Application of 17-hydroxy-jolkinolide B in preparation of anti-depression drug

A technology of eupholide and eupholide, which is applied in the field of preparation of antidepressant drugs, and can solve the problem of no antidepressant activity being found

Inactive Publication Date: 2021-02-19
南京温博生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No studies found its antidepressant activity

Method used

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  • Application of 17-hydroxy-jolkinolide B in preparation of anti-depression drug
  • Application of 17-hydroxy-jolkinolide B in preparation of anti-depression drug
  • Application of 17-hydroxy-jolkinolide B in preparation of anti-depression drug

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Embodiment Construction

[0016] The substantive content of the present invention will be described below in conjunction with specific embodiments, but the protection scope of the present invention cannot be limited thereto.

[0017] 1. Experimental materials

[0018] Healthy Kunming male mice, weighing (28±2) g, were fed adaptively for one week before use.

[0019] The purity of 17-hydroxypetrolactone B is more than or equal to 98%, and it is ultrasonically dispersed in 0.5% sodium carboxymethyl cellulose solution to prepare 17-hydroxypetrolactone B solution for later use.

[0020] 2. Experimental method

[0021] 1. Modeling, grouping and administration

[0022] Depression modeling method: using chronic unpredictable stimuli, 2 different stimuli are randomly given to mice at unfixed time points every day, including: (1) Tail clamping: use long tail clamps to clamp the base of the mouse tail (1cm from the base of the tail) (2) swimming in cold water at 4°C for 3 minutes; (3) fasting for 24 hours; (4...

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Abstract

The invention discloses application of 17-hydroxy-jolkinolide B in preparation of an anti-depression drug. A tail suspension test and a forced swimming test are to place depression model animals in asevere environment, so that the animals cannot escape to generate discontinuously immobile despairing states. The anti-depression drug can relieve the despairing degrees of the depression model animals, so that the immobile states can be reversed, and the depression symptoms can be relieved. Experimental researches find that the 17-hydroxy-jolkinolide B can relieve the despairing degrees of depression model mice, and has an anti-depression effect, and therefore has a prospect of being developed into the anti-depression drug.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of 17-hydroxypetiolide B in the preparation of antidepressants. Background technique [0002] Depression is a common mental illness with the characteristics of high morbidity, disability and recurrence. With the increase of modern people's life pressure and work pressure, the incidence of depression is gradually increasing. According to the statistics of the World Health Organization, there are more than 300 million people with depression in the world in 2019, and the incidence of depression in China will increase to 7.35% in 2020, which will rise to the second place after heart disease (different antidepressant drugs have different effects on Effects of blood coagulation in patients with depression, Laboratory Medicine and Clinics, 2020). [0003] Drug therapy is the most important treatment method for depression. Antidepressant drugs can fundamentally improve the d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P25/24
CPCA61K31/365A61P25/24
Inventor 姜东花其他发明人请求不公开姓名
Owner 南京温博生物科技有限公司
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