Negative pressure phototherapy device

Abstract

The invention discloses a negative pressure phototherapy device which comprises an electric driving device, a light-emitting surface component, an absorbing layer, a negative pressure giving layer, a negative pressure pump component and a negative pressure pipeline. According to the light-emitting surface component, a planar optical waveguide component can be adopted to provide a surface light source, and a flexible OLED light-emitting panel can also be adopted to provide a surface light source. For a negative pressure phototherapy device adopting a planar optical waveguide component, the optical waveguide component is provided with a hole channel and is integrated with a negative pressure device, so that the wound can be cured synchronously by negative pressure and phototherapy, and meanwhile, the optical waveguide component can convert a point light source into an area light source so as to realize large-area treatment. According to the negative pressure phototherapy device adopting the flexible OLED light-emitting panel, due to the fact that the OLED light-emitting panel is provided with the hole channels and is integrated with the negative pressure device, the wound can be cured synchronously through negative pressure and phototherapy, and meanwhile the OLED light-emitting panel can provide an area light source so that large-area treatment can be achieved.

Description

Technical Field

[0001] The present invention belongs to the technical field of phototherapy, and in particular relates to a negative pressure phototherapy device. Background Art

[0002] In the mid-to-late 20th century, technologies such as low light laser treatment and photobiomodulation (PBM) appeared, both of which used light as a means of treating diseases in the medical field (Michael R. Hamblin, Ying-ying Huang, Handbook of Photomedicine, CRC Press). In recent years, many studies have shown that red light to near-infrared light can help promote the regeneration of tissues such as collagen and skin cells, and can be used in anti-wrinkle beauty, promoting wound healing, removing spots and scars, and other fields (Chan Hee Nam et al., Dermatologic Surgery, 2017, 43: 371-380; Daniel Barolet, Semin Cutan Med Surg, 2008, 27: 227-238; Yongmin Jeon, Adv. Mater. Technol. 2018, 1700391). With the rapid development of micro-light therapy and photobiomodulation technology, more and more phototherapy products have emerged, especially wearable phototherapy products, such as phototherapy masks, phototherapy hair growth caps, phototherapy shaping clothes, eye phototherapy devices, etc., which have become the ideal home beauty, body or health care products for more and more people. The light source used in phototherapy products can emit light with a peak wavelength between 400-1400nm, preferably red light and near-infrared light with a peak wavelength between 600-970nm. Light in this band has the effects of anti-wrinkle, skin regeneration, freckle removal, and even anti-inflammatory (such as styes, acne), wound healing, and scar reduction (Daniel Barolet, Semin Cutan Med Surg, 27: 227-238, 2008).

[0003] In recent years, wound treatment methods based on negative pressure have become a widely used medical method. A large number of studies and practices have shown that negative pressure can absorb excess pus, reduce edema, and eliminate obstacles to cell movement and reproduction, thereby accelerating wound healing. There are already some negative pressure wound therapy (NPWT) devices on the market, such as PICO produced by Smith & Nephew in the United States, which can use the negative pressure principle to treat wounds. However, wound healing is still relatively slow with only NPWT devices, and the use of NPWT devices has a certain time limit, generally needing to be replaced in about 7 days. If the wound has not healed by then, a new device needs to be replaced to continue treatment. Given that red light illumination has been proven to promote wound healing, if negative pressure therapy and phototherapy can be combined, it can further shorten the wound healing time, relieve pain, and reduce treatment costs.

[0004] Patent application US20180116877A1 discloses a multifunctional wound treatment dressing, which includes at least two of a negative pressure system, an electrical stimulation system, a light stimulation system, and a mechanical stimulation system, wherein the light stimulation system includes light energy conduction and / or light energy emission components. Although the application mentions that the light stimulation system can be combined with a negative pressure device, it is only generally disclosed, and the specific combination of the negative pressure system and the light stimulation system is not disclosed, nor is the use of a planar optical waveguide component disclosed. In addition, the application only integrates point light sources or line light sources (including IR sources and UV sources), and is not suitable for large-area treatment.

[0005] CN114904145A discloses a wound treatment system, comprising a wound dressing, a negative pressure source and a light-emitting device. However, the light-emitting device in the application is arranged in the receiving space of the wound dressing, that is, directly above the part to be treated, and is preferably an array of point light sources. This arrangement cannot form a surface light source.

[0006] The inventor's previous patent application CN118490992A discloses a photoelectric device that combines a visible light surface light source with a near-infrared (NIR) point light source or line light source, specifically, the point light source or line light source is arranged on the side of the optical waveguide device and the surface light source is arranged under the first surface of the optical waveguide device, thereby achieving optical path coupling with the optical waveguide device. However, the negative pressure device is not used in this application, and the use of an OLED surface light source under the surface of the optical waveguide device will result in the inability to combine with negative pressure therapy, thereby failing to achieve a negative pressure effect, and therefore cannot be used as a wound healing device.

[0007] Patent application US2010 / 0303409A1 discloses a solid-state light source, which includes an optical pump, a waveguide component and a down converter. The application does not disclose the application of the solid-state light source in the field of phototherapy, and the optical waveguide component in the application is tubular and can only transmit light from one end to the other end, and cannot convert it into a surface light source.

[0008] Patent application EP4403148A1 discloses a wound healing device, which integrates a negative pressure system and a phototherapy system, wherein the phototherapy system uses an external light source to transmit light to a dielectric layer (which may be air), which is then transmitted to a light guide through the dielectric layer and finally irradiated on the wound. However, the external light source does not actually have any physical contact or connection with the light guide, and in this case, the light intensity loss is large, which affects the treatment effect.

[0009] On the other hand, OLED is naturally a surface light source, a cold light source, not dazzling, and has the characteristics of being thin and light, making it very easy to integrate into a flexible substrate. This makes OLED an ideal light source choice for wearable applications, and related patent applications have also covered various fields in recent years. Patent applications CN205108772, CN204951964, and CN102481456 all mention that OLED light sources can be used as wearable products for medical treatment. US2009 / 0030489A1 and US 2010 / 0179469A1 mentioned the use of OLED with a wavelength of about 450nm as a light source to treat pediatric jaundice. The inventor's previous application CN111450421A proposed combining a TTA-UC material layer to convert the red, green or yellow light emitted by a flexible OLED into blue light to treat jaundice; application CN203694423 and the inventor's previous application CN109173071 mentioned the use of OLED to prepare a phototherapy mask; the inventor's previous patent applications CN111481833A, CN111514466A, CN111544774A and CN112754764A respectively mentioned the use of OLED to prepare a phototherapy cap, phototherapy shaping clothing, phototherapy socks and phototherapy Band-Aids. However, although flexible OLEDs can meet the needs of phototherapy products in terms of form and function, they are usually prepared on a whole plastic substrate and need to be tightly sealed throughout, which is contrary to the function of the negative pressure device that requires holes to be left for air extraction.

[0010] The inventor's previous application CN113594141A disclosed a flexible OLED light-emitting module, which includes an OLED surface light source with holes and has good air permeability. However, the application does not integrate a negative pressure device, which also reduces the effect of wound healing.

[0011] The present invention adopts a planar optical waveguide component with channels, which can convert a point light source into a planar light source, or uses a planar light source with channels, such as an OLED light-emitting panel, and integrates it with a negative pressure device to achieve simultaneous healing of wounds by negative pressure and light therapy. Summary of the invention

[0012] The present invention aims to provide a negative pressure phototherapy device to solve at least some of the above problems. The negative pressure phototherapy device of the present invention can use a planar optical waveguide component to provide a surface light source, and can also use a flexible OLED light-emitting panel to provide a surface light source. For the negative pressure phototherapy device using a planar optical waveguide component, since the optical waveguide component has a channel and is integrated with the negative pressure device, negative pressure and phototherapy can be used to simultaneously heal the wound. At the same time, the optical waveguide component can convert the point light source into a surface light source to achieve large-area treatment. For the negative pressure phototherapy device using a flexible OLED light-emitting panel, since the OLED light-emitting panel has a channel and is integrated with the negative pressure device, negative pressure and phototherapy can be used to simultaneously heal the wound. At the same time, the OLED light-emitting panel itself can provide a surface light source to achieve large-area treatment.

[0013] According to one embodiment of the present invention, a negative pressure phototherapy device is disclosed, comprising:

[0014] Electric drive device, luminous surface component, absorption layer, negative pressure providing layer, negative pressure pump component, negative pressure pipeline;

[0015] Wherein, the light emitting surface component includes a light source component and an optical waveguide component;

[0016] The light source component is electrically connected to the electric drive device,

[0017] The light source component is connected to the optical waveguide component, and the light emitted by the light source component is incident from the edge of the optical waveguide component.

[0018] The negative pressure pump component is connected to the negative pressure pipeline, and the negative pressure providing layer is provided with a negative pressure pipeline.

[0019] The absorption layer is arranged between the negative pressure providing layer and the part to be treated.

[0020] The optical waveguide component is arranged between the absorption layer and the part to be treated, and the optical waveguide component is provided with at least one channel penetrating the upper and lower surfaces thereof.

[0021] The optical waveguide component is planar and has at least one light-emitting surface, the area of ​​which is not less than 5 cm 2 .

[0022] According to another embodiment of the present invention, a negative pressure phototherapy device is also disclosed, comprising:

[0023] Electric drive device, luminous surface component, absorption layer, negative pressure providing layer, negative pressure pump component, negative pressure pipeline;

[0024] Wherein, the light-emitting surface component comprises at least one flexible OLED light-emitting panel;

[0025] The flexible OLED light-emitting panel is electrically connected to the electric drive device,

[0026] The negative pressure pump component is connected to the negative pressure pipeline, and the negative pressure providing layer is provided with a negative pressure pipeline.

[0027] The absorption layer is arranged between the negative pressure providing layer and the part to be treated.

[0028] The at least one flexible OLED light-emitting panel is arranged between the absorption layer and the part to be treated, and the flexible OLED light-emitting panel is provided with at least one hole penetrating the upper and lower surfaces thereof,

[0029] The flexible OLED light-emitting panel has at least one light-emitting surface, the area of ​​which is not less than 5 cm 2 .

[0030] The negative pressure phototherapy device disclosed in the present invention adopts an optical waveguide component with a hole or an OLED light-emitting panel with a hole, so that it can be integrated with a negative pressure device to achieve the combination of negative pressure therapy and phototherapy. Not only can negative pressure be used to accelerate wound closure, but phototherapy can also be used to further accelerate cell regeneration and fade scars.

[0031] The optical waveguide component used in the present invention is planar and can convert a point light source or a line light source into a planar light source, thereby achieving large-area treatment.

[0032] The optical waveguide component and the light source component of the present invention are connected directly or through a light-conducting component. This connection method has no light intensity loss or very little light intensity loss, thereby improving the phototherapy effect.

[0033] The light source component of the present invention may be integrated on the optical waveguide component or not. When the optical waveguide component and the light source component are arranged separately, the planar optical waveguide component can realize a highly three-dimensional structure and can fit the part to be treated well.

[0034] The optical waveguide component and the light source component of the present invention can also be detachably connected, so that the optical waveguide component and the light source component can be separated. After use, the optical waveguide component, the absorption layer, the negative pressure providing layer, etc. can be disassembled and discarded, thereby realizing the disposable use of the product, while the electric drive device and the light source component can be reused, thereby improving the hygiene level, being more suitable for medical use, greatly reducing production costs, and avoiding environmental pollution problems caused by the light source being discarded together.

[0035] The optical waveguide component, absorption layer and negative pressure providing layer of the present invention can also be arranged together on a flexible shell. Since the optical waveguide component, absorption layer, negative pressure providing layer and / or flexible shell can be prepared independently, there is more room for material selection, which can ensure 3D forming and better fit when worn; at the same time, it can be suitable for wound treatment in different parts of the body.

