80 results about "Anti glycation" patented technology

The invention provides new inhibitors of protein glycation, identified from compound libraries by a high throughput screening assay. The anti-glycation agents so identified are characterized by a variety of chemical structures and are useful for the prevention or treatment of age-, diabetes-, and smoking-related complications, including neuropathy, nephropathy, ocular pathologies, or the loss of mechanical properties of collagenous tissues. Among compounds identified as having the anti-glycation activity, of special interest are epinephrine and its analogs, in particular D-epinephrine and its analogs, which are particularly useful for the prevention or treatment of age-, diabetes-, and smoking-related ocular pathologies.

The invention discloses a composition with an anti-glycosylation effect and an application thereof. The anti-glycosylation composition consists of the following components in parts by mass: 0.1 to 5 parts of an osmanthus fragrans flower extract, 0.1 to 5 parts of a pomegranate extract and 0.01 to 0.1 part of a canarium album fruit extract, wherein the mass content of polyphenol in the osmanthus fragrans flower extract is greater than or equal to 10 percent, the mass content of verbascoside in the osmanthus fragrans flower extract is greater than or equal to 10 percent, the mass content of polyphenol in the pomegranate extract is greater than or equal to 30%, the mass content of punicalagin in the pomegranate extract is greater than or equal to 8%, wherein the mass content of polyphenol inthe canarium album fruit extract is greater than or equal to 10%, and the mass content of hydroxytyrosol in the canarium album fruit extract is greater than or equal to 3%. Through the synergistic effect of the osmanthus fragrans flower extract, the pomegranate extract and thecanarium album fruit extract which have a specific proportion and specific quality, anti-glycation capacity of skins is improved in three aspects that generation of a fibroblast glycosylation reaction end product CML is remarkably reduced, generation of AGEs is reduced, and SOD expression is increased.