Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Human papilloma virus treatment

A technology of papilloma virus and symptoms, applied in the direction of virus, gene therapy, antiviral agent, etc.

Inactive Publication Date: 2005-10-05
0747128 B C LTD
View PDF25 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is currently no safe and reliable way to treat or prevent the above warts or diseases by targeting the immune system

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0071] As described in WO 99 / 07860, a fusion polypeptide containing Mycobacterium bovis BCG Hsp65 coupled with E7 protein of type 16 HPV is recombinantly produced and prepared into a preparation. Hsp65 is a member of the Hsp60 family of stress proteins. In the process of human clinical trials testing the efficacy of this fusion polypeptide in the treatment of anal high-grade squamous intraepithelial injury (HSIL), the following observations were made.

[0072] In the treatment of anal HSIL, 22 patients participated in a randomized, double-blind, placebo-controlled multi-channel HspE7 trial. Eligible patients have confirmed anal HSIL by biopsy and are human immunodeficiency virus (HIV) negative. The cells obtained from anal cotton swabs are used to type the patient’s HPV, but the patient is not required to have HPV-16. Individual injuries are not classified as HPV. The patient received three subcutaneous injections of 100 μg of HpsE7 or placebo, one month apart. Through anal Pap sm...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Disclosed is a method of treating a wart in a subject by administering to the subject a composition containing (1) a heat shock protein or an immunostimulatory fragment thereof, and (2) a protein of a human papilloma virus or an antigenic fragment thereof. Also disclosed is a method of treating a human papilloma virus infection in a subject infected or suspected of being infected with a human papilloma virus of a first type by administering to the subject a composition containing (1) a heat shock protein or an antigenic fragment thereof, and (2) a protein of a human papilloma virus of a second type or an antigenic fragment thereof, where the first type and second type are different.

Description

Invention field [0001] The present invention relates to the treatment of human papilloma virus infection. Background of the invention [0002] Human papillomavirus (HPV) infection is a common disease. HPV can be transmitted sexually, and it is estimated that 20-80% of sexually active adults have been infected with this virus. However, most infections are asymptomatic, and infections can lead to the development of genital warts (which are epidemic in about 1-5% of adults) and cancer of the anogenital tract. Another type of cancer, cervical cancer is closely related to HPV (Frazer, Genitourin. Med. 72:398-403, 1996). HPV types 6, 11, 16, 18, 31, and 33 are usually associated with increased cancer risk, and types 16 and / or 18 are detected in more than 90% of cervical cancers (van Driel et al., Ann. Med. 28:471 -477, 1996). Types 6 and 11 are also associated with anogenital warts. For a review of papillomavirus and its related pathologies, see Fields et al., eds., Virology, 3rd editi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/09A61K35/76A61K38/16A61K39/12A61K39/295A61K39/39A61K48/00A61P31/12A61P31/20A61P35/00
CPCA61K2039/53A61K2039/6043A61K39/12A61K38/164C12N2710/20034A61K39/39A61K38/162A61K39/295A61K2039/55516A61K2039/70A61P17/12A61P31/12A61P31/20A61P35/00
Inventor 约翰·尼夫斯蒂芬·戈德斯通马克·温尼特马文·西格尔莱斯莉·布克斯
Owner 0747128 B C LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com