[0036] The flexible OLED light-emitting panel of the present invention is planar, so that large-area treatment can be achieved. The light emitted by the flexible OLED light-emitting panel can be directly irradiated on the part to be treated, without the need for light conduction and light intensity loss, thereby improving the phototherapy effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 It is a schematic diagram of the structure of a single-layer OLED device.

[0038] Figure 2 It is a schematic diagram of the structure of a stacked OLED device.

[0039] Figure 3 It is a cross-sectional schematic diagram of the flexible OLED light-emitting panel of the present invention.

[0040] Figure 4a-4b It is a partial plan view of the flexible OLED light-emitting panel with holes of the present invention.

[0041] Figure 5a-5e yes Figure 4a Schematic diagram of the cross-sectional structure along the AA' cutting line.

[0042] Figure 6a It is a schematic diagram of the cross-sectional structure of the flexible OLED light-emitting panel of the present invention with a supporting substrate before punching.

[0043] Figure 6b It is a schematic diagram of the cross-sectional structure of the flexible OLED light-emitting panel of the present invention with a supporting substrate after being punched.

[0044] Figure 7a It is a cross-sectional schematic diagram of the negative pressure phototherapy device of the first embodiment of the present invention.

[0045] Figure 7b It is a cross-sectional schematic diagram of a negative pressure phototherapy device according to a second embodiment of the present invention.

[0046] Figure 8a It is a cross-sectional schematic diagram of a negative pressure phototherapy device according to a third embodiment of the present invention.

[0047] Figure 8b It is a cross-sectional schematic diagram of a negative pressure phototherapy device according to a fourth embodiment of the present invention.

[0048] Figure 8c It is a cross-sectional schematic diagram of a negative pressure phototherapy device according to a fifth embodiment of the present invention.

[0049] Figures 9a-9d It is a schematic cross-sectional view of the optical waveguide component of the present invention.

[0050] Fig.10a It is a schematic diagram of an optical connection structure for connecting a light-conducting component and a light source component according to the present invention.

[0051] Fig.10b It is a schematic diagram of another optical connection structure for connecting a light conducting component and an optical waveguide component according to the present invention. DETAILED DESCRIPTION

[0052] The technical solution of the present invention is further described below by specific implementation methods. It should be understood by those skilled in the art that the embodiments are only to help understand the present invention and should not be regarded as specific limitations of the present invention.

[0053] The structure of a typical single-layer OLED device 100 is as follows: Figure 1 As shown. The OLED device 100 includes an anode layer 101, a hole injection layer (HIL) 102, a hole transport layer (HTL) 103, an electron blocking layer (EBL) 104, an emitting layer (EML) 105, a hole blocking layer (HBL) 106, an electron transport layer (ETL) 107, an electron injection layer (EIL) 108, a cathode layer 109, and a capping layer (CPL) 110. In a bottom emission device, the anode layer 101 is a transparent or semi-transparent material, including but not limited to ITO, IZO, MoO x (molybdenum oxide), etc., whose transparency is generally greater than 50%, preferably greater than 70%; cathode layer 109 is a material with high reflectivity, including but not limited to Al, Ag, etc., with a reflectivity greater than 70%, preferably greater than 90%. In the top emission device, anode layer 101 is a material or a combination of materials with high reflectivity, including but not limited to Ag, Ti, Cr, Pt, Ni, TiN, and the above materials combined with ITO and / or MoO x (molybdenum oxide) combination, usually the reflectivity is greater than 50%; preferably, greater than 80%; more preferably, greater than 90%; and the cathode layer 109 should be a semi-transparent or transparent conductive material, including but not limited to MgAg alloy, MoO x, Yb, Ca, ITO, IZO or a combination thereof, and its transparency is generally greater than 30%; preferably, greater than 50%. The electron injection layer 108 can be a single layer of metal such as Yb, or an organic material such as LiQ. The light-emitting layer 105 generally also includes at least one host material and at least one light-emitting material, while the electron blocking layer 104 and the hole blocking layer 106 are optional layers, and the capping layer 110 may not be required in the bottom-emitting device. The hole injection layer 102 can be a single material layer, such as the commonly used HATCN; the hole injection layer 102 can also be a hole transport material doped with a certain proportion of p-type conductive doping material, usually the doping ratio is not higher than 5%, and the commonly used ratio is between 1% and 3%.

[0054] The structure of a typical stacked OLED device 200 is as follows: Figure 2 As shown, it includes an anode layer 201, a first light-emitting unit 202, a charge generation layer (CGL) 203, a second light-emitting unit 204, and a cathode layer 205. The first light-emitting unit 202 and the second light-emitting unit 204 may further include several organic layers from 102 to 108 in the single-layer light-emitting device 100, and the light-emitting layers of the first light-emitting unit and the second light-emitting unit may be the same or different. The charge generation layer 203 is generally composed of an n-type material and a p-type material, and a buffer layer may also be added, as described in patent application CN112687811A. If the stacked device is a top-emitting device, a capping layer (not shown in the figure) may also be added on the cathode layer 205. Figure 2 The device shown is a double-unit stacked device, and a third light-emitting unit and a second charge generation layer can be added to form a triple-unit stacked device. The preparation of single-layer and stacked OLED devices is well known in the industry and will not be described in detail here.

[0055] A flexible OLED light source can be a flexible OLED light emitting panel. A cross-sectional view of a flexible OLED light emitting panel is shown in Figure 3The flexible OLED light-emitting panel 300 includes a flexible substrate 301, an OLED device 302, a pair of contact electrodes 304 electrically connected to the OLED device 302, and a flexible encapsulation layer 303 but exposing the contact electrodes 304. The flexible substrate 301 can be an ultra-thin flexible glass, preferably a non-fragile material, including but not limited to plastic (PET, PEN, PI), textiles, leather, paper, metal foil or a combination thereof. In particular, the substrate 301 can be a material (such as PI, i.e., Polyimide polyimide material) that is previously coated on a supporting base plate in the form of a solution, and is used for device preparation after curing and flattening. After the device preparation is completed, it is peeled off from the supporting base plate using a laser and transferred to other flexible films as needed. A moisture barrier layer (not shown) may be additionally coated on the flexible substrate 301. The OLED device 302 can be a bottom-emitting device or a top-emitting device, preferably a top-emitting device because of its higher luminous efficiency. The OLED device 302 may be a single-layer structure or a laminated structure. The laminated structure is preferred because it has a longer life at the same brightness and because a thicker film layer is conducive to improving the production yield. The organic material in the OLED device 302 may be formed by thermal evaporation in a vacuum chamber (vacuum evaporation method), or may be partially or completely formed using a solution method, including but not limited to ink jet printing, spin coating, organic vapor spray printing (OVJP), etc. The flexible encapsulation layer 303 may be an ultra-thin glass adhered to the device using UV curing glue. The preferred flexible encapsulation layer 303 is a thin film encapsulation layer, and the thickness is usually above 5μm, such as a single-layer inorganic thin film, or a multilayer structure of alternating organic and inorganic thin films, formed by PECVD, ALD, printing, spin coating, etc. The contact electrode 304 may include at least one anode contact and one cathode contact. On this basis, a light extraction layer, a front cover film, a rear cover film, an external circuit (such as an FPC circuit board), etc. can also be added. The specific description can be found in Chinese patent application CN108644628A, which is incorporated by reference in its entirety. It is not within the scope of the present application. Such a flexible OLED light-emitting panel is a flexible OLED light source when it is electrically connected to an external electric drive (regardless of whether it is in an on or off state), and is one of the basic components of the present invention. The OLED devices in the above-mentioned flexible OLED light-emitting panel all use a common organic layer, especially a common organic light-emitting layer, that is, a non-pixelated process, and can only emit light of one color at a fixed working point. The above-mentioned flexible OLED light-emitting panel can emit at least one wavelength of light in the range of 400-2000nm, and preferably, the above-mentioned flexible OLED light-emitting panel can emit at least one wavelength of light in the range of 450-1000nm.If it is used in scenarios such as facial masks and Band-Aids, it is preferred to use red light and near-infrared OLED light-emitting panels, that is, the above-mentioned flexible OLED light-emitting panel can emit at least one light with a wavelength between 600-970nm.

[0056] As used herein, "near infrared light" refers to light with a wavelength in the 700-2500nm band. In particular, in the application scenario of phototherapy, "near infrared light" can represent a portion of this band, such as 700-1400nm light. As used herein, "visible light" refers to light with a wavelength in the 400-700nm range. As used herein, "deep red light" refers to light with a wavelength in the 660-700nm range. As used herein, "red light" refers to light with a wavelength in the 600-660nm range.

[0057] As used herein, a wavelength "above" a certain wavelength refers to a wavelength greater than or equal to a certain wavelength, for example, "light above 600nm" refers to light with a wavelength ≥ 600nm. Correspondingly, a wavelength "below" a certain wavelength refers to a wavelength less than (shorter than) equal to a certain wavelength. For example, "light below 400nm" refers to light with a wavelength ≤ 400nm.

[0058] As used herein, "organic small molecule material" refers to any organic or organometallic material that is not a polymer. As long as it has a precise structure, the molecular weight of the small molecule can be very large. Dendritic polymers with a well-defined structure can be considered small molecules. Preferably, the organic small molecule refers to an organic compound with a molecular weight of less than 10,000; more preferably, an organic compound with a molecular weight of less than 5,000; most preferably, an organic compound with a molecular weight of less than 2,000.

[0059] As used herein, "light-conducting component" refers to an optical component that conducts light emitted by a point light source or a line light source from one end of the component to the other end with a loss of no more than 50%, preferably no more than 20%, and more preferably no more than 10%. The material of the light-conducting component is selected from optical fiber, or any other component that can achieve total reflection inside the conducting channel.

[0060] As used herein, "optical waveguide component" refers to a component that converts a point light source or a line light source into a surface light source, and its loss is not higher than 90%, preferably, not higher than 70%, and more preferably, not higher than 50%. The optical waveguide component can be a composite structure, for example, comprising an optical waveguide body, a reflective layer, a scattering structure and a combination thereof, or it can be a single-layer structure, for example, nanoparticles with scattering properties are doped into the interior of the optical waveguide body. Preferably, the optical waveguide body is a transparent film layer with a high refractive index. The refractive index of the optical waveguide body is greater than or equal to 1.4, preferably, greater than or equal to 1.45, and more preferably, greater than or equal to 1.49. The optical waveguide body is preferably made of a flexible material. The scattering structure of the optical waveguide component may contain nanoparticles, including but not limited to, SiO x , Al2O3, CaCO3, Ba S Oxide particles such as O4, TiO2, ZrO, ZnO, or metal particles such as Ag, Pt, Cu, Au, or organic particles such as polystyrene microspheres (PS), polymethyl methacrylate (PMMA), silicone, or a combination thereof. Preferably, the nanoparticles include oxide particles, metal particles, organic particles, or a combination thereof. The diameter of the nanoparticles should be between 10nm-1000nm, preferably between 100-1000nm, and more preferably between 100-800nm. The scattering structure of the optical waveguide component can be arranged in the form of a film layer on the side of the optical waveguide body away from the reflective layer, or can be doped at intervals inside the optical waveguide body.

[0061] As used herein, "optical coupling" refers to light exiting from one medium and arriving at / entering another medium.

[0062] As used herein, "luminous uniformity of a luminous surface" refers to the ratio of the light intensity values ​​of any two regions on the entire luminous surface. For example, if the light intensity value of a certain region of the luminous surface is A and the light intensity value of another region is B, then "luminous uniformity" refers to the ratio of A / B. The ratio of A / B is within the range of 1±0.5, preferably within the range of 1±0.3, and more preferably within the range of 1±0.1. When the ratio of A / B is equal to 1 or is closer to 1, the luminous uniformity is better.

