Liquid phase adsorption chromatographic separation column

Abstract

The utility model discloses a liquid phase adsorption chromatographic separation column, which comprises a column tube, a first sieve plate fixedly connected to the inner side of the column tube, a second sieve plate fixedly connected to the inner side of the column tube, a third sieve plate fixedly connected to the inner side of the column tube, a first filler arranged between the first sieve plate and the second sieve plate, and a second filler arranged between the second sieve plate and the third sieve plate. In the using process, after the upper column head and the lower column head are installed on the column pipe correspondingly, the supporting spring drives the push rod to move through the sliding block under the action of the elastic force of the supporting spring, and the push rod drives the first hook-and-loop fastener to move through the push plate; the first hook-and-loop fastener drives the sealing gaskets to move through the second hook-and-loop fastener, the upper sealing gasket is tightly attached to the upper column head, the lower sealing gasket is tightly attached to the lower column head, the sealing gaskets are made of rubber materials, the sealing effect is good, and therefore the sealing performance of the connecting positions of the upper column head and the lower column head and the column pipe can be improved in the using process; and the leakage condition is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of chromatographic separation columns, in particular to a liquid phase adsorption chromatographic separation column. Background Art

[0002] Liquid adsorption chromatography separation technology is a high-efficiency physical separation technology. Its core component is the chromatographic separation column. The separation principle is to dissolve the mixed component sample in a mobile phase. The mobile phase flows through the chromatographic filler filled in the chromatographic separation column at a certain flow rate under a large pressure. Due to the different adsorption forces of the chromatographic filler on different components, different components will flow through the chromatographic filler at different flow rates, and the time of component outflow and the content of the component will be detected in the detector of the liquid chromatograph, so as to achieve the purpose of separation and detection. The chromatographic column is generally made of high-grade stainless steel with a smooth inner wall. The function of the sieve plate is to hold the solid phase adsorbent to prevent it from flowing out of the separation column and interfering with the detection effect.

[0003] According to CN 202141704 U, a liquid adsorption chromatography separation column is disclosed, which includes: a bracket, which is arranged on the inner wall of the column tube and is used to carry a movable sieve plate; the movable sieve plate is arranged on the sieve plate bracket on the inner wall of the column tube and is used to carry a filler, and different fillers are filled on both sides of the movable sieve plate. Through this structure, an effect of simultaneously detecting and analyzing two components in one detection operation is achieved, thereby reducing the number of detection times, reducing detection costs, increasing detection speed, and improving detection efficiency.

[0004] However, there are some problems when using the device. When using the device, the column head and the column tube are threadedly connected, there is a gap at the connection between the column head and the column tube, the sealing is poor, and leakage is prone to occur. For the problems in the relevant technology, no effective solution has been proposed yet. Utility Model Content

[0005] In view of the problems in the related technology, the utility model proposes a liquid adsorption chromatographic separation column to overcome the above technical problems existing in the existing related technology.

[0006] To this end, the specific technical solutions adopted by the utility model are as follows:

[0007] A liquid adsorption chromatography separation column, comprising a column tube, a first sieve plate fixedly connected to the inner side of the column tube, a second sieve plate fixedly connected to the inner side of the column tube, a third sieve plate fixedly connected to the inner side of the column tube, a first filler disposed between the first sieve plate and the second sieve plate, and a second filler disposed between the second sieve plate and the third sieve plate;

[0008] A sleeve rod is provided on the inner side of the column tube, and the sleeve rod is fixedly connected to the column tube. A slider is provided on the inner side of the sleeve rod, and the slider is slidably connected to the sleeve rod. A push rod is provided on the top of the slider, and the push rod is fixedly connected to the slider. A supporting spring is provided at the bottom of the slider, and a push plate is fixedly connected to the other end of the push rod, and the push plate is slidably connected to the column tube.

[0009] As a further solution of the utility model, an upper column head is provided on the column tube, and the upper column head is threadedly connected to the column tube.

[0010] As a further solution of the utility model, a lower column head is provided at the bottom of the column tube, and the lower column head is threadedly connected to the column tube.

[0011] As a further solution of the utility model, one end of the support spring is fixedly connected to the slider, and the other end of the support spring is fixedly connected to the sleeve rod.

[0012] As a further solution of the utility model, the push rod passes through the sleeve rod, and the push rod is slidably connected to the sleeve rod.

[0013] As a further solution of the utility model, a first Velcro is provided on the top of the push plate, the first Velcro is fixedly connected to the push plate, a second Velcro is provided on the top of the first Velcro, and a sealing gasket is provided on the top of the second Velcro.

