A hemolysis device, saccharification liquid system and multifunctional all-in-one machine

Abstract

The present invention provides a hemolysis device, a saccharification liquid circuit system and a multifunctional all-in-one machine. The hemolysis device includes a substrate, a hemolysis cavity and a waste liquid cavity. The hemolysis cavity has a hemolysis chamber for mixing a blood sample and a hemolytic agent to form a mixed liquid to be tested. The waste liquid cavity has a waste liquid chamber for collecting the mixed liquid to be tested overflowing from the hemolysis chamber and for collecting waste liquid for testing. The hemolysis device of the present invention can not only achieve the mixing of the blood sample and the hemolytic agent in the hemolysis cavity, but also prevent the mixed liquid to be tested from spilling out of the hemolysis device, which can reduce the maintenance work of the instrument. At the same time, the waste liquid cavity can also collect waste liquid for testing. The waste liquid cavity and the hemolysis cavity are arranged to be formed by the same substrate, so that the two can be installed synchronously, which is conducive to saving the internal space of the instrument and facilitating the overall layout of the instrument.

Description

Technical Field

[0001] The present invention relates to the technical field of sample analysis, and in particular to a hemolysis device, a saccharification liquid path system and a multifunctional all-in-one machine. Background Art

[0002] Glycated hemoglobin analyzer is an instrument commonly used for clinical diagnosis of diabetes. It reflects whether the physical signs of the person being tested are normal by measuring and testing various glycated hemoglobin in the blood. In order to separate the glycated hemoglobin in the blood, the glycated hemoglobin analyzer generally includes a hemolysis device, which is used to mix the patient's blood sample with a hemolytic agent to release the glycated hemoglobin in the red blood cells.

[0003] Existing hemolysis devices are generally designed as open single-cavity structures, with an open top and only one cavity. The blood sample and the hemolytic agent are mixed in the cavity to form a mixed liquid to be tested and transported to the subsequent detection position (such as an optical detection pool). This type of hemolysis device is prone to spilling the mixed liquid to be tested from the cavity, affecting the surrounding environment of the hemolysis device and causing trouble for instrument care. In addition, some hemolysis devices have two or more cavities, but due to their unreasonable structural design, a portion of the mixed liquid to be tested will still spill from the cavity.

[0004] In addition, the glycosylated hemoglobin analyzer will produce test waste liquid during the test process, but the amount of the test waste liquid is not large. The existing glycosylated hemoglobin analyzer needs to set up a container to collect the test waste liquid. The container and the hemolysis device will occupy the internal space of the glycosylated hemoglobin analyzer, which is not conducive to the overall spatial layout of the instrument. Especially for some multifunctional all-in-one machines (realizing two functional tests and analyses, such as routine blood tests and glycosylated hemoglobin tests), the method of setting up the container and the hemolysis device separately is even more detrimental to the internal spatial layout of the instrument. Summary of the invention

[0005] The present invention provides a hemolysis device, a saccharification liquid circuit system and a multifunctional all-in-one machine, so as to achieve the purpose of reducing nursing care and optimizing instrument layout.

[0006] To this end, according to the first aspect, an embodiment provides a hemolysis device, comprising:

[0007] matrix;

[0008] The hemolysis chamber is formed by a part of the base body and has a hemolysis chamber for mixing the blood sample and the hemolytic agent to form a mixed solution to be tested.

[0009] In some embodiments of the hemolysis device, a liquid guiding structure is formed between the hemolysis chamber and the waste liquid chamber for introducing the mixed liquid to be tested in the hemolysis chamber into the waste liquid chamber.

[0010] In some embodiments of the hemolysis device, a liquid guiding surface inclined from top to bottom toward the waste liquid chamber is provided on the top of the hemolysis chamber, and the liquid guiding surface forms the liquid guiding structure.

[0011] In some embodiments of the hemolysis device, the hemolysis chamber is provided with a liquid conducting hole near the top thereof, and the liquid conducting hole forms the liquid conducting structure.

[0012] In some embodiments of the hemolysis device, the hemolysis chamber has at least one hemolysis chamber inlet and at least one hemolysis chamber outlet connected to the hemolysis chamber, the hemolysis chamber outlet is located at the bottom of the hemolysis chamber, and the hemolysis chamber inlet is located near the bottom of the hemolysis chamber.

[0013] In some embodiments of the hemolysis device, the inner wall surface of the hemolysis chamber is formed by a continuous arc surface connected end to end.

