Improved medicated leaven traditional Chinese medicine processing method

Abstract

The invention discloses an improved medicated leaven traditional Chinese medicine processing method which comprises the following steps: (1) taking 100kg of wheat flour and 100kg of bran, sieving and uniformly mixing; taking 90 kg of red beans and 90 kg of bitter apricot kernels, grinding into powder, and uniformly mixing; (2) taking 100 kg of fresh sweet wormwood, 100 kg of fresh red-knees herb and 100 kg of fresh xanthium sibiricum, mashing, adding 165 kg of water, and squeezing to obtain juice; (3) uniformly mixing the medicine juice in the step (2) and the medicine powder in the step (1), shaping the mixture in a mold, cutting the mixture into square soft blocks, spreading the square soft blocks on a stainless steel plate, treating the square soft blocks in a pulsating vacuum sterilization cabinet, taking out the square soft blocks, and naturally cooling the square soft blocks; and (4) diluting aspergillus oryzae spores with flour which is 10 times of the mass of the aspergillus oryzae spores, putting the diluted aspergillus oryzae spores into a gauze bag, uniformly beating the gauze bag on the soft blocks treated in the step (3), putting the soft blocks in a greenhouse with the temperature of 28 + / -3 DEG C and the relative humidity of 70-80% for fermentation culture, and taking out the soft blocks. The medicated leaven obtained by the method is uniform in quality, relatively good in quality stability and beneficial to industrial production.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine processing, and in particular to an improved method for preparing Liushenqu traditional Chinese medicine. Background Art

[0002] Qu-type Chinese medicine is an important part of Chinese medicine slices. It originated very early in my country and is widely used in clinical practice. It is made by mixing a variety of Chinese medicines through fermentation. There are many types of it, such as Liushenqu and red yeast rice, and the most widely used is Liushenqu. The origin of the name of Liushenqu was first recorded in "Yao Xing Lun" written by Zhen Quan, a doctor in the Tang Dynasty. It is derived from six raw materials, including Artemisia annua, Polygonum hydropiper, Xanthium sibiricum, red bean, bitter almond, and wheat. According to records, Liushenqu is called Liushenqu because the six raw materials, including Artemisia annua, Polygonum hydropiper, Xanthium sibiricum, red bean, bitter almond, and wheat, are named after the six gods of White Tiger, Azure Dragon, Vermilion Bird, Black Tortoise, Gou Chen, and Teng Snake, which means that the six gods gather together and are fermented to extract their essence and soften them. It has the function of strengthening the spleen and stomach and eliminating the stagnation of the spleen and stomach.

[0003] The 2015 edition of the "Zhejiang Province Traditional Chinese Medicine Processing Specifications" stipulates: Liu Shen Qu [Processing] Take 100kg of wheat flour and 100kg of bran, sieve and mix; take 90kg of red beans and 90kg of bitter almonds, grind them into powder and mix them; then take 100kg of fresh Artemisia annua, 100kg of fresh Polygonum hydropiper, and 100kg of fresh Xanthium sibiricum, mash them, add appropriate amount of water, and squeeze to extract juice. Mix with the above-mentioned wheat flour, bran, red beans, and almonds, stir well, cut into soft blocks with a length and width of about 1.5cm, spread on a plaque, put Aspergillus oryzae spores (diluted with 10 times the amount of flour) into a gauze bag, and pat them evenly on the soft blocks. Place in a greenhouse at 28℃ and a relative humidity of 70-80%, wait until it is covered with "yellow clothes", take it out, and dry it.

[0004] The traditional process of Liu Shen Qu uses natural fermentation, which results in large differences between products from different origins or different batches of the same origin, poor quality stability, and other problems, resulting in many market complaints. Summary of the invention

[0005] The purpose of the present invention is to solve the problem of poor quality uniformity and stability of Liu Shen Qu products, and to provide an improved method for preparing Liu Shen Qu traditional Chinese medicine. The obtained Liu Shen Qu has uniform quality and good quality stability, which is conducive to industrial production.

[0006] The technical solution adopted by the present invention to solve the technical problem is: An improved method for preparing Liushenqu Chinese medicine comprises the following steps: (1) Take 100 kg of wheat flour and 100 kg of bran, sieve and mix well; separately take 90 kg of red beans and 90 kg of bitter almonds, grind them into powder and mix well; (2) Take 100 kg of fresh Artemisia annua, 100 kg of fresh Polygonum hydropiper, and 100 kg of fresh Xanthium sibiricum, mash them, add 165 kg of water, and squeeze to extract juice; (3) mixing the drug juice of step (2) and the drug powder of step (1) evenly, placing the mixture in a mold to shape it, cutting it into square soft blocks, spreading it on a stainless steel plate, placing it in a pulse vacuum sterilizer for treatment, and taking it out to cool naturally; (4) Dilute the Aspergillus oryzae spores with 10 times the weight of flour, put them into a gauze bag, and evenly pat them on the soft block treated in step (3). After fermentation and cultivation in a greenhouse at 28±3° C. and a relative humidity of 70-80%, take them out.

