A liquid phase nozzle atomization device for a chromatographic tandem mass spectrometer

Abstract

The present application relates to the technical field of liquid chromatography-mass spectrometry, and discloses a liquid phase nozzle atomizing device of a chromatographic tandem mass spectrometer, including an atomizing chamber housing, an atomizing assembly installed on the atomizing chamber housing, and an adjustable mounting seat fixed on the atomizing chamber housing, a sliding sleeve passing through and slidably connected to the adjustable mounting seat, and a connecting seat is rotatably connected to the end of the sliding sleeve away from the atomizing chamber housing, and a liquid inlet channel, a liquid storage cavity and a multi-stage liquid outlet channel connected in sequence are provided in the connecting seat, and the liquid inlet channel and the multi-stage liquid outlet channel respectively pass through the two ends of the connecting seat, and a fixed plate is provided in the sliding sleeve, and mounting holes are provided on the fixed plate along its circumference, and atomizing nozzles are connected in the mounting holes. The present application makes the multi-stage liquid outlet channel connected to a number of atomizing nozzles by rotating the connecting seat at different angles, and changes the number of atomizing nozzles involved in the work, thereby increasing the atomization amount and improving the atomization effect.

Description

Technical Field

[0001] The present application relates to the technical field of liquid chromatography-mass spectrometry, and in particular to a liquid phase nozzle atomization device of a chromatography-tandem mass spectrometer. Background Art

[0002] The ion source is the bridge between the liquid chromatography and the mass spectrometry analyzer. It is an interface device that ionizes the neutral atoms or molecules in the liquid sample and draws out the ion beam from it. Therefore, its function is to ionize and vaporize the target to be detected. According to the different ionization methods, the ion source can be divided into three types: electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization (APPI). Among them, the most commonly used in clinical practice are ESI ion source and APCI ion source.

[0003] Currently, most of the existing atomization devices are single nozzles. The atomization volume produced by a single nozzle is small, resulting in poor atomization effect. The detector receives fewer charged ions, resulting in inaccurate data analysis. When a single nozzle is blocked, the nozzle can only be replaced or cleaned, affecting work efficiency. Summary of the invention

[0004] In order to improve the problem that existing atomization devices produce small atomization amounts, resulting in inaccurate data analysis, the present application provides a liquid phase nozzle atomization device for a chromatographic tandem mass spectrometer.

[0005] The present application provides a liquid phase nozzle atomization device for a chromatographic tandem mass spectrometer, which adopts the following technical solution:

[0006] A liquid phase nozzle atomization device for a chromatographic tandem mass spectrometer comprises an atomization chamber shell, an atomization assembly is installed on the atomization chamber shell, the atomization assembly comprises an adjustable mounting seat fixed on the atomization chamber shell, a sliding sleeve passes through and is slidably connected to the adjustable mounting seat, an end of the sliding sleeve away from the atomization chamber shell is rotatably connected to a connecting seat, a liquid inlet channel, a liquid storage cavity and a multi-stage liquid outlet channel connected in sequence are provided in the connecting seat, the liquid inlet channel and the multi-stage liquid outlet channel respectively pass through the two ends of the connecting seat, a fixing plate is provided in the sliding sleeve, a plurality of mounting holes are provided on the fixing plate along the circumference thereof, atomization nozzles are connected to the plurality of mounting holes, wherein the multi-stage liquid outlet channel is connected to the plurality of atomization nozzles by rotating the connecting seat at different angles.

[0007] By adopting the above technical scheme, the solution first enters the liquid storage chamber from the liquid inlet channel, and the solution is distributed to the atomizing nozzle connected thereto by means of the multi-stage liquid outlet channel; by rotating the connecting seat, the multi-stage liquid inlet channel is connected to the atomizing nozzle, thereby adjusting the number of atomizing nozzles in operation, increasing the atomization amount, increasing the number of charged ions received by the detector, and improving the accuracy of sample detection and analysis.