[0014] In some embodiments of the hemolysis device, the inner wall surface includes a first section of the inner wall surface and a second section of the inner wall surface, the second section of the inner wall surface is connected to the first section of the inner wall surface and is located below the first section of the inner wall surface, the hemolysis chamber entrance is arranged opposite to the second section of the inner wall surface, and the second section of the inner wall surface can generate an upward support force on the hemolytic agent entering the hemolysis chamber from the hemolysis chamber entrance, so that the hemolytic agent flows toward the first section of the inner wall surface.

[0015] In some embodiments of the hemolysis device, the inner wall surface of the first section is an arc surface, and the inner wall surface of the second section is an inverted cone surface.

[0016] In some embodiments of the hemolysis device, the inlet of the hemolysis chamber is arranged in a transitional manner from high to low, and the lower end thereof is connected to the hemolysis chamber.

[0017] In some embodiments of the hemolysis device, the hemolysis chamber has two hemolysis chamber inlets, and the two hemolysis chamber inlets are spaced apart along the circumferential direction.

[0018] In some embodiments of the hemolysis device, a filter membrane is further provided at the inlet of the hemolysis chamber to block impurities in the hemolysis chamber.

[0019] In some embodiments of the hemolysis device, the waste liquid chamber has at least one waste liquid chamber inlet and at least one waste liquid chamber outlet connected to the waste liquid chamber, the waste liquid chamber outlet is located near the bottom of the waste liquid chamber, and the waste liquid chamber inlet is located at the upper part of the waste liquid chamber.

[0020] In some embodiments of the hemolysis device, at least a portion of the bottom wall of the waste liquid chamber is inclined toward the waste liquid chamber outlet to form a waste liquid guide surface, which facilitates the conduction of the test mixed liquid and the detection waste liquid out of the waste liquid chamber.

[0021] In some embodiments of the hemolysis device, the waste liquid chamber has three waste liquid chamber inlets and one waste liquid chamber outlet, and the three waste liquid chamber inlets and one waste liquid chamber outlet are arranged in a row from top to bottom.

[0022] In some embodiments of the hemolysis device, the hemolysis device also includes an overflow cavity, which is formed by a portion of the base body, and the overflow cavity has an overflow chamber, and an overflow chamber discharge port is arranged at the bottom of the overflow chamber, and the overflow chamber is respectively connected to the hemolysis chamber and the waste liquid chamber, and is used for receiving the mixed liquid to be tested overflowing from the hemolysis chamber and the detection waste liquid and / or the mixed liquid to be tested overflowing from the waste liquid chamber, and discharging it from the overflow chamber discharge port.

[0023] According to the second aspect, an embodiment provides a saccharification fluid circuit system, which includes the hemolysis device according to the first aspect of the present invention.

[0024] According to the third aspect, an embodiment provides a multifunctional all-in-one machine, comprising the hemolysis device according to the second aspect of the present invention.

[0025] In some embodiments of the multifunctional all-in-one machine, a routine blood test fluid system is further included for implementing routine blood test, and the routine blood test fluid system is connected to the hemolysis device in the saccharification fluid system.

[0026] Implementing the embodiments of the present invention will have the following beneficial effects:

[0027] According to the hemolysis device, saccharification liquid circuit system and multifunctional all-in-one machine in the above embodiments, since the hemolysis device has a hemolysis chamber and a waste liquid chamber, the hemolysis device can not only achieve the mixing of the blood sample and the hemolytic agent in the hemolysis chamber, but also prevent the mixed liquid to be tested from spilling out of the hemolysis device, which can reduce the maintenance work of the instrument. At the same time, the waste liquid chamber can also collect the waste liquid for detection, and the waste liquid chamber and the hemolysis chamber are arranged to be formed by the same matrix, which can make the hemolysis device more compact in structure, and the overflowed mixed liquid to be tested can more easily flow into the waste liquid chamber. At the same time, the waste liquid chamber and the hemolysis chamber can also be installed synchronously, which is beneficial to saving the internal space of the instrument and facilitating the overall layout of the instrument. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0029] in:

[0030] Figure 1 A schematic structural diagram of a hemolysis device provided according to an embodiment of the present invention is shown;

[0031] Figure 2 A schematic structural diagram of a hemolysis device provided by an embodiment of the present invention from another angle is shown;

[0032] Figure 3 A structural schematic diagram of a hemolysis device provided in another angle according to an embodiment of the present invention is shown;

[0033] Figure 4 A cross-sectional view of a hemolysis device provided according to an embodiment of the present invention is shown;

[0034] Figure 5 A cross-sectional view of another hemolysis device provided according to an embodiment of the present invention is shown;

