Raw material quantitative weighing method and device for preparing metformin compound sustained release preparation

Abstract

The invention discloses a raw material quantitative weighing method and device for preparing a metformin compound sustained release preparation, and relates to the technical field of physical weighing, the raw material quantitative weighing device comprises a raw material mixing box, the top of the raw material mixing box is fixedly provided with a related frame, the top of the related frame is fixedly provided with an annular supporting plate, and the annular supporting plate is fixedly provided with an annular groove; a variable weighing mechanism is arranged on the outer surface wall of the annular supporting plate, a boosting discharging mechanism is arranged at the top of the annular supporting plate and comprises an assembling plate, the bottom of the assembling plate is fixedly installed at the top of the annular supporting plate, a locking sleeve is fixedly installed in the assembling plate, and the locking sleeve is fixedly installed on the top of the annular supporting plate. According to the mechanism, a sectional raw material lowering method is adopted, raw materials are subjected to fluffy treatment in advance, the characteristic that powder particle raw materials are prone to being stacked is improved, the raw materials are transferred into a designated container in a slow scattering mode, it is guaranteed that the weighing assembly more easily captures tiny numerical value changes, and the weighing accuracy is improved. And the error between each raw material and the set standard value is reduced.

Description

Technical Field

[0001] The invention relates to the technical field of physical weighing, and in particular to a method and a device for quantitatively weighing raw materials for preparing a metformin compound sustained-release preparation. Background Art

[0002] Metformin combined sustained-release preparation is a drug used to treat type 2 diabetes. It combines metformin and other active ingredients and achieves the long-term effect of the drug through sustained-release technology.

[0003] The main raw materials for the preparation of metformin compound sustained-release preparations include metformin, other active ingredients and various excipients. Metformin is the primary ingredient, which enables the drug to reduce the production of glucose in the liver and increase the body's sensitivity to insulin, thereby achieving the purpose of lowering blood sugar. The addition of various excipients can control the drug release rate, improve the physical properties of the drug, and improve the drug's stability and patient compliance.

[0004] However, the existing metformin compound sustained-release preparation raw material quantitative weighing device has the following shortcomings: Metformin compound sustained-release preparation is a type of solid oral medication, and the preparation process of the drug must be strictly carried out in accordance with a verified formula. Any deviation in the auxiliary material ingredients may have an adverse effect on the quality and efficacy of the final product. With the development of technology, the existing pharmaceutical raw material weighing equipment has the ability to automatically discharge and continuously weigh. The raw material release amount is mostly controlled by a designated valve body. However, the mechanical discharge accuracy is low. Each weighing of the raw materials will have a certain error with the standard value, affecting the subsequent finished product qualification rate.

[0005] Therefore, we proposed a method and device for quantitatively weighing raw materials for the preparation of metformin compound sustained-release preparations, so as to solve the above-mentioned problems. Summary of the invention

[0006] The purpose of the present invention is to provide a method and device for quantitatively weighing raw materials for the preparation of metformin compound sustained-release preparations. Through the auxiliary material discharge mechanism, the mechanism can complete the lowering of raw materials in three steps, the first stage is traditional physical release, the second stage is dispersed release, and the third stage is intermittent release. The purpose is to fully break up the granular powdery raw materials, so that the raw materials entering the material transport pipe sleeve are more expanded and loose, and the raw materials are prevented from falling into the material collection barrel in a clustered manner in the third stage of lowering, and then the weighing component is used to control the actual data to solve the problems raised by the above-mentioned background technology.