[0063] As used herein, "down conversion layer" refers to a film layer that converts high energy light (short wavelength light, such as ultraviolet light, blue light, etc.) into low energy light (long wavelength light, such as red light, deep red light, near infrared light, etc.). The down conversion layer comprises a down conversion material, and the down conversion material includes but is not limited to fluorescent materials, perovskite materials, quantum dot materials, organic small molecule luminescent materials, graphene, etc. The preparation of the "down conversion layer" is already known to those skilled in the art and will not be repeated here.

[0064] As used herein, "encapsulation layer" refers to a film layer having water and oxygen barrier properties, preferably a thin film encapsulation layer. A physical protective film layer (hard coating) may also be provided on the surface of the encapsulation layer to prevent physical scratches and wear.

[0065] As used herein, "negative pressure wound healing (NPWT)" refers to a treatment method that uses a micropump to apply negative pressure to the wound to promote wound healing.

[0066] As used herein, "negative pressure pump component" refers to a device capable of performing negative pressure suction on a wound, including but not limited to a negative pressure pump, etc.

[0067] As used herein, "the area ratio of the holes relative to the light-emitting surface" refers to the ratio of the sum of the cross-sectional areas of the holes on the entire light-emitting surface to the area of ​​the entire light-emitting surface.

[0068] According to one embodiment of the present invention, a negative pressure phototherapy device is disclosed, comprising:

[0069] Electric drive device, luminous surface component, absorption layer, negative pressure providing layer, negative pressure pump component, negative pressure pipeline;

[0070] Wherein, the light emitting surface component includes a light source component and an optical waveguide component;

[0071] The light source component is electrically connected to the electric drive device,

[0072] The light source component is connected to the optical waveguide component, and the light emitted by the light source component is incident from the edge of the optical waveguide component.

[0073] The negative pressure pump component is connected to the negative pressure pipeline, and the negative pressure providing layer is provided with a negative pressure pipeline.

[0074] The absorption layer is arranged between the negative pressure providing layer and the part to be treated.

[0075] The optical waveguide component is arranged between the absorption layer and the part to be treated, and the optical waveguide component is provided with at least one hole penetrating the upper and lower surfaces thereof, so as to realize negative pressure therapy while performing phototherapy;

[0076] The optical waveguide component is planar and has at least one light-emitting surface, the area of ​​which is not less than 5 cm 2 .

[0077] According to one embodiment of the present invention, the optical waveguide component has a first surface, a second surface opposite to the first surface, and a side surface between the first surface and the second surface, and the light source component is connected to the optical waveguide component so that the light emitted by the light source component is incident from the side surface of the optical waveguide component.

[0078] According to one embodiment of the present invention, the flexible OLED light-emitting panel has a light-emitting surface, and the area of ​​the light-emitting surface is not less than 5 cm 2 .

[0079] According to an embodiment of the present invention, the optical waveguide component comprises an optical waveguide body, and the optical waveguide component is flexible.

[0080] According to an embodiment of the present invention, the optical waveguide component has a three-dimensional structure.

[0081] According to an embodiment of the present invention, the material of the optical waveguide body includes a transparent material with a high refractive index.

[0082] According to an embodiment of the present invention, the refractive index of the transparent material is greater than or equal to 1.4.

[0083] According to an embodiment of the present invention, the refractive index of the transparent material is greater than or equal to 1.49.

[0084] According to one embodiment of the present invention, the material of the optical waveguide body includes any one of flexible glass, silicone, PET (polyethylene terephthalate), PEN (polyethylene naphthalate), PMMA (polymethyl methacrylate), and PI (polyimide).

[0085] According to an embodiment of the present invention, the optical waveguide body is an optical waveguide having a grating structure on its surface.

[0086] According to an embodiment of the present invention, the optical waveguide component further comprises a scattering structure.

[0087] According to an embodiment of the present invention, the scattering structure includes a scattering layer and / or scattering points.

[0088] According to an embodiment of the present invention, the scattering structure includes nanoparticles. In some specific embodiments, the scattering layer includes nanoparticles. The scattering points include nanoparticles.

[0089] According to one embodiment of the present invention, the nanoparticles include oxide particles, metal particles, organic particles, or a combination thereof.

[0090] According to one embodiment of the present invention, the oxide particles include SiO x , Al2O3, CaCO3, BaSO4, TiO2, ZrO, ZnO. The metal particles include one or more of Ag, Pt, Cu, Au. The organic particles include one or more of polystyrene microspheres (PS), polymethyl methacrylate (PMMA), and silica gel.

[0091] According to an embodiment of the present invention, the diameter of the nanoparticles is between 10 nm and 1000 nm.

[0092] According to one embodiment of the present invention, the diameter of the nanoparticles is between 100-1000 nm.

[0093] According to one embodiment of the present invention, the diameter of the nanoparticles is between 100-800 nm.

[0094] According to an embodiment of the present invention, the scattering structure is arranged on one side or inside the optical waveguide body or a combination thereof.

[0095] According to an embodiment of the present invention, the optical waveguide component further comprises a reflective layer, and the reflective layer is arranged on a side of the optical waveguide body away from the site to be treated.

[0096] According to an embodiment of the present invention, the reflective layer is a film layer with high reflectivity.

[0097] According to an embodiment of the present invention, the reflectivity of the film layer is greater than or equal to 50%.

[0098] According to an embodiment of the present invention, the reflectivity of the film layer is greater than or equal to 70%.

[0099] According to an embodiment of the present invention, the reflectivity of the film layer is greater than or equal to 90%.

[0100] According to an embodiment of the present invention, the reflective layer includes any one or more of a metal reflective layer, a metal oxide reflective layer, and a non-metal reflective layer.

[0101] According to an embodiment of the present invention, the metal reflective layer includes a metal thin film layer such as silver, aluminum, copper, etc.

[0102] According to an embodiment of the present invention, the metal oxide reflective layer includes a metal oxide thin film layer formed by any one or more of titanium dioxide, tin oxide, indium oxide, and zinc oxide.

[0103] According to an embodiment of the present invention, the non-metallic reflective layer includes a non-metallic film layer composed of any one or two of carbon, magnesium fluoride, and magnesium dysprosium fluoride.

[0104] According to an embodiment of the present invention, the scattering layer comprises particles or nanowires.

[0105] According to an embodiment of the present invention, the optical waveguide component includes, from top to bottom, stacked reflective layers, an optical waveguide body and a scattering structure.

[0106] According to an embodiment of the present invention, the optical waveguide component comprises, from top to bottom, stacked reflective layers and an optical waveguide body, wherein a scattering structure (eg, a scattering point) is disposed inside the optical waveguide body.

[0107] According to an embodiment of the present invention, the light source component includes at least one LED lamp bead, at least one laser, or at least one OLED.

[0108] According to an embodiment of the present invention, the light source component includes at least one LED lamp bead or at least one laser.

[0109] According to an embodiment of the present invention, the light source component comprises a plurality of light emitting devices, and the peak wavelengths of the lights emitted by the plurality of light emitting devices are the same or different.

[0110] According to an embodiment of the present invention, the light source component includes two light emitting devices, and the peak wavelengths of the lights emitted by the two light emitting devices differ by 50 nm or more.

[0111] According to one embodiment of the present invention, the peak wavelengths of the lights emitted by the two light-emitting devices differ by 50 nm, 100 nm, 200 nm, 300 nm, 400 nm, 500 nm, 600 nm or 700 nm.

[0112] According to an embodiment of the present invention, the peak wavelength of the light emitted by the light emitting surface is in the range of 400-500 nm, and the optical waveguide component further comprises a down conversion layer, and the down conversion layer is arranged on one side of the optical waveguide body.

[0113] According to an embodiment of the present invention, the down conversion layer is arranged on a side of the optical waveguide body close to the part to be treated.

[0114] According to an embodiment of the present invention, the down conversion layer is arranged on a side of the optical waveguide body away from the site to be treated.

[0115] According to one embodiment of the present invention, the optical waveguide component includes, from top to bottom, stacked reflection layers, down conversion layers, an optical waveguide body and a scattering structure.

[0116] According to one embodiment of the present invention, the optical waveguide component includes, from top to bottom, stacked reflective layers, an optical waveguide body, a down-conversion layer and a scattering structure.

[0117] According to one embodiment of the present invention, the optical waveguide component includes, from top to bottom, a stacked reflection layer, an optical waveguide body, a scattering structure, a down-conversion layer and a packaging layer.

[0118] According to an embodiment of the present invention, the material of the lower conversion layer includes one or more of fluorescent materials, perovskite materials, quantum dot materials, organic small molecule light-emitting materials, and graphene.

[0119] According to one embodiment of the present invention, the negative pressure phototherapy device further comprises at least one light transmission component and at least one optical connection structure;

[0120] The light source component is connected to the light transmission component,

[0121] The light-conducting component is connected to the light-waveguide component,

[0122] The optical connection structure is arranged between the light source component and the light conducting component, and / or between the light conducting component and the optical waveguide component, and at least one optical connection structure enables the two connected components to be separable.

[0123] Herein, the expression “the optical connection structure is provided between the light source component and the light conduction component, and / or between the light conduction component and the optical waveguide component, and at least one optical connection structure makes the two connected components separable” includes at least the following situations: a first situation, the optical connection structure is provided only between the light source component and the light conduction component, and the light source component and the light conduction component are detachably separable (i.e., the light source component and the light conduction component are detachably connected via the optical connection structure); a second situation, the optical connection structure is provided only between the light conduction component and the optical waveguide component, and the light conduction component and the optical waveguide component are detachably separable (i.e., the light conduction component and the optical waveguide component are detachably connected via the optical connection structure); a third situation, the optical connection structure is provided between the light source component and the light conduction component, and is provided between the light conduction component and the optical waveguide component, and the light source component and the light conduction component are detachably separable, while the light conduction component and the optical waveguide component are detachably separable (i.e., the light source component and the light conduction component are detachably connected via the optical connection structure, while the light conduction component and the optical waveguide component are detachably connected via the optical connection structure).

[0124] According to an embodiment of the present invention, the optical connection structure is disposed between the light source component and the light transmission component, and enables the light source component and the light transmission component to be detachable.

[0125] According to an embodiment of the present invention, the optical connection structure comprises a hole, and the light conducting component is inserted into the hole.

[0126] According to an embodiment of the present invention, the optical connection structure further includes a spring sheet, a buckle, a rubber ring or a combination thereof.

[0127] According to an embodiment of the present invention, the material of the light-conducting component includes optical fiber.

[0128] According to one embodiment of the present invention, the negative pressure phototherapy device further comprises a housing, and the light source component and the electric driving device are integrated in the housing.

[0129] According to an embodiment of the present invention, the light source component is arranged at an edge of the optical waveguide component.

[0130] According to an embodiment of the present invention, the light source component is arranged on a side surface of the optical waveguide component.

[0131] According to an embodiment of the present invention, the peak wavelength of the light emitted by the light emitting surface (ie, the light emitting surface of the optical waveguide component) is in the range of 400-1400 nm.

[0132] According to an embodiment of the present invention, the peak wavelength of the light emitted by the light emitting surface (ie, the light emitting surface of the optical waveguide component) is in the range of 600-1400 nm.

[0133] According to an embodiment of the present invention, the light-emitting surface component further comprises a skin-friendly layer, and the skin-friendly layer is arranged on the light-emitting surface (ie, the light-emitting surface of the optical waveguide component).

[0134] According to an embodiment of the present invention, the light emitting surface component includes an optical waveguide component, a down conversion layer and a skin-friendly layer stacked in sequence.

[0135] According to an embodiment of the present invention, the material of the skin-friendly layer includes any one of cotton, silk, linen, yarn, and medical silicone. Preferably, the material of the skin-friendly layer is transparent medical silicone.

[0136] According to one embodiment of the present invention, the light emitting surface (i.e., the light emitting surface of the optical waveguide component) has a light emitting area of ​​not less than 10 cm 2 .