[0035] Figure 6 A cross-sectional view of another hemolysis device provided according to an embodiment of the present invention is shown;

[0036] Figure 7 A cross-sectional view of another hemolysis device provided according to an embodiment of the present invention is shown;

[0037] Figure 8 A layout diagram of an inlet of a hemolysis chamber of a hemolysis device provided in an embodiment of the present invention is shown;

[0038] Fig. 9 Another layout diagram of the inlet of the hemolysis chamber of a hemolysis device provided according to an embodiment of the present invention is shown;

[0039] Fig.10 Another layout diagram of the inlet of the hemolysis chamber of a hemolysis device provided according to an embodiment of the present invention is shown;

[0040] Fig.11 A cross-sectional view of another hemolysis device provided according to an embodiment of the present invention is shown.

[0041] Description of main component symbols:

[0042] 100-base; 200-hemolysis chamber; 300-waste liquid chamber; 400-overflow chamber; 110-liquid guiding structure; 120-mounting hole; 210-hemolysis chamber; 220-liquid guiding surface; 230-hemolysis chamber entrance; 240-hemolysis chamber exit; 250-first section inner wall surface; 260-second section inner wall surface; 310-waste liquid chamber; 320-waste liquid chamber entrance; 330-waste liquid chamber exit; 410-overflow chamber; 420-overflow chamber outlet. DETAILED DESCRIPTION

[0043] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the relevant drawings. The preferred embodiments of the present invention are given in the drawings. However, the present invention can be implemented in many other different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present invention more thorough and comprehensive.

[0044] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0045] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0046] In one aspect of the present invention, the present invention provides a multifunctional all-in-one machine, which can be an instrument capable of realizing two functional detection and analysis, such as routine blood test and glycosylated hemoglobin test, in which case the multifunctional all-in-one machine at least includes a saccharification liquid circuit system for realizing glycosylated hemoglobin analysis and a routine blood liquid circuit system for realizing routine blood test. Of course, the multifunctional all-in-one machine can also be designed as an instrument capable of realizing more functional detection and analysis.

[0047] The multifunctional all-in-one machine is generally equipped with a frame, various motion mechanisms, detection mechanisms and necessary liquid circuit systems (such as the aforementioned blood routine liquid circuit system and saccharification liquid circuit system) installed on the frame. The motion mechanism can be, for example, a related mechanism for completing sample suction, sampling and sample transportation. The detection mechanism is generally implemented by an optical detection cell (of course, other detection methods can also be considered). The liquid circuit system is used to form a mixed liquid to be tested and transport the mixed liquid to be tested to the optical detection cell for detection according to a set timing. At the same time, it can also complete the recovery of waste liquid. The optical detection cell detects the mixed liquid to be tested and outputs the result.

[0048] The saccharification liquid circuit system and the multifunctional all-in-one machine in the embodiment of the present invention make the liquid circuit system simpler and facilitate the layout of the liquid circuit system inside the machine because the hemolysis device with a new structure is adopted.

[0049] The saccharification liquid circuit system (hereinafter referred to as "liquid circuit system") in the embodiment of the present invention includes various devices and necessary pipelines such as a circulation pool, a high-pressure pump, a pressure relief valve, a solenoid valve, a hemolysis device, an optical detection pool, etc. It should be particularly pointed out that during a detection cycle of the liquid circuit system, detection waste liquid will be generated. Generally, a container for collecting the detection waste liquid will be specially set up in the liquid circuit system, and corresponding pipelines need to be arranged in combination with the container, which will be detrimental to the layout of the liquid circuit system.

[0050] In this regard, the embodiment of the present invention redesigns the hemolysis device to have both hemolysis function and waste liquid collection function. The test waste liquid can be directly introduced into the hemolysis device, which is conducive to the simplified design of the liquid path system and the layout of the liquid path system on the multi-function all-in-one machine.

[0051] In the embodiment of the present invention, please refer to Figure 1-3 The hemolysis device includes a base 100, a hemolysis chamber 200 and a waste liquid chamber 300. The hemolysis chamber 200 is formed by a part of the base 100. The hemolysis chamber 200 has a hemolysis chamber 210 for mixing the blood sample and the hemolytic agent to form a mixed liquid to be tested. The waste liquid chamber 300 is also formed by a part of the base 100. The waste liquid chamber 300 has a waste liquid chamber 310 for collecting the mixed liquid to be tested overflowing from the hemolysis chamber 210 and for collecting the detection waste liquid.

