Consumable placing structure for full-automatic immunofluorescence staining instrument

Through the modular replaceable consumable placement structure, the problems of unstable consumable placement structure and low level of equipment automation in existing equipment are solved, and the rapid replacement and stable fixation of TIP racks and waste liquid recycling bottles are achieved, which improves the degree of automation and operation simplicity of equipment.

CN222567812UActive Publication Date: 2025-03-07YICHANG MICRON SILICON VALLEY LIFE TECH CO LTD
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Patent Information

Application Number
CN202421325222.6
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-06-11
Publication Date
2025-03-07
Estimated Expiration
2034-06-11

AI Technical Summary

Technical Problem

In the existing fully automatic immunofluorescence staining device, the consumable placement structure usually adopts a straight plate structure, which leads to the problem of shaking and deviation during preparation or use. Most of the equipment is not fully automatic, and it is necessary to integrate reagent preparation, pipetting, sample filling, mixing, cleaning, incubation and disinfection functions to complete the dyeing of the culture plate.

Method used

It adopts a modular replaceable consumable placement structure, including panels, TIP racks and waste liquid recovery units. Through the design of mounting plates, through holes, overlapping plates and limiting plates, the TIP racks and waste liquid recovery bottles are quickly replaced and stable.

Benefits of technology

The stability and flexibility of the consumable placement structure are realized, and the TIP rack and waste liquid recycling bottle can be flexibly replaced according to different dyeing items, which simplifies operation, avoids the problem of shaking and deviation, and improves the degree of automation of the equipment.

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Abstract

The utility model belongs to the field of immunofluorescence staining instruments, and provides a consumable placement structure for a full-automatic immunofluorescence staining instrument, which comprises a panel and a TIP (Transfer Instrument Part) frame, the TIP frame comprises a mounting plate, a plurality of through holes are formed in the mounting plate, the through holes are used for clamping TIP heads, a first lap joint plate is fixed to the side wall of the mounting plate and arranged in the circumferential direction of the mounting plate, and a limiting plate is fixed to the bottom end of the first lap joint plate; a first window matched with the mounting plate is formed in the panel, a limiting hole matched with the limiting plate is formed in the panel, the mounting plate is embedded into the first window, the first lapping plate is lapped on the panel, the limiting plate is embedded into the limiting hole, and a supporting plate is mounted at the bottom of the panel. According to the consumable placement structure, a modularized replaceable structure is adopted, the structure is stable, devices such as a TIP frame can be flexibly replaced according to different dyeing items, and one-machine multi-item dyeing is achieved.
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Description

Technical Field

[0001] The utility model belongs to the field of immunofluorescence staining instruments, and in particular relates to a consumables placement structure for a full-automatic immunofluorescence staining instrument. Background Art

[0002] The fully automatic immunofluorescence staining equipment commonly found on the market is usually used for glass slide staining. There are relatively few equipment for culture plate staining, and most of the equipment for culture plate staining is not fully automatic. Equipment used for culture plate staining needs to integrate reagent preparation, pipetting, sample addition, mixing, cleaning, incubation, and disinfection functions to automatically complete the entire staining process. In existing culture plate staining equipment, the consumable placement structure is usually set as a straight plate structure, and devices such as TIP racks, reagent racks, and recovery boxes are usually placed directly on the straight plate structure. Although it is easy to replace, it is prone to shaking and deviation during the preparation process or use. Utility Model Content

[0003] In view of the shortcomings of the prior art, the utility model provides a consumables placement structure for a fully automatic immunofluorescence staining instrument, which adopts a modular replaceable structure. Not only is the structure stable, but the TIP rack and other devices can also be flexibly replaced according to different staining projects, thereby realizing multi-project staining with one machine.

[0004] In order to achieve the above-mentioned object, the utility model adopts the following technical scheme: a consumables placement structure for a fully automatic immunofluorescence staining instrument, comprising a panel and a TIP rack;

[0005] The TIP frame includes a mounting plate, a plurality of through holes are formed on the mounting plate, and the through holes are used to clamp the TIP head. A first lap plate is fixed on the side wall of the mounting plate, the first lap plate is parallel to the mounting plate, and the first lap plate is arranged along the circumference of the mounting plate. A limit plate is fixed on the bottom end of the first lap plate, and the limit plate is perpendicular to the mounting plate.

[0006] The panel is provided with a first window adapted to the mounting plate and a limiting hole adapted to the limiting plate, the mounting plate is embedded in the first window, the first lap plate is overlapped on the panel, the limiting plate is embedded in the limiting hole, and a support plate is installed at the bottom of the panel.

[0007] Preferably, the plurality of through holes are distributed in a matrix.

[0008] Preferably, chamfered structures are provided at both ends of the limiting plate.

[0009] Preferably, a guard plate is fixed on the top of the first lap plate.

