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Comprehensive testing method for rat cognitive behaviors

A comprehensive testing and behavioral technology used in basic medical research to address the lack of executive memory assessment, impact, etc.

Active Publication Date: 2020-10-09
JIUJIANG UNIVERSITY
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AI Technical Summary

Problems solved by technology

[0007] Most of these experiments are based on adversity and passive environment, which is a stress in itself, and the additional pressure affects the test results; and these separate social interaction ability and exploration behavior, which is not conducive to rats. A comprehensive assessment of emotions and behaviors, and a lack of assessment of executive memory based on the prefrontal gyrus

Method used

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  • Comprehensive testing method for rat cognitive behaviors
  • Comprehensive testing method for rat cognitive behaviors
  • Comprehensive testing method for rat cognitive behaviors

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Experimental program
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Embodiment

[0038] In this round of experiments, 9 SD rats (9 weeks old, weighing 310-330 g) were randomly divided into 3 groups, 3 rats in each group, for blank group, stress group and drug group.

[0039] In the blank group (Null), without external intervention, the numbers of the 3 rats are respectively N-1, N-2, and N-3.

[0040]Stress group: On the basis of the blank group, manual intervention was carried out, and restraint stress (Restraint Stress, RS) was applied. The numbers of the 3 rats were RS-1, RS-2, and RS-3, respectively. Each subject was lured into a semi-cylinder tube, which was blocked by a slide at a pressure close to a threshold such that they were immobilized. External hypertension lasted 4 hours a day for 7 consecutive days. When the pressure-time is over, the animals are allowed to return to the husbandry cage and have access to water and food. Animals were left in the chamber for 10 min to acclimate before implementation.

[0041] Drug group: On the basis of the...

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Abstract

The invention provides an EBAS (Environmental Enrichment Based Acquisition System) evaluation system and discloses a comprehensive testing method for rat cognitive behaviors. The method is a comprehensive testing method for cognitive behaviors such as emotions, anxiety, society and the like of rats on the basis of EE (Environmental Enrichment), the testing is carried out under the condition of weakening the external stress environment without artificial separation, the rat cognitive behaviors are completely instinctive exploratory behaviors, and the method can be used for exploring material basis of neural circuit of hippocampus CA1 / CA3 and prefrontal cortex (PFC), is scientific for evaluating animal behavior change under actions of various drugs and medical intervention and can offer assistance for investigation of influence of drugs or medical intervention on change of cranial nerve or synaptic transmitter.

Description

technical field [0001] The EBAS (Environmental Enrichment Based Acquisition System) evaluation system provided by the invention relates to the field of basic medical research, in particular to a comprehensive test method for rat cognitive behavior. Background technique [0002] The cognitive behavior test of rats (rats) is a basic zoological experiment for the study of neuropharmacology and mental diseases, a scientific study to verify the effectiveness and feasibility of drugs, and an environmental impact on animal behavior and epigenetics. Research justification. At present, there are many types of experiments to study animal behavior. Among them, there are probably open field experiments (open field), sucrose preference experiments, and tail suspension experiments used for anxiety behavior and exploratory behavior. If the ability of spatial learning and memory is included, There is also the water maze (MWM) experiment. [0003] 1. Mine experiment: place the rat in the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K29/00G06N3/08G06K9/62
CPCA01K29/005G06N3/08G06F18/214
Inventor 袁荣华于晓雪陈义吉袁谷梁袁谷麦扈婧朱嘉静
Owner JIUJIANG UNIVERSITY
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