Low-temperature storage device with stable structure

By introducing internal buffer stabilization components and rotational regulation components into the cryopreservation device, the problems of device structure instability and cell precipitation and agglomeration are solved, and effective protection and efficient preservation of stem cells are achieved.

CN222148811UActive Publication Date: 2024-12-13SHANDONG HUAHANG MEDICAL TECH CO LTD
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Patent Information

Application Number
CN202420137159.7
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-01-19
Publication Date
2024-12-13
Estimated Expiration
2034-01-19

AI Technical Summary

Technical Problem

The existing low-temperature storage devices lack buffer support structure, which leads to damage to stem cells during external impact, and the fixed storage cylinder is prone to precipitation and agglomeration in a low-temperature environment, affecting the quality and vitality of storage.

Method used

A cryostat storage device including an internal buffer stabilization assembly and a rotational adjustment assembly is designed. The buffer assembly absorbs impact through elastic material and a transmission system, and the rotational adjustment assembly maintains the cell suspension state through continuous rotation to prevent precipitation and agglomeration.

Benefits of technology

Effectively prevent stem cells from being damaged by external shock or vibration, maintain a stable state of cells, and maintain a more stable and uniform low-temperature environment through rotation, maximizing the survival rate and preservation effect of cells.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model relates to the technical field of low-temperature storage devices, in particular to a low-temperature storage device with a stable structure. The technical problems that in the using process of the low-temperature preservation device, a protection structure for buffering and supporting is lacked in the low-temperature preservation device, internal stem cells can be unnecessarily damaged when the low-temperature preservation device is subjected to external impact, and an internal storage barrel is mostly of a fixed structure and is prone to precipitation and caking in a low-temperature environment after being stored for a long time are solved. According to the technical scheme, the low-temperature preservation device with the stable structure comprises a heat preservation outer cylinder, a heat preservation inner container, an internal buffering and stabilizing assembly, a stem cell storage inner cylinder, an internal rotation adjusting assembly and a low-temperature generator. According to the stem cell storage device, extra supporting force can be provided by arranging the internal buffering and stabilizing assembly, external impact or vibration energy can be absorbed, the device is prevented from being deformed or broken due to external force or vibration in the storage process, stem cells in the storage barrel are kept in a stable state, and the stem cells are prevented from being damaged unnecessarily.
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Description

Technical Field

[0001] The utility model relates to the technical field of low-temperature storage devices, in particular to a low-temperature storage device with a stable structure. Background Art

[0002] Stem cells are special cells with the ability to self-replicate and differentiate. They can develop into various cell types through different differentiation pathways and have important medical and scientific research value. After stem cells are extracted, they need to be stored in an extremely low temperature environment to prolong the survival time of stem cells. Therefore, a low-temperature preservation device for stem cells is needed. However, when the existing low-temperature preservation device is in use, the internal protective structure of the buffer support is lacking, resulting in unnecessary damage or denaturation of the stem cells stored inside when the device is subjected to external impact. In addition, the internal storage tube is mostly a fixed structure. After long-term storage, stem cells are prone to precipitation and agglomeration in a low-temperature environment, which is not conducive to later use and research, thereby affecting their preservation quality and vitality. Therefore, it is urgent to set up a low-temperature preservation device with a stable protective structure to improve the internal structural strength, effectively prevent the influence of external impact on the internal stem cells, and prevent unnecessary damage to the stem cells. A structure that allows the storage tube to rotate is added to prevent the internal stem cells from precipitation and agglomeration. Utility Model Content

[0003] In order to overcome the problem that the low-temperature preservation device lacks a protective structure for buffering support during use, the stem cells inside will be unnecessary damaged when subjected to external impact, and the internal storage tube is mostly a fixed structure, which is prone to precipitation and agglomeration in a low-temperature environment after long-term storage.

[0004] The technical solution of the utility model is: a structurally stable low-temperature preservation device, comprising a heat-insulating outer cylinder, a heat-insulating inner liner, an internal buffering and stabilizing component, a stem cell storage inner cylinder, an internal rotating and adjusting component, and a low-temperature generator; the heat-insulating inner liner is arranged inside the heat-insulating outer cylinder; the internal buffering and stabilizing component for improving the internal structural stability of the device is arranged inside the heat-insulating outer cylinder; the stem cell storage inner cylinder is arranged at the inner side end of the internal buffering and stabilizing component, and the heat-insulating outer cylinder is arranged inside the heat-insulating outer cylinder for better storing stem cells and increasing the practicality of the device; and the low-temperature generator is installed at the side end of the heat-insulating outer cylinder.