[0010] Preferably, a reagent bottle rack is detachably mounted on the panel, and the reagent bottle rack is used for placing reagent bottles.

[0011] Preferably, a waste liquid recovery unit is installed on the panel, and the waste liquid recovery unit is used for waste liquid recovery.

[0012] Preferably, the waste liquid recovery unit includes a lower cylinder, an upper cylinder, an annular connecting plate, and a waste liquid recovery bottle, the upper end of the lower cylinder is open, and the upper and lower ends of the upper cylinder are open, the diameter of the upper cylinder is larger than that of the lower cylinder, the upper cylinder and the lower cylinder are sealed and connected through the annular connecting plate, the waste liquid recovery bottle is embedded in the lower cylinder, a second window is provided on the panel, the upper cylinder is adapted to the second window, the upper cylinder is clamped in the second window, a second lap plate is fixed to the top end of the outer wall of the upper cylinder along the circumferential direction, an annular groove adapted to the second lap plate is provided on the panel, and the second lap plate is embedded in the annular groove.

[0013] Preferably, a positioning plate is fixed to the outer side wall of the second lap plate, a positioning groove is formed on the inner side wall of the annular groove, and the positioning plate is embedded in the positioning groove.

[0014] Preferably, the waste liquid recovery bottle is compatible with the lower cylinder.

[0015] Preferably, a third window is provided on the panel, and a recovery box is provided below the third window, wherein the recovery box is used for recovering the TIP head.

[0016] Compared with the prior art, the beneficial effects of the utility model are:

[0017] 1. The utility model provides a consumables placement structure for a fully automatic immunofluorescence staining instrument. The TIP rack can be removed by moving the TIP rack upward so that the mounting plate is detached from the first window. The operation is very simple and is conducive to the rapid replacement of the TIP rack. Moreover, when the TIP head is placed in the through hole, the panel and the support plate can protect the TIP head to avoid interference with the TIP head from the outside.

[0018] 2. The utility model provides a consumables placement structure for a fully automatic immunofluorescence staining instrument. The waste liquid recovery bottle can be lifted up to take out the waste liquid recovery bottle. The operation is very simple and is conducive to the rapid replacement of the waste liquid recovery bottle. The upper cylinder and the lower cylinder can collect the waste liquid splashed to the outside of the waste liquid recovery bottle to avoid the waste liquid from contaminating the panel. At the same time, the lower cylinder can be lifted up to take out the upper cylinder and the lower cylinder. The operation is very simple. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 A schematic diagram of a three-dimensional structure of a consumable placement structure for a fully automatic immunofluorescence staining instrument provided in an embodiment of the utility model;

[0020] Figure 2 A schematic diagram of the three-dimensional structure of a TIP rack for placing consumables of a fully automatic immunofluorescence staining instrument provided in an embodiment of the utility model;

[0021] Figure 3 A schematic diagram of a top view of a consumable placement structure for a fully automatic immunofluorescence staining instrument provided in an embodiment of the utility model;

[0022] Figure 4 A schematic diagram of the three-dimensional structure of a panel of a consumable placement structure for a fully automatic immunofluorescence staining instrument provided in an embodiment of the utility model;

[0023] Figure 5 A three-dimensional structural schematic diagram of a lower cylinder and an upper cylinder and related parts of a consumables placement structure for a fully automatic immunofluorescence staining instrument provided in an embodiment of the utility model.

[0024] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0025] 1. Panel; 2. TIP rack; 3. Reagent bottle rack; 4. Waste liquid recovery unit; 5. Support plate; 101. First window; 102. Second window; 103. Third window; 104. Limiting hole; 105. Positioning groove; 201. Mounting plate; 202. Through hole; 203. First lap plate; 204. Limiting plate; 205. Guard plate; 401. Lower tube; 402. Upper tube; 403. Ring connecting plate; 404. Waste liquid recovery bottle; 405. Second lap plate; 406. Positioning plate. DETAILED DESCRIPTION

[0026] The present invention will be further described in detail below in conjunction with specific embodiments so that those skilled in the art can understand the present invention more clearly.

[0027] It should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integrally formed structure. For ordinary technicians in this field, the specific meanings of such terms in this patent can be understood according to specific circumstances.

[0028] Example 1

[0029] like Figure 1 As shown, this embodiment provides a consumable placement structure for a fully automatic immunofluorescence staining instrument, including a panel 1 and a TIP rack 2;

[0030] like Figure 2As shown, the TIP rack 2 includes a mounting plate 201, and a plurality of through holes 202 are provided on the mounting plate 201. The through holes 202 can be used to clamp TIP heads of different specifications such as 50ul, 200ul, and 1000ul. A first lap plate 203 is fixed on the side wall of the mounting plate 201. The top of the first lap plate 203 is flush with the top of the mounting plate 201. The first lap plate 203 is parallel to the mounting plate 201. The first lap plate 203 is arranged circumferentially along the mounting plate 201. Three limiting plates 204 are fixed to the bottom end of the first lap plate 203. The limiting plates 204 are perpendicular to the mounting plate 201, one of the limiting plates 204 is parallel to the width direction of the mounting plate 201, and the other two limiting plates 204 are parallel to the length direction of the mounting plate 201.