[0052] The matrix 100 is used to contain at least a blood sample, a hemolytic agent, a mixed solution to be tested formed by the blood sample and the hemolytic agent, and a waste liquid for testing. Therefore, the matrix 100 should be made of a material with relatively stable chemical properties, such as glass or other polymer materials.

[0053] In addition, the base 100 should be designed as an open structure and extend into a columnar structure in the vertical direction, so that the hemolysis chamber 210 and the waste liquid chamber 310 inside the base 100 can be connected to the outside world, making it easier to transport the corresponding liquid to the hemolysis chamber 210 and the waste liquid chamber 310.

[0054] In the embodiment of the present invention, since the hemolysis device has a hemolysis chamber 200 and a waste liquid chamber 300, the hemolysis device can not only achieve mixing of the blood sample and the hemolytic agent in the hemolysis chamber 200, but also prevent the mixed liquid to be tested from spilling out of the hemolysis device, which can reduce the maintenance work of the instrument. At the same time, the waste liquid chamber 300 can also collect the waste liquid for detection, and the waste liquid chamber 300 and the hemolysis chamber 200 are arranged to be formed by the same matrix 100, which can make the hemolysis device more compact in structure, and the overflowed mixed liquid to be tested can more easily flow into the waste liquid chamber 310. At the same time, the hemolysis chamber 200 and the waste liquid chamber 300 can also be installed synchronously, which is beneficial to saving the internal space of the instrument and facilitating the overall layout of the instrument.

[0055] It should be noted that the hemolysis chamber 200 and the waste liquid chamber 300 in the embodiment of the present invention can be combined in various ways. Figure 1 The two can be arranged side by side, for example, they can be close together; they can also be nested, for example, the hemolysis chamber 200 is set in the waste liquid chamber 300. In addition, the ends of the hemolysis chamber 200 and the waste liquid chamber 300 can be flush, or one is high and the other is low. In short, under the guidance of making the hemolysis device have both hemolysis function and waste liquid collection function, the base 100, the hemolysis chamber 200 and the waste liquid chamber 300 can be variously deformed in structure.

[0056] In one embodiment, the tops of the hemolysis chamber 200 and the waste liquid chamber 300 are flush, which can ensure the uniformity of the appearance of the hemolysis device, make its structure more regular, and make the hemolysis device smoother and more beautiful in appearance and structure.

[0057] At this time, the base 100 can be constructed into a relatively regular rectangular parallelepiped, cylindrical structure or other structure, the hemolysis chamber 200 and the waste liquid chamber 300 are tightly attached together, and the surfaces of the two except the top are connected to form a connected plane, and the hemolysis chamber 210 and the waste liquid chamber 310 are formed in the space enclosed by the plane.

[0058] In another embodiment, the top of the waste liquid chamber 300 is higher than the top of the hemolysis chamber 200 , so that the mixed solution to be tested in the hemolysis chamber 200 can easily flow into the waste liquid chamber 300 .

[0059] Please refer to Figure 1-3The overall shape of the substrate 100 can also be configured into a regular structure, such as a rectangular parallelepiped structure, but as for the hemolysis chamber 200 and the waste liquid chamber 300, the tops of the two are not in the same plane. For example, the waste liquid chamber 300 can be formed by extending a predetermined distance from the top of the substrate 100 to the bottom thereof, and the hemolysis chamber 200 can be formed by extending a predetermined distance from a certain position near the top of the substrate 100 to the bottom thereof, as shown in FIG. Figure 1 In the example shown, the top of the hemolysis chamber 200 is sunken into the base 100 .

[0060] In other embodiments, the top of the waste liquid chamber 300 is lower than the top of the hemolysis chamber 200. It should be noted that only when the mixed liquid to be tested in the hemolysis chamber 200 is large and rises above the top of the waste liquid chamber 300, the mixed liquid to be tested will flow into the waste liquid chamber 300. In order to prevent the mixed liquid to be tested from overflowing out of the matrix 100, the top of the hemolysis chamber 200 should be provided with a guide structure for guiding the liquid into the waste liquid chamber 300, such as an inclined surface inclined toward the waste liquid chamber 300.

[0061] In the embodiment where the top of the waste liquid chamber 300 is lower than the top of the hemolysis chamber 200, the hemolysis device can be further designed. For example, the waste liquid chamber 300 can be designed as a structure surrounding the hemolysis chamber 200. It can be understood that when the waste liquid chamber 300 and the hemolysis chamber 200 are both designed as cylindrical structures, a better way is to arrange the waste liquid chamber 300 and the hemolysis chamber 200 coaxially. At this time, the distance from the outer wall of the hemolysis chamber 200 to the inner wall of the waste liquid chamber 300 is the same at every location, which is conducive to making the mixed liquid to be tested in the hemolysis chamber 200 flow evenly into the waste liquid chamber 300.