[0014] As a further solution of the utility model, the sealing pad is fixedly connected to the second Velcro, and the sealing pad is made of rubber material.

[0015] The beneficial effects of the utility model are:

[0016] 1. Through the set sleeve rod, push rod, support spring and sealing gasket, after the upper column head and the lower column head are respectively installed on the column tube during use, the support spring drives the push rod to move through the slider under the action of its own elastic force, the push rod drives the first Velcro to move through the push plate, and the first Velcro drives the sealing gasket to move through the second Velcro, so that the upper sealing gasket is tightly attached to the upper column head, and the lower sealing gasket is tightly attached to the lower column head. Moreover, the sealing gasket is made of rubber material and has a good sealing effect, so that the sealing performance of the connection between the upper column head and the lower column head and the column tube can be improved during use, and no leakage will occur;

[0017] 2. By setting the first Velcro, the second Velcro and the sealing gasket, when the sealing gasket is damaged and needs to be replaced during use, the sealing gasket and the second Velcro can be peeled off from the first Velcro according to their own characteristics, and the sealing gasket can be removed, and then the second Velcro on the new sealing gasket can be glued to the first Velcro, and the sealing gasket can be installed to complete the replacement of the sealing gasket. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0019] Figure 1 It is a schematic diagram of the overall structure of a liquid adsorption chromatography separation column according to an embodiment of the utility model;

[0020] Figure 2 It is a schematic diagram of the installation structure of the second sieve plate of a liquid adsorption chromatography separation column according to an embodiment of the utility model;

[0021] Figure 3 A liquid adsorption chromatography separation column according to an embodiment of the utility model Figure 2 A schematic diagram of the structure at A;

[0022] Figure 4 It is a schematic diagram of the installation structure of a slider of a liquid adsorption chromatography separation column according to an embodiment of the utility model.

[0023] In the figure: 1. column tube; 2. upper column head; 3. lower column head; 4. first sieve plate; 5. second sieve plate; 6. third sieve plate; 7. first filler; 8. second filler; 9. sleeve rod; 10. slider; 11. push rod; 12. support spring; 13. push plate; 14. first Velcro; 15. second Velcro; 16. sealing gasket. DETAILED DESCRIPTION

[0024] To further illustrate each embodiment, the present invention provides drawings, which are part of the disclosure of the present invention and are mainly used to illustrate the embodiments. They can be used in conjunction with the relevant descriptions in the specification to explain the operating principles of the embodiments. With reference to these contents, ordinary technicians in the field should be able to understand other possible implementation methods and advantages of the present invention. The components in the figures are not drawn to scale, and similar component symbols are generally used to represent similar components.

[0025] According to an embodiment of the utility model, a liquid adsorption chromatography separation column is provided.

[0026] Please refer to the instruction manual Figure 1-4According to an embodiment of the utility model, a liquid adsorption chromatography separation column comprises a column tube 1, a first sieve plate 4 is fixedly connected to the inner side of the column tube 1, a second sieve plate 5 is fixedly connected to the inner side of the column tube 1, a third sieve plate 6 is fixedly connected to the inner side of the column tube 1, a first filler 7 is arranged between the first sieve plate 4 and the second sieve plate 5, a second filler 8 is arranged between the second sieve plate 5 and the third sieve plate 6, this arrangement can detect the content of specific components in the sample, a sleeve rod 9 is arranged inside the column tube 1, the sleeve rod 9 is fixedly connected to the column tube 1, a slider 10 is arranged inside the sleeve rod 9, the slider 10 is slidably connected to the sleeve rod 9, a push rod 11 is arranged on the top of the slider 10, the push rod 11 is fixedly connected to the slider 10, a support spring 12 is arranged at the bottom of the slider 10, the other end of the push rod 11 is fixedly connected to a push plate 13, and the push plate 13 is slidably connected to the column tube 1.

[0027] In one embodiment, please refer to the attached specification Figure 1 and 2 As a further solution of the utility model, an upper column head 2 is provided on the column tube 1, and the upper column head 2 is threadedly connected to the column tube 1. A lower column head 3 is provided at the bottom of the column tube 1, and the lower column head 3 is threadedly connected to the column tube 1. This arrangement facilitates the installation of the upper column head 2 and the lower column head 3 on the column tube 1.

[0028] In one embodiment, please refer to the attached specification Figure 3 and 4 As a further solution of the utility model, one end of the support spring 12 is fixedly connected to the slider 10, and the other end of the support spring 12 is fixedly connected to the sleeve rod 9. The push rod 11 penetrates the sleeve rod 9, and the push rod 11 is slidably connected to the sleeve rod 9. This arrangement enables the sealing gasket 16 to fit tightly against the upper column head 2 and the lower column head 3 respectively.

