Vesicles of high molecular weight silicone polyethers
a silicone polyether and high molecular weight technology, applied in the field of silicone vesicles of high molecular weight silicone polyethers, can solve the problems of limiting processing conditions, lack of durability, and lack of durability of silicone vesicles formed from self-assembly procedures
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example 1-3
[0050]A vesicle dispersion was successfully prepared by dispersing 44.3 g of SPE1 in a mixture of 73.77 g ethanol and 165.39 g water. A uniform dispersion with milky appearance was observed. The average particle size was 0.274 μm, as summarized in Table 1 as Example 1.
[0051]A uniform dispersion with even smaller particle size was made from SPE1 by further homogenizing through a high pressure, high shear unit like Microfluidizer, summarized in Table 1 as Example 2.
[0052]A stable dispersion of SPE1 with small particle size in largely water was prepared by further stripping off the volatile alcohol solvent. As shown by Example 3 in Table 1, the final dispersion has a composition of 20% SPE vesicles, 5% alcohol and 75% water.
TABLE 1Example123Dispersion typeNeat SPENeat SPENeat SPEMix MethodMixedMixed,Microfluidized,MicroFluidizedstrippedEtOH, g73.77073.77026.49SPE1 g44.28044.28015.89De-ionized water, g165.39165.3959.37Batch, before strip, g101.75Volatiles Removed, g22.6Final batch size,...
examples 4-6
Vitamin A Palmitate Entrapped in High DP SPE Vesicle Dispersion
[0053]The following examples show vitamin A palmitate can be incorporated into high DP SPEs stable vesicles in water dispersions.
[0054]A uniform dispersion was prepared by mixing 9.74 g of vitamin A palmitate with 44.74 g of SPE1 and isopropanol and ethanol, as described in Table 2, Example 4. Water was incorporated and mechanically mixed to form a uniform dispersion. The final mixture was a yellowish dispersion with average particle size of 0.367 μm.
[0055]The vitamin A palmitate entrapped SPE dispersion can be further reduced in particle size by passing through a high pressure, high shear processor like Microfluidizer, as described by Example 5 in Table 2. The final dispersion was a smooth, yellowish dispersion with average particle size of about 0.137 μm.
[0056]The vitamin A palmitate entrapped SPE dispersion can be made stable in an aqueous mixture with minimal alcohol present. As illustrated in Table 2, the volatile a...
examples 7-10
[0057]Two sets of vesicle dispersions were prepared for Cyro-TEM evaluations, following similar procedures as described in the examples above. The formulations for the vesicle dispersions are summarized in Tables 3 and 4. The Cryo-TEM images are shown in FIGS. 1 and 2.
TABLE 3Example78Process HistoryAs MadeMixed, then strippedSPE1, g25.3622.84IPA, g75.4767.96Water, g150.22135.27Batch size before strip, g251.05226.06Volatile removed, g68.05Batch size after strip, g158.01Vesicle dispersion composition% SPE110.114.5% Alcohol30.10.0% Water59.885.5Dispersion appearancewater-white clearmilky dispersionAverage particle size Mv, μm0.03140.591D(v, 0.5), μm0.029770.508D(v, 0.9), μm0.0441.078
TABLE 4Example910Process HistoryMixedMixed, then strippedSPE2 g25.2822.88IPA, g75.2868.12Water, g150.15135.87Batch size before strip, g250.71226.86Volatile removed, g69.31Batch size after strip, g157.55Vesicle dispersion compositionWt. % SPE10.114.5Wt. % Alcohol30.00.0Wt. % Water59.985.5Dispersion appearanc...
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