts of radix angelicae, 6-10 parts of ligusticum wallichii, 4-8parts of liquorice, 2-4 parts of radix puerariae, 2-4 parts of dendrobe, 4-6 parts of polygonum multiflorum, 2-4 parts of poria cocos, 6-8 parts of atractylodes macrocephala, 8-10 parts of saffron crocus, 6-8 parts of rhodiola. The composition is simple to prepare, can effectively utilize epigenetic factors of plant stem cells to maintain skin efficacy, effectively enables epidermis to be in a young state, and eliminates glycoprotein.

The invention discloses a source type anti-glycation formula for eliminating 98 percent of glycation reaction chain occurrence source, which consists of the following materials in parts by weight: 10 to 20 parts of glutathione, 20 to 30 parts of lipoic acid, 10 to 15 parts of mineral extract composition, 10 to 15 parts of mogroside, 10 to 15 parts of ginkgo fruit extract, 80 to 100 parts of deionized water and 10 to 15 parts of free radical scavenger. A preparation method disclosed by the invention includes the following steps: dosing, mixing and packaging. The source type anti-glycation formula can conveniently eliminate the source in a full glycation reaction chain, so the glycation effect in the body can be prevented, treated and inhibited; and thereby the source type anti-glycation formula can be applied to treat and prevent glycation-related symptoms including diabetes, atherosclerosis, arthritis, mental symptom and visual impairment.

A method for the measurement and analysis of skin fluorescence across multiple subjects. The method includes illuminating each subject with an excitation wavelength, detecting a peak fluorescence level within a corresponding emission wavelength range, determining relative levels of skin glycation for each subject, and evaluating the efficacy of a skin treatment based on the relative levels of skin glycation. The method can include ranking and normalizing the peak fluorescence levels for each subject, and the method is suitable for use in placebo-controlled studies of anti-glycation skin therapies.

The invention discloses anti-glycation essence and a preparation method thereof. The anti-glycation essence is prepared from the following components in percentage by weight: 0.01 to 0.1% of a chelating agent, 0.1 to 0.5% of a thickening agent, 1 to 15% of a humectant, 1 to 13% of an emollient, 0.5 to 2% of an emulsifier, 0.1 to 2% of an anti-allergy agent, 1 to 12% of a skin conditioner, 0.01 to0.2% of a pH conditioning agent, 0.5 to 2% of a stabilizing agent, 1 to 2.3% of an antiseptic and the balance purified water. The invention also provides a preparation method of the anti-glycation essence. According to the anti-glycation essence, the anti-glycation essence is prepared from multiple safe and effective raw material components, oxidation resistance is converted into self-oxidation, the preparation process is easy to operate, and the problems that formula components are unstable and potential safety hazards exist are effectively solved.

Disclosed is the use of partially purified extracellular metabolite isolated from Bacillus coagulans MTCC 5856 to prevent skin aging. More specifically the invention discloses the anti-collagenase, anti-elastase, anti-glycation activity and enhancement of TGF-β, epidermal growth factor and hyaluronic acid expression in human dermal fibroblasts, of extracellular metabolites isolated from Bacillus coagulans MTCC 5856.

The invention relates to a plant extract, in particular to application of a golden camellia extract to improvement of anti-glycation activity and inhibition of cell fat accumulation. The invention provides an application of a golden camellia extract in preparation of a composition for improving anti-glycation and inhibiting cell fat accumulation. The golden camellia extraction can improve the ability of removing highly-glycated end products, inhibit fat accumulation, reduce the fat content in cells and achieve the effect of reducing fat.

The invention relates to novel guanidine derivatives in the cinnamic series of general formula (I):The invention also relates to the process for preparing said guanidine derivatives and also to synthetic intermediates.Finally, the invention relates to the use of the guanidine derivatives for the preparation of compositions with anti-glycation properties, especially in cosmetology.

The invention discloses a cosmetic composition with functions of whitening and removing freckles and whitening and freckle removing cosmetics containing the cosmetic composition. The cosmetic composition is prepared from, by weight, 0.001-15 parts of a whitening and freckle removing agent and 0.1-7 parts of an anti-glycation agent. The cosmetic composition with functions of whitening and removingthe freckles and the whitening and freckle removing cosmetics containing the cosmetic composition comprise the cosmetic composition with the functions of whitening and removing the freckles, a cosmetic substrate and water, and are characterized in that parts by weight of the cosmetic substrate is 0.0001-70; the whitening and freckle removing cosmetics containing the cosmetic composition comprise atoning lotion, essence, an emulsion, a facial cream, a facial mask, shower gel, a facial cleanser, a sunscreen cream, an eye cream, a foundation make-up and a BB cream. The cosmetic composition withthe functions of whitening and removing the freckles and the whitening and freckle removing cosmetics containing the cosmetic composition are safe and reliable, and abandon traditional chemical cosmetics except for strong-toxicity substances containing mercury, hydroquinone preparations and the like, because adopted traditional Chinese medicine skin care cosmetics are natural and safe, the effectsare significant, and by utilizing mixed processing of traditional Chinese medicine, the purposes of whitening, removing freckles, not damaging the skin and being not harmful to the human body are achieved.

The invention discloses an anti-glycation composition and a preparation method. The anti-glycation composition comprises the following components in percentage by weight: moisturizing agent 3.61-13.1%, chelating agent 0.02-0.1%, antioxidant 0.3-0.6 and the balance water; also includes anti-glycation agent, said anti-glycation agent includes Chizhi extract, sweet-scented osmanthus flower extract and carnosine, and the weight percent content of each component of anti-glycation agent in anti-glycation composition is Chizhi extract 0.5~12%, Osmanthus fragrans extract 0.5-12% and carnosine 0.05-0.5%. The present invention can effectively improve the anti-glycation effect by compounding various functional ingredients, prevent, suppress or improve the problems of dark yellow skin and uneven skin color caused by saccharification, and at the same time brighten the skin color, reduce skin wrinkles, and improve the appearance of the skin. Texture, and restore skin elasticity.

The invention provides methods, compositions, and dietary formulations useful for preventing or treating dermatitis, promoting healthy skin, and retarding skin aging. The methods comprise administering to an animal a therapeutically effective amount of a combination of at least two of one or more antioxidants; one or more anti-glycation agents; one or more body fat reducing agents; one or more insulin sensitivity enhancing agents; and one or more anti-inflammatory agents.

The invention discloses an anti-glycation collagen peptide and a preparation method thereof. The anti-glycation collagen peptide is prepared by the following steps: S1, preparing a total protein crude extract; S2, preparing a crude collagen extract; S3, refining the crude collagen extract; S4, preparing the collagen peptide; S5, preparing the anti-glycation collagen peptide; The prepared anti-glycation collagen peptide is rich in G 1 y-Hyp-Pro-G 1 y-Arg-Pro-G 1 y-Hyp sequences, the molecular weight range is 850-1800 Daltons, and the anti-glycation collagen peptide is safe, is free of toxic and side effects, is easy to digest, exhibits an anti-glycation effect, can be used as a raw material of drugs, health-care foods and foods, can be added into acid beverages, and can be used for improving skin moisture wrinkles and improving vascular elasticity.