[0008] Optionally, the atomizing nozzle includes a sleeve, a capillary channel is opened through the sleeve, and an atomizing gas channel is arranged around the capillary channel in the sleeve; a connecting part is arranged at the inlet end of the sleeve, the connecting part is sleeved and connected in the mounting hole, a limiting block is arranged on the connecting part, and a limiting groove cooperating with the limiting block is arranged in the mounting hole; an air inlet connected to the atomizing gas channel is opened on the side wall of the sleeve near one end of the connecting part, and a first air path is arranged on the side wall of the sliding sleeve, the first air path runs through the interior of the fixed plate and is connected to the air inlet, and the first air path is connected to an external inert gas tank.

[0009] By adopting the above technical solution, a capillary channel is set in the sleeve, and an atomizing gas channel is set to assist the atomization of the solution, which is beneficial to improving the atomization effect of the solution; at the same time, the sleeve is sleeved in the mounting hole, and when the capillary channel is blocked, the sleeve is conveniently replaced, and the limit block and the limit groove are used to cooperate to increase the stability of the sleeve connection.

[0010] Optionally, a second air path is provided through the outer wall of the sliding sleeve, an air outlet communicating with the second air path is provided on the inner wall of the sliding sleeve, and an electric heating element is provided in the second air path.

[0011] By adopting the above technical solution, the gas in the second gas path is heated by the electric heating element, and the atomized sample solution is further volatilized by the heated gas, which is conducive to the Coulomb explosion of the atomized droplets and the generation of charged ions.

[0012] Optionally, an electrode plate is fixedly connected inside the sliding sleeve, and the electrode plate is respectively connected to a plurality of atomizing nozzles, and one side of the electrode plate extends outside the sliding sleeve and is electrically connected to an external high voltage.

[0013] By adopting the above technical solution, electrospray is generated by high voltage to further ionize the sample, and the electrode plates form an electric field. The ionized ions gain energy in the electric field. This energy enables the ions to overcome the obstacles in front of the mass analyzer and enter the mass analyzer of the mass spectrometer.

[0014] Optionally, a positioning assembly is provided near the connection between the connecting seat and the sliding sleeve, and the positioning assembly includes a positioning block. A mounting groove is provided on the side wall of the connecting seat. The positioning block is slidably connected in the mounting groove. An elastic member is provided between the positioning block and the inner wall of the mounting groove. One end of the elastic member is connected to the positioning block, and the other end of the elastic member is connected to the inner wall of the mounting groove. A plurality of positioning grooves cooperating with the positioning block are provided on the inner wall of the sliding sleeve.

[0015] By adopting the above technical solution, when the connecting seat is rotated, the positioning block is clamped in the positioning grooves at different positions to limit the rotation of the connecting seat, while ensuring that the multi-stage liquid outlet channels on the connecting seat are connected to the atomizing nozzle.

[0016] Optionally, a sealing gasket is provided at the connection between the connecting seat and the sliding sleeve, the sealing gasket is fixed to the inner wall of the sliding sleeve and abuts against the fixing plate, the other side of the sealing gasket abuts against the end face of the connecting seat, and the sealing gasket is provided with through holes corresponding to the plurality of mounting holes.

[0017] By adopting the above technical solution, a sealing gasket is provided to increase the sealing performance of the connection between the connecting seat and the sliding sleeve to avoid solution leakage. At the same time, a through hole is provided on the sealing gasket so that the sealing gasket does not affect the circulation of the solution between the connecting seat and the sliding sleeve.

[0018] Optionally, an end cover is provided at the connection between the connecting seat and the sliding sleeve, and the end cover is sleeved on the connecting seat and the sliding sleeve. A limiting ring is provided at one end of the end cover close to the connecting seat, and an anti-slip protrusion is provided on the outer wall of the connecting seat. The limiting ring abuts against the anti-slip protrusion, and the other end of the end cover is threadedly connected to the sliding sleeve.

