Microwave synthesis nano-liposome preparation device

Abstract

The utility model discloses a microwave synthesis nano-liposome preparation device which comprises a working table, a microwave part is arranged at the top of the working table, a storage box is arranged at the top of the microwave part, a filtering assembly is arranged on one side of the microwave part, and a conveying assembly used for conveying materials is arranged at the joint of the storage box and the filtering assembly. The conveying assembly comprises a conveying pipe arranged at the bottom of the storage box. Through the design of the microwave part, the material storage box, the conveying assembly, the filtering assembly and the freezing part, the microwave part, the material storage box and the filtering assembly are connected through the conveying assembly, materials in the material storage box are directly conveyed into the microwave part to be synthesized and prepared into flowing nano-liposome during use, and then the flowing nano-liposome is filtered through the filtering assembly; and finally, freeze-drying the filtered nano-liposome to prepare nano-liposome powder, and directly connecting a plurality of devices to reduce the contact between the nano-liposome and air.

Description

Technical Field

[0001] The utility model relates to the technical field of preparation devices, in particular to a microwave synthesis nano liposome preparation device. Background Art

[0002] When preparing liposomes by microwave-freeze drying, the existing nanoliposome preparation device cannot prepare from raw materials to freeze-dried powder in one line. During the preparation, it is necessary to first prepare the nanoliposomes by a microwave device, and then filter and freeze-dry the nanoliposomes by a filtering device and a freeze-drying device. When preparing the liposomes, the prepared liposomes need to be transported from multiple devices, thereby increasing the contact between the liposomes and the air, thereby increasing the occurrence of their oxidation reactions, and thus affecting the stability of the liposomes. Utility Model Content

[0003] The purpose of the utility model is to provide a microwave synthesis nano liposome preparation device to solve the problems raised in the above background technology.

[0004] To achieve the above-mentioned purpose, the utility model provides the following technical scheme: a microwave synthetic nanoliposome preparation device, comprising a workbench, a microwave component is arranged on the top of the workbench, a material storage box is arranged on the top of the microwave component, a filtering component is arranged on one side of the microwave component, a conveying component for conveying materials is arranged at the connection between the material storage box and the filtering component, the conveying component comprises a transmission pipe arranged at the bottom of the material storage box, the transmission pipe is connected through the top of the microwave component, the filtering component comprises a box body fixedly connected to one side of the microwave component, a filter frame is arranged inside the box body, and a freezing component for freeze-drying materials is arranged on one side of the workbench.

[0005] Preferably, a motor for rotating the filter frame is disposed at the bottom of the filter frame, an opening piece is disposed at the top of the box body, and the motor is fixedly connected to the top of the workbench.

[0006] Preferably, a feed pump is fixedly connected to the top of the microwave component, one end of the transmission tube away from the storage box is fixedly connected to the input end of the feed pump, and a first feed pipe is provided at the output end of the feed pump.

[0007] Preferably, the opening member includes a box cover arranged on the top of the box body, a first sealing ring is inserted and connected in the middle of the box cover, the first material delivery pipe is inserted and connected in the middle of the first sealing ring, a second sealing ring is arranged at the bottom of the first sealing ring, a sealing groove is opened on the top of the box body, and the second sealing ring is inserted and connected inside the sealing groove.

[0008] Preferably, a second material delivery pipe is provided on one side of the box body, and the second material delivery pipe is provided at the input end of the refrigeration component.

[0009] Preferably, support frames for supporting the storage box are arranged at the four corners of the bottom end of the storage box, a support groove is opened at the top of the support frame, the storage box is inserted and connected inside the support groove, and the support frame is fixedly connected to the top of the microwave component.

[0010] Technical effects and advantages of the utility model:

[0011] The utility model connects the microwave component, the material storage box, the filter component and the freezing component through the design of the microwave component, the material storage box and the filter component through the conveying component. When in use, the material in the material storage box is directly conveyed to the microwave component for synthesis to prepare flowing nano liposomes, which are then filtered through the filtering component. Finally, the filtered nano liposomes are freeze-dried to prepare nano liposome powder. By directly connecting multiple devices, the contact between the nano liposomes and the air is reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 It is a schematic diagram of the three-dimensional structure of the utility model.