[0007] To achieve the above object, the present invention provides the following technical solution: a raw material quantitative weighing device for preparing a metformin compound sustained-release preparation, comprising a raw material mixing box, a related frame is fixedly installed on the top of the raw material mixing box, and a ring-shaped support plate is fixedly installed on the top of the related frame; The outer wall of the annular support plate is provided with a variable weighing mechanism, and the top of the annular support plate is provided with a boosting unloading mechanism; The auxiliary material discharge mechanism includes an assembly plate, the bottom of which is fixedly mounted on the top of the annular support plate, a locking sleeve is fixedly mounted inside the assembly plate, a material transport pipe sleeve is fixedly inserted into the inner surface wall of the locking sleeve, a first load-bearing frame is fixedly mounted on the front surface of the assembly plate, the top of the first load-bearing frame is fixedly sleeved on the outer surface wall of the material transport pipe sleeve, a return pipe is movably arranged inside the material transport pipe sleeve, a sealing joint is fixedly mounted at the front end of the return pipe, a connecting pipe is fixedly connected to the outer surface wall of the material transport pipe sleeve, a feeding funnel is fixedly connected to the top of the connecting pipe, and a screen is arranged inside the feeding funnel A grafting plate is fixedly installed on the rear surface of the assembly plate, a third electric telescopic assembly is fixedly installed on the bottom of the grafting plate, the axial end of the third electric telescopic assembly is fixedly inserted in the end of the reflux pipe, a second load-bearing frame is fixedly installed on the rear surface of the assembly plate, a pumping unit is fixedly installed on the rear surface of the second load-bearing frame, a feed end of the pumping unit is fixedly connected to a group of conveying pipes, a group of feed ends of the conveying pipes all penetrate the outer wall of the reflux pipe and are connected to the inside of the reflux pipe, a first discharge square pipe is provided at the discharge end of the pumping unit, and a four-part sealing plate is movably provided on the inner surface wall of the sealing joint.

[0008] Preferably, the variable weighing mechanism includes a positioning ring tooth, which is fixedly mounted on the outer wall of the annular support plate, and an upper sliding sleeve and a lower sliding sleeve are fixedly mounted on the top and bottom of the positioning ring tooth respectively, and a traveling support plate is movably inserted inside the upper sliding sleeve and the lower sliding sleeve.

[0009] Preferably, a mechanical variable component is fixedly installed on the top of one of the traveling pallets, and a driving gear is fixedly sleeved on the output end of the mechanical variable component, and the positioning ring gear is meshingly connected with the driving gear.

[0010] Preferably, an external frame is fixedly installed between the front surfaces of the two traveling pallets, a linkage cross plate is movably provided on the rear surface of the external frame, a second electric telescopic component is fixedly installed inside the external frame, a merging frame is fixedly sleeved on the axial end of the second electric telescopic component, and the top of the merging frame is connected to the bottom of the linkage cross plate.

[0011] Preferably, an electrical control box is fixedly installed on one end of the outer wall of the linkage horizontal plate, an inductive metering component is fixedly connected to the top of the electrical control box, a contact tray is fixedly provided at the inductive end of the inductive metering component, an independent power supply is fixedly installed on the top of the linkage horizontal plate, a group of wires are fixedly connected to the output end of the independent power supply, the output ends of a group of the wires are all connected to the wiring terminals of the electrical control box, an adapter is fixedly connected to the bottom of the linkage horizontal plate, a group of information lines are fixedly connected to the inside of the adapter, and the input ends of a group of the information lines are all connected to the output end of the electrical control box.

[0012] Preferably, a first electric telescopic component is fixedly installed at one end of the outer wall of the electrical control box, a parallel plate is fixedly sleeved on the axial end of the first electric telescopic component, a first drive component is fixedly installed on the top of the parallel plate, and a slotted plate is fixedly sleeved on the output end of the first drive component.

[0013] Preferably, the slotted plate is movably connected to a zoom component inside, two fastening sleeves are fixedly mounted on the outer wall of the zoom component, and a gathering barrel is placed on the top of the contact tray.

[0014] Preferably, a second driving assembly is fixedly installed on the top of the grafting plate, and a base is fixedly sleeved on the output end of the second driving assembly. A group of extension plates are fixedly connected to the outer wall of the base, and a distribution box is fixedly installed on one end of the outer wall of each of the extension plates. The bottom of each of the distribution boxes is fixedly connected to a lowering joint, and a first controllable valve is provided inside each of the lowering joints.

[0015] A group of metal brackets are welded on the top of the associated frame, and an adjustable foot is fixedly installed on the bottom of each metal bracket. The bottom of the raw material mixing box is fixedly connected to a second discharge square pipe, and a second controllable valve is arranged inside the second discharge square pipe.

[0016] A weighing method of a raw material quantitative weighing device for preparing a metformin compound sustained-release preparation comprises the following steps: Step 1: Select a specified number of raw materials and place them in the corresponding sub-boxes in turn. Manually import the data of each raw material through the peripheral components of the electrical control box, and set the expected standard weight values ​​of various raw materials in turn.