[0137] According to one embodiment of the present invention, the light emitting surface (i.e., the light emitting surface of the optical waveguide component) has a light emitting area of ​​not less than 20 cm 2 .

[0138] According to an embodiment of the present invention, the light emitting uniformity of the light emitting surface (ie, the light emitting surface of the optical waveguide component) is within the range of 1±0.5.

[0139] According to an embodiment of the present invention, the light emitting uniformity of the light emitting surface (ie, the light emitting surface of the optical waveguide component) is within the range of 1±0.3.

[0140] According to an embodiment of the present invention, the light emitting uniformity of the light emitting surface (ie, the light emitting surface of the optical waveguide component) is within the range of 1±0.1.

[0141] According to an embodiment of the present invention, the cross-sectional shape of the channel is circular, polygonal or elliptical.

[0142] According to an embodiment of the present invention, the cross-sectional shape of the hole is circular, and the diameter of the hole is between 0.1-2 mm.

[0143] According to an embodiment of the present invention, the cross-sectional shape of the hole is circular, and the diameter of the hole is between 0.2-1 mm.

[0144] According to an embodiment of the present invention, the cross-sectional shape of the hole is circular, and the diameter of the hole is between 0.2-0.5 mm.

[0145] According to one embodiment of the present invention, the shortest distance between the centers of the channels is between 1-10 mm.

[0146] According to one embodiment of the present invention, the shortest distance between the centers of the holes is between 1-5 mm.

[0147] According to one embodiment of the present invention, the negative pressure pump component further includes a collecting component, and the collecting component is connected to the negative pressure pipeline.

[0148] According to one embodiment of the present invention, the electric drive device is electrically connected to the negative pressure pump component.

[0149] According to an embodiment of the present invention, the material of the absorption layer is any one or more of gauze, cotton cloth, non-woven fabric, bamboo fiber, and pulp.

[0150] According to one embodiment of the present invention, the negative pressure phototherapy device further comprises a filter layer, and the filter layer is arranged between the absorption layer and the negative pressure applying layer.

[0151] According to one embodiment of the present invention, the material of the negative pressure applying layer includes any one of foam material, non-woven material and the like.

[0152] According to one embodiment of the present invention, the edges of the holes are sealed by melting a protective film and / or a flexible film.

[0153] According to one embodiment of the present invention, the channels are formed by a method selected from the following group: punching, dry etching, wet etching, laser etching, plasma bombardment, and combinations thereof.

[0154] According to an embodiment of the present invention, the area ratio of the hole relative to the light emitting surface (i.e., the light emitting surface of the optical waveguide component) is between 0.01% and 50%;

[0155] According to an embodiment of the present invention, the area ratio of the channel relative to the light emitting surface (i.e., the light emitting surface of the optical waveguide component) is between 0.1% and 30%;

[0156] According to an embodiment of the present invention, the area ratio of the hole to the light emitting surface (ie, the light emitting surface of the optical waveguide component) is between 0.2% and 10%.

[0157] According to another embodiment of the present invention, a negative pressure phototherapy device is also disclosed, comprising:

[0158] Electric drive device, luminous surface component, absorption layer, negative pressure providing layer, negative pressure pump component, negative pressure pipeline;

[0159] Wherein, the light-emitting surface component comprises at least one flexible OLED light-emitting panel;

[0160] The flexible OLED light-emitting panel is electrically connected to the electric drive device,

[0161] The negative pressure pump component is connected to the negative pressure pipeline, and the negative pressure providing layer is provided with a negative pressure pipeline.

[0162] The absorption layer is arranged between the negative pressure providing layer and the part to be treated.

[0163] The at least one flexible OLED light-emitting panel is arranged between the absorption layer and the part to be treated, and the flexible OLED light-emitting panel is provided with at least one hole penetrating the upper and lower surfaces thereof, so as to realize negative pressure therapy while performing light therapy;

[0164] The flexible OLED light-emitting panel has at least one light-emitting surface, the area of ​​which is not less than 5 cm 2 .

[0165] According to one embodiment of the present invention, the flexible OLED light-emitting panel has a light-emitting surface, and the area of ​​the light-emitting surface is not less than 5 cm 2 .

[0166] According to an embodiment of the present invention, the light-emitting surface component comprises a plurality of flexible OLED light-emitting panels. The peak wavelengths of light emitted by the plurality of flexible OLED light-emitting panels are the same or different.

[0167] According to one embodiment of the present invention, the peak wavelengths of the light emitted by the light-emitting surface (i.e., the light-emitting surface of the flexible OLED light-emitting panel) differ by 50nm or more. In some specific embodiments, the peak wavelengths of the light emitted by the light-emitting surface (i.e., the light-emitting surface of the flexible OLED light-emitting panel) differ by 50nm, 100nm, 200nm, 300nm, 400nm, 500nm, 600nm or 700nm.

[0168] According to one embodiment of the present invention, the peak wavelengths of light emitted by at least one flexible OLED light-emitting panel differ by 50nm or more. In some specific embodiments, the peak wavelengths of light emitted by a flexible OLED light-emitting panel may be different, and the peak wavelengths may differ by 50nm or more. In some specific embodiments, the peak wavelengths of light emitted by at least one flexible OLED light-emitting panel differ by 50nm, 100nm, 200nm, 300nm, 400nm, 500nm, 600nm or 700nm.

[0169] According to one embodiment of the present invention, the peak wavelength of light emitted by the light-emitting surface (i.e., the light-emitting surface of the flexible OLED light-emitting panel) is in the range of 400-500nm, and the light-emitting surface component further includes a down-conversion layer, which is arranged between the light-emitting surface and the part to be treated.

[0170] According to an embodiment of the present invention, the material of the lower conversion layer includes one or more of fluorescent materials, perovskite materials, quantum dot materials, organic small molecule light-emitting materials, and graphene.

[0171] According to an embodiment of the present invention, the peak wavelength of the light emitted by the light-emitting surface (ie, the light-emitting surface of the flexible OLED light-emitting panel) is within the range of 400-1400 nm.

[0172] According to an embodiment of the present invention, the peak wavelength of the light emitted by the light-emitting surface (ie, the light-emitting surface of the flexible OLED light-emitting panel) is within the range of 600-1400 nm.

[0173] According to an embodiment of the present invention, the light-emitting surface component further comprises a skin-friendly layer, and the skin-friendly layer is arranged between the light-emitting surface (ie, the light-emitting surface of the flexible OLED light-emitting panel) and the part to be treated.

[0174] According to one embodiment of the present invention, the light-emitting surface component includes a flexible OLED light-emitting panel, a down-conversion layer and a skin-friendly layer stacked in sequence.

[0175] According to an embodiment of the present invention, the material of the skin-friendly layer includes any one of cotton, silk, linen, yarn, and medical silicone. Preferably, the material of the skin-friendly layer is transparent medical silicone.

[0176] According to one embodiment of the present invention, the light-emitting surface (i.e., the light-emitting surface of the flexible OLED light-emitting panel) has a light-emitting area of ​​not less than 10 cm 2 .

[0177] According to one embodiment of the present invention, the light-emitting surface (i.e., the light-emitting surface of the flexible OLED light-emitting panel) has a light-emitting area of ​​not less than 20 cm2 .

[0178] According to an embodiment of the present invention, the light emitting uniformity of the light emitting surface (ie, the light emitting surface of the flexible OLED light emitting panel) is within the range of 1±0.5.

[0179] According to an embodiment of the present invention, the light emitting uniformity of the light emitting surface (ie, the light emitting surface of the flexible OLED light emitting panel) is within the range of 1±0.3.

[0180] According to an embodiment of the present invention, the light emitting uniformity of the light emitting surface (ie, the light emitting surface of the flexible OLED light emitting panel) is within the range of 1±0.1.

[0181] According to an embodiment of the present invention, the cross-sectional shape of the channel is circular, polygonal or elliptical.

[0182] According to an embodiment of the present invention, the cross-sectional shape of the hole is circular, and the diameter of the hole is between 0.1-2 mm.

[0183] According to an embodiment of the present invention, the cross-sectional shape of the hole is circular, and the diameter of the hole is between 0.2-1 mm.

[0184] According to an embodiment of the present invention, the cross-sectional shape of the hole is circular, and the diameter of the hole is between 0.2-0.5 mm.

[0185] According to one embodiment of the present invention, the shortest distance between the centers of the channels is between 1-10 mm.

[0186] According to one embodiment of the present invention, the shortest distance between the centers of the holes is between 1-5 mm.

[0187] According to one embodiment of the present invention, the negative pressure pump component further includes a collecting component, and the collecting component is connected to the negative pressure pipeline.

[0188] According to one embodiment of the present invention, the electric drive device is electrically connected to the negative pressure pump component.

[0189] According to an embodiment of the present invention, the material of the absorption layer is any one or more of gauze, cotton cloth, non-woven fabric, bamboo fiber, and pulp.

[0190] According to one embodiment of the present invention, the negative pressure phototherapy device further comprises a filter layer, and the filter layer is arranged between the absorption layer and the negative pressure applying layer.

[0191] According to one embodiment of the present invention, the material of the negative pressure applying layer includes any one of foam material, non-woven material and the like.

[0192] According to one embodiment of the present invention, the edges of the holes are sealed by melting a protective film and / or a flexible film.

[0193] According to one embodiment of the present invention, the channels are formed by a method selected from the following group: punching, dry etching, wet etching, laser etching, plasma bombardment, and combinations thereof.

[0194] According to an embodiment of the present invention, the area ratio of the hole relative to the light-emitting surface (that is, the light-emitting surface of the flexible OLED light-emitting panel) is between 0.01% and 50%;

[0195] According to an embodiment of the present invention, the area ratio of the hole relative to the light-emitting surface (that is, the light-emitting surface of the flexible OLED light-emitting panel) is between 0.1% and 30%;

[0196] According to an embodiment of the present invention, the area ratio of the hole to the light-emitting surface (ie, the light-emitting surface of the flexible OLED light-emitting panel) is between 0.2% and 10%.

[0197] The present invention uses an optical waveguide component or an OLED light-emitting panel to provide a surface light source, and the optical waveguide component and the OLED light-emitting panel are provided with channels to ensure the circulation of gas and liquid. When combined with a negative pressure device, it can achieve the dual wound healing functions of negative pressure and phototherapy, and can achieve large-area treatment. When an optical waveguide component is used to provide a surface light source, the light source component in the present invention can be integrated on the side of the optical waveguide component, and can also be further configured into a detachable mode through a light-conducting component to achieve a disposable effect. In addition, when the light source emits blue light, the light-emitting surface component can also include a down-conversion layer to down-convert the blue light into red light and light with a longer wavelength, such as near-infrared light.

[0198] The present invention will be further described below in conjunction with the accompanying drawings, but the present invention is not limited thereto.

[0199] Figure 3 The substrate, encapsulation layer, and front and rear cover films used in the flexible OLED light-emitting panel shown are usually artificial materials with poor air permeability, and under normal circumstances, the entire light-emitting surface is closed without any gaps. However, the negative pressure wound healing device requires a gap for pumping air and liquid, so if the OLED light-emitting panel is to be combined with the negative pressure system, a gap needs to be opened on the OLED panel.