[0005] Preferably, an internal buffer stabilization component can be used to provide additional support force and absorb the energy of external impact or vibration to prevent the device from being deformed or broken due to external force or vibration during storage, thereby keeping the stem cells in the storage barrel in a stable state and preventing the stem cells from unnecessary damage. The internal rotation adjustment component can use rotation to continuously maintain the cell suspension state and prevent cell precipitation and agglomeration. The continuous and stable rotation can provide a more stable and uniform low-temperature environment, thereby maximizing the cell survival rate and preservation effect.

[0006] Preferably, the internal buffer stabilization component includes an adjustment groove, a buffer spring, a pressure-bearing sliding block, a transmission support plate and a protective support plate; an adjustment groove is opened on the inner wall of the thermal insulation liner; a buffer spring is arranged on the inner wall of the adjustment groove, and the buffer spring inside the adjustment groove can make the protective support plate have an elastic range of movement.

[0007] Preferably, the side end of the buffer spring is elastically connected to a pressure-bearing sliding block; the upper end of the pressure-bearing sliding block is fixedly connected to a transmission support plate; the upper end of the transmission support plate is hingedly connected to a protective support plate for supporting the stem cell storage inner cylinder to stabilize it. When impacted by the outside world, the shaking of the stem cell storage inner cylinder is transmitted to the protective support plate; the transmission support plate cooperates with the pressure-bearing sliding block to squeeze toward the buffer spring, which has the effect of dispersing the vibration impact force, supporting and protecting the stem cell storage inner cylinder, and stabilizing the internal structure of the device.

[0008] Preferably, the internal rotation adjustment component includes a first drive motor, a transmission rod, a rotating turntable, a driving latch, a driven concave tooth groove, a stem cell storage drawer, a second drive motor, an adjustment screw, a limiting movable sleeve, a supporting connecting plate and a lifting frame bottom plate; the first drive motor is installed at the lower end of the thermal insulation outer cylinder; a transmission rod is provided at the output end of the first drive motor; a rotating turntable is installed at the upper end of the transmission rod, and the first drive motor can drive the transmission rod to rotate, thereby rotating the rotating turntable.

[0009] Preferably, a driving latch is provided at the upper end of the rotating turntable for rotating the stem cell storage inner cylinder to avoid internal cell deposition; a driven concave tooth groove is installed at the lower end of the stem cell storage inner cylinder for cooperating with the driving latch; and the driving latch and the driven concave tooth groove are meshed, and the rotating turntable causes the driving latch to rotate, and when the driven concave tooth groove at the lower end of the stem cell storage inner cylinder contacts the driving latch, the stem cell storage inner cylinder can rotate.

[0010] Preferably, a stem cell storage drawer is provided inside the stem cell storage inner cylinder; and a plurality of stem cell storage drawers are provided; a second drive motor is installed at the lower end of the heat-insulating outer cylinder; an adjusting screw is provided at the output end of the second drive motor, and the second drive motor can drive the adjusting screw to rotate, thereby making the external limiting movable sleeve move up and down.

[0011] Preferably, the outer end portion of the adjusting screw is threadedly connected to a limiting movable sleeve; the side end portion of the limiting movable sleeve is fixedly connected to a supporting connecting plate for transmission; the side end portion of the supporting connecting plate is fixedly connected to a lifting frame bottom plate for raising the stem cell storage inner cylinder for easy removal, and the limiting movable sleeve drives the supporting connecting plate to move synchronously, so that the lifting frame bottom plate can lift the stem cell storage inner cylinder to a high degree, making it convenient to take out the stem cells stored inside, reducing the risk of accidents caused by improper human operation, and ensuring the safe storage and use of stem cells.

[0012] Beneficial effects of the utility model:

[0013] 1. During the use of the existing cryopreservation device, there is a lack of a buffer support protection structure inside, which causes unnecessary damage or denaturation of the stem cells stored inside the device when the device is subjected to external impact. In addition, the internal storage tube is mostly a fixed structure. After long-term storage, the stem cells are prone to precipitation and agglomeration in a low-temperature environment, which is not conducive to later use and research, thereby affecting their preservation quality and vitality. Therefore, the internal buffer stabilization component can provide additional support force to absorb the energy of external impact or vibration to prevent the device from being deformed or broken due to external force or vibration during storage, keep the stem cells in the storage barrel in a stable state, and prevent the stem cells from being damaged. The internal rotation adjustment component can use rotation to continuously maintain the cell suspension state and prevent the occurrence of cell precipitation and agglomeration. The continuous and stable rotation can provide a more stable and uniform low-temperature environment, thereby maximizing the survival rate and preservation effect of the cells.