[0062] In the embodiments listed above, it can be understood that, in the process of the mixed liquid to be tested flowing from the hemolysis chamber 200 into the waste liquid chamber 300, a better way is to allow the mixed liquid to be tested to adhere to the outer wall of the hemolysis chamber 200. Therefore, in some specific embodiments, the outer wall of the hemolysis chamber 200 can be designed to be inclined, and the specific angle of inclination can be determined according to actual needs.

[0063] It should be pointed out that the combination relationship between the substrate 100, the hemolysis chamber 200 and the waste liquid chamber 300 in the above embodiments is intended to be illustrative and not exhaustive. The substrate 100, the hemolysis chamber 200 and the waste liquid chamber 300 can be constructed into various shapes, and they can be combined in any appropriate manner.

[0064] In one embodiment, a liquid guiding structure 110 is formed between the hemolysis chamber 210 and the waste liquid chamber 310 , and the liquid guiding structure 110 is used to introduce the mixed solution to be tested in the hemolysis chamber 210 into the waste liquid chamber 310 .

[0065] Here, the embodiment in which the top of the waste liquid chamber 300 is higher than the top of the hemolysis chamber 200 is used as an example for description. Figure 1 The liquid guiding structure 110 can be formed between the waste liquid chamber 300 and the hemolysis chamber 200, for example, it can be set on the outer wall of the hemolysis chamber 200. The design of the liquid guiding structure 110 is conducive to allowing the mixed liquid to be tested to enter the waste liquid chamber 310 quickly and smoothly.

[0066] In a specific embodiment, a liquid guiding surface 220 is disposed on the top of the hemolysis chamber 200 and is inclined from top to bottom toward the waste liquid chamber 300 , and the liquid guiding surface 220 forms a liquid guiding structure 110 .

[0067] When the mixed solution to be tested fills the entire hemolysis chamber 210 , the mixed solution to be tested can flow into the waste liquid chamber 310 along the liquid guide surface 220 .

[0068] Furthermore, in some more specific embodiments, the angle between the liquid guiding surface 220 and the horizontal plane can be limited to between 0° and 30°, and the overall length of the liquid guiding surface 220 cannot be too large, thereby reducing the speed at which the mixed liquid to be tested leaves the liquid guiding surface 220, so that it can flow into the waste liquid chamber 310 along the outer wall of the hemolysis chamber 200.

[0069] In other more specific embodiments, the liquid guiding surface 220 does not have to be designed to be a plane, it can also be a wrapping surface with raised ends (similar to an arc surface). In the process of the mixed liquid to be tested flowing into the waste liquid chamber 310, the mixed liquid to be tested can be restricted by the liquid guiding surface 220, so that it flows to the waste liquid chamber 310 along a prescribed path.

[0070] In another specific embodiment, the hemolysis chamber 200 is provided with a liquid conducting hole (not shown in the figure) near the top thereof, and the liquid conducting hole forms a liquid conducting structure 110 .

[0071] When the mixed liquid to be tested rises to the liquid guiding hole, the mixed liquid to be tested can pass through the liquid guiding hole and enter the waste liquid chamber 310 .

[0072] Furthermore, in some more specific embodiments, the inner wall of the liquid guide hole is inclined, with its lower end facing the waste liquid chamber 310 , so that the mixed liquid to be tested can easily flow into the waste liquid chamber 310 .

[0073] In one embodiment, please refer to Figure 1-3 The hemolysis chamber 200 has at least one hemolysis chamber inlet 230 and at least one hemolysis chamber outlet 240 connected to the hemolysis chamber 210 . The hemolysis chamber outlet 240 is located at the bottom of the hemolysis chamber 200 , and the hemolysis chamber inlet 230 is located near the bottom of the hemolysis chamber 200 .

[0074] The hemolysis chamber inlet 230 is used for the hemolysis agent to enter the hemolysis chamber 210. The hemolysis agent can be injected into the hemolysis chamber 210 through a syringe or other device. During the process of the hemolysis agent entering the hemolysis chamber 210, due to the aforementioned setting of the position of the hemolysis chamber inlet 230, the hemolysis agent can perform a back and forth mixing movement under the reaction force of the inner wall of the hemolysis chamber 210. The reaction force combined with the force generated by the syringe during suction and exhalation is beneficial to improving the mixing effect and mixing speed of the hemolysis agent and the blood sample, thereby helping to save a single detection cycle.