[0017] Step 2: Place the equipment reasonably according to site conditions, use the machine-variable components and related components to coordinate, adjust the position of the weighing components, avoid the equipment being easily disturbed by external conditions during operation, place the aggregate barrel gently on the contact tray, turn on the second electric telescopic component, and move the aggregate barrel horizontally to the middle of the equipment, so that the aggregate barrel is accurately placed at the discharge port of the material transport pipe sleeve, and then controlled by the relevant electronic components of the electrical control box to complete the peeling setting and put the induction metering component in the zero state.

[0018] Step 3: Start releasing the raw materials in one of the sub-boxes. After being processed by the screen assembly, the raw materials are fully broken up and then enter the material transport pipe sleeve. The third electric telescopic assembly is further activated and acts on the sealing joint to push the raw materials inside the material transport pipe sleeve forward.

[0019] Step 4: During the process, the raw materials gradually fall from the discharge end of the material transport sleeve into the collecting barrel. As the volume of the raw materials increases, the continuously increasing weight value is measured by the induction metering component and imported into the electrical control box in real time. It is monitored by relevant electronic components and the pushing speed of the third electric telescopic component is controlled according to the numerical performance, and the falling amount of the raw materials is adjusted.

[0020] Step 5: After the weighing of one raw material is completed, turn on the extraction unit to continuously extract the trapped air in the reflux pipe and the conveying pipe, so that a strong adsorption force is generated at the air inlet end of the reflux pipe, forcing the four-part sealing plate to retract into the reflux pipe, and fully extract the residual material in the material transport pipe sleeve, and use the designated container to complete the residual material recovery from the first discharge square pipe.

[0021] Step six: Through the above method, the raw materials in each subsequent sub-box are weighed in turn, and after each raw material is weighed, the first electric telescopic component and its connected components can be used to complete the dumping of the raw materials in the gathering barrel and gather them into the raw material mixing box.

[0022] Compared with the prior art, the present invention has the following beneficial effects: 1. The present invention sets up a booster unloading mechanism, which can complete the unloading of raw materials in three steps. The first stage is traditional physical release, the second stage is dispersed release, and the third stage is intermittent release. The purpose is to fully break up the granular powdery raw materials, so that the raw materials entering the material transport pipe sleeve are more expanded and loose, and avoid the raw materials from falling into the gathering barrel in a clustered manner in the third stage. Then, the weighing component is used to better control the actual data. The mechanism adopts a segmented raw material unloading method, fluffs the raw materials in advance, improves the characteristic that the powder granular raw materials are easy to cluster, and transfers the raw materials to the designated container in a slowly scattered manner, ensuring that the weighing component can more easily capture small numerical changes and reduce the error between each raw material and the set standard numerical value.

[0023] 2. The present invention sets up a boosting material discharge mechanism, which uses a parallel pushing method to complete the final lowering of the raw materials. Before changing different raw materials for weighing, the extraction unit can be started first, so that the air inlet end of the reflux pipe forms a strong adsorption force, which is used to induce the air in the material transport pipe sleeve, forcing the retained raw materials therein to be continuously extracted into the reflux pipe with the movement of the air flow. On the one hand, the material transport pipe sleeve is cleaned to avoid mixing with the subsequent raw materials. On the other hand, each type of residual material can be recovered one by one using an independent container to reduce raw material waste. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1A main structural stereogram of a method for quantitatively weighing raw materials for preparing a compound sustained-release preparation of metformin and a device thereof according to the present invention; Figure 2 A side view of a method for quantitatively weighing raw materials for preparing a compound sustained-release preparation of metformin and a stereoscopic diagram of the device thereof; Figure 3 A method for quantitatively weighing raw materials for preparing a compound sustained-release preparation of metformin according to the present invention and a bottom-side structural stereogram of the device thereof; Figure 4 It is an enlarged stereoscopic diagram of a method for quantitatively weighing raw materials for preparing a compound sustained-release preparation of metformin and a variable weighing mechanism structure in the device of the present invention; Figure 5 The invention provides a method and device for quantitatively weighing raw materials for preparing a metformin compound sustained-release preparation. Figure 4 The enlarged stereogram of the structure at B in the middle; Figure 6 It is an enlarged stereoscopic diagram of a method for quantitatively weighing raw materials for preparing a compound sustained-release preparation of metformin and a structure connected to an external rack in the device of the present invention; Figure 7 It is an enlarged stereoscopic diagram of the structure of the material-boosting mechanism in a method for quantitatively weighing raw materials for preparing a compound sustained-release preparation of metformin according to the present invention and a device thereof; Figure 8 The present invention provides a method and device for quantitatively weighing raw materials for preparing a metformin compound sustained-release preparation. Figure 7 A magnified stereoscopic image of the structure at center A; Fig. 9 The present invention is a method for quantitatively weighing raw materials for preparing a compound sustained-release preparation of metformin and an enlarged stereoscopic view of the connected structure of the assembly plates in the device.