[0014] 2. Adjusting the buffer spring inside the groove can make the protective support plate have an elastic range of movement. When impacted by the outside world, the shaking of the stem cell storage inner cylinder is transmitted to the protective support plate; cooperate with the transmission support plate to make the pressure-bearing sliding block squeeze against the buffer spring, which has the effect of dispersing the vibration impact force, plays a role in supporting and protecting the stem cell storage inner cylinder, and makes the internal structure of the device stable;

[0015] 3. The first driving motor can drive the transmission rotating rod to rotate, thereby rotating the rotating turntable, and the rotating turntable rotates the driving latch gear. When the driven concave tooth groove at the lower end of the stem cell storage inner cylinder contacts the driving latch gear, the stem cell storage inner cylinder can rotate. The second driving motor can drive the adjusting screw to rotate, thereby causing the external limiting movable sleeve to move up and down. The limiting movable sleeve drives the supporting connecting plate to move synchronously, so that the lifting frame bottom plate can lift the stem cell storage inner cylinder to a high degree, making it convenient to take out the stem cells stored inside, reducing the risk of accidents caused by improper human operation, and ensuring the safe storage and use of stem cells. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1What is shown is a three-dimensional structural schematic diagram of the low-temperature storage device of the utility model;

[0017] Figure 2 The figure shows a three-dimensional structure diagram of the internal buffer stabilization component of the low-temperature storage device of the utility model;

[0018] Figure 3 The present invention is a schematic diagram of the three-dimensional structure of the first driving motor of the low-temperature storage device;

[0019] Figure 4 The present invention is a schematic diagram of the three-dimensional structure of the driving latch of the low-temperature storage device of the present invention;

[0020] Figure 5 The figure shows a three-dimensional structure diagram of a driven concave tooth groove of a low-temperature storage device of the present invention;

[0021] Figure 6 Shown is a schematic diagram of the three-dimensional structure of the lifting frame bottom plate of the low-temperature storage device of the present invention.

[0022] Explanation of the reference numerals: 1. Insulation outer cylinder; 2. Insulation inner liner; 3. Internal buffer stabilization component; 4. Inner cylinder for stem cell storage; 5. Internal rotation adjustment component; 6. Low-temperature generator; 301. Adjustment groove; 302. Buffer spring; 303. Pressure-bearing sliding block; 304. Transmission support plate; 305. Protection support plate; 501. First drive motor; 502. Transmission rotating rod; 503. Rotating turntable; 504. Driving latch; 505. Driven concave tooth groove; 506. Stem cell storage drawer; 507. Second drive motor; 508. Adjustment screw; 509. Limiting movable sleeve; 510. Support connecting plate; 511. Lifting frame bottom plate. DETAILED DESCRIPTION

[0023] The utility model is further described below in conjunction with the accompanying drawings and embodiments.

[0024] Example 1

[0025] See also Figure 1-Figure 2The utility model provides an embodiment: a low-temperature storage device with a stable structure, including a heat-insulating outer cylinder 1, a heat-insulating inner liner 2, an internal buffering and stabilizing component 3, a stem cell storage inner cylinder 4, an internal rotation adjustment component 5, and a low-temperature generator 6; the heat-insulating outer cylinder 1 is provided with a heat-insulating inner liner 2; the heat-insulating outer cylinder 1 is provided with an internal buffering and stabilizing component 3 for improving the stability of the internal structure of the device; the inner side end of the internal buffering and stabilizing component 3 is provided with a stem cell storage inner cylinder 4, and the heat-insulating outer cylinder 1 is provided with an internal rotation adjustment component 5 for better storage of stem cells and increasing the practicality of the device; the side end of the heat-insulating outer cylinder 1 is installed with a low-temperature generator 6, and the internal buffering and stabilizing component 3 includes an adjustment groove 301, a buffer spring 302, a pressure-bearing sliding block 303, a transmission support plate 304 and a protective support plate 305; An adjusting groove 301 is provided on the inner wall of the heat-insulating inner tank 2; a buffer spring 302 is provided on the inner wall of the adjusting groove 301; the buffer spring 302 inside the adjusting groove 301 can allow the protective support plate 305 to have a range of elastic movement; the side end of the buffer spring 302 is elastically connected to a pressure-bearing sliding block 303; the upper end of the pressure-bearing sliding block 303 is fixedly connected to a transmission support plate 304; the upper end of the transmission support plate 304 is hingedly connected to a protective support plate 305 for supporting the stem cell storage inner cylinder 4 to stabilize it, and when impacted by the outside world, the shaking of the stem cell storage inner cylinder 4 is transmitted to the protective support plate 305; the transmission support plate 304 cooperates with the pressure-bearing sliding block 303 to squeeze the buffer spring 302, which has the effect of dispersing the vibration impact force, supporting and protecting the stem cell storage inner cylinder 4, and stabilizing the internal structure of the device.