[0019] By adopting the above technical solution, the stability of the connection between the connecting seat and the sliding sleeve is increased by arranging the end cover, thereby preventing the connecting seat from being separated from the sliding sleeve during rotation.

[0020] The adjusting base can be adjusted by the adjustment means to move the adjusting member in a direction opposite to the adjustment plate, and the adjusting member can be adjusted by the adjustment means to move the adjusting member in a direction opposite to the adjustment plate.

[0021] By adopting the above technical solution, by setting the adjustment plate 1 and the adjustment plate 2, the horizontal displacement of the atomization assembly installed on the adjustable mounting seat can be adjusted, and by setting the adjustment rod 1 and the adjustment rod 2, the displacement of the adjustment plate 1 and the adjustment plate 2 can be accurately adjusted.

[0022] Optionally, a sleeve is fixedly connected to a side of the adjustment plate 2 away from the adjustment plate 1, the sliding sleeve is slidably connected in the sleeve, and a locking member for limiting the movement of the sliding sleeve is provided on the sleeve.

[0023] By adopting the above technical solution, the sliding sleeve is slidably connected in the sleeve, and the position of the sliding sleeve in the sleeve is limited by the locking member, so as to adjust the height of the atomization assembly.

[0024] Optionally, an adapter connected to the liquid inlet channel is provided at the end of the connecting seat, and the adapter is used to connect to an external liquid inlet pipe. A positioning mark is provided on the outer wall of the connecting seat, and a plurality of positioning points are provided on the circumferential side of the outer wall of the sliding sleeve, wherein when the connecting seat rotates, the positioning mark corresponds to one of the positioning points.

[0025] By adopting the above technical solution, the connection with the external liquid inlet pipe is facilitated by setting an adapter; positioning marks and positioning points are set on the connecting seat, which is conducive to the connecting seat to quickly determine the rotation angle or position and accurately switch the number of atomizing nozzles in operation.

[0026] To summarize, the present application includes at least one of the following beneficial technical effects: by rotating the connecting seat, the atomizing nozzles at different positions are connected to the multi-stage liquid outlet channel, thereby adjusting the number of atomizing nozzles in operation, increasing the atomization amount, increasing the number of charged ions received by the detector, and improving the accuracy of sample detection and analysis. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a structural schematic diagram of a liquid phase nozzle atomization device of a chromatographic tandem mass spectrometer of the present application.

[0028] Figure 2 It is a structural schematic diagram of the atomization component of the present application.

[0029] Figure 3 It is a cross-sectional view of the atomization assembly of the present application.

[0030] Figure 4 It is a cross-sectional view of the atomization assembly of the present application.

[0031] Figure 5 It is a structural schematic diagram of the multi-stage liquid outlet channel of the present application.

[0032] Figure 6 yes Figure 3 Enlarged view of part A in the middle.

[0033] Figure 7 yes Figure 4 Enlarged view of part B in the middle.

[0034] Figure 8 It is a structural schematic diagram of the adjustable mounting seat of the present application.

[0035] Figure numerals: 1, atomizing chamber housing; 2, adjustable mounting seat; 21, mounting plate; 22, adjusting plate 1; 221, slide groove 1; 222, guide rail 2; 223, push plate 1; 23, adjusting plate 2; 231, slide groove 2; 232, push plate 2; 24, adjusting rod 1; 25, adjusting rod 2; 26, sleeve; 27, locking member; 28, mounting groove; 3, sliding sleeve; 31, fixing plate; 311, mounting hole; 312, limiting groove; 32, first gas path; 33, second gas path; 34, gas outlet; 35, electric heating element; 36, fixed Positioning slot; 37, positioning point; 38, groove; 4, connecting seat; 41, liquid inlet channel; 42, liquid storage chamber; 43, multi-stage liquid outlet channel; 431, first channel; 432, second channel; 433, third channel; 44, adapter; 45, positioning mark; 46, anti-drop protrusion; 5, atomizing nozzle; 51, sleeve; 52, capillary channel; 53, connecting part; 54, limit block; 55, atomizing gas channel; 56, air inlet; 6, electrode plate; 7, positioning block; 71, elastic part; 8, end cover; 81, limit ring; 9, sealing gasket. DETAILED DESCRIPTION

[0036] Embodiments of the present application are described in detail below, examples of which are shown in the accompanying drawings.