[0075] The aforementioned setting of the position of the hemolysis chamber outlet 240 is conducive to quickly discharging the mixed solution to be tested or other liquids in the hemolysis chamber 210 out of the hemolysis chamber 210 .

[0076] In a specific embodiment, the inner wall of the hemolysis chamber 210 is formed by a continuous arc surface that is connected end to end. The arc surface facilitates the back and forth movement of the liquid in the hemolysis chamber 210, which can increase the time of the aforementioned back and forth interlaced mixing and intensify the back and forth interlaced mixing movement, thereby facilitating improving the mixing effect.

[0077] Further, in a more specific embodiment, please refer to Figure 4 The inner wall surface of the hemolysis chamber 210 includes a first section inner wall surface 250 and a second section inner wall surface 260. The second section inner wall surface 260 is connected to the first section inner wall surface 250 and is located below the first section inner wall surface 250. The hemolysis chamber inlet 230 is arranged opposite to the second section inner wall surface 260. The second section inner wall surface 260 can generate an upward force on the hemolytic agent entering the hemolysis chamber 210 from the hemolysis chamber inlet 230, so that the hemolytic agent flows toward the first section inner wall surface 250.

[0078] It can be understood at this point that since the entire inner wall surface is formed by an arc surface, when the second section of the inner wall surface 260 is provided and the second section of the inner wall surface 260 is enabled to generate a supporting force on the hemolytic agent, combined with the setting of the hemolytic chamber inlet 230, the hemolytic agent entering the hemolytic chamber 210 can cause the liquid in the hemolytic chamber 210 to generate a vortex. At this time, the back-and-forth interlaced mixing motion becomes more intense, and the hemolytic agent will rise and fall along the inner wall surface, thereby further improving the mixing effect of the hemolytic agent and the blood sample.

[0079] For more specific embodiments, please refer to Figure 4 The first section inner wall surface 250 is an arc surface, and the second section inner wall surface 260 is an inverted cone surface, which is easy to process and shape the inner wall surface. Of course, please refer to Figure 5 In some other more specific embodiments, the first section inner wall surface 250 and the second section inner wall surface 260 may also adopt other curved surface structures, such as a spherical surface. In some possible embodiments, some small protrusions may be formed on the surface of the inner wall surface to achieve a better mixing effect.

[0080] In addition, please refer to Figure 5-6 The second inner wall surface 260 does not necessarily have to be a curved surface, and can also be a cylindrical surface or some other planes. When a cylindrical surface is used, the second inner wall surface 260 can form a continuous inner wall surface with the first inner wall surface 250.

[0081] In some specific embodiments, please refer to Figure 7 The hemolysis chamber inlet 230 is arranged in a transitional manner from high to low, and its lower end is connected to the hemolysis chamber 210 .

[0082] When the hemolytic agent enters the hemolytic chamber 210 through the hemolytic chamber inlet 230, the hemolytic agent will accumulate a certain amount of kinetic energy, so that it can enter the hemolytic chamber 210 at a higher speed, thereby causing a greater impact on the inner wall surface of the hemolytic chamber 210, and at the same time, it can also make the hemolytic agent perform a more sustained back and forth mixing motion, thereby improving the mixing effect.

[0083] Furthermore, in the embodiment where the inner wall surface of the hemolysis chamber 210 is formed by the first inner wall surface 250 and the second inner wall surface 260, the inclined hemolysis chamber inlet 230 faces the second inner wall surface 260, thereby achieving a better mixing effect of the hemolytic agent and the blood sample.

[0084] In some specific embodiments, please refer to Figure 8-10 The hemolysis chamber 200 has two hemolysis chamber inlets 230 , and the two hemolysis chamber inlets 230 are arranged at intervals along the circumferential direction.

[0085] The two hemolysis chamber inlets 230 can be used as the input ports of the hemolysis agent at the same time, which is conducive to the rapid entry of the hemolysis agent into the hemolysis chamber 210. The two hemolysis chamber inlets 230 can also be designed in this way, where one hemolysis chamber inlet 230 is designed as the input port of the hemolysis agent, and the other hemolysis chamber inlet 230 is designed as the output port of the mixed solution to be tested. This design method is conducive to making the pipeline connection of the liquid system simpler and can also shorten the detection cycle.