[0025] In the figure: 1, raw material mixing box; 2, associated frame; 3, annular support plate; 4, variable weighing mechanism; 401, positioning ring gear; 402, upper sliding sleeve; 403, lower sliding sleeve; 404, traveling support plate; 405, external frame; 406, machine variable component; 407, driving gear; 408, linkage horizontal plate; 409, electrical control box; 410, inductive metering component; 411, contact tray; 412, first electric telescopic component; 413, parallel plate; 414, first driving component; 415, slotted plate; 416, zoom component; 417, fastening sleeve; 418, material collecting barrel; 419, independent power supply; 420, wire; 421, adapter; 422, information line; 423, second electric telescopic component; 424, closing The first load-bearing frame comprises a plurality of frames, a plurality of frames, a plurality of frames, and a plurality of frames. The first load-bearing frame comprises a plurality of frames, a plurality of frames, and a plurality of frames. The first load-bearing frame comprises a plurality of frames, a plurality of frames, and a plurality of frames. The first load-bearing frame comprises a plurality of frames, a plurality of frames, and a plurality of frames. The first load-bearing frame comprises a plurality of frames, a plurality of frames, and a plurality of frames. The first load-bearing frame comprises a plurality of frames, a plurality of frames, and a plurality of frames. The first load-bearing frame comprises a plurality of frames, a plurality of frames, and a plurality of frames. The first load-bearing frame comprises a plurality of frames, a plurality of frames, and a plurality of frames. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the implementation regulations described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] Please refer to the attached Figure 1 -Attached Fig. 9 As shown, the present invention provides a technical solution: a raw material quantitative weighing device for preparing metformin compound sustained-release preparations, comprising a raw material mixing box 1, a related frame 2 is fixedly installed on the top of the raw material mixing box 1, a ring-shaped support plate 3 is fixedly installed on the top of the related frame 2, a variable weighing mechanism 4 is provided on the outer wall of the ring-shaped support plate 3, and a material-boosting mechanism 5 is provided on the top of the ring-shaped support plate 3.

[0028] according to Figure 1 , Figure 2 , Figure 3 , Figure 7 , Figure 8 and Fig. 9As shown, the auxiliary feeding mechanism 5 includes an assembly plate 501, the bottom of which is fixedly mounted on the top of the annular support plate 3, a locking sleeve 502 is fixedly mounted inside the assembly plate 501, a material transporting sleeve 503 is fixedly inserted into the inner surface wall of the locking sleeve 502, a first load-bearing frame 504 is fixedly mounted on the front surface of the assembly plate 501, the top of the first load-bearing frame 504 is fixedly sleeved on the outer surface wall of the material transporting sleeve 503, a return pipe 505 is movably arranged inside the material transporting sleeve 503, a sealing joint 506 is fixedly mounted at the front end of the return pipe 505, a connecting pipe 507 is fixedly connected to the outer surface wall of the material transporting sleeve 503, a feeding funnel 508 is fixedly connected to the top of the connecting pipe 507, and a screen assembly is arranged inside the feeding funnel 508 Component 509, a grafting plate 510 is fixedly installed on the rear surface of the assembly plate 501, a third electric telescopic component 517 is fixedly installed on the bottom of the grafting plate 510, the axial end of the third electric telescopic component 517 is fixedly inserted at the end of the return pipe 505, a second load-bearing frame 518 is fixedly installed on the rear surface of the assembly plate 501, a pumping unit 519 is fixedly installed on the rear surface of the second load-bearing frame 518, a feed end of the pumping unit 519 is fixedly connected to a group of conveying pipes 520, the feed ends of a group of conveying pipes 520 all penetrate the outer wall of the return pipe 505 and are connected to the inside of the return pipe 505, a first discharge square tube 521 is provided at the discharge end of the pumping unit 519, and a four-part sealing plate 522 is movably provided on the inner wall of the sealing joint 506.