[0013] Figure 2 It is a front sectional structural schematic diagram of the utility model.

[0014] Figure 3 For this utility model Figure 2 A schematic diagram of the enlarged structure of part A.

[0015] Figure 4 It is a partial three-dimensional structural schematic diagram of the utility model.

[0016] In the figure: 1. workbench; 2. microwave component; 3. storage box; 4. conveying assembly; 401. transmission pipe; 402. feed pump; 403. first feed pipe; 5. filtering assembly; 501. box body; 502. box cover; 503. filter frame; 504. motor; 505. first sealing ring; 506. second sealing ring; 6. second feed pipe; 7. freezing component; 8. support frame; 801. support groove. DETAILED DESCRIPTION

[0017] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0018] The utility model provides Figure 1-4The microwave synthesis nanoliposome preparation device shown comprises a workbench 1, a microwave component 2 is arranged on the top of the workbench 1, a material storage box 3 is arranged on the top of the microwave component 2, a filtering component 5 is arranged on one side of the microwave component 2, a conveying component 4 for conveying materials is arranged at the connection between the material storage box 3 and the filtering component 5, the conveying component 4 comprises a transmission pipe 401 arranged at the bottom of the material storage box 3, the transmission pipe 401 is connected through the top of the microwave component 2, the filtering component 5 comprises a box body 501 fixedly connected to one side of the microwave component 2, a filter frame 503 is arranged inside the box body 501, a freezing component 7 for freeze-drying materials is arranged on one side of the workbench 1, a motor 504 for rotating the filter frame 503 is arranged at the bottom of the filter frame 503, an opening piece is arranged on the top of the box body 501, and the motor 504 is fixedly connected to the top of the workbench 1.

[0019] It should be noted that a tightening valve is provided in the middle of the transmission tube 401 to tighten the pipeline interface, which is convenient for operators to operate and clean, saving time and effort; the microwave component 2 is an ultraviolet catalytic synthesizer with model YM-ZCW-1000W, and the storage box 3 is boxed for holding raw materials.

[0020] Furthermore, when in use, the material in the storage box 3 is directly transported to the microwave component 2 for synthesis to prepare flowing nanoliposomes, then filtered through the filter component 5, and finally the filtered nanoliposomes are freeze-dried to prepare nanoliposome powder. By directly connecting multiple devices, the contact between nanoliposomes and air is reduced.

[0021] Specifically, a feed pump 402 is fixedly connected to the top of the microwave component 2 , one end of the transmission tube 401 away from the storage box 3 is fixedly connected to the input end of the feed pump 402 , and a first feed pipe 403 is provided at the output end of the feed pump 402 .

[0022] It should be noted that the transmission tube 401 is used to connect the feed pump 402 and the storage box 3, and the middle part of the transmission tube 401 is located inside the microwave component 2. The microwave component 2 is a microwave reactor. The liposome emulsion is placed in the microwave reactor through the transmission tube 401 and heated by microwave radiation. The microwaves can cause the liposome components to quickly form a nano-liposome structure in the aqueous phase. The transmission tube 401 is then extracted from the microwave component 2 through the feed pump 402, and the liposomes are transported to the inside of the box 501 through the first feed tube 403.

[0023] Specifically, the opening member includes a box cover 502 arranged on the top of the box body 501, a first sealing ring 505 is inserted and connected in the middle of the box cover 502, a first feed pipe 403 is inserted and connected in the middle of the first sealing ring 505, a second sealing ring 506 is arranged at the bottom of the first sealing ring 505, a sealing groove is opened on the top of the box body 501, and the second sealing ring 506 is inserted and connected in the inside of the sealing groove.