[0037] In the description of this specification, the description with reference to the terms "certain embodiments", "one embodiment", "some embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with the embodiments or examples are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any one or several embodiments or examples in a suitable manner.

[0038] The present application embodiment discloses a liquid phase nozzle atomization device for a chromatographic tandem mass spectrometer, referring to Figure 1-5, including an atomization chamber shell 1, on which an atomization assembly is installed, the atomization assembly includes an adjustable mounting seat 2 fixed on the atomization chamber shell 1, a sliding sleeve 3 passing through and slidably connected to the adjustable mounting seat 2, a hollow tubular structure in the sliding sleeve 3, and a connecting seat 4 rotatably connected to one end of the sliding sleeve 3 away from the atomization chamber shell 1, a liquid inlet channel 41, a liquid storage cavity 42 and a multi-stage liquid outlet channel 43 connected in sequence are provided in the connecting seat 4, the liquid inlet channel 41 and the multi-stage liquid outlet channel 43 respectively pass through the two ends of the connecting seat 4, a plurality of mounting holes 311 are provided on the fixed plate 31 along its circumference, the positions of the plurality of mounting holes 311 correspond to the multi-stage liquid outlet channel 43, and atomizing nozzles 5 are connected to the plurality of mounting holes 311, wherein the multi-stage liquid outlet channel 43 is connected to the plurality of atomizing nozzles 5 by rotating the connecting seat 4 at different angles.

[0039] Reference Figure 5 The multi-stage liquid outlet channel 43 includes a first channel 431, a plurality of second channels 432 and a plurality of third channels 433 distributed circumferentially on the connecting seat 4. The first channel 431 is located at the axial center of the mounting seat. The distance between the third channel 433 and the axial center is greater than the distance between the second channel 432 and the axial center of the connecting seat 4. The second channel 432 is a fan-shaped channel. When the connecting seat 4 rotates, when the third channel 433 is connected to the atomizing nozzle 5 at its corresponding position, it is ensured that the second channel 432 is always connected to the atomizing nozzle 5 at its corresponding position, so as to ensure that the number of atomizing nozzles 5 connected to the multi-stage liquid outlet channel 43 is continuously increased or decreased.

[0040] An adapter 44 connected to the liquid inlet channel 41 is provided at the end of the connecting seat 4, and the adapter 44 is used to connect the external liquid inlet pipe. A positioning mark 45 is provided on the outer wall of the connecting seat 4, and a plurality of positioning points 37 are provided on the circumferential side of the outer wall of the sliding sleeve 3. When the connecting seat 4 rotates, the positioning mark 45 corresponds to one of the positioning points 37.

[0041] The adapter 44 is provided to facilitate connection with the external liquid inlet pipe; the positioning mark 45 and the positioning point 37 are provided on the connecting seat 4, which is conducive to the connecting seat 4 to quickly determine the rotation angle or position and accurately switch the number of the atomizing nozzles 5 in operation.

[0042] Reference Figure 3 and Figure 7The atomizing nozzle 5 includes a sleeve 51, a capillary channel 52 is formed in the sleeve 51, and an atomizing gas channel 55 is formed around the capillary channel 52 in the sleeve 51; a connecting portion 53 is formed at the inlet end of the sleeve 51, and the connecting portion 53 is sleeved and connected in the mounting hole 311, and a limiting block 54 is formed on the connecting portion 53, and a limiting groove 312 matched with the limiting block 54 is formed in the mounting hole 311; an air inlet 56 connected to the atomizing gas channel 55 is formed on the side wall of the sleeve 51 near one end of the connecting portion 53, and a first air path 32 is formed on the side wall of the sliding sleeve 3, and the first air path 32 runs through the interior of the fixing plate 31 and is connected to the air inlet 56, and the first air path 32 is connected to an external inert gas tank.