[0029] according to Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 6 As shown, the variable weighing mechanism 4 includes a positioning ring gear 401, which is fixedly mounted on the outer wall of the annular support plate 3, and an upper sliding sleeve 402 and a lower sliding sleeve 403 are respectively fixedly mounted on the top and bottom of the positioning ring gear 401, and a traveling support plate 404 is movably inserted inside the upper sliding sleeve 402 and the lower sliding sleeve 403. By presetting the above, this part of the components enables the mechanism to flexibly rotate around the annular support plate 3 for one circle, and the working position of the mechanism can be reasonably set according to site conditions to avoid being restricted by external factors.

[0030] according to Figure 4 and Figure 6 As shown, a mechanical variable component 406 is fixedly installed on the top of a traveling pallet 404, and a driving gear 407 is fixedly sleeved on the output end of the mechanical variable component 406, and the positioning ring gear 401 is meshed and connected with the driving gear 407.

[0031] according to Figure 6As shown, an external frame 405 is fixedly installed between the front surfaces of the two traveling pallets 404, and a linkage cross plate 408 is movably provided on the rear surface of the external frame 405. A second electric telescopic component 423 is fixedly installed inside the external frame 405, and a merging frame 424 is fixedly sleeved on the axial end of the second electric telescopic component 423. The top of the merging frame 424 is connected to the bottom of the linkage cross plate 408. By presetting the above components, the material collecting barrel 418 can be reasonably raised to provide necessary space for dumping raw materials and avoid being restricted by components.

[0032] according to Figure 4 and Figure 6 As shown, an electrical control box 409 is fixedly installed at one end of the outer wall of the linkage horizontal plate 408, an inductive metering component 410 is fixedly connected to the top of the electrical control box 409, and a contact tray 411 is fixedly provided at the inductive end of the inductive metering component 410, an independent power supply 419 is fixedly installed on the top of the linkage horizontal plate 408, and a group of wires 420 are fixedly connected to the output end of the independent power supply 419, and the output ends of the group of wires 420 are all connected to the wiring terminals of the electrical control box 409, and an adapter 421 is fixedly connected to the bottom of the linkage horizontal plate 408, and a group of information lines 422 are fixedly connected to the inside of the adapter 421, and the input ends of the group of information lines 422 are all connected to the output ends of the electrical control box 409.

[0033] according to Figure 4 , Figure 5 and Figure 6 As shown, a first electric telescopic component 412 is fixedly installed at one end of the outer wall of the electrical control box 409, a parallel plate 413 is fixedly sleeved on the axial end of the first electric telescopic component 412, a first driving component 414 is fixedly installed on the top of the parallel plate 413, and a slotted plate 415 is fixedly sleeved on the output end of the first driving component 414.

[0034] according to Figure 4 , Figure 5 and Figure 6 As shown, the inside of the slotted plate 415 is movably connected with a zoom assembly 416 , the outer wall of the zoom assembly 416 is fixedly mounted with two fastening sleeves 417 , and a gathering barrel 418 is placed on the top of the contact tray 411 .

[0035] according to Fig. 9 As shown, a second driving assembly 511 is fixedly installed on the top of the grafting plate 510, and a base 512 is fixedly sleeved on the output end of the second driving assembly 511. A group of extension plates 513 are fixedly connected to the outer wall of the base 512. A distribution box 514 is fixedly installed at one end of the outer wall of each extension plate 513. The bottom of each distribution box 514 is fixedly connected to a lowering joint 515, and a first controllable valve 516 is provided inside each lowering joint 515.

[0036] according to Figure 1 , Figure 2 and Figure 3 As shown, a group of metal brackets 6 are welded to the top of the associated frame 2, and an adjustable foot 7 is fixedly installed at the bottom of each metal bracket 6. The bottom of the raw material mixing box 1 is fixedly connected to a second discharge square pipe 8, and a second controllable valve 9 is provided inside the second discharge square pipe 8.

