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Blood processing method, blood processing device, method of measuring hemoglobins and device for measuring hemoglobins

A hemoglobin and blood processing technology, which is applied in the field of hemoglobin measurement, can solve the problems of easily hindering the measurement of hemoglobin, slowing down the unfolding speed, and not unfolding, etc., and achieve the effect of simple hemoglobin determination and simple measurement

Inactive Publication Date: 2004-08-18
PANASONIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since hemoglobin has a red pigment with absorption wavelength on the long wavelength side, it is easy to interfere with the measurement of hemoglobin if the concentration is high
[0012] For example, in the measurement of hemoglobins by immunochromatography, the measurement value of the antigen excess region, which is one of the characteristics of the immune reaction, is low, which causes operational errors
In addition, due to the increase in the viscosity of the blood sample sample due to a large amount of hemoglobin, the development speed of the blood sample sample in the solid phase matrix of the immunochromatography device either slows down or does not develop at all.

Method used

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  • Blood processing method, blood processing device, method of measuring hemoglobins and device for measuring hemoglobins
  • Blood processing method, blood processing device, method of measuring hemoglobins and device for measuring hemoglobins
  • Blood processing method, blood processing device, method of measuring hemoglobins and device for measuring hemoglobins

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Embodiment approach 1

[0048] In this embodiment, the blood processing method of the present invention will be described with reference to the drawings. figure 1 It is a flowchart of the blood processing method of the present invention.

[0049] Such as figure 1 As shown, the blood processing method of this embodiment includes: a step St1 of preparing a blood sample sample and a hemolyzing agent, and a step St2 of preparing a mixed sample by mixing the blood sample sample and a hemolyzing agent. The hemolytic agent here is a solid drug that destroys the membrane of red blood cells.

[0050] "Blood specimen sample" refers to blood collected from a subject including a human by a common blood collection method (such as intravenous injection or lancet) or blood preserved before measurement.

[0051] A hemolytic agent uses a solid drug that destroys the membrane of red blood cells. For example, it is preferably prepared into a powder form by freeze-drying so as not to substantially contain water.

[...

Embodiment approach 2

[0084] In this embodiment, a blood processing device that can be used in the blood processing method and hemoglobin measurement method described in Embodiment 1 above will be described with reference to the drawings. image 3 (a) and image 3 (b) is a diagram showing the blood processing device of this embodiment.

[0085] Such as image 3 As shown in (a), the blood processing apparatus 10a of this embodiment includes a base material 11 for supplying a blood sample sample and a hemolyzing agent (not shown) ). In addition, a hemolytic agent is a solid drug that destroys the membrane of red blood cells. The hemolytic agent is first added to the substrate in a solution state, and then freeze-dried to be loaded on the substrate in a dry state. Preferably, the hemolytic agent is carried on the substrate in a dry state in a region capable of contacting the blood sample.

[0086] As the substrate 11 for supplying the blood specimen sample, it can be from a lithographic state (in...

Embodiment approach 3

[0094] In this embodiment, an apparatus for measuring hemoglobin in a blood sample sample by a dry chemical measurement method (hereinafter referred to as a hemoglobin measuring apparatus) will be described. The hemoglobin measuring device includes a hemolyzing agent in an amount sufficient to partially hemolyze a blood sample sample, an elutable detection substance that specifically binds to hemoglobins, and an immobilized substance that specifically binds to hemoglobins.

[0095] The "hemolyzing agent in an amount capable of partially hemolyzing" used here is the same as that described in Embodiment 1 above.

[0096] The above detection substance is a labeled substance that specifically binds to the hemoglobins to be measured. Such labels are well known in the art, for example colloidal gold, enzymes (e.g. horseradish peroxidase, grape oxidase), radioactive isotopes (e.g. iodine ( 125 I. 121 I), carbon ( 14 C), sulfur ( 35 S), tritium ( 3 H), indium ( 112 In) and techn...

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Abstract

A blood processing method according to the present invention includes Step St1 of preparing a blood specimen sample and a hemolyzing agent, and Step St2 of mixing the blood specimen sample and the hemolyzing agent to prepare a mixture sample. In this case, the hemolyzing agent is a solid reagent for destroying erythrocyte membranes.

Description

technical field [0001] The present invention relates to blood treatment methods for disrupting erythrocyte membranes and to the determination of hemoglobins. Background technique [0002] At present, in the field of clinical examination, point-of-care testing (hereinafter abbreviated as POCT) has attracted much attention. The so-called POCT is a general term for displaying clinical examinations at the medical site, and indicating that the time from sample sampling to results is the most important. Therefore, in general, in the field of clinical examinations, ease of operation, rapid determination, and low cost are required. This is of course no exception in the determination of blood components. [0003] Blood can be broadly divided into a cellular component and a fluid component. Among the cellular components are red blood cells, white blood cells, and platelets. The liquid component includes blood plasma. [0004] In a blood sample, the volume ratio of erythrocytes to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/543G01N33/72
CPCG01N33/721
Inventor 北胁文久重藤修行河村达朗
Owner PANASONIC CORP
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