[0086] exist Figure 8-10 In the example shown, it can be known that when there are two hemolysis chamber inlets 230, the two hemolysis chamber inlets 230 can be set on the same side of the hemolysis chamber 200, or on different sides of the hemolysis chamber 200, and even the two hemolysis chamber inlets 230 can be in different height planes.

[0087] In some specific embodiments, a filter membrane may be further provided at the hemolysis chamber inlet 230 , and the filter membrane is used to block impurities in the hemolysis chamber 210 .

[0088] This can be understood in conjunction with the aforementioned syringe. During the liquid aspiration process of the syringe, the impurities inside the hemolysis chamber 210 will be isolated by the filter membrane. During the next liquid discharge process of the syringe, its impact force can flush the impurities adsorbed on the filter membrane away from the filter membrane, and then the impurities are discharged from the hemolysis chamber 210 through the hemolysis chamber outlet 240.

[0089] In one embodiment, please refer to Figure 1-3 The waste liquid chamber 300 has at least one waste liquid chamber inlet 320 and at least one waste liquid chamber outlet 330 connected to the waste liquid chamber 310, the waste liquid chamber outlet 330 is located near the bottom of the waste liquid chamber 300, and the waste liquid chamber inlet 320 is located at the upper part of the waste liquid chamber 300.

[0090] The waste liquid chamber inlet 320 is used to connect with other components in the liquid circuit system, such as a circulation pool, a high-pressure pump and a pressure relief valve, and is used to introduce the test waste liquid flowing out of these components into the waste liquid chamber 310. The waste liquid chamber outlet 330 is used to discharge the test waste liquid in the waste liquid chamber 310 and the mixed liquid to be tested that flows into the waste liquid chamber 310 from the hemolysis chamber 210 mentioned above out of the waste liquid chamber 310.

[0091] Furthermore, in a specific embodiment, at least a portion of the bottom wall of the waste liquid chamber 310 is inclined toward the waste liquid chamber outlet 330 to form a waste liquid guide surface, which facilitates the guide of the test mixed liquid and the detection waste liquid out of the waste liquid chamber 310 .

[0092] In a specific embodiment, please refer to Figure 3 The waste liquid chamber 300 has three waste liquid chamber inlets 320 and one waste liquid chamber outlet 330, and the three waste liquid chamber inlets 320 and one waste liquid chamber outlet 330 are arranged in a row from top to bottom.

[0093] Setting the three waste liquid chamber inlets 320 at different heights can better receive the detection waste liquid transmitted from other components. For example, the waste liquid discharged from the high-pressure pump can select the waste liquid chamber inlet 320 at a lower position to prevent the detection waste liquid from causing a large impact on the waste liquid chamber 310.

[0094] In one embodiment, please refer to Fig.11 The hemolysis device also includes an overflow cavity 400, which is formed by a portion of the base 100. The overflow cavity 400 has an overflow chamber 410. An overflow chamber outlet 420 is provided at the bottom of the overflow chamber 410. The overflow chamber 410 is respectively connected to the hemolysis chamber 210 and the waste liquid chamber 310, and is used to receive the mixed liquid to be tested overflowing from the hemolysis chamber 210 and the detection waste liquid and / or the mixed liquid to be tested overflowing from the waste liquid chamber 310, and discharge them from the overflow chamber outlet 420.

[0095] By providing the overflow cavity 400, the overflow chamber 410 can provide an additional liquid storage chamber for the hemolysis chamber 210 and the waste liquid chamber 310, so that when the flow rate is too large, the overflow chamber 410 can receive excess liquid to ensure that the liquid in the hemolysis device will not spill out.

[0096] In combination with the foregoing, the overflow chamber 400 can be designed with a structure similar to the aforementioned hemolysis chamber 200 and waste liquid chamber 300. As a preferred solution, the overflow chamber 400 can be connected between the hemolysis chamber 200 and the waste liquid chamber 300. At this time, the size of the hemolysis device can be controlled to a certain extent, and the liquid can also flow quickly into the overflow chamber 410 when the flow rate is too large.

[0097] It should be noted that the base 100, the hemolysis chamber 200, the waste liquid chamber 300 and the overflow chamber 400 can be manufactured by mechanical processing, especially when processing the hemolysis chamber 210, the waste liquid chamber 310 and the overflow chamber 410, CNC processing can be used. In addition, if possible, they can also be formed by injection molding.

[0098] In addition, please refer to Figure 1 A mounting hole 120 is also provided on the base 100 for mounting the hemolysis device at an appropriate position, for example, on the frame of the aforementioned multifunctional machine.