[0037] The effect achieved by the entire mechanism is: first, the equipment is moved to the designated working area, and the bottom of each adjustable foot 7 is fully in contact with the ground, and then the external line is connected to the main power supply of the equipment and the independent power supply 419 in turn, in order to provide energy for multiple electrical components, select the required raw materials, and place each raw material in each sub-box 514 in turn.

[0038] During the preparation stage, manually operate the components on the electrical control box 409, import the information of each raw material into the relevant components therein, set the standard value of the expected weight of each raw material, turn on the machine variable component 406, and act on the driving gear 407. By utilizing the meshing connectivity between the positioning ring gear 401 and the driving gear 407, and the movable connectivity between the upper sliding sleeve 402 and the lower sliding sleeve 403 and the traveling pallet 404, the external frame 405 and its connected components are driven to slowly rotate around the annular pallet 3, shift the position of the weighing component, and move it away from the interference position of the site. After the position is determined, further turn on the second electric telescopic component 423, extend its inner axis outward, push the linkage cross plate 408 and its connected components, and move the material collecting barrel 418 to the middle of the equipment to ensure that the discharge end of the material transport pipe sleeve 503 is within the opening range of the material collecting barrel 418.

[0039] During the unloading stage of the equipment, the first controllable valve 516 and the screen assembly 509 are opened synchronously, so that the raw materials in one of the sub-boxes 514 continue to fall into the feeding funnel 508. When the raw materials come into contact with the screen assembly 509, the vibration generated causes the raw materials to be quickly dispersed and fall into the material transport sleeve 503 in a diffused manner. During the process, each first controllable valve 516 is controlled by the relevant components in the electrical control box 409 to preliminarily control the amount of raw materials transferred to the material transport sleeve 503, and then the third electric telescopic assembly 517 is opened to extend its inner axis outward and act on The reflux pipe 505 and the sealing joint 506 push the raw materials retained in the material transport sleeve 503, and the raw materials are sprinkled into the material collecting barrel 418 from the discharge end of the material transport sleeve 503. As the volume of the raw materials in the material collecting barrel 418 increases, the resulting weight change can be directly applied to the contact tray 411, and the data measurement is completed by the induction metering component 410. The real-time changing data can be shared with related components in the electrical control box 409. The purpose is to repeatedly compare with the standard numerical value, adjust the pushing rate of the third electric telescopic component 517 according to the rate of increase of the numerical value, and control the amount of raw material falling.

[0040] During the residual material cleaning stage, after one type of raw material is weighed, the extraction unit 519 is turned on, and the air retained in the reflux pipe 505 and the conveying pipe 520 is continuously extracted through the rotation of the mechanical impeller, so that a strong adsorption force is generated at the air inlet end of the reflux pipe 505, and the movable connection between the sealing joint 506 and the four-part sealing plate 522 is utilized to force the four-part sealing plate 522 to retract into the inside of the reflux pipe 505, thereby inducing the air flow inside the material transport pipe sleeve 503. Then, the residual material retained in the material transport pipe sleeve 503 will be continuously extracted into the reflux pipe 505 along with the air flow, and then transported by the reflux pipe 505 and the conveying pipe 520, thereby stopping the residual material from being discharged from the first discharge square pipe 521.

[0041] During the raw material replacement stage, after one raw material is weighed, the driving component in the scaling component 416 is turned on, and the movable connection between the slotted plate 415 and the scaling component 416 is used to drive the two fastening sleeves 417 to move relative to each other until the two fastening sleeves 417 are in close contact with the outer wall of the aggregate barrel 418, thereby completing the fixation of the aggregate barrel 418 body. The first electric telescopic component 412 then lifts the aggregate barrel 418 away from the top of the contact tray 411, and then the first driving component 414 is started to drive the aggregate barrel 418 to tilt toward the side of the assembly plate 501, thereby completing the dumping of the internal raw materials. Each weighed raw material is concentrated in the interior of the raw material mixing box 1.