[0043] A second gas path 33 is provided through the outer wall of the sliding sleeve 3 , an air outlet 34 communicating with the second gas path 33 is provided on the inner wall of the sliding sleeve 3 , and an electric heating element 35 is provided in the second gas path 33 .

[0044] An electrode plate 6 is fixedly connected inside the sleeve 3. The electrode plate 6 is respectively connected to a plurality of atomizing nozzles 5. One side of the electrode plate 6 extends outside the sleeve 3 and is electrically connected to an external high voltage. The voltage of the high voltage is 3-8 kV. Electrospray is generated by high voltage to further ionize the sample. The electrode plate 6 forms an electric field. The ionized ions gain energy in the electric field. The energy enables the ions to overcome the obstacles in front of the mass analyzer and enter the mass analyzer of the mass spectrometer.

[0045] Reference Figure 3 and Figure 6 A positioning assembly is provided near the connection between the connecting seat 4 and the sliding sleeve 3, and the positioning assembly includes a positioning block 7. A mounting groove 28 is provided on the side wall of the connecting seat 4. The positioning block 7 is slidably connected in the mounting groove 28. An elastic member 71 is provided between the positioning block 7 and the inner wall of the mounting groove 28. The elastic member 71 is a spring. One end of the elastic member 71 is connected to the positioning block 7, and the other end of the elastic member 71 is connected to the inner wall of the mounting groove 28. A plurality of positioning grooves 36 cooperating with the positioning block 7 are provided on the inner wall of the sliding sleeve 3.

[0046] When the connecting seat 4 is rotated, the end of the positioning block 7 abuts against the inner wall of the sliding sleeve 3, and the positioning block 7 is compressed in the mounting groove 28. When the positioning block 7 is rotated to the position of the positioning groove 36, the elastic member 71 releases the elastic potential energy to push the positioning block 7 out, and the positioning block 7 is clamped in the positioning groove 36 to limit the rotation of the connecting seat 4, while ensuring that the multi-stage liquid outlet channel 43 on the connecting seat 4 is accurately docked with the atomizing nozzle 5.

[0047] A sealing gasket 9 is provided at the connection between the connecting seat 4 and the sliding sleeve 3, and a groove 38 is provided on the inner wall of the sliding sleeve 3. The circumference of the sealing gasket 9 is clamped in the groove 38, one side surface of the sealing gasket 9 abuts against the surface of the fixing plate 31, and the other side surface of the sealing gasket 9 abuts against the end face of the connecting seat 4. The sealing gasket 9 is provided with through holes corresponding to a plurality of mounting holes 311.

[0048] The sealing gasket 9 is provided to increase the sealing performance of the connection between the connecting seat 4 and the sliding sleeve 3 to avoid leakage of the solution. Meanwhile, a through hole is provided on the sealing gasket 9 so that the sealing gasket 9 does not affect the circulation of the solution between the connecting seat 4 and the sliding sleeve 3 .

[0049] An end cap 8 is provided at the connection between the connection seat 4 and the sliding sleeve 3. The end cap 8 is sleeved on the connection seat 4 and the sliding sleeve 3. A limit ring 81 is provided at one end of the end cap 8 close to the connection seat 4. An anti-slip protrusion 46 is provided on the outer wall of the connection seat 4. The limit ring 81 abuts against the anti-slip protrusion 46. The other end of the end cap 8 is threadedly connected to the sliding sleeve 3. The end cap 8 is provided to increase the stability of the connection between the connection seat 4 and the sliding sleeve 3, so as to prevent the connection seat 4 from being separated from the sliding sleeve 3 when rotating.