[0029] In one embodiment, please refer to the attached specification Figure 2 and 3 As a further solution of the utility model, a first Velcro 14 is provided on the top of the push plate 13, and the first Velcro 14 is fixedly connected to the push plate 13. A second Velcro 15 is provided on the top of the first Velcro 14, and a sealing gasket 16 is provided on the top of the second Velcro 15. The sealing gasket 16 is fixedly connected to the second Velcro 15, and the sealing gasket 16 is made of rubber material. This arrangement of the sealing gasket 16 has a good sealing effect and is convenient for replacing the sealing gasket 16.

[0030] During use, after the upper column head 2 and the lower column head 3 are respectively installed on the column tube 1, the support spring 12 drives the push rod 11 to move through the slider 10 under the action of the elastic force of the support spring 12 itself, and the push rod 11 drives the first magic patch 14 to move through the push plate 13, and the first magic patch 14 drives the sealing gasket 16 to move through the second magic patch 15, so that the upper sealing gasket 16 is tightly attached to the upper column head 2, and the lower sealing gasket 16 is tightly attached to the lower column head 3. Moreover, the sealing gasket 16 is made of rubber material with good sealing effect, so that the sealing performance of the connection between the upper column head 2 and the lower column head 3 and the column tube 1 can be improved during use, and leakage will not occur. When in use, the sample enters the column tube 1 through the upper column head 2, and the sample first passes through the first filler 7. Due to the specificity of the first filler 7, a certain One component has properties, and then the sample passes through the second filler 8, and according to the specificity of the second filler 8, it adsorbs another component. Due to the different adsorption properties of the two components in different fillers, the time for flowing out of the chromatographic column will also be different, and finally the specific component content and the time peak of flowing out of the chromatographic column are detected in the detector. When the sealing gasket 16 is damaged and needs to be replaced during use, the upper column head 2 and the lower column head 3 are removed, and then the sealing gasket 16 and the second Velcro 15 can be removed from the first Velcro 14 according to their own properties, and the sealing gasket 16 can be removed, and then the second Velcro 15 on the new sealing gasket 16 is glued to the first Velcro 14, and the sealing gasket 16 can be installed to complete the replacement of the sealing gasket 16.

[0031] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A liquid adsorption chromatography separation column, comprising a column tube (1), characterized in that: A first sieve plate (4) is fixedly connected to the inner side of the column tube (1), a second sieve plate (5) is fixedly connected to the inner side of the column tube (1), a third sieve plate (6) is fixedly connected to the inner side of the column tube (1), a first filler (7) is provided between the first sieve plate (4) and the second sieve plate (5), and a second filler (8) is provided between the second sieve plate (5) and the third sieve plate (6); A sleeve rod (9) is provided inside the column tube (1), and the sleeve rod (9) is fixedly connected to the column tube (1); a slider (10) is provided inside the sleeve rod (9), and the slider (10) is slidably connected to the sleeve rod (9); a push rod (11) is provided on the top of the slider (10), and the push rod (11) is fixedly connected to the slider (10); a support spring (12) is provided at the bottom of the slider (10); the other end of the push rod (11) is fixedly connected to a push plate (13), and the push plate (13) is slidably connected to the column tube (1).

2. A liquid adsorption chromatography separation column according to claim 1, characterized in that: An upper column head (2) is provided on the column tube (1), and the upper column head (2) is threadedly connected to the column tube (1).

3. A liquid adsorption chromatography separation column according to claim 1, characterized in that: A lower column head (3) is provided at the bottom of the column tube (1), and the lower column head (3) is threadedly connected to the column tube (1).

4. A liquid adsorption chromatography separation column according to claim 1, characterized in that: One end of the support spring (12) is fixedly connected to the slider (10), and the other end of the support spring (12) is fixedly connected to the sleeve rod (9).

5. A liquid adsorption chromatography separation column according to claim 1, characterized in that: The push rod (11) passes through the sleeve rod (9), and the push rod (11) is slidably connected to the sleeve rod (9).

6. A liquid adsorption chromatography separation column according to claim 1, characterized in that: A first Velcro (14) is provided on the top of the push plate (13), the first Velcro (14) is fixedly connected to the push plate (13), a second Velcro (15) is provided on the top of the first Velcro (14), and a sealing pad (16) is provided on the top of the second Velcro (15).

7. A liquid adsorption chromatography separation column according to claim 6, characterized in that: The sealing pad (16) is fixedly connected to the second Velcro (15), and the sealing pad (16) is made of rubber material.

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