[0042] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A raw material quantitative weighing device for the preparation of metformin compound sustained-release preparations, characterized in that: It comprises a raw material mixing box (1), a related frame (2) is fixedly mounted on the top of the raw material mixing box (1), and a ring-shaped support plate (3) is fixedly mounted on the top of the related frame (2); The outer wall of the annular support plate (3) is provided with a variable weighing mechanism (4), and the top of the annular support plate (3) is provided with a material-boosting unloading mechanism (5); The auxiliary material discharge mechanism (5) comprises an assembly plate (501), the bottom of which is fixedly mounted on the top of the annular support plate (3), a locking sleeve (502) is fixedly mounted inside the assembly plate (501), a material transport pipe sleeve (503) is fixedly inserted into the inner surface wall of the locking sleeve (502), a first load-bearing frame (504) is fixedly mounted on the front surface of the assembly plate (501), the top of the first load-bearing frame (504) is fixedly sleeved on the outer surface wall of the material transport pipe sleeve (503), a return pipe (505) is movably arranged inside the material transport pipe sleeve (503), a sealing joint (506) is fixedly mounted at the front end of the return pipe (505), a connecting pipe (507) is fixedly connected to the outer surface wall of the material transport pipe sleeve (503), a feeding funnel (508) is fixedly connected to the top of the connecting pipe (507), and a screen is arranged inside the feeding funnel (508). A net assembly (509), a grafting plate (510) is fixedly mounted on the rear surface of the assembly plate (501), a third electric telescopic assembly (517) is fixedly mounted on the bottom of the grafting plate (510), an axial end of the third electric telescopic assembly (517) is fixedly inserted at the end of the return pipe (505), a second load-bearing frame (518) is fixedly mounted on the rear surface of the assembly plate (501), a pumping unit (519) is fixedly mounted on the rear surface of the second load-bearing frame (518), a feed end of the pumping unit (519) is fixedly connected to a group of conveying pipes (520), the feed ends of the group of conveying pipes (520) all penetrate the outer wall of the return pipe (505) and are connected to the inside of the return pipe (505), a first discharge square pipe (521) is provided at the discharge end of the pumping unit (519), and a four-part sealing plate (522) is movably provided on the inner wall of the sealing joint (506).

2. The raw material quantitative weighing device for preparing metformin compound sustained-release preparation according to claim 1, characterized in that: The variable weighing mechanism (4) comprises a positioning ring tooth (401), the positioning ring tooth (401) being fixedly mounted on the outer wall of the annular support plate (3), an upper sliding sleeve (402) and a lower sliding sleeve (403) being fixedly mounted on the top and bottom of the positioning ring tooth (401), respectively, and a traveling support plate (404) being movably inserted inside the upper sliding sleeve (402) and the lower sliding sleeve (403).

3. The raw material quantitative weighing device for preparing metformin compound sustained-release preparation according to claim 2, characterized in that: A mechanical variable component (406) is fixedly mounted on the top of one of the traveling pallets (404), a driving gear (407) is fixedly sleeved on the output end of the mechanical variable component (406), and the positioning ring gear (401) is meshingly connected with the driving gear (407).

4. The raw material quantitative weighing device for preparing metformin compound sustained-release preparation according to claim 3, characterized in that: An external frame (405) is fixedly installed between the front surfaces of the two traveling pallets (404); a linkage transverse plate (408) is movably provided on the rear surface of the external frame (405); a second electric telescopic component (423) is fixedly installed inside the external frame (405); a merging frame (424) is fixedly sleeved on the axial end of the second electric telescopic component (423); and the top of the merging frame (424) is connected to the bottom of the linkage transverse plate (408).

5. The raw material quantitative weighing device for preparing metformin compound sustained-release preparation according to claim 4, characterized in that: An electrical control box (409) is fixedly mounted on one end of the outer wall of the linkage horizontal plate (408); an inductive metering component (410) is fixedly connected to the top of the electrical control box (409); a contact tray (411) is fixedly provided at the inductive end of the inductive metering component (410); an independent power supply (419) is fixedly mounted on the top of the linkage horizontal plate (408); a group of wires (420) are fixedly connected to the output end of the independent power supply (419); the output ends of the group of wires (420) are all connected to the wiring terminals of the electrical control box (409); an adapter (421) is fixedly connected to the bottom of the linkage horizontal plate (408); a group of information wires (422) are fixedly connected to the inside of the adapter (421); the input ends of the group of information wires (422) are all connected to the output end of the electrical control box (409).

