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Diisopropylphosphonoalkanes as topical agents for treatment of sensory discomfort

A local and therapeutic effect technology, applied in the direction of anti-toxic agents, medical preparations containing active ingredients, pharmaceutical formulas, etc.

Pending Publication Date: 2022-05-27
艾威药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No biological activity of this diisopropyl compound has been previously reported

Method used

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  • Diisopropylphosphonoalkanes as topical agents for treatment of sensory discomfort
  • Diisopropylphosphonoalkanes as topical agents for treatment of sensory discomfort
  • Diisopropylphosphonoalkanes as topical agents for treatment of sensory discomfort

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0032] Embodiment 1: A therapeutic article comprising a compound of formula 1 and a delivery vehicle carrying said compound of formula 1 in said therapeutic article:

[0033]

[0034] wherein, R is n-pentyl, n-hexyl, n-heptyl, and / or n-nonyl;

[0035] The delivery medium is suitable for topical delivery.

Embodiment approach 2

[0036] Embodiment 2: The therapeutic article of Embodiment 1, wherein the compound is 1-diisopropylphosphonopentane.

Embodiment approach 3

[0037] Embodiment 3: The therapeutic article of Embodiment 1, wherein the compound is 1-diisopropylphosphonohexane.

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Abstract

The present invention provides diisopropylphosphonoalkanes as topical agents for the treatment of sensory discomfort. The present invention relates generally to the field of therapeutic compounds. More specifically, the present invention relates to certain diisopropylphosphonoalkanes as described herein: DIPA-1-5, DIPA-1-6, DIPA-1-7, DIPA-1-8, and DIPA-1-9, which are collectively referred to herein as' DIPA compounds', as well as to the use of diisopropylphosphonoalkanes, such as diisopropylphosphonoalkanes, such as diisopropylphosphonoalkanes, such as diisopropylphosphonoalkanes. These diisopropylphosphono alkanes are useful, for example, in the treatment of disorders including sensory discomfort, skin retardation, dermatitis, ocular pain and discomfort, thermal discomfort, thermal stress, redness and / or night sweat, post-operative hypothermia, post-anesthesia shivering, fatigue, exhaustion, depression, cognitive dysfunction, and are useful for enhancing cognitive function.

Description

[0001] The present application is a divisional application of Chinese Patent Application No. 201510191871.0 with an application date of April 21, 2015, entitled "Diisopropylphosphonoalkanes as topical agents for the treatment of sensory discomfort". technical field [0002] The present invention generally relates to the field of therapeutic compounds. More specifically, the present invention relates to certain diisopropylphosphonoalkanes as described herein (collectively referred to herein as "DIPA compounds" DIPA-1-5, DIPA-1-6, DIPA-1-7 , DIPA-1-8, and DIPA-1-9), these diisopropylphosphonoalkanes, for example, are useful in the treatment of disorders (eg, diseases) including: discomfort (eg, caused by irritation, itching, or pain) ), skin dysesthesia, atopic dermatitis, eye pain and discomfort, heat discomfort, heat stress, flushing and / or night sweats (vasomotor symptoms), postoperative hypothermia, post-anesthesia chills, fatigue, exhaustion, Depression, cognitive impairme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/662A61P39/00A61P25/28A61P17/00A61P25/24A61P11/02
Inventor 魏德烽
Owner 艾威药业有限公司
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