[0099] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0100] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A hemolysis device, characterized in that: include: matrix; A hemolysis chamber, wherein the hemolysis chamber is formed by a portion of the base body and has a hemolysis chamber for mixing a blood sample and a hemolytic agent to form a mixed solution to be tested; and a waste liquid cavity, the waste liquid cavity being formed by a part of the base, the waste liquid cavity having a waste liquid chamber for collecting the mixed liquid to be tested overflowing from the hemolysis chamber and for collecting the detection waste liquid; a liquid guide structure is formed between the hemolysis chamber and the waste liquid chamber, for introducing the mixed liquid to be tested in the hemolysis chamber into the waste liquid chamber; The top of the hemolysis chamber is provided with a liquid guiding surface which is inclined from top to bottom toward the waste liquid chamber, and the liquid guiding surface forms the liquid guiding structure; Alternatively, the hemolysis chamber is provided with a liquid conducting hole near the top thereof, and the liquid conducting hole forms the liquid conducting structure.

2. The hemolysis device according to claim 1, characterized in that: The hemolysis chamber has at least one hemolysis chamber inlet and at least one hemolysis chamber outlet connected to the hemolysis chamber, the hemolysis chamber outlet is located at the bottom of the hemolysis chamber, and the hemolysis chamber inlet is located near the bottom of the hemolysis chamber.

3. The hemolysis device according to claim 2, characterized in that: The inner wall surface of the hemolysis chamber is formed by a continuous arc surface connected end to end.

4. The hemolysis device according to claim 3, characterized in that: The inner wall surface includes a first section inner wall surface and a second section inner wall surface, the second section inner wall surface is connected to the first section inner wall surface and is located below the first section inner wall surface, the hemolysis chamber entrance is arranged opposite to the second section inner wall surface, and the second section inner wall surface can generate an upward support force on the hemolytic agent entering the hemolysis chamber from the hemolysis chamber entrance, so that the hemolytic agent flows toward the first section inner wall surface.

5. The hemolysis device according to claim 4, characterized in that: The inner wall surface of the first section is an arc surface, and the inner wall surface of the second section is an inverted cone surface.

6. The hemolysis device according to claim 2, characterized in that: The inlet of the hemolysis chamber is arranged in a transitional manner from high to low, and the lower end thereof is connected to the hemolysis chamber.

7. The hemolysis device according to claim 2, characterized in that: The hemolysis chamber body has two hemolysis chamber inlets, and the two hemolysis chamber inlets are arranged at intervals along the circumferential direction.

8. The hemolysis device according to claim 2, characterized in that: A filter membrane is also provided at the entrance of the hemolysis chamber to block impurities in the hemolysis chamber.

9. The hemolysis device according to claim 1, characterized in that: The waste liquid chamber has at least one waste liquid chamber inlet and at least one waste liquid chamber outlet connected to the waste liquid chamber, the waste liquid chamber outlet is located near the bottom of the waste liquid chamber, and the waste liquid chamber inlet is located at the upper part of the waste liquid chamber.

10. The hemolysis device according to claim 9, characterized in that: At least a portion of the bottom wall of the waste liquid chamber is inclined toward the waste liquid chamber outlet to form a waste liquid guide surface, which is convenient for guiding the mixed liquid to be tested and the detection waste liquid out of the waste liquid chamber.

11. The hemolysis device according to claim 9, characterized in that: The waste liquid chamber has three waste liquid chamber inlets and one waste liquid chamber outlet, and the three waste liquid chamber inlets and one waste liquid chamber outlet are arranged in a row from top to bottom.

12. The hemolysis device according to claim 1, characterized in that: The hemolysis device also includes an overflow cavity, which is formed by a part of the base body. The overflow cavity has an overflow chamber, and an overflow chamber discharge port is arranged at the bottom of the overflow chamber. The overflow chamber is respectively connected to the hemolysis chamber and the waste liquid chamber, and is used to receive the mixed liquid to be tested overflowing from the hemolysis chamber and the detection waste liquid and / or the mixed liquid to be tested overflowing from the waste liquid chamber, and discharge it from the overflow chamber discharge port.

13. A saccharification liquid circuit system, characterized in that: Comprising the hemolysis device according to any one of claims 1-12.

14. A multifunctional machine, characterized in that: Comprising the saccharification liquid circuit system according to claim 13.

15. The multifunctional machine according to claim 14, wherein: It also includes a routine blood test fluid system for implementing routine blood test, and the routine blood test fluid system is connected to the hemolysis device in the saccharification fluid system.

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