Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of product for detecting TRPC6 gene or expression product thereof

A technology for expressing products and products, applied in the field of biomedicine, can solve the unreported problems related to TRPC62 type diabetes, and achieve significant clinical effects

Active Publication Date: 2022-01-04
NINGXIA MEDICAL UNIV
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report on the relationship between TRPC6 and islet β-cell pyroptosis and type 2 diabetes

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of product for detecting TRPC6 gene or expression product thereof
  • Application of product for detecting TRPC6 gene or expression product thereof
  • Application of product for detecting TRPC6 gene or expression product thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1 Materials and methods

[0031] 1.1 Materials

[0032] 1.2 Animal model and grouping

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of biomedicine, in particular to application of a product for detecting a TRPC6 gene or an expression product of the TRPC6 gene, more particularly application of the product for detecting the TRPC6 gene or the expression product of the TRPC6 gene in preparation of a tool for diagnosing type 2 diabetes mellitus. The type 2 diabetes mellitus is caused by insular beta cell pyroptosis. The product comprises a product for detecting an mRNA level of the TRPC6 gene, a product for detecting a protein level of the TRPC6 or a product for detecting a DNA methylation level of a promoter region of the TRPC6 gene. According to the application, the correlation between the TRPC6 gene or the expression product thereof and insular islet beta pyroptosis and the type 2 diabetes mellitus is found for the first time, and research proves that the TRPC6 is highly expressed in the insular beta pyroptosis caused by homocysteine, so that a theoretical basis is provided for early diagnosis and prognosis evaluation of the type 2 diabetes mellitus from a molecular level in the future, and the application has a great clinical significance.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of a product for detecting TRPC6 gene or its expression product. Background technique [0002] Diabetes mellitus is a collective term for heterogeneous metabolic disorders, the main manifestation of which is chronic hyperglycemia. The pathogenesis is mainly due to the destruction of pancreatic β cells, including insulin resistance, progressive insulin secretion or both. It is a disease that seriously endangers human health due to its insidious onset, high incidence and many complications. Worldwide, 415 million people live with diabetes, and an estimated 193 million people have undiagnosed diabetes. Among them, type 2 diabetes accounts for more than 90% of diabetic patients, leading to microvascular and macrovascular complications, causing profound psychological and physical distress to patients and caregivers, and placing a huge burden on the healthcare sys...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/158C12Q2600/154
Inventor 马胜超揭育祯高源张晴丁宁张辉姜怡邓
Owner NINGXIA MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com