[0200] Figure 4a-4bA partial plan view of a flexible OLED light-emitting panel 400 with holes is shown, which has a plurality of holes 401. Each hole 401 has a center o, a diameter d, and a spacing s between holes. We define the hole area ratio F as the ratio of the sum of the cross-sectional areas of the holes on the entire flexible OLED panel to the area of ​​the entire flexible OLED panel. Figure 4a-4b In the embodiment, all the channels 401 have the same diameter, and the channel spacing is equal in both the x and y directions. Figure 4a In such an array of equal-area channels arranged equidistantly, the channel area ratio F is the ratio of the channel area contained in the unit triangle 402 to the area of ​​the entire triangle. Note that in some embodiments, the channels 401 can be arranged non-equidistantly, for example, they are arranged equidistantly in the x direction with a spacing s1, and they are arranged equidistantly in the y direction with a spacing s2, where s1≠s2. In other embodiments, the channels 401 can also be arranged non-equidistantly in a single direction. However, preferably, the channels 401 are arranged equidistantly in at least one direction of the x or y axis, and more preferably, the channels 401 are arranged equidistantly in both the x and y directions. The channels 401 can also have different diameters d from each other. For example, channels with larger openings (i.e., larger diameter d) can be used in the main area of ​​the wound, while channels with relatively smaller openings (i.e., smaller diameter d) can be used at the edge of the wound. According to the actual application needs, the pore area ratio F should be between 0.01%-50%, preferably between 0.1%-30%, and more preferably between 0.2%-10%. In order to ensure a certain gas and liquid permeability and minimize the loss of light-emitting area, the pore diameter d should be between 0.1-2mm, preferably between 0.2-1mm, and more preferably between 0.2-0.5mm. For the same reason, the pore spacing s should be controlled between 1-10mm, preferably between 1-5mm. In addition Figure 4a-4b In addition to the circular hole shown above, the cross section of the hole can also be other shapes, including but not limited to polygons (such as squares, hexagons, rectangles, triangles, diamonds, strips, etc.), ellipses, etc., which are not drawn here one by one. For the convenience of processing, the cross section of the hole is preferably circular or regular polygonal; more preferably circular. The flexible OLED light-emitting panel also needs to prepare contact electrodes 403, such as Figure 4a-4b The electrode strips on the periphery of the panel are shown in . These contact electrodes will be electrically connected to the external circuit (such as an FPC circuit board) after the device is packaged so as to be driven by an external power supply. The final product can be realized using a single flexible OLED light-emitting panel 400, or it can be realized by splicing multiple flexible OLED light-emitting panels 400. Each flexible OLED light-emitting panel can emit the same color of light or different colors of light. The specific splicing method can refer to the description in the inventor's previous application US20190376650.

[0201] When the flexible OLED light-emitting panel 400 is prepared as a light therapy product (such as a light-emitting mask) in a single piece, the light-emitting area is usually large. In this case, in order to reduce the voltage drop generated when the current passes through the electrode with a lower block resistivity, some metal wires (buslines) such as Figure 4b 4031 and 4032 shown in . If the OLED light-emitting panel adopts a bottom-emitting device structure, the resistivity of the anode (usually ITO) is usually large, and its square resistance is generally around 10-25ohm / sq, that is, a metal wire can be prepared on the anode in advance to reduce the resistivity; if the OLED light-emitting panel adopts a top-emitting device structure, the resistivity of the cathode (usually MgAg alloy) is usually large, and its square resistance is generally between 1-30ohm / sq, so a metal wire can be prepared on the cathode to reduce the resistivity. The specific method of preparing the metal wire can refer to the inventor's previous patent US8,927,308. Figure 4b The metal wires 4031 and 4032 shown in the figure are only examples. The arrangement of the metal wires is well known to those skilled in the art and will not be described in detail here.

[0202] along Figure 4a The cross-sectional view of the structure 500 along the AA' cutting line is as follows: Figure 5a As shown, it includes a flexible substrate 501, an OLED device 502, an encapsulation layer 503, and a contact electrode 504. From the AA' cross section, the flexible substrate 501, the OLED device 502, and the encapsulation layer 503 are all covered with holes 507 (corresponding to Figure 4a-4b4 ), but note that from the plan view of FIG4 , they are still continuous in the area outside the channel 401. During the preparation process, the flexible substrate 501 is attached to a supporting substrate 505 to ensure the normal process flow. The supporting substrate 505 is generally hard, such as glass, silicon wafer, etc. If the flexible substrate 501 is a solid film, such as PET, PEN, aluminum foil, etc., Kapton tape can be used to fix the flexible substrate 501 on the supporting substrate 505, and a solid film coated with a moisture barrier layer can also be selected; preferably, the PI solution is applied to the supporting substrate 505 by spin coating, printing, spraying, etc. and cured to form the flexible substrate 501. Note that the supporting substrate 505 will eventually be removed and will not appear in the final product. One solution to increase the air permeability of the flexible OLED light-emitting panel is to perform a hole punching process on the flexible substrate 501 before preparing the OLED device 502. If the flexible substrate 501 is a solid film, it can be punched first and then applied to the supporting substrate 505. If it is applied to the supporting substrate 505 in the form of a solution, it can be punched after curing. Here, it is preferred to use a solution method to apply PI and solidify to form the flexible substrate 501. The thickness of the flexible substrate 501 is generally 25-500μm, preferably 30-200μm, and more preferably 50-100μm. In order to ensure accuracy and controllability, punching can be performed by punching by punching, wet etching, dry etching, laser, etc., preferably laser drilling is used to form a plurality of channels 507 on the flexible substrate 501, which have a center o, a diameter d, and a spacing s between two adjacent channels. Thereafter, an OLED device 502 is prepared on the flexible substrate 501 having the channels 507. Since the thickness of the flexible substrate is at least 25 μm, and the overall thickness of the OLED device 501 is generally in the order of 1-2 μm, the organic film or metal electrode film layer of the OLED device will not cover the channel 507 during the preparation process. Moreover, due to in-situ growth, the center of the channel of one layer of the OLED device coincides with the center of the channel on the substrate. After the device is prepared, it needs to be packaged, preferably using a thin film package, which is generally less than 10 μm thick. At this time, since the packaging process is generally isotropic, part of the packaging layer 5031 will cover all sides of the OLED device 502 and part or even all sides of the flexible substrate 501, so that the OLED device 502 can be effectively protected from being corroded from the side by water and oxygen in the environment. Although the encapsulation layer will wrap a part of the side wall, since the encapsulation layer itself is very thin, the part covering the side wall will be thinner, generally less than 5μm, and the diameter of the channel is at least 0.1mm, i.e. 100μm. Therefore, it can be considered that the channel diameter d' after encapsulation is reduced by 10% or less compared with the diameter d before encapsulation, and the channel center of the encapsulation layer, OLED device layer and substrate layer are all coincident.After the package is completed, the flexible substrate 501 needs to be peeled off from the supporting substrate 505. There are several methods for this. First, the FPC circuit board 508 can be electrically connected to the contact electrode 504, and then the protective film 506 is applied on the packaging layer 503, such as. Figure 5b As shown. The FPC circuit board 508 can be in a continuous film form connected to an external power supply. Preferably, it is in a grid-like or frame-like form and only connects the contact electrode 504 and completely exposes the encapsulation layer 503. The use of the FPC circuit board 508 in the OLED light-emitting panel can refer to the inventor's previous application US20190376650. The protective film 506 can be applied to the flexible panel in the form of a laminate, and then the flexible substrate 501 is peeled off from the supporting substrate 505. If the flexible substrate 501 is a solid film, the tape can be directly torn off. If it is a PI film, laser peeling is required, and laser peeling of the PI film is preferably used. The material of the protective film includes but is not limited to artificial materials such as PET, PEN, PI, FPC circuit boards, and silicone. It can also be a natural material with good air permeability such as silk, cotton and linen. If it is such a natural material with good air permeability, no additional holes are required. If the protective film 506 is an airtight material, it also needs to be punched, such as Figure 5c As shown. The position of the hole on the protective film 506 should correspond to the position of the hole 507 formed on the flexible substrate and the OLED device, that is, its center point coincides with the center point o of the hole 507 or the coincidence degree is more than 50%. Here, the coincidence degree refers to the ratio of the area of ​​the overlapping part of the hole of the protective film and the hole A in the vertical projection of the substrate plane to the vertical projection area of ​​the hole A; preferably, the coincidence degree of the hole is more than 70%. The diameter of the hole on the protective film 506 is D, preferably D≥d. The hole on the protective film 506 can be punched in advance, so that when laminating, it is necessary to perform a positioning operation to ensure alignment with the inherent hole 507; another solution is to perform the punching operation after laminating. The advantage of this is that no additional alignment is required to ensure that the center of the protective film is basically aligned with the existing center point o, but the disadvantage is that there is a risk of damaging the OLED device during the punching process. Punching of the protective film can be performed by stamping, laser, etc. In the second method, the protective film 506 can also be an FPC circuit board that has integrated circuits. This has an advantage: generally, a positioning system is provided when making circuit connections (bonding), so that the circuit connections (bonding) can be made simultaneously during the lamination, solving the problem of channel alignment. In this case, no additional FPC circuit board 508 is required. The thickness of the protective film 506 is generally 25-500μm, preferably 50-200μm. If the flexible OLED light-emitting panel uses a top-emitting device, the protective film needs to be light-transmitting, with a transmittance of more than 10%, preferably a transmittance of more than 20%, and more preferably a transmittance of more than 50%. The third method is as follows Figure 5d As shown, when the flexible substrate 501 is peeled off from the supporting substrate 505, a transfer film 5061 can be first applied to the panel 530, and then the flexible substrate 501 can be peeled off from the supporting substrate 505, and then the flexible substrate 501 together with the OLED device 502 and the encapsulation layer 503 thereon are transferred and attached to the flexible film 509, and then the transfer film 5061 is removed. The FPC circuit board 508 can be electrically connected to the contact electrode 504 before the transfer, or it can be electrically connected after the transfer film 5061 is removed. If the OLED device 502 is a bottom-emitting device, the flexible film 509 is required to be transparent. If the flexible film 509 is an airtight film, such as various plastics or silicone materials, it also needs to be punched so that it has a plurality of channels E, such as Figure 5e As shown in , punching can be achieved by stamping, laser and other methods. At this time, the position of the hole on the flexible film 509 should be aligned with the existing hole 507, that is, its center point coincides with the center point o of the hole 507 or the overlap is more than 50%. Here, the overlap refers to the ratio of the area of ​​the overlapping part of the hole of the flexible film and the hole A in the vertical projection of the substrate plane to the vertical projection area of ​​the hole A. Preferably, the overlap of the hole is more than 70%. It is also possible to punch holes from top to bottom, and the hole diameter D' is not larger than the hole diameter d' of the hole 507 to ensure that the existing devices and packaging layers are not damaged. Figure 5e As shown by the arrow in , this method can ensure that the center of the hole on the flexible membrane 509 coincides with the existing center. The flexible membrane 509 may already have a hole, and the diameter should not be less than the diameter d of the hole 507. The two holes need to be aligned during transfer. Of course, the flexible membrane 509 can also be a skin-friendly protective material with its own gaps, such as natural materials with good air permeability such as silk, cotton and linen, so that no additional punching is required. The thickness of the flexible membrane 509 is generally 25-500μm, preferably 50-200μm. Finally, a protective film 506 can also be added to the encapsulation layer 503 of the flexible light-emitting panel 540. The method and selection are as described above and will not be repeated.

