Collagen and squalane composition, preparations thereof, and preparation methods and applications of composition and preparations

Abstract

The invention relates to a collagen and squalane composition. The composition comprises 0.1-20 parts by weight of collagen, 0.1-30 parts by weight of squalane and 1-150 parts by weight of a pharmaceutically acceptable carrier. The invention also relates to preparations containing the collagen and squalane composition, and a preparation method and an application of the composition. The collagen and squalane composition has the advantages of high biological availability, excellent curative effect, good stability, carrying and use convenience and the like.

Description

technical field

[0001] The invention relates to the technical field of medical products, in particular to a collagen squalane composition and its preparation, its preparation method and application. Background technique

[0002] Acne is a common chronic hair follicle and sebaceous gland inflammatory skin disease in adolescence. According to the survey, the incidence rate of acne among teenagers aged 12 to 25 is as high as 85%, and it mostly occurs on the face, and acne and its wounds are easy to form pigmentation after healing, which affects people's appearance. Studies have found that the main pathogenic factors of acne include skin allergies, excessive sebum production, hyperkeratosis of hair follicle orifice epithelium, and proliferation of Propionibacterium acnes in hair follicles. In addition, heredity, psychological factors, endocrine disorders, lipopolysaccharides, stimulating diet, high temperature and certain chemical factors may also cause acne.

[0003] Skin all...

Examples

Embodiment 1-9

[0059] Examples 1-9 Preparation of Collagen Squalane Emulsion and Study on Transdermal Penetration Rate

[0060] The composition of the collagen squalane emulsion in Examples 1-9 is shown in Table 1.

[0061] Table 1

[0062]

[0063] The preparation method of collagen squalane emulsion in embodiment 1-9 may further comprise the steps:

[0064] 1) According to Table 1, weigh or measure the amount of squalane and its surfactants described in Examples 1-9 respectively, put them together, stir evenly, add an appropriate amount of distilled water, and use a high-speed homogenizer to Stir, 10000 rpm, until squalane emulsion is formed;

[0065] 2) According to Table 1, weigh or measure the collagen of the composition amount described in Examples 1-9, respectively add them to the squalane emulsion prepared in step 1), and adjust the pH to 0.1% acetic acid solution to 4.0-7.5, add an appropriate amount of distilled water, set the volume to 100ml, and mix evenly to prepare a c...

Embodiment 10-18

[0081] Examples 10-18 Preparation of Collagen Squalane Dressing Patches

[0082] The collagen squalane emulsions prepared in Examples 1-9 were prepared into collagen squalane dressings according to the following preparation methods.

[0083] The preparation method of embodiment 10-18 collagen squalane dressing patch, comprises the following steps:

[0084] 1) Fold the non-woven fabric, put it into an aluminum foil bag, add 20ml of the collagen squalane microemulsion prepared in any one of the examples 1-9 to each aluminum foil bag, number, seal;

[0085] 2) with Co 60 Irradiated at 15-25Kgy / h for 3h-5h to sterilize.

Embodiment 19

[0086] Example 19 Study on Particle Size of Collagen Squalane Emulsion

[0087] Adopt laser particle size analyzer (Delsa Nano C particle Analyzer, Beckman Co μlter), measure the particle size distribution of embodiment 1-2 collagen squalane emulsion, the results are shown in Figure 2-Figure 3 .

[0088] Wherein the test condition and result of embodiment 1 are as follows:

[0089] Temperature: 24.8°C

[0090] Thinner: water

[0091] Refractive index: 1.3328

[0092] Viscosity: 0.8919

[0093] Scattering intensity: 9736(cP)

[0094] The particle size-intensity distribution table of table 4 embodiment 1

[0095]

[0096]

[0097] It can be seen from the statistics in the above table that D (10%): 51.90 (nm) D (50%): 95.80 (nm) D (90%): 180.60 (nm).

[0098] The test condition and result of embodiment 2 are as follows:

[0099] Temperature: 0.1°C;

[0100] Thinner: water;

[0101] Refractive index: 1.3345;

[0102] Viscosity: 1.7831;

[0103] Scattering inte...

technical field

[0001] The invention relates to the technical field of medical products, in particular to a collagen squalane composition and its preparation, its preparation method and application. Background technique

[0002] Acne is a common chronic hair follicle and sebaceous gland inflammatory skin disease in adolescence. According to the survey, the incidence rate of acne among teenagers aged 12 to 25 is as high as 85%, and it mostly occurs on the face, and acne and its wounds are easy to form pigmentation after healing, which affects people's appearance. Studies have found that the main pathogenic factors of acne include skin allergies, excessive sebum production, hyperkeratosis of hair follicle orifice epithelium, and proliferation of Propionibacterium acnes in hair follicles. In addition, heredity, psychological factors, endocrine disorders, lipopolysaccharides, stimulating diet, high temperature and certain chemical factors may also cause acne.

[0003] Skin all...

Examples

Embodiment 1-9

[0059] Examples 1-9 Preparation of Collagen Squalane Emulsion and Study on Transdermal Penetration Rate

[0060] The composition of the collagen squalane emulsion in Examples 1-9 is shown in Table 1.

[0061] Table 1

[0062]

[0063] The preparation method of collagen squalane emulsion in embodiment 1-9 may further comprise the steps:

[0064] 1) According to Table 1, weigh or measure the amount of squalane and its surfactants described in Examples 1-9 respectively, put them together, stir evenly, add an appropriate amount of distilled water, and use a high-speed homogenizer to Stir, 10000 rpm, until squalane emulsion is formed;

[0065] 2) According to Table 1, weigh or measure the collagen of the composition amount described in Examples 1-9, respectively add them to the squalane emulsion prepared in step 1), and adjust the pH to 0.1% acetic acid solution to 4.0-7.5, add an appropriate amount of distilled water, set the volume to 100ml, and mix evenly to prepare a c...

Embodiment 10-18

[0081] Examples 10-18 Preparation of Collagen Squalane Dressing Patches

[0082] The collagen squalane emulsions prepared in Examples 1-9 were prepared into collagen squalane dressings according to the following preparation methods.

[0083] The preparation method of embodiment 10-18 collagen squalane dressing patch, comprises the following steps:

[0084] 1) Fold the non-woven fabric, put it into an aluminum foil bag, add 20ml of the collagen squalane microemulsion prepared in any one of the examples 1-9 to each aluminum foil bag, number, seal;

[0085] 2) with Co 60 Irradiated at 15-25Kgy / h for 3h-5h to sterilize.

Embodiment 19

[0086] Example 19 Study on Particle Size of Collagen Squalane Emulsion

[0087] Adopt laser particle size analyzer (Delsa Nano C particle Analyzer, Beckman Co μlter), measure the particle size distribution of embodiment 1-2 collagen squalane emulsion, the results are shown in Figure 2-Figure 3 .

[0088] Wherein the test condition and result of embodiment 1 are as follows:

[0089] Temperature: 24.8°C

[0090] Thinner: water

[0091] Refractive index: 1.3328

[0092] Viscosity: 0.8919

[0093] Scattering intensity: 9736(cP)

[0094] The particle size-intensity distribution table of table 4 embodiment 1

[0095]

[0096]

[0097] It can be seen from the statistics in the above table that D (10%): 51.90 (nm) D (50%): 95.80 (nm) D (90%): 180.60 (nm).

[0098] The test condition and result of embodiment 2 are as follows:

[0099] Temperature: 0.1°C;

[0100] Thinner: water;

[0101] Refractive index: 1.3345;

[0102] Viscosity: 1.7831;

[0103] Scattering inte...

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