[0007] The inventors have found that by improving the original method of preparing Liu Shen Qu as a traditional Chinese medicine and controlling specific sterilization methods and sterilization parameters, the quality of the obtained Liu Shen Qu can be greatly improved. The obtained Liu Shen Qu has uniform quality and good quality stability, which is conducive to industrial production.

[0008] Preferably, the pulsation times of the pulsation vacuum sterilization are set to 2 to 3 times.

[0009] Preferably, the temperature of the pulsating vacuum sterilization is set to 100-115° C., and the time is 5 to 15 minutes.

[0010] Preferably, the upper limit of pulsation of the pulsation vacuum sterilization is 20 to 40 KPa, and the lower limit of pulsation is -40 to -20 KPa.

[0011] Preferably, in step (4), the amount of Aspergillus oryzae spores used is 220-230 g.

[0012] The beneficial effects of the present invention are that the obtained Liushenqu has uniform quality and good quality stability, which is conducive to industrial production. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 It is the six divine songs produced by existing technology; Figure 2 It is a six-magic diagram produced by the process of the present invention. DETAILED DESCRIPTION

[0014] The technical solution of the present invention is further described in detail below through specific embodiments.

[0015] In the present invention, unless otherwise specified, the raw materials and equipment used can be purchased from the market or are commonly used in the art. The methods in the following embodiments, unless otherwise specified, are all conventional methods in the art.

[0016] Embodiment 1: An improved method for preparing Liushenqu Chinese medicine comprises the following steps: (1) Take 100 kg of wheat flour and 100 kg of bran, sieve and mix well; separately take 90 kg of red beans and 90 kg of bitter almonds, grind them into powder and mix well; (2) Take 100 kg of fresh Artemisia annua, 100 kg of fresh Polygonum hydropiper, and 100 kg of fresh Xanthium sibiricum, mash them, add 165 kg of water, and squeeze to extract juice; (3) mixing the medicinal juice of step (2) and the medicinal powder of step (1), placing the mixture in a mold for shaping, cutting it into square soft blocks with a length, width and height of about 1.5 cm, spreading it on a stainless steel plate, placing it in a pulsating vacuum sterilizer for treatment, and taking it out for natural cooling; the pulsating vacuum sterilization parameters are set as follows: pulsation times 3 times, temperature 100° C., time 5 min, pulsation upper limit 20 KPa, pulsation lower limit -20 KPa; (4) 220 g of Aspergillus oryzae spores (source: Shandong Hezhong Kangyuan Biotechnology Co., Ltd.) were diluted with 10 times the weight of flour and placed in a gauze bag. The mixture was evenly spread on the soft block treated in step (3), and fermented in a greenhouse at 25° C. and a relative humidity of 70%. After the spores were covered with yellow coat (about 72 hours), they were taken out. Figure 2 ).

[0017] Embodiment 2: An improved method for preparing Liushenqu Chinese medicine comprises the following steps: (1) Take 100 kg of wheat flour and 100 kg of bran, sieve and mix well; separately take 90 kg of red beans and 90 kg of bitter almonds, grind them into powder and mix well; (2) Take 100 kg of fresh Artemisia annua, 100 kg of fresh Polygonum hydropiper, and 100 kg of fresh Xanthium sibiricum, mash them, add 165 kg of water, and squeeze to extract juice; (3) mixing the medicinal juice of step (2) and the medicinal powder of step (1), placing the mixture in a mold for shaping, cutting it into square soft blocks with a length, width and height of about 1.5 cm, spreading it on a stainless steel plate, placing it in a pulsating vacuum sterilizer for treatment, and taking it out for natural cooling; the pulsating vacuum sterilization parameters are set as follows: pulsation times 3 times, temperature 100° C., time 5 min, pulsation upper limit 20 KPa, pulsation lower limit -20 KPa; (4) 230 g of Aspergillus oryzae spores (source: Shandong Hezhong Kangyuan Biotechnology Co., Ltd.) were diluted with 10 times the weight of flour and placed in a gauze bag. The mixture was evenly spread on the soft block treated in step (3), and fermented in a greenhouse at 31° C. and a relative humidity of 80%. After the spores were covered with yellow skin (about 72 hours), they were taken out. Figure 2 ).