[0050] Reference Figure 1 and Figure 8 The adjustable mounting seat 2 includes a mounting plate 21, on which an adjusting plate 1 22 and an adjusting plate 23 are provided for moving longitudinally and transversely thereof. The mounting plate 21, the adjusting plate 1 22 and the adjusting plate 23 are all provided with accommodating holes for the atomizing assembly to pass through. The adjusting plate 1 22 is slidably connected to the mounting plate 21, and a guide rail 1 (not marked in the figure) is provided on the side of the mounting plate 21 away from the atomizing chamber housing 1. A slide groove 1 221 cooperating with the guide rail 1 is provided on the adjusting plate 1 22. The mounting plate 21 is rotatably connected to the adjusting plate 1 along one side of the moving direction of the adjusting plate 1 The section rod 24 and the adjusting plate 22 are provided with a push plate 223 cooperating with the adjusting rod 24, and the middle position of the adjusting rod 24 is threadedly connected to the push plate 223; the adjusting plate 23 is slidably connected to the adjusting plate 22, and the adjusting plate 23 is provided with a slide groove 231 cooperating with the guide rail 222, and the adjusting plate 23 is rotatably connected with the adjusting rod 25 on one side along the moving direction of the adjusting plate 23, and the adjusting plate 23 is provided with a push plate 232 cooperating with the adjusting rod 25, and the middle position of the adjusting rod 25 is threaded on the push plate 232.

[0051] By setting the adjustment plate 1 22 and the adjustment plate 2 23, the horizontal displacement of the atomization assembly installed on the adjustable mounting seat 2 can be adjusted. By setting the adjustment rod 1 24 and the adjustment rod 25, the displacement of the adjustment plate 1 22 and the adjustment plate 2 23 can be accurately adjusted.

[0052] A sleeve 26 is fixedly connected to one side of the second adjustment plate 23 away from the first adjustment plate 22 , and the sliding sleeve 3 is slidably connected in the sleeve 26 . A locking member 27 for limiting the movement of the sliding sleeve 3 is provided on the sleeve 26 .

[0053] The sliding sleeve 3 is slidably connected in the sleeve 26 , and the position of the sliding sleeve 3 in the sleeve 26 is limited by the locking member 27 , so as to adjust the height of the atomizing assembly.

[0054] The implementation principle of the liquid phase nozzle atomization device of a chromatography tandem mass spectrometer in an embodiment of the present application is: when in use, the solution first enters the liquid storage chamber 42 from the liquid inlet channel 41, and the solution is distributed to the atomizing nozzle 5 connected thereto by using the multi-stage liquid outlet channel 43; by rotating the connecting seat 4, the multi-stage liquid inlet channel 41 is connected to the atomizing nozzle 5, thereby adjusting the number of atomizing nozzles 5 in operation, increasing the atomization amount, increasing the number of charged ions received by the detector, and improving the accuracy of sample detection and analysis. The solution passes through the capillary channel 52 in the sleeve 51, and is connected to the external gas tank through the first gas path 32, so that the atomizing gas channel 55 is filled with inert gas, and the sleeve 51 is connected to the electrode plate 6 and connected to a high voltage, which is conducive to the atomization of the solution at the outlet of the capillary channel 52 and improves the atomization effect of the solution; the gas in the second gas path 33 is heated by the electric heating element 35, and the atomized sample solution is further volatilized by the heated gas under the action of the atomized gas, which is conducive to the Coulomb explosion of the atomized droplets and the generation of charged ions, which is conducive to providing an atomization effect.

[0055] Although the embodiments of the present application have been shown and described above, it can be understood that the above embodiments are exemplary and cannot be understood as limitations on the present application. Ordinary technicians in this field can change, modify, replace and modify the above embodiments within the scope of the present application.