[0024] It should be noted that the filter frame 503 is a frame with filter holes, the diameter of the filter holes is 50 to 100 meshes, and the impurities in the liposomes are filtered through the filter frame 503. When in use, the liposomes are first input into the filter frame 503 through the first feeding pipe 403, and then the motor 504 is turned on, and the filter frame 503 is driven by the motor 504 to rotate, thereby driving the liquid inside the filter frame 503 to rotate, and the liquid flows out through the filter holes on the filter frame 503, and the liquid flows into the interior of the box body 501; the first dense The sealing ring 505 is used to seal the connection between the first feed pipe 403 and the box cover 502, and the second sealing ring 506 is used to seal the connection between the box body 501 and the box cover 502 to prevent liquid from flowing out from the connection between the first feed pipe 403 and the box cover 502 and the connection between the box body 501 and the box cover 502. The box body 501 and the box cover 502 are connected by bolts. When the filter frame 503 needs to be cleaned, the box cover 502 is opened and the filter frame 503 located in the box body 501 is cleaned.

[0025] Specifically, a second material delivery pipe 6 is disposed on one side of the box body 501 , and the second material delivery pipe 6 is disposed at the input end of the freezing element 7 .

[0026] It should be noted that the second feed pipe 6 is used to transport the filtered liposomes in the box 501 to the inside of the freezing part 7; the freezing part 7 is a shell-and-tube cooler, which cools the liposomes by heat exchange when in use.

[0027] Specifically, support frames 8 for supporting the storage box 3 are arranged at the four corners of the bottom end of the storage box 3, a support groove 801 is opened at the top of the support frame 8, the storage box 3 is inserted and connected inside the support groove 801, and the support frame 8 is fixedly connected to the top of the microwave component 2.

[0028] It should be noted that the support frame 8 is in the shape of a cubic rod, and there are four of them, which are respectively arranged at the bottom of the storage box 3, and a support groove 801 is opened at the top of the support frame 8. When in use, the four corners of the bottom end of the storage box 3 are respectively inserted into the four support grooves 801. While the storage box 3 is supported by the support grooves 801, the movement of the storage box 3 is prevented from occurring by the outer wall of the support grooves 801.

[0029] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A microwave synthesis nanoliposome preparation device, comprising a workbench (1), characterized in that: A microwave component (2) is arranged on the top of the workbench (1), a material storage box (3) is arranged on the top of the microwave component (2), a filter assembly (5) is arranged on one side of the microwave component (2), a conveying assembly (4) for conveying materials is arranged at the connection between the material storage box (3) and the filter assembly (5), the conveying assembly (4) comprises a transmission pipe (401) arranged at the bottom of the material storage box (3), the transmission pipe (401) is connected through the top of the microwave component (2), the filter assembly (5) comprises a box body (501) fixedly connected to one side of the microwave component (2), a filter frame (503) is arranged inside the box body (501), and a freezing component (7) for freeze-drying materials is arranged on one side of the workbench (1).

2. The microwave synthesis nanoliposome preparation device according to claim 1, characterized in that: A motor (504) for rotating the filter frame (503) is arranged at the bottom of the filter frame (503), an opening piece is arranged at the top of the box body (501), and the motor (504) is fixedly connected to the top of the workbench (1).

3. The microwave synthesis nanoliposome preparation device according to claim 2, characterized in that: The top end of the microwave component (2) is fixedly connected to a feed pump (402), the end of the transmission tube (401) away from the material storage box (3) is fixedly connected to the input end of the feed pump (402), and the output end of the feed pump (402) is provided with a first feed pipe (403).

4. The microwave synthesis nanoliposome preparation device according to claim 3, characterized in that: The opening member comprises a box cover (502) arranged on the top of the box body (501), a first sealing ring (505) is inserted and connected in the middle of the box cover (502), the first material delivery pipe (403) is inserted and connected in the middle of the first sealing ring (505), a second sealing ring (506) is arranged at the bottom of the first sealing ring (505), a sealing groove is opened at the top of the box body (501), and the second sealing ring (506) is inserted and connected in the inside of the sealing groove.

5. The microwave synthesis nanoliposome preparation device according to claim 4, characterized in that: A second material delivery pipe (6) is provided on one side of the box body (501), and the second material delivery pipe (6) is provided at the input end of the freezing element (7).

6. The microwave synthesis nanoliposome preparation device according to claim 1, characterized in that: Support frames (8) for supporting the material storage box (3) are arranged at the four corners of the bottom end of the material storage box (3), a support groove (801) is provided at the top end of the support frame (8), the material storage box (3) is inserted and connected inside the support groove (801), and the support frame (8) is fixedly connected to the top end of the microwave component (2).

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