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Erythrocyte membrane coated bionic blood hexavalent chromium reduction remover/magnetic nanomotor and preparation method and application thereof

A red blood cell membrane and magnetic nanotechnology, applied in the field of biomedical materials, can solve problems such as poor biocompatibility, achieve protective activity, improve biocompatibility, and broad application prospects

Active Publication Date: 2019-09-20
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the nature of ascorbic acid, when it enters the complex blood environment, it may react with some oxygen-containing free radicals in the blood and be inactivated, that is, there is poor biocompatibility

Method used

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  • Erythrocyte membrane coated bionic blood hexavalent chromium reduction remover/magnetic nanomotor and preparation method and application thereof
  • Erythrocyte membrane coated bionic blood hexavalent chromium reduction remover/magnetic nanomotor and preparation method and application thereof
  • Erythrocyte membrane coated bionic blood hexavalent chromium reduction remover/magnetic nanomotor and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] Hydrothermal Synthesis of Fe 3 o 4 NPs. Weigh 2.7g (10mmol) of ferric trichloride hexahydrate and fully dissolve it in 80mL of ethylene glycol. 7.2 g of sodium acetate and 0.9 g of sodium citrate were added with stirring. Stirring was continued for 30 min, and the mixture was transferred to a high-temperature reactor at 200° C. for 20 h. After natural cooling, the product was washed several times with deionized water and ethanol successively by magnetic separation method, and the product was vacuum-dried at 60°C. Magnetic Fe 3 o 4 NPs transmission electron microscopy such as figure 1 As shown, the size is about 200nm.

[0044] Weigh 150mg Fe 3 o 4 Disperse in 90mL of water, add 1.5mL of hydrazine hydrate solution (50%) to it, and after ultrasonication for 30min, add 210mL of water to it to make the pH of the solution = 9-10, continue to drop 96μL of TEOS into the solution, and stir at 90°C After reacting for 2 hours, the product was washed with water three tim...

Embodiment 2

[0050] Hydrothermal Synthesis of Fe 3 o 4 NPs. Weigh 2.7g (10mmol) of ferric trichloride hexahydrate and fully dissolve it in 80mL of ethylene glycol. 7.2 g of sodium acetate and 0.9 g of sodium citrate were added with stirring. Stirring was continued for 30 min, and the mixture was transferred to a high-temperature reactor at 150° C. for 25 h. After natural cooling, the product was washed several times with deionized water and ethanol successively by magnetic separation method, and the product was vacuum-dried at 60°C. Weigh 150mg Fe 3 o 4 Disperse in 90mL of water, add 1.5mL of hydrazine hydrate solution (50%) to it, and after ultrasonication for 30min, add 210mL of water to it to make the pH of the solution = 9-10, continue to add 96μLTEOS dropwise to the solution, and stir at 90°C for reaction After 2 hours, the product was washed with water three times by magnetic separation. Continue to disperse the solid product in 210mL water, add 2.4mL hydrazine hydrate and 0.4...

Embodiment 3

[0055] Hydrothermal Synthesis of Fe 3 o 4 NPs. Weigh 2.7g (10mmol) of ferric trichloride hexahydrate and fully dissolve it in 80mL of ethylene glycol. 7.2 g of sodium acetate and 0.9 g of sodium citrate were added with stirring. Stirring was continued for 30 min, and the mixture was transferred to a high-temperature reactor at 250° C. for 15 h. After natural cooling, the product was washed several times with deionized water and ethanol successively by magnetic separation method, and the product was vacuum-dried at 60°C. Weigh 150mg Fe 3 o 4 Disperse in 90mL of water, add 1.5mL of hydrazine hydrate solution (50%) to it, and after ultrasonication for 30min, add 210mL of water to it to make the pH of the solution = 9-10, continue to add 96μLTEOS dropwise to the solution, and stir at 90°C for reaction After 2 hours, the product was washed with water three times by magnetic separation. Continue to disperse the solid product in 210mL water, add 2.4mL hydrazine hydrate and 0.4...

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Abstract

The invention discloses an erythrocyte membrane coated bionic blood hexavalent chromium reduction remover / magnetic nanomotor and a preparation method and application thereof. By electrostatic self-assembly, magnetic ferroferric oxide particles are externally coated with mesoporous silica through hexadecyl trimethyl ammonium bromide serving as a template agent, then step-by-step modification of ammonium-rich organics and reducing substances in mesoporous passages is performed, and finally, erythrocyte membranes are adopted for coating to obtain the bionic blood hexavalent chromium reduction remover / magnetic nanomotor with high biocompatibility. The reduction remover / magnetic nanomotor is capable of freely getting in and out of erythrocytes, proper movement of the nanomotor in the erythrocytes can be controlled through an external alternating magnetic field so as to realize complete contact between the remover and hexavalent chromium in the erythrocytes, the hexavalent chromium is reduced into low-toxicity trivalent chromium by a reducing agent, and then the trivalent chromium is captured under the trivalent chromium complexing action of the ammonium-rich organics in the mesoporous passages, so that sequential reduction and removal of chromium in blood is realized.

Description

technical field [0001] The invention belongs to biomedical materials, in particular to a red blood cell membrane-wrapped bionic blood hexavalent chromium reduction remover / magnetic nanomotor and its preparation method and application. Background technique [0002] With the rapid development of industrial economy, the application of heavy metals in our country is gradually increasing. Chromium is the seventh most abundant element on earth, and Cr(III) and Cr(VI) are two common valence states of chromium in the environment. However, the toxicity of Cr(Ⅵ) to the human body is much higher than that of Cr(Ⅲ), and it is easy to accumulate for a long time after being absorbed by the human body. Cr(Ⅵ) exists in the form of chromate and dichromate in the physiological environment of the human body. After entering the blood, it can pass through SO4 2- The transport system carrier is combined to enter the red blood cell, and after entering the cell, it is combined with hemoglobin. A...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/46A61K31/375A61K38/06A61K45/06A61K47/69A61P39/02
CPCA61K9/5068A61K31/375A61K38/06A61K45/06A61K9/0009A61P39/02A61K47/6923
Inventor 万密密王蒙毛春初美琳王星文方乐怡
Owner NANJING NORMAL UNIVERSITY
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