Claims

1. A liquid phase nozzle atomization device for a chromatographic tandem mass spectrometer, comprising an atomization chamber housing (1), on which an atomization assembly is mounted, characterized in that: The atomization assembly comprises an adjustable mounting seat (2) fixed on the atomization chamber housing (1); a sliding sleeve (3) passes through and is slidably connected to the adjustable mounting seat (2); an end of the sliding sleeve (3) away from the atomization chamber housing (1) is rotatably connected to a connecting seat (4); a liquid inlet channel (41), a liquid storage cavity (42) and a multi-stage liquid outlet channel (43) are provided in the connecting seat (4) and are connected in sequence; the liquid inlet channel (41) and the multi-stage liquid outlet channel (43) respectively pass through the two ends of the connecting seat (4); the sliding sleeve (3) is rotatably connected to the connecting seat (4) at one end away from the atomization chamber housing (1); and the connecting seat (4) is provided with a liquid inlet channel (41), a liquid storage cavity (42) and a multi-stage liquid outlet channel (43) which are connected in sequence. A fixing plate (31) is arranged in the sleeve (3), and a plurality of mounting holes (311) are provided on the fixing plate (31) along its circumference, and a plurality of the mounting holes (311) are connected to atomizing nozzles (5), wherein the multi-stage liquid outlet channel (43) is connected to the plurality of atomizing nozzles (5) by rotating the connecting seat (4) at different angles; and the atomizing nozzles (5) at different positions are connected to the multi-stage liquid outlet channel (43) by rotating the connecting seat (4), thereby adjusting the number of atomizing nozzles (5) in operation; The multi-stage liquid outlet channel (43) comprises a first channel (431), a plurality of second channels (432) and a plurality of third channels (433) which are distributed circumferentially on the connecting seat (4); the first channel (431) is located at the axial center of the mounting seat; the distance between the third channel (433) and the connecting seat axial center is greater than the distance between the second channel (432) and the connecting seat axial center; the second channel (432) is a fan-shaped channel; when the connecting seat (4) rotates and the third channel (433) is connected to the atomizing nozzle (5) at its corresponding position, the second channel (432) is always connected to the atomizing nozzle (5) at its corresponding position, so that the number of atomizing nozzles (5) connected to the multi-stage liquid outlet channel (43) is continuously increased or decreased; The atomizing nozzle (5) comprises a sleeve (51), a capillary channel (52) is formed through the sleeve (51), and an atomizing gas channel (55) is formed around the capillary channel (52) in the sleeve (51); a connecting portion (53) is provided at the inlet end of the sleeve (51), the connecting portion (53) is sleeve-connected in the mounting hole (311), a limiting block (54) is provided on the connecting portion (53), and the mounting hole (311) is provided with a spacer. 1) is provided with a limiting groove (312) cooperating with a limiting block (54); an air inlet (56) connected to an atomizing gas channel (55) is provided on a side wall of the sleeve (51) near one end of the connecting portion (53); a first air path (32) is provided on the side wall of the sliding sleeve (3); the first air path (32) runs through the interior of the fixing plate (31) and is connected to the air inlet (56); the first air path (32) is connected to an external inert gas tank; A positioning assembly is provided near the connection between the connecting seat (4) and the sliding sleeve (3), and the positioning assembly includes a positioning block (7). A mounting groove (28) is provided on the side wall of the connecting seat (4). The positioning block (7) is slidably connected in the mounting groove (28). An elastic member (71) is provided between the positioning block (7) and the inner wall of the mounting groove (28). One end of the elastic member (71) is connected to the positioning block (7), and the other end of the elastic member (71) is connected to the inner wall of the mounting groove (28). A plurality of positioning grooves (36) cooperating with the positioning block (7) are provided on the inner wall of the sliding sleeve (3).

2. The liquid phase spray head atomization device of the chromatographic tandem mass spectrometer according to claim 1, characterized in that: A second air path (33) is provided through the outer wall of the sliding sleeve (3), an air outlet (34) communicating with the second air path (33) is provided on the inner wall of the sliding sleeve (3), and an electric heating element (35) is provided in the second air path (33).