[0203] In some embodiments, the holes can be punched after the OLED device and the encapsulation layer are completed. Figure 6a As shown in FIG, a flexible substrate 601 is attached to a support substrate 605, on which a prepared OLED device 602 and a complete encapsulation layer 603 are provided, as well as a contact electrode 604 exposed outside the encapsulation layer 603. Since the total thickness of the entire OLED device 602 and the encapsulation layer 603 is generally about 10-15 μm, it can be cut from top to bottom by laser (e.g. Figure 6a As shown by the arrow in the middle, precise etching is performed to form Figure 6bThe hole 607 shown. A mask can also be set on the completed device, and then plasma bombardment is used in the PECVD chamber to form holes on the encapsulation layer 603 and the OLED device 602, and then the holes are formed on the flexible substrate 601 by laser or stamping. The hole 607 has a diameter d and a spacing s. The FPC circuit board 606 can be attached before punching or after punching. This method exposes the side 6021 of the OLED device 602, which may cause the device performance to deteriorate. At this time, a protective film and / or a flexible film can be applied in the subsequent process, and then the edge of the hole can be sintered by laser or high temperature. Since the general protective film and the flexible film can be made of plastic or silicone, they will melt under laser or high temperature burning, and the side of the hole can be sealed after cooling and re-solidification to avoid exposure of the OLED organic layer. It is also possible to drill holes through after the protective film and / or the flexible film is applied, that is, the protective film, the encapsulation layer, the OLED device, the flexible substrate, and the flexible film are drilled together, and then the edge is sealed at high temperature. This method avoids the use of alignment and simplifies the process. In other embodiments, improvements can be made on the basis of the above. Specifically, the OLED device is first packaged, such as first using PECVD to deposit a 1-2 μm thick semiconductor film, including but not limited to SiO x (Silicon oxide), AlO x (aluminum oxide), SiN x (silicon nitride), etc. Then, holes are punched, as described above. Then, the organic layer is printed to continue the encapsulation, and on this basis, it can be transferred back to PECVD to make the second semiconductor film and print the second organic layer. In this way, the side 6021 of the OLED device can be protected by the encapsulation layer. This multi-layer encapsulation process is well known in the industry and will not be described in detail here.

[0204] Figure 7aThe cross-sectional schematic diagram of the negative pressure phototherapy device 700 of the first embodiment of the present invention is shown, which includes a flexible OLED light-emitting panel 701 (i.e., a light-emitting surface component), an absorption layer 703, an electric drive device 704, a negative pressure giving layer 705, a negative pressure pump component 706, and a negative pressure pipeline 707. Among them, the light-emitting surface component is formed by a flexible OLED light-emitting panel of a surface light source, that is, the light-emitting surface component is a surface light source, and the light-emitting direction of the flexible OLED light-emitting panel 701 is toward the part to be treated, as shown by the arrow. As described above, a series of channels 7010 are arranged on the flexible OLED light-emitting panel 701. The flexible OLED light-emitting panel here can emit light with a peak wavelength of 400-1400nm, preferably, red light, deep red light and near infrared light of 600-1400nm. The flexible OLED light-emitting panel 701 is connected to the electric drive device 704 through an electrical connector 7040. The electrical connector 7040 includes but is not limited to one or more of thin film metal, transparent conductive material, and FPC lead. The electric drive device 704 includes but is not limited to a power source, a charging device (preferably a wireless charging device), a Bluetooth communication device, a chip, a lead, a circuit board, a switch and other devices. One or more. The power source includes a battery, and the battery can be selected from one or more of a thin film battery, a micro battery, a button battery, a chemical battery, a lithium battery, and a hydrogen battery. The electric drive device 704 can also be wirelessly connected to an external electronic device through a Bluetooth communication device, and controlled by an external electronic device, such as a switch, light and dark adjustment, and partition control, for example, only lighting up the red light emitting device, or lighting up the red light emitting device and the near-infrared light emitting device at the same time. The external electronic device can be a smart phone, a smart watch, a tablet computer, a laptop computer and other devices. Further, the external electronic device can also be controlled in conjunction with an application (APP). Note that although the electric drive device 704 and the negative pressure pump component 706 are drawn as two independent components, the negative pressure pump component 706 can also be driven by the electric drive device 704, and / or, the negative pressure pump component 706 can be arranged in the same housing as the electric drive device 704. A skin-friendly layer can also be arranged on the flexible OLED light-emitting panel 701, which is no longer drawn in the figure. The material of the skin-friendly layer can be selected from mesh fabrics made of natural cotton, silk, linen, etc. to ensure light transmittance; it can also be a transparent material such as medical silicone, preferably transparent medical silicone. A series of channels are also provided on the skin-friendly layer (the channels run through the upper and lower surfaces of the skin-friendly layer), and are aligned one by one with the channels of the flexible OLED light-emitting panel 701. Preferably, the channels on the skin-friendly layer and the flexible OLED light-emitting panel 701 are formed at the same time, for example, by laser etching at the same time.

[0205] Figure 7aThe absorption layer 703 is mainly used to absorb other liquids such as blood and pus, and its preparation materials include gauze, cotton cloth, non-woven fabrics, bamboo fiber, pulp and combinations thereof. The negative pressure pump component 706 includes a micro pump for generating negative pressure, and is connected to the negative pressure giving layer 705 through a negative pressure pipe 707. The negative pressure giving layer 705 provides physical support for the negative pressure pipe 707, so that the negative pressure pipe 707 can be directly attached to the absorption layer 703 and aim at the area to be treated to draw air. The negative pressure giving layer 705 can further include a series (at least one) of micro pipes and channels connected to the outlet 7070 of the negative pressure pipe 707, so that the negative pressure can be evenly distributed throughout the area to be treated, improving the treatment effect. The negative pressure pump component 706 can also include a collecting component (the collecting component is connected to the negative pressure pipe 707, and is no longer drawn in the figure), which can absorb those liquids or solids that pass through the absorption layer 703. Figure 7a The negative pressure phototherapy device may further include a filter layer (not shown in the figure) between the absorption layer 703 and the negative pressure providing layer 05, and the filter layer may block some solid matter to avoid blocking the negative pressure pipe 707 and contaminating the negative pressure pump component 706. The negative pressure pump component 706 also includes an electric drive device (not shown in the figure) for driving the pump. Preferably, the electric drive device of the negative pressure pump and the electric drive device 704 of the flexible OLED light-emitting panel 701 may be the same electric drive device. Figure 7a The negative pressure phototherapy device 700 can turn on the negative pressure pump to perform negative pressure healing treatment on the wound, and at the same time can turn on the flexible OLED light-emitting panel to form a light-emitting surface to perform phototherapy on the wound, accelerate wound healing and fade scars.

[0206] Figure 7b The figure shows a cross-sectional schematic diagram of a negative pressure phototherapy device 710 using an OLED surface light source according to a second embodiment of the present invention, which includes a flexible OLED light-emitting panel 711 (i.e., a light-emitting surface component), an absorption layer 713, an electric drive device 714, a negative pressure providing layer 715, a negative pressure pump component 716, and a negative pressure pipeline 717. The flexible OLED light-emitting panel 711 is connected to the electric drive device 714 via an electrical connector 7140. Figure 7aOn the basis of the above, the device adds a down-conversion layer 712. At this time, the light-emitting surface is a flexible OLED light-emitting panel 711, and emits light with a peak wavelength of 400-600nm, preferably, 400-560nm. The absorption peak of the down-conversion layer 712 is within the range of + / -20nm of the peak wavelength of the outgoing light of the flexible OLED light-emitting panel 711, and its emission peak is within the range of +100nm and above of the peak wavelength of the outgoing light of the flexible OLED light-emitting panel 711. Preferably, the emission peak of the down-conversion layer 712 is 600nm and above. The material of the down-conversion layer 712 may include but is not limited to fluorescent materials, perovskite materials, quantum dot materials, organic small molecule luminescent materials, graphene, etc. Note that when using the down-conversion layer 712, it is necessary to set an encapsulation layer (not shown in the figure) between it and the part to be treated to protect the down-conversion material from water and oxygen invasion. Similarly, there are a series of channels 7110 on the down-conversion layer 712 and the encapsulation layer, and the channels run through the encapsulation layer, the down-conversion layer 712 and the flexible OLED light-emitting panel 711. The channel formation method is similar to the above, and can be formed by laser etching together with the flexible OLED light-emitting panel 711 after the down-conversion layer 712 and its encapsulation layer are completed. Of course, a skin-friendly layer can also be provided on the encapsulation layer, which is no longer drawn in the figure. The negative pressure giving layer 715 can further include a series (at least one) of micro-channels and channels to connect them to the outlet 7170 of the negative pressure pipeline 717, so that the negative pressure can be evenly distributed throughout the area to be treated, thereby improving the treatment effect.

[0207] The cross-sectional schematic diagram of the negative pressure phototherapy device 800 according to the third embodiment of the present invention is shown in FIG. Figure 8a As shown, it includes at least one light source component 801, an optical waveguide component 802, an absorption layer 803, an electric drive device 804, a negative pressure providing layer 805, a negative pressure pump component 806 and a negative pressure pipeline 807. The optical waveguide component 802 converts the light emitted by the light source component 801 into a surface light source to form a light-emitting surface. Among them, a series of channels 8020 are also provided on the optical waveguide component 802. The light source component 801 can be a point light source, a line light source, or a surface light source. Preferably, the light source component 801 includes but is not limited to LED lamp beads, lasers or OLEDs. Preferably, the light source component 801 includes LED lamp beads or lasers. The special negative pressure phototherapy device in the present invention can convert a point light source or a line light source into a surface light source even if LED lamp beads or lasers are used, thereby enabling large-area treatment without being limited to the more expensive OLEDs. The light source component 801 emits light with a peak wavelength of 400-1400nm. Preferably, the light source component 801 emits blue light with a peak wavelength of 400-480nm, or red light, deep red light and near infrared light with a peak wavelength of 600-1400nm. The light source component 801 may include multiple light emitting devices, for example, multiple LED lamp beads (such as Figure 8a), preferably, the plurality of LED lamp beads can emit light of different colors, for example, at least one LED lamp bead emits red light and deep red light with a peak wavelength of 600-700nm, and at least another LED lamp bead emits near infrared light with a peak wavelength of 700-1400nm. The light source component 801 is connected to the electric drive device 804 through an electrical connector 8040.

[0208] The light source component 801 can be fixed to the edge (i.e., the side) of the optical waveguide component 802 by optical glue. The light emitted by the light source component 801 is converted into a surface light source by the optical waveguide component 802, and is emitted from one side in the form of a light-emitting surface. As shown by the arrow in the figure, the emission direction points to the part to be treated. The area of ​​the entire optical waveguide component 802 is the area to be treated. The area of ​​the optical waveguide component 802 (i.e., the light-emitting area of ​​the light-emitting surface of the optical waveguide component 802) is not less than 5cm 2 , preferably, not less than 10cm 2 , more preferably, not less than 20cm 2 . The optical waveguide component 802 is flexible. Preferably, the optical waveguide component 802 is a three-dimensional structure designed according to the part to be treated and can fit tightly with the part to be treated. The optical waveguide component 802 in the present invention can convert an incident point light source or line light source into a surface light source for emission, and by reasonably setting the structure, such as adding a scattering structure, etc., uniform ground light source emission can be achieved. The uniformity of light emitted by the optical waveguide component 802 refers to the ratio of the light intensity values ​​of any two areas on the entire light-emitting surface. The uniformity of light emitted by the optical waveguide component 802 is within the range of 1±0.5, preferably within the range of 1±0.3, and more preferably within the range of 1±0.1.

