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A comprehensive test method for rat cognitive behavior

A comprehensive test and behavioral technology, applied in the field of basic medical research, can solve problems such as impact, lack of executive memory evaluation, etc.

Active Publication Date: 2022-02-25
JIUJIANG UNIV
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Problems solved by technology

[0007] Most of these experiments are based on adversity and passive environment, which is a stress in itself, and the additional pressure affects the test results; and these separate social interaction ability and exploration behavior, which is not conducive to rats. A comprehensive assessment of emotions and behaviors, and a lack of assessment of executive memory based on the prefrontal gyrus

Method used

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  • A comprehensive test method for rat cognitive behavior
  • A comprehensive test method for rat cognitive behavior
  • A comprehensive test method for rat cognitive behavior

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Experimental program
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Embodiment

[0038] In this round of experiments, 9 SD rats (9 weeks old, weighing 310-330 g) were randomly divided into 3 groups, 3 rats in each group, for blank group, stress group and drug group.

[0039] In the blank group (Null), without external intervention, the numbers of the 3 rats are respectively N-1, N-2, and N-3.

[0040]Stress group: On the basis of the blank group, manual intervention was carried out, and restraint stress (Restraint Stress, RS) was applied. The numbers of the 3 rats were RS-1, RS-2, and RS-3, respectively. Each subject was lured into a semi-cylinder tube, which was blocked by a slide at a pressure close to a threshold such that they were immobilized. External hypertension lasted 4 hours a day for 7 consecutive days. When the pressure-time is over, the animals are allowed to return to the husbandry cage and have access to water and food. Animals were left in the chamber for 10 min to acclimate before implementation.

[0041] Drug group: On the basis of the...

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Abstract

The present invention provides a comprehensive test method for cognitive behavior of rats, which is a comprehensive evaluation method for cognitive behaviors of rats such as emotion, anxiety, and society established in an active enrichment environment (Environmental Enrichment, EE), without artificial The test is carried out separately, and it is carried out under the condition of weakening the external stress environment. It is completely out of instinctive exploration behavior, which can explore the material basis of the neural circuits of hippocampal CA1 / CA3 and prefrontal gyrus (PFC). Animal behavior changes under various drugs and medical interventions are very scientific, and can help to investigate the changes of drugs or medical interventions on brain nerves or synaptic transmitters.

Description

technical field [0001] The EBAS (Environmental Enrichment Based Acquisition System) evaluation system provided by the invention relates to the field of basic medical research, in particular to a comprehensive test method for rat cognitive behavior. Background technique [0002] The cognitive behavior test of rats (rats) is a basic zoological experiment for the study of neuropharmacology and mental diseases, a scientific study to verify the effectiveness and feasibility of drugs, and an environmental impact on animal behavior and epigenetics. Research justification. At present, there are many types of experiments to study animal behavior. Among them, there are probably open field experiments (open field), sucrose preference experiments, and tail suspension experiments used for anxiety behavior and exploratory behavior. If the ability of spatial learning and memory is included, There is also the water maze (MWM) experiment. [0003] 1. Mine experiment: place the rat in the c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01K29/00G06N3/08G06K9/62
CPCA01K29/005G06N3/08G06F18/214
Inventor 袁荣华于晓雪陈义吉袁谷梁袁谷麦扈婧朱嘉静
Owner JIUJIANG UNIV
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