6. The raw material quantitative weighing device for preparing metformin compound sustained-release preparation according to claim 5, characterized in that: A first electric telescopic component (412) is fixedly mounted on one end of the outer wall of the electrical control box (409); a parallel plate (413) is fixedly sleeved on the shaft end of the first electric telescopic component (412); a first driving component (414) is fixedly mounted on the top of the parallel plate (413); and a slotted plate (415) is fixedly sleeved on the output end of the first driving component (414).

7. The raw material quantitative weighing device for preparing metformin compound sustained-release preparation according to claim 6, characterized in that: The slotted plate (415) is movably connected to a zoom assembly (416) inside, two fastening sleeves (417) are fixedly mounted on the outer wall of the zoom assembly (416), and a material collecting barrel (418) is placed on the top of the contact tray (411).

8. The raw material quantitative weighing device for preparing metformin compound sustained-release preparation according to claim 7, characterized in that: A second driving assembly (511) is fixedly mounted on the top of the grafting plate (510); a base (512) is fixedly sleeved on the output end of the second driving assembly (511); a group of extension plates (513) are fixedly connected to the outer wall of the base (512); a distribution box (514) is fixedly mounted on one end of the outer wall of each extension plate (513); a lowering joint (515) is fixedly connected to the bottom of each distribution box (514); and a first controllable valve (516) is provided inside each lowering joint (515).

9. The raw material quantitative weighing device for preparing metformin compound sustained-release preparation according to claim 8, characterized in that: A group of metal brackets (6) are welded to the top of the associated frame (2), and an adjustable support foot (7) is fixedly installed at the bottom of each metal bracket (6). The bottom of the raw material mixing box (1) is fixedly connected to a second discharge square pipe (8), and a second controllable valve (9) is provided inside the second discharge square pipe (8).

10. A weighing method of a raw material quantitative weighing device for preparing a metformin compound sustained-release preparation, characterized in that: The method of using the raw material quantitative weighing device for preparing the metformin compound sustained-release preparation according to claim 9 comprises the following steps: S1: Select a specified number of raw materials and place them in a corresponding sub-box (514) in sequence, manually import the data of each raw material through the external components of the electrical control box (409), and set the standard weight values ​​of various raw materials in sequence; S2: According to the site conditions, the equipment is placed reasonably, and the machine-variable component (406) and related components are used to coordinate and adjust the position of the weighing component to avoid the equipment being easily disturbed by external conditions during operation. The material collecting barrel (418) is gently placed on the contact tray (411), and the second electric telescopic component (423) is turned on to translate the material collecting barrel (418) to the middle of the equipment so that the material collecting barrel (418) is accurately placed at the discharge port of the material transport pipe sleeve (503). The relevant electronic components of the electrical control box (409) are then used to control and complete the peeling setting, so that the induction metering component (410) is in a zero state; S3: starting to release the raw materials in one of the sub-boxes (514), the raw materials are fully broken up after being processed by the screen assembly (509), and then enter the material transporting pipe sleeve (503), further starting the third electric telescopic assembly (517), and acting on the sealing joint (506), pushing the raw materials inside the material transporting pipe sleeve (503) forward; S4: During the process, the raw material gradually falls from the discharge end of the material transport sleeve (503) into the material collecting barrel (418). As the volume of the raw material increases, the continuously increasing weight value is measured by the induction metering component (410) and imported into the electrical control box (409) in real time. The relevant electronic components monitor and control the pushing speed of the third electric telescopic component (517) and adjust the falling amount of the raw material according to the numerical performance. S5: When the weighing of one raw material is completed, the extraction unit (519) is turned on to continuously extract the trapped air in the reflux pipe (505) and the conveying pipe (520), so that a strong adsorption force is generated at the air inlet end of the reflux pipe (505), forcing the four-part sealing plate (522) to retract into the reflux pipe (505), fully extracting the residual material in the conveying pipe sleeve (503), and using a designated container to complete the recovery of the residual material from the first discharge square pipe (521); S6: Through the above method, the raw materials in each subsequent distribution box (514) are weighed in turn, and after each raw material is weighed, the first electric telescopic component (412) and its connected components can be used to complete the dumping of the raw materials in the gathering barrel (418) and gather them into the raw material mixing box (1).

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