[0018] Embodiment 3: An improved method for preparing Liushenqu Chinese medicine comprises the following steps: (1) Take 100 kg of wheat flour and 100 kg of bran, sieve and mix well; separately take 90 kg of red beans and 90 kg of bitter almonds, grind them into powder and mix well; (2) Take 100 kg of fresh Artemisia annua, 100 kg of fresh Polygonum hydropiper, and 100 kg of fresh Xanthium sibiricum, mash them, add 165 kg of water, and squeeze to extract juice; (3) mixing the medicinal juice of step (2) and the medicinal powder of step (1), placing the mixture in a mold for shaping, cutting it into square soft blocks with a length, width and height of about 1.5 cm, spreading it on a stainless steel plate, placing it in a pulsating vacuum sterilizer for treatment, and taking it out for natural cooling; the pulsating vacuum sterilization parameters are set as follows: pulsation times 3 times, temperature 100° C., time 5 min, pulsation upper limit 20 KPa, pulsation lower limit -20 KPa; (4) 227 g of Aspergillus oryzae spores (source: Shandong Hezhong Kangyuan Biotechnology Co., Ltd.) were diluted with 10 times the weight of flour and placed in a gauze bag. The mixture was evenly spread on the soft block treated in step (3), and fermented in a greenhouse at 28° C. and a relative humidity of 75%. After the spores were covered with yellow skin (about 72 hours), they were taken out. Figure 2 ).

[0019] According to the scheme of Example 3, the pulsating vacuum sterilization parameters are replaced and the following implementation is performed: Through the test results of the above pulsation vacuum sterilizer 5 conditions (temperature, time, pulsation number, pulsation upper limit, pulsation lower limit), the process requirements were finally selected: temperature 100-115℃, time 5-15min, pulsation number 2-3 times, pulsation upper limit 20-40KPa, pulsation lower limit -40--20KPa, which can greatly improve product quality and also improve the work efficiency of large-scale production.

[0020] Comparative Example: According to the different sterilization methods of the method in Example 3, the following implementation is carried out: Under the same conditions, there were extremely significant statistical differences in product quality statistics among natural fermentation, moist heat sterilization, infrared sterilization, microwave sterilization and pulsating vacuum sterilization (P<0.001).

[0021] According to the 2015 edition of the "Zhejiang Province Traditional Chinese Medicine Processing Specifications", the same three batches of processing were performed as in Examples 1-3, and the Liushenqu product was shown in Figure 1 .contrast Figure 1 and Figure 2 Combined with sensory evaluation, we can know that:

[0022] The above-described embodiment is only a preferred solution of the present invention and does not limit the present invention in any form. There are other variations and modifications without exceeding the technical solution described in the claims.

Claims

1. An improved method for preparing Liushenqu Chinese medicine, characterized in that: The following steps are involved: (1) Take 100 kg of wheat flour and 100 kg of bran, sieve and mix well; separately take 90 kg of red beans and 90 kg of bitter almonds, grind them into powder and mix well; (2) Take 100 kg of fresh Artemisia annua, 100 kg of fresh Polygonum hydropiper, and 100 kg of fresh Xanthium sibiricum, mash them, add 165 kg of water, and squeeze to extract juice; (3) mixing the medicinal juice of step (2) and the medicinal powder of step (1) evenly, placing the mixture in a mold for shaping, cutting it into square pieces, spreading it on a stainless steel plate, placing it in a pulse vacuum sterilizer for treatment, and taking it out to cool naturally; (4) The Aspergillus oryzae spores are diluted with 10 times the weight of flour and placed in a gauze bag, and evenly patted on the soft block treated in step (3). After fermentation and cultivation in a greenhouse at 28±3° C. and a relative humidity of 70-80%, the spores are taken out.

2. The improved method for preparing Liushenqu Chinese medicine according to claim 1, characterized in that: The pulsation times of the pulsation vacuum sterilization are set to 2 to 3 times.

3. The improved method for preparing Liushenqu Chinese medicine according to claim 1, characterized in that: The temperature of the pulsating vacuum sterilization is set at 100-115° C. and the time is 5-15 minutes.

4. The improved method for preparing Liushenqu Chinese medicine according to claim 1, characterized in that: The upper limit of the pulsation of the pulsation vacuum sterilization is 20 to 40 KPa, and the lower limit of the pulsation is -40 to -20 KPa.

5. The improved method for preparing Liushenqu Chinese medicine according to claim 1, characterized in that: In step (4), the amount of Aspergillus oryzae spores is 220-230 g.

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