[0026] Example 2

[0027] See also Figure 3-Figure 6In this embodiment, the internal rotation adjustment component 5 includes a first driving motor 501, a transmission rotating rod 502, a rotating disk 503, a driving latch 504, a driven concave tooth groove 505, a stem cell storage drawer 506, a second driving motor 507, an adjusting screw 508, a limiting movable sleeve 509, a supporting connecting plate 510 and a lifting frame bottom plate 511; the first driving motor 501 is installed at the lower end of the heat preservation outer cylinder 1; the transmission rotating rod 502 is provided at the output end of the first driving motor 501; the rotating disk is installed at the upper end of the transmission rotating rod 502 503, the first driving motor 501 can drive the transmission rotating rod 502 to rotate, so as to rotate the rotating disk 503, and the upper end of the rotating disk 503 is provided with a driving latch 504 for rotating the stem cell storage inner cylinder 4 to avoid the internal cell deposition; the lower end of the stem cell storage inner cylinder 4 is provided with a driven concave tooth groove 505 for cooperating with the driving latch 504; and the driving latch 504 and the driven concave tooth groove 505 are meshed, and the rotating disk 503 makes the driving latch 504 rotate, and when the driven concave tooth groove 505 at the lower end of the stem cell storage inner cylinder 4 is engaged with the driving latch 504, ... driving latch 504 rotates. When the stem cell storage inner cylinder 4 contacts the driving latch 504, the stem cell storage inner cylinder 4 can rotate, and a stem cell storage drawer 506 is arranged inside the stem cell storage inner cylinder 4; and the stem cell storage drawer 506 is arranged in multiple groups; a second driving motor 507 is installed at the lower end of the heat preservation outer cylinder 1; an adjusting screw 508 is arranged at the output end of the second driving motor 507, and the second driving motor 507 can drive the adjusting screw 508 to rotate, so that the external limiting movable sleeve 509 can move up and down, and the outer end of the adjusting screw 508 is threadedly connected to the limiting movable sleeve The movable sleeve 509; the side end of the limiting movable sleeve 509 is fixedly connected with a supporting connecting plate 510 for transmission; the side end of the supporting connecting plate 510 is fixedly connected with a lifting frame bottom plate 511 for raising the stem cell storage inner cylinder 4 for easy taking, and the limiting movable sleeve 509 drives the supporting connecting plate 510 to move synchronously, so that the lifting frame bottom plate 511 can lift the stem cell storage inner cylinder 4 to a high degree, making it convenient to take out the stem cells stored inside, reducing the risk of accidents caused by improper human operation, and ensuring the safe storage and use of stem cells.

[0028] When working, the buffer spring 302 in the adjusting groove 301 is first used to make the protective support plate 305 have an elastic range of movement. When subjected to external impact, the shaking of the stem cell storage inner cylinder 4 is transmitted to the protective support plate 305; the transmission support plate 304 is used to squeeze the pressure-bearing sliding block 303 toward the buffer spring 302, which has the effect of dispersing the vibration impact force, and plays a role in supporting and protecting the stem cell storage inner cylinder 4, so that the internal structure of the device is stable;

[0029] Finally, the first driving motor 501 can be used to drive the transmission rotating rod 502 to rotate, thereby rotating the rotating turntable 503, and the rotating turntable 503 rotates the driving latch 504. When the driven concave tooth groove 505 at the lower end of the stem cell storage inner cylinder 4 contacts the driving latch 504, the stem cell storage inner cylinder 4 can rotate, and the second driving motor 507 can drive the adjusting screw 508 to rotate, so that the external limiting movable sleeve 509 moves up and down, and the limiting movable sleeve 509 drives the supporting connecting plate 510 to move synchronously, so that the lifting frame bottom plate 511 can lift the stem cell storage inner cylinder 4 to a high degree, so as to facilitate the removal of the stem cells stored inside, reduce the accidental risks caused by improper human operation, and ensure the safe storage and use of stem cells.

