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Platinum complexes and methods for inhibiting tumor cell proliferation

a technology of complexes and tumor cells, applied in the direction of platinum organic compounds, biocide, drug compositions, etc., can solve the problems of complex-based therapy on cellular signaling and the therapeutic importance of such interactions that have yet to be explored

Inactive Publication Date: 2005-12-29
KAY HEIDI +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The patent is about a new type of platinum complex that can be used to treat diseases like cancer and tumors. The technical effect of this invention is that it provides a new tool for treating these conditions using a new type of therapy."

Problems solved by technology

However, the potential impact of platinum-complex-based therapy on cellular signaling and the therapeutic importance of such interactions have yet to be explored.

Method used

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  • Platinum complexes and methods for inhibiting tumor cell proliferation
  • Platinum complexes and methods for inhibiting tumor cell proliferation
  • Platinum complexes and methods for inhibiting tumor cell proliferation

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Embodiment Construction

[0004] The subject invention concerns platinum complexes and methods for inducing apoptosis and inhibiting tumor cell growth and for treating animals having tumors, cancers, and oncological disease conditions using the subject platinum complexes. Platinum complexes of the subject invention are shown in the Table below:

DesignationStructureIC50CisPtA549: 9.9 ± 4.0 Calu-1: 8.6 ± 45 Panc-1: 4.5 ± 1.9 T-24: 1.3 ± 0.4CPA-1A549: 50 ± 23 Calu-1: 26 ± 11 Panc-1: 19 ± 8.1 T-24: 6.2 ± 1.1CPA-2A549: >1000 Calu-1: 497 Panc-1: 890 T-24: 560CPA-3A549: >250 Calu-1: >250 Panc-1: 94 ± 65 T-24: 23 / 152 / >250CPA-4(“dirty mix”)A549: 50 ± 23 Calu-1: 26 ± 11 Panc-1: 19 ± 8.1 T-24: 6.2 ± 1.1CPA-4(“clean”)same as aboveA549: >250Calu-1: >250Panc-1: >250T-24: >250CPA-5A549: 213 Calu-1: 181 Panc-1: >250 T-24: 111CPA-6CPA-7A549: 20 Calu-1: —Panc-1: 6.0 T-24: —CPA-8A549: >250 Calu-1: —Panc-1: >250 T-24: —CPA-9A549: >250 Calu-1: —Panc-1: 6.0 T-24: —CPA-10A549: >250 Calu-1: —Panc-1: 6.0 T-24: —CPA-11A549: 138 Calu...

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Abstract

The subject invention concerns platinum complexes that exhibit antitumor cell and / or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.

Description

CROSS-REFERENCE TO RELATED APPLICATION [0001] This application claims the benefit of U.S. Provisional Application Ser. No. 60 / 534,575, filed Jan. 6, 2004, the disclosure of which is incorporated herein by reference in its entirety.BACKGROUND OF THE INVENTION [0002] Platinum complexes, the prototype of cisplatin, have been widely used as active anticancer agents (Ardizzoni et al., 1999; Nitiss, 2002) in a variety of human tumors, including testicular, ovarian, bladder carcinoma, head and neck, and non-small cell lung cancers. The outcome of treatments with cisplatin and other platinum-containing compounds is strongly linked to their alkylating effects on DNA. However, the potential impact of platinum-complex-based therapy on cellular signaling and the therapeutic importance of such interactions have yet to be explored. Reports show that cisplatin induces activation of members of the mitogen-activated protein kinase (MAPK) pathways (Persons et al., 1999; Sanchez-Perez et al., 1998), w...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/28C07F15/00
CPCC07F15/0093A61P35/00
Inventor KAY, HEIDIPALMER, JAY W.STANKO, JOSEPH A.SEBTI, SAID M.
Owner KAY HEIDI