3. The liquid phase spray head atomization device of the chromatographic tandem mass spectrometer according to claim 1, characterized in that: An electrode plate (6) is fixedly connected inside the sliding sleeve (3), and the electrode plate (6) is respectively connected to a plurality of atomizing nozzles (5). One side of the electrode plate (6) extends outside the sliding sleeve (3) and is electrically connected to an external high voltage.

4. The liquid phase spray head atomization device of the chromatographic tandem mass spectrometer according to claim 1, characterized in that: A sealing gasket (9) is provided at the connection between the connecting seat (4) and the sliding sleeve (3); the sealing gasket (9) is fixed to the inner wall of the sliding sleeve (3) and abuts against the fixing plate (31); the other side of the sealing gasket (9) abuts against the end surface of the connecting seat (4); and the sealing gasket (9) is provided with through holes corresponding to a plurality of mounting holes (311).

5. The liquid phase spray head atomization device of the chromatographic tandem mass spectrometer according to claim 1, characterized in that: An end cover (8) is provided at the connection between the connecting seat (4) and the sliding sleeve (3), and the end cover (8) is sleeved on the connecting seat (4) and the sliding sleeve (3). A limiting ring (81) is provided at one end of the end cover (8) close to the connecting seat (4), and an anti-slip protrusion (46) is provided on the outer wall of the connecting seat (4). The limiting ring (81) abuts against the anti-slip protrusion (46), and the other end of the end cover (8) is threadedly connected to the sliding sleeve (3).

6. The liquid phase spray head atomization device of the chromatographic tandem mass spectrometer according to claim 1, characterized in that: The adjustable mounting seat (2) comprises a mounting plate (21), on which an adjustment plate 1 (22) and an adjustment plate 2 (23) are arranged to move longitudinally and transversely thereof, and each of the mounting plate (21), the adjustment plate 1 (22) and the adjustment plate 2 (23) is provided with a receiving hole through which an atomizing component can pass, the adjustment plate 1 (22) is slidably connected to the mounting plate (21), a guide rail 1 is arranged on a side of the mounting plate (21) away from the atomizing chamber housing (1), and a slide groove 1 (221) cooperating with the guide rail 1 is arranged on the adjustment plate 1 (22), and an adjustment rod 1 (24) is rotatably connected to the mounting plate (21) along a side of the moving direction of the adjustment plate 1 (22), so that the mounting plate (21) can be moved in a controlled manner. The adjusting plate 1 (22) is provided with a push plate 1 (223) cooperating with the adjusting rod 1 (24), and the middle position of the adjusting rod 1 (24) is threadedly connected to the push plate 1 (223); the adjusting plate 2 (23) is slidably connected to the adjusting plate 1 (22), and the adjusting plate 2 (23) is provided with a slide groove 2 (231) cooperating with the guide rail 2 (222); one side of the adjusting plate 2 (23) along the moving direction of the adjusting plate 2 (23) is rotatably connected with the adjusting rod 2 (25), and the adjusting plate 2 (23) is provided with a push plate 2 (232) cooperating with the adjusting rod 2 (25), and the middle position of the adjusting rod 2 (25) is threadedly connected to the push plate 2 (232).

7. The liquid phase spray head atomization device of the chromatographic tandem mass spectrometer according to claim 6, characterized in that: A sleeve (26) is fixedly connected to the side of the second adjustment plate (23) away from the first adjustment plate (22), the sliding sleeve (3) is slidably connected in the sleeve (26), and a locking member (27) is provided on the sleeve (26) for limiting the movement of the sliding sleeve (3).

8. The liquid phase spray head atomization device for a chromatographic tandem mass spectrometer according to claim 1, characterized in that: An adapter (44) connected to the liquid inlet channel (41) is provided at the end of the connecting seat (4), and the adapter (44) is used to connect an external liquid inlet pipe. A positioning mark (45) is provided on the outer wall of the connecting seat (4), and a plurality of positioning points (37) are provided on the circumferential side of the outer wall of the sliding sleeve (3), wherein when the connecting seat (4) rotates, the positioning mark (45) corresponds to one of the positioning points (37).

Images