[0209] A specific cross-sectional schematic diagram of an optical waveguide component is shown in FIG. Figure 9aAs shown, the optical waveguide component 900 can be further divided into several components, including but not limited to an optical waveguide body 901, a reflective layer 902 and a scattering layer 903. The reflective layer 902 is arranged on the side of the optical waveguide body 901 away from the part to be treated; the scattering layer 903 is arranged on the side of the optical waveguide body 901 close to the part to be treated. The optical waveguide body 901 can be a transparent material with a high refractive index, and the refractive index is greater than or equal to 1.4, preferably greater than or equal to 1.45, and more preferably greater than or equal to 1.49. The material of the optical waveguide body 901 includes but is not limited to flexible glass, silicone (Silicon), PET, PEN, PMMA, PI, etc. The optical waveguide body 901 can also be an optical waveguide with a grating structure on the surface. The reflective layer 902 can be a film layer with high reflectivity, and the reflectivity of the film layer is greater than or equal to 50%, preferably greater than or equal to 70%, and more preferably greater than or equal to 90%. The reflective layer 902 can include any one or more of a metal reflective layer, a metal oxide reflective layer, and a non-metallic reflective layer. The metal reflective layer may include a metal film layer such as silver, aluminum, copper, etc. The metal oxide reflective layer may include a metal oxide film layer formed by any one or more of titanium dioxide, tin oxide, indium oxide, and zinc oxide. The non-metallic reflective layer may include a non-metallic film layer composed of any one or two of carbon, magnesium fluoride, and magnesium dysprosium fluoride. The scattering layer 903 may be a transparent film layer doped with scattering nanoparticles, or a micro-nano structure formed on the surface of the optical waveguide body 901 to achieve scattering. The material of the transparent film layer may be various transparent organic macromolecular polymers, including but not limited to PMMA, PET, PEN, PI, etc. The scattering layer 903 may contain nanoparticles, including but not limited to SiO x , oxide particles such as Al2O3, CaCO3, BaSO4, TiO2, ZrO, ZnO, or metal particles such as Ag, Pt, Cu, Au, or organic particles such as polystyrene microspheres (PS), polymethyl methacrylate (PMMA), silica gel, or a combination thereof. The diameter of the nanoparticles should be between 10nm-1000nm, preferably between 100-1000nm, and more preferably between 100-800nm. Scattering points can be further added to the optical waveguide component 900, such as Figure 9aThe scattering structures 9030 in the optical waveguide body 901 are distributed at intervals throughout the optical waveguide body 901. When the optical waveguide material is an organic material, scattering nanoparticles can be injected into a specified area before the optical waveguide material is solidified during the preparation process to achieve scattering points. Alternatively, an organic material with the same refractive index can be poured between multiple optical waveguide units, and scattering nanoparticles can be added therein, and then solidified to achieve regionalized scattering points. The scattering layer 903 and the scattering points 9030 are collectively referred to as scattering structures, which can be used separately or in combination. The material of the scattering points is the same as or different from that of the scattering layer, including but not limited to SiO x , Al2O3, CaCO3, BaSO4, TiO2, ZrO, ZnO and other oxides, or Ag, Pt, Cu, Au and other metals, or polystyrene microspheres (PS), polymethyl methacrylate (PMMA), silicone and other organic substances, or a combination thereof. The optical waveguide component 900 may also include an optical waveguide body 901 and a reflective layer 902, and the scattering structure is uniformly doped in the optical waveguide body 901 in the form of nanoparticles to achieve scattering. For example, scattering nanoparticles may be doped in an organic polymer material used to prepare the optical waveguide body, and the doped material (e.g., silicone doped with scattering nanoparticles) may be molded to form an optical waveguide body having scattering properties. In this case, the scattering structure may no longer be provided separately. In some specific embodiments, the reflective layer may be prepared on the optical waveguide body by metal sputtering, thermal evaporation, etc., or may be coated on the optical waveguide body by a solution method with dissolved metal particles or nanowires, including but not limited to silver paste, copper paste, silver nanowires, carbon nanowires, etc. The scattering layer can also be prepared by a solution method, where the nanoparticles are first uniformly dissolved in a matrix, which can be various organic macromolecular polymers, and then coated on the optical waveguide body.

[0210] In the optical waveguide component 900, a series of channels 904 are passed through from the scattering layer 903 to the optical waveguide body 901 and then to the reflective layer 902. These channels allow gas and liquid to pass through. The diameter of the channel is between 1-2 mm, preferably between 0.2-1 mm, and more preferably between 0.2-0.5 mm. The shortest distance between the centers of the channels is between 1-10 mm, preferably between 1-5 mm. Since the channel is filled with air, its optical refractive index is 1.0, and the optical refractive index of the optical waveguide body 901 is 1.45 and above, which is higher than that of air. Therefore, part of the light inside the optical waveguide body will be totally reflected at the channel interface, which increases the uniformity of the light emitted by the optical waveguide body, while the other part of the light refracted from the channel can still reach the treatment site. Therefore, the reasonably arranged channels do not affect the phototherapy effect. The channels can be formed by wet etching, dry etching, and laser etching.

[0211] Figure 9b and 9c The structures of the other two optical waveguide components 910 and 920 are respectively given. Figure 9b The cross-sectional view of the optical waveguide component 910 in FIG. 1 shows that a down-conversion layer 915 is further arranged between the optical waveguide body 911 and the reflective layer 912, and a scattering layer 913 is arranged on the lower surface of the optical waveguide body 911; Fig.9c The middle and lower conversion layer 925 is arranged between the optical waveguide body 921 and the scattering layer 923, and the reflective layer 922 is arranged on the upper surface of the optical waveguide body 921. The channels 914 and 924 in the two structures penetrate all the film layers. The lower conversion layers 915 and 925 have an absorption peak and an emission peak, and their absorption peak is within the range of + / -20nm of the peak wavelength of the output light of the light source component, and their emission peak is within the range of +100nm and above of the peak wavelength of the output light of the light source component. Preferably, the emission peak of the lower conversion layers 915 and 925 is 600nm and above. The material of the lower conversion layers 915 and 925 may include but is not limited to fluorescent materials, perovskite materials, quantum dot materials, organic small molecule luminescent materials, graphene, etc.

[0212] Figure 9d Another cross-sectional schematic diagram of an optical waveguide component 930 with a down-conversion layer is provided. In this case, the down-conversion layer 935 is arranged between the scattering layer 933 and the part to be treated. In order to ensure that the down-conversion layer 935 is not invaded by water and oxygen, an encapsulation layer 936 is also required to be arranged between the down-conversion layer 935 and the part to be treated (i.e., on the side of the down-conversion layer 935 away from the optical waveguide body 931). The reflective layer 932 is arranged on the upper surface of the optical waveguide body 931. The channels 934 all penetrate all the film layers. The down-conversion layer 935 can also be prepared by a solution method, where the down-conversion material is dissolved in a solvent and then coated on one side of the optical waveguide component, and then cured into a film. In another embodiment, the down-conversion material, such as granular materials such as quantum dots and perovskites or soluble materials such as organic small molecules, can also be doped into the optical waveguide component (such as the optical waveguide body) to directly realize down-conversion inside the optical waveguide component (not shown in the figure). The entire optical waveguide component and other film layers can be prepared and cured by a solution method, and a layer of optical glue can also be coated between different film layers for fixing. In another embodiment, the entire optical waveguide component and other film layers may be further integrated on a housing, and the film layers may be fixed together by a structural design on the housing.

[0213] Figure 8a The negative pressure pump component 806 also includes an electric drive device (not shown in the figure) for driving the pump. Preferably, the electric drive device of the negative pressure pump and the electric drive device 804 of the light source component 801 can be the same electric drive device. Figure 8aThe negative pressure phototherapy device 800 can turn on the negative pressure pump to perform negative pressure healing treatment on the wound, and at the same time, it can also turn on the light source component 801 to perform phototherapy on the wound, thereby accelerating wound healing and fading scars.

[0214] The cross-sectional schematic diagram of the negative pressure phototherapy device 810 according to the fourth embodiment of the present invention is shown in FIG. Figure 8b As shown, at this time, the light source component 811 is arranged outside the optical waveguide component 812, electrically connected to the electric drive device 814 through the electrical connector 8141, and optically coupled to the light transmission component 818 through the optical connection structure 8190. The light transmission component 818 transmits light to the other end and optically couples with the optical waveguide component 812 through the optical connection structures 8191 and 8192, and finally emits light from one side of the optical waveguide component 812 in the form of a surface light source. As shown by the arrow in the figure, the light emission direction of the light emitting surface points to the part to be treated. An absorption layer 813, a negative pressure giving layer 815, and a negative pressure pump component 816 connected through a negative pressure pipeline 817 are further arranged on the side of the optical waveguide component 812 away from the part to be treated. At the same time, a series of channels 8120 (channels 8120 run through the entire optical waveguide component 812) are also arranged on the optical waveguide component 812 to ensure that the negative pressure can be transmitted to the part to be treated and that the liquid can be absorbed by the absorption layer 813 through the channels 8120. The light transmission component 818 can transmit light energy from one end to the other end with low loss or even nearly lossless, with a loss of no more than 50%, preferably no more than 20%, and more preferably no more than 10%. The light transmission component 818 is preferably an optical fiber. Generally, when light propagates in the optical fiber, total reflection occurs, so it can be transmitted from one end to the other end almost without loss. It should be understood that any tubular or sheet-like component that can form total reflection of the internal light path can be used as a light transmission component. The light source component 811 and the light transmission component 818 are optically coupled through the optical connection structure 8190, that is, the light emitted by the light source component 811 is transmitted to the light transmission component 818. Similarly, the light at the other end of the light transmission component 818 can be optically coupled to the optical waveguide component 812 through the optical connection structures 8191 and 8192. Note that at this time, the light source component 811 and the electric drive device 814 can be arranged in the same housing. Preferably, the negative pressure pump component 816 can share an electric drive device 814 with the light source component 811 and be arranged in the same housing. The light transmission component 818 can be close to the negative pressure pipe 817, making the whole device more concise and beautiful. It should be noted that although only one light source component 811 is drawn in the figure, it can include multiple light emitting devices, and each light emitting device can also have its own corresponding light transmission component.

[0215] An example of an optical connection structure 1000 for connecting a light transmission component and a light source component is shown in FIG. Fig.10aAs shown, at this time, multiple light source components 1001 are connected to the electric drive device 1004 through the electrical connector 10041 and are installed together in the housing 1006. The light transmission component 1002 is inserted through the reserved channel 1005 and directly contacts the light source component 1001. At this time, the light emitted by the light source component 1001 can be optically coupled with the light transmission component 1002, and the reserved channel 1005 is an optical connection structure. In order to fix the light transmission component 1002, the channel 1005 can also include a fixing device 10050, including but not limited to a spring sheet, a buckle, a rubber ring, etc. At this time, the light source component 1001 and the light transmission component 1002 can be easily disassembled. For example, the separation of the two can be achieved by simply pulling the light transmission component 1002 out of the channel 1005. As shown in FIG. Fig.10a The optical connection structure 1000 shown can also be used to connect a light-conducting component with an optical waveguide component, that is, a hole is opened in the optical waveguide component, and then the light-conducting component 1002 is directly inserted, which can realize the detachable separation of the light-conducting component and the optical waveguide component. Another example of an optical connection structure 1010 for connecting a light-conducting component with an optical waveguide component is shown in FIG. Fig.10b As shown, the light transmission component 1012 is connected to the optical waveguide component 1013 by an optical glue 1015. At this time, the optical glue is an optical connection structure, and the connection between the light transmission component 1012 and the optical waveguide component 1013 is irreversible, and the two cannot be easily separated. The optical connection structure of the present invention is not limited to the above situation. Any structure known in the prior art that can be used to connect the light source component and the light transmission component, or the structure that can be used to connect the light transmission component and the optical waveguide component can be used in the present invention. The above situation is only an example.

[0216] like Figure 8bThe advantage of the negative pressure phototherapy device 810 shown is that the optical connection structure 8190, 8191 and 8192 allows the light source to be separated from other components. When the absorption layer 813 is saturated, the entire optical waveguide component 812, the absorption layer 813, the negative pressure giving layer 815, and even the negative pressure pump component 816 and the negative pressure pipeline 817 can be discarded, replaced with new components, and connected to the original light source component 811 (and the electric drive device 814), and the treatment course is repeated. Because the service life of light sources such as LEDs and lasers is very long, and other components generally need to be discarded and replaced after 7 days, at this time the light source is far from reaching the service life, so the light source can be retained and reused, which is both economical and environmentally friendly. Generally, the optical waveguide component can be made of materials such as plastic and silicone. Preferably, the optical waveguide component is a flexible material and has a low preparation cost. It is also easy to integrate different film layers, doped nanomaterials, etc. during the preparation process. The most important thing is that the optical waveguide component can be formed in a pre-cast model to achieve a three-dimensional structure that can better fit human skin. Down-conversion materials are usually low-cost and can be prepared using a solution method, which matches the flexible preparation process. Therefore, both parts can achieve low cost and high fit. Since the optical connection structure is detachable, the optical waveguide components, down-conversion layer, etc. are disposable, which can also ensure hygiene and avoid cross infection.