[0030] Through the above steps, the internal buffer stabilization component 3 can provide additional support force to absorb the energy of external impact or vibration to prevent the device from being deformed or broken due to external force or vibration during storage, keep the stem cells in the storage barrel in a stable state, and prevent the stem cells from unnecessary damage. The internal rotation adjustment component 5 can use rotation to continuously maintain the cell suspension state and prevent the occurrence of cell precipitation and agglomeration. The continuous and stable rotation can provide a more stable and uniform low-temperature environment, thereby maximizing the survival rate and preservation effect of the cells.

[0031] The embodiments of the present invention are described in detail above in conjunction with the accompanying drawings, but the present invention is not limited to the above embodiments, and various changes can be made within the knowledge scope of those skilled in the art without departing from the purpose of the present invention.

Claims

1. A low-temperature storage device with a stable structure, comprising a heat-insulating outer cylinder (1); characterized in that: The device also comprises a heat-insulating inner liner (2), an internal buffering and stabilizing component (3), a stem cell storage inner cylinder (4), an internal rotation adjusting component (5), and a low-temperature generator (6); the heat-insulating outer cylinder (1) is provided with a heat-insulating inner liner (2); the heat-insulating outer cylinder (1) is provided with an internal buffering and stabilizing component (3) for improving the stability of the internal structure of the device; the inner side end of the internal buffering and stabilizing component (3) is provided with a stem cell storage inner cylinder (4); the heat-insulating outer cylinder (1) is provided with an internal rotation adjusting component (5) for better storage of stem cells and increasing the practicality of the device; and the side end of the heat-insulating outer cylinder (1) is provided with a low-temperature generator (6).

2. A structurally stable cryopreservation device according to claim 1, characterized in that: The internal buffer stabilization component (3) comprises an adjustment groove (301), a buffer spring (302), a pressure-bearing sliding block (303), a transmission support plate (304) and a protective support plate (305); the inner wall of the heat-insulating inner container (2) is provided with an adjustment groove (301); and the inner wall of the adjustment groove (301) is provided with a buffer spring (302).

3. A structurally stable cryogenic storage device according to claim 2, characterized in that: The side end of the buffer spring (302) is elastically connected to a pressure-bearing sliding block (303); the upper end of the pressure-bearing sliding block (303) is fixedly connected to a transmission support plate (304); the upper end of the transmission support plate (304) is hingedly connected to a protective support plate (305) for supporting the stem cell storage inner cylinder (4) to stabilize it.

4. A structurally stable cryopreservation device according to claim 1, characterized in that: The internal rotation adjustment component (5) comprises a first driving motor (501), a transmission rotating rod (502), a rotating disk (503), a driving latch (504), a driven concave tooth groove (505), a stem cell storage drawer (506), a second driving motor (507), an adjustment screw (508), a limit movable sleeve (509), a supporting connecting plate (510) and a lifting frame bottom plate (511); the first driving motor (501) is installed at the lower end of the heat-insulating outer cylinder (1); and the output end of the first driving motor (501) is provided with a transmission rotating rod (502); A rotating disc (503) is installed on the upper end of the transmission rotating rod (502).

5. A structurally stable cryopreservation device according to claim 4, characterized in that: The upper end of the rotating turntable (503) is provided with a driving latch (504) for rotating the stem cell storage inner cylinder (4) to prevent the internal cells from being deposited; the lower end of the stem cell storage inner cylinder (4) is provided with a driven concave tooth groove (505) for cooperating with the driving latch (504); The driving latch teeth (504) and the driven concave tooth grooves (505) are meshed with each other.

6. A structurally stable cryopreservation device according to claim 5, characterized in that: A stem cell storage drawer (506) is arranged inside the stem cell storage inner cylinder (4); and a plurality of stem cell storage drawers (506) are arranged; a second drive motor (507) is installed at the lower end of the heat preservation outer cylinder (1); and an adjusting screw (508) is arranged at the output end of the second drive motor (507).

7. A structurally stable cryopreservation device according to claim 6, characterized in that: The outer end of the adjusting screw rod (508) is threadedly connected to a limit movable sleeve (509); the side end of the limit movable sleeve (509) is fixedly connected to a supporting connecting plate (510) for transmission.

8. A structurally stable cryopreservation device according to claim 7, characterized in that: A lifting frame bottom plate (511) is fixedly connected to the side end of the supporting connecting plate (510) and is used to lift the stem cell storage inner cylinder (4) for easy removal.