[0217] The cross-sectional schematic diagram of the negative pressure phototherapy device 820 according to the fifth embodiment of the present invention is shown in FIG. Figure 8c As shown, it includes at least one light source component 821, an optical waveguide component 822, an absorption layer 823, an electric driving device 824, a negative pressure providing layer 825, a negative pressure pump component 826 and a negative pressure pipeline 827. The optical waveguide component 822 converts the light emitted by the light source component 821 into a surface light source to form a light-emitting surface. Among them, a series of channels 8220 are also arranged on the optical waveguide component 822. The light source component 821 is connected to the electric driving device 824 through an electrical connector 8240. The negative pressure providing layer 825 may further include a series (at least one) of microchannels and channels to connect them to the outlet 8270 of the negative pressure pipeline 827. Figure 8aOn the basis of the negative pressure phototherapy device 800 shown, a skin-friendly layer 828 is provided between the optical waveguide component 822 and the part to be treated. The material of the skin-friendly layer can be selected from a mesh fabric composed of natural cotton, silk, linen, etc. to ensure light transmittance; it can also be a transparent material such as medical silicone, preferably transparent medical silicone. A series of channels are also provided on the skin-friendly layer 828 (the channels run through the upper and lower surfaces of the skin-friendly layer 828), and are aligned one by one with the channels of the optical waveguide component 822. Preferably, the channels on the skin-friendly layer 828 and the optical waveguide component 822 are formed at the same time, for example, by laser etching at the same time. When using this negative pressure phototherapy device, the negative pressure pump can be turned on at the same time to promote wound healing, and the light source component can be turned on to use light to further stimulate cell regeneration, further accelerate wound healing and reduce scars. Of course, it can also be used independently at different stages of wound healing.

[0218] The negative pressure phototherapy device disclosed in the present invention sets a light source outside the area to be treated, so that the light emitted by the light source is incident from the edge of the optical waveguide component to form a light-emitting surface. Therefore, a hole can be made on the optical waveguide component without affecting the light source setting, so that it can be integrated with the negative pressure device to achieve the combination of negative pressure therapy and phototherapy. Not only can negative pressure be used to accelerate wound closure, but phototherapy can also be used to further accelerate cell regeneration and reduce scars. In addition, the optical waveguide component used in the present invention is in a planar shape, which can convert a point light source or a line light source into a planar light source, thereby achieving large-area treatment.

[0219] On the other hand, the negative pressure phototherapy device disclosed in the present invention can directly use a surface light source such as a flexible OLED light-emitting panel, and form a series of holes thereon to allow gas and liquid to pass through. Combined with a negative pressure system, it can accelerate wound healing and fade scars.

[0220] It should be understood that the various embodiments described herein are only examples and are not intended to limit the scope of the present invention. Therefore, as will be apparent to those skilled in the art, the claimed invention may include variations of the specific embodiments and preferred embodiments described herein. Many of the materials and structures described herein may be replaced with other materials and structures without departing from the spirit of the present invention. It should be understood that the various theories about why the present invention works are not intended to be restrictive.

Claims

1. A negative pressure phototherapy device, comprising: Electric drive device, luminous surface component, absorption layer, negative pressure providing layer, negative pressure pump component, negative pressure pipeline; in, The light-emitting surface component includes a light source component and an optical waveguide component; The light source component is electrically connected to the electric drive device, The light source component is connected to the optical waveguide component, and the light emitted by the light source component is incident from the edge of the optical waveguide component. The negative pressure pump component is connected to the negative pressure pipeline, and the negative pressure providing layer is provided with a negative pressure pipeline. The absorption layer is arranged between the negative pressure providing layer and the part to be treated. The optical waveguide component is arranged between the absorption layer and the part to be treated, and the optical waveguide component is provided with at least one channel penetrating the upper and lower surfaces thereof. The optical waveguide component is planar and has at least one light-emitting surface, the area of ​​which is not less than 5 cm 2 .

2. The negative pressure phototherapy device according to claim 1, characterized in that: The optical waveguide component includes an optical waveguide body, and the optical waveguide component is flexible; preferably, the optical waveguide component has a three-dimensional structure; preferably, the material of the optical waveguide body includes a transparent material with a high refractive index; the refractive index of the transparent material is greater than or equal to 1.4, preferably, greater than or equal to 1.49; preferably, the material of the optical waveguide body includes any one of flexible glass, silicone, PET, PEN, PMMA, and PI; or, the optical waveguide body is an optical waveguide with a grating structure on the surface.

3. The negative pressure phototherapy device according to claim 2, characterized in that: The optical waveguide component further comprises a scattering structure; preferably, the scattering structure is arranged on one side or inside the optical waveguide body or a combination thereof; preferably, the scattering structure comprises a scattering layer and / or scattering points; preferably, the scattering structure comprises nanoparticles; preferably, the nanoparticles comprise oxide particles, metal particles, organic particles, or a combination thereof; preferably, the oxide particles comprise SiO x , Al2O3, CaCO3, BaSO4, TiO2, ZrO, ZnO or more; the metal particles include one or more of Ag, Pt, Cu, Au; the organic particles include one or more of polystyrene microspheres, polymethyl methacrylate, silica gel; preferably, the diameter of the nanoparticles is between 10nm-1000nm, preferably, between 100-1000nm, more preferably, between 100-800nm.

4. The negative pressure phototherapy device according to claim 2, characterized in that: The optical waveguide component further includes a reflective layer, which is arranged on a side of the optical waveguide body away from the part to be treated; preferably, the reflective layer is a film layer with high reflectivity, and the reflectivity of the film layer is greater than or equal to 50%, preferably, greater than or equal to 70%, and more preferably, greater than or equal to 90%; preferably, the reflective layer includes any one or more of a metal reflective layer, a metal oxide reflective layer, and a non-metallic reflective layer.

5. The negative pressure phototherapy device according to claim 1, characterized in that: The light source component includes two light emitting devices. Preferably, the peak wavelengths of light emitted by the two light emitting devices differ by 50 nm or more.

6. The negative pressure phototherapy device according to claim 2, characterized in that: The peak wavelength of light emitted by the light-emitting surface is in the range of 400-500nm, and the optical waveguide component further comprises a down-conversion layer, which is arranged on one side of the optical waveguide body; preferably, the material of the down-conversion layer comprises one or more of fluorescent materials, perovskite materials, quantum dot materials, organic small molecule luminescent materials, and graphene.

7. The negative pressure phototherapy device according to claim 1, characterized in that: further comprising at least one light-conducting component and at least one optical connection structure; The light source component is connected to the light transmission component, The light-conducting component is connected to the light-waveguide component, The optical connection structure is arranged between the light source component and the light transmission component, and / or between the light transmission component and the optical waveguide component, and at least one optical connection structure enables the two connected components to be detachably separated.

8. The negative pressure phototherapy device according to claim 7, characterized in that: The optical connection structure comprises a hole, and the light-conducting component is inserted into the hole; preferably, the optical connection structure further comprises a spring sheet, a buckle, a rubber ring or a combination thereof.

9. The negative pressure phototherapy device according to claim 1, characterized in that: The light therapy device further comprises a housing, in which the light source component and the electric drive device are integrated.

10. The negative pressure phototherapy device according to claim 1, characterized in that: The light source part is disposed at an edge of the optical waveguide part.

11. A negative pressure phototherapy device, comprising: Electric drive device, luminous surface component, absorption layer, negative pressure providing layer, negative pressure pump component, negative pressure pipeline; in, The light-emitting surface component includes at least one flexible OLED light-emitting panel; The flexible OLED light-emitting panel is electrically connected to the electric drive device, The negative pressure pump component is connected to the negative pressure pipeline, and the negative pressure providing layer is provided with a negative pressure pipeline. The absorption layer is arranged between the negative pressure providing layer and the part to be treated. The at least one flexible OLED light-emitting panel is arranged between the absorption layer and the part to be treated, and the flexible OLED light-emitting panel is provided with at least one hole penetrating the upper and lower surfaces thereof, The flexible OLED light-emitting panel has at least one light-emitting surface, the area of ​​which is not less than 5 cm 2 .

12. The negative pressure phototherapy device according to claim 11, characterized in that: The peak wavelengths of light emitted by the light-emitting surfaces differ by 50 nm or more. Preferably, the peak wavelengths of light emitted by at least one flexible OLED light-emitting panel differ by 50 nm or more.

13. The negative pressure phototherapy device according to claim 11, characterized in that: The peak wavelength of light emitted by the light-emitting surface is in the range of 400-500nm, and the light-emitting surface component further includes a down-conversion layer, which is arranged between the light-emitting surface and the part to be treated; preferably, the material of the down-conversion layer includes one or more of fluorescent materials, perovskite materials, quantum dot materials, organic small molecule luminescent materials, and graphene.

14. The negative pressure phototherapy device according to claim 1 or 11, characterized in that: The peak wavelength of the light emitted by the light emitting surface is within the range of 400-1400nm; preferably, the peak wavelength of the light emitted by the light emitting surface is within the range of 600-1400nm.

15. The negative pressure phototherapy device according to claim 1 or 11, characterized in that: The light-emitting surface component further includes a skin-friendly layer, which is arranged between the light-emitting surface and the part to be treated; preferably, the material of the skin-friendly layer includes any one of cotton, silk, linen, gauze, and medical silicone; preferably, the material of the skin-friendly layer is transparent medical silicone.

16. The negative pressure phototherapy device according to claim 1 or 11, characterized in that: The luminous area of ​​the luminous surface is not less than 10cm 2 , preferably, not less than 20cm 2 .

17. The negative pressure phototherapy device according to claim 1 or 11, characterized in that: The luminous uniformity of the luminous surface is within the range of 1±0.5, preferably, within the range of 1±0.3, and more preferably, within the range of 1±0.

1.

18. The negative pressure phototherapy device as described in claim 1 or 11, characterized in that: The cross-sectional shape of the hole is circular, polygonal or elliptical; preferably, the cross-sectional shape of the hole is circular, and the diameter of the hole is between 0.1-2 mm, preferably, between 0.2-1 mm, more preferably, between 0.2-0.5 mm; the shortest distance between the centers of the holes is between 1-10 mm, preferably, between 1-5 mm.

19. The negative pressure phototherapy device according to claim 1 or 11, characterized in that: The negative pressure pump component further includes a collecting component, and the collecting component is connected to the negative pressure pipeline.

20. The negative pressure phototherapy device according to claim 1 or 11, characterized in that: The electric drive device is electrically connected to the negative pressure pump component.

21. The negative pressure phototherapy device according to claim 1 or 11, characterized in that: The preparation materials of the absorption layer include gauze, cotton cloth, non-woven fabric, bamboo fiber, pulp and a combination thereof.

22. The negative pressure phototherapy device according to claim 1 or 11, characterized in that: The invention further comprises a filter layer, wherein the filter layer is arranged between the absorption layer and the negative pressure imparting layer.

23. The negative pressure phototherapy device according to claim 1 or 11, wherein: The edges of the holes are sealed by melting the protective film and / or the flexible film.

24. The negative pressure phototherapy device of claim 1 or 11, wherein the hole is formed by a method selected from the following group: stamping, dry etching, wet etching, laser etching, plasma bombardment, and a combination thereof.

25. The negative pressure phototherapy device according to claim 1 or 11, wherein: The area ratio of the hole to the light-emitting surface is between 0.01% and 50%; Preferably, the area ratio of the hole to the light-emitting surface is between 0.1% and 30%; More preferably, the area ratio of the hole to the light emitting surface is between 0.2% and 10%.

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