[0031] like Figure 3 As shown, the panel 1 is provided with a first window 101 adapted to the mounting plate 201, the panel 1 is provided with a limiting hole 104 adapted to the limiting plate 204, the mounting plate 201 is embedded in the first window 101, the first lap plate 203 is overlapped on the panel 1, the limiting plate 204 is embedded in the limiting hole 104, and a support plate 5 is installed at the bottom of the panel 1.

[0032] Based on the above structure, the consumable placement structure provided in this embodiment is used for a fully automatic immunofluorescence staining instrument. When the TIP rack needs to be replaced according to different staining projects, the mounting plate 201 can be lifted upward so that the mounting plate 201 is separated from the first window 101, and at the same time, the limiting plate 204 is separated from the limiting hole 104, and the mounting plate 201 can be removed. Disassembly or installation is very convenient, and the TIP rack can be flexibly replaced according to different staining projects to achieve multi-project staining with one machine.

[0033] Among them, the setting of the limiting plate 204 can not only limit the mounting plate 201 to prevent the mounting plate 201 from shaking and deviating, but also based on the position distribution of the three limiting plates 204, the mounting plate 201 can only be placed into the first window 101 along one direction, which can avoid the mounting plate 201 from being switched to the left or right direction.

[0034] The support plate 5 can not only support the panel 1, but also when the TIP head is placed in the through hole 202, the panel 1 and the support plate 5 can protect the TIP head to prevent external interference to the TIP head.

[0035] In this embodiment, the plurality of through holes 202 are distributed in a matrix, which is beneficial to the orderly arrangement of the TIP heads.

[0036] The two ends of the limiting plate 204 are provided with chamfered structures, which is conducive to the limiting plate 204 sliding into the limiting hole 104 quickly, thereby accelerating the installation speed.

[0037] A guard plate 205 is fixed to the top of the first lap plate 203. The guard plate 205 is arranged along the circumference of the first lap plate 203 to prevent the TIP head from being disturbed by the outside world.

[0038] Example 2

[0039] Please refer again Figure 1 On the basis of Example 1, a reagent bottle rack 3 is detachably mounted on the panel 1, and the reagent bottle rack 3 is used to place reagent bottles.

[0040] Specifically, a strip hole is opened on the panel 1, and the reagent bottle rack 3 is clamped in the strip hole. The reagent bottle rack 3 can be taken out by lifting the reagent bottle rack 3, and reagent bottle racks of different quantities and specifications can be selected according to different staining projects.

[0041] Example 3

[0042] Please refer again Figure 1 On the basis of Example 1, a waste liquid recovery unit 4 is installed on the panel 1, and the waste liquid recovery unit 4 is used for waste liquid recovery.

[0043] Specifically, Figure 4-5 As shown, the waste liquid recovery unit 4 includes a lower cylinder 401, an upper cylinder 402, an annular connecting plate 403, and a waste liquid recovery bottle 404. The upper end of the lower cylinder 401 is open, and the upper and lower ends of the upper cylinder 402 are open, wherein the diameter of the upper cylinder 402 is larger than that of the lower cylinder 401, the upper cylinder 402, the lower cylinder 401, and the annular connecting plate 403 are coaxial, the outer diameter of the annular connecting plate 403 is the same as the diameter of the upper cylinder 402, the inner diameter of the annular connecting plate 403 is the same as the diameter of the lower cylinder 401, and the lower end of the upper cylinder 402 is sealed and connected to the outer ring of the annular connecting plate 403, and the lower cylinder 401 The upper end is sealed and connected with the inner ring of the annular connecting plate 403, that is, the upper tube 402 is sealed and connected with the lower tube 401 through the annular connecting plate 403, the waste liquid recovery bottle 404 is embedded in the lower tube 401, and a second window 102 is opened on the panel 1, the upper tube 402 is adapted to the second window 102, the upper tube 402 is clamped in the second window 102, and a second lap plate 405 is fixed along the circumferential direction at the top end of the outer wall of the upper tube 402, and an annular groove adapted to the second lap plate 405 is opened on the panel 1, and the second lap plate 405 is embedded in the annular groove.

[0044] By lifting the waste liquid recovery bottle 404, the waste liquid recovery bottle 404 can be directly taken out, the operation is very simple, and it is conducive to the rapid replacement of the waste liquid recovery bottle 404, and the upper tube 402 and the lower tube 401 can collect the waste liquid splashed to the outside of the waste liquid recovery bottle 404 to avoid the waste liquid from contaminating the panel 1. At the same time, the lower tube 401 can be lifted up to take out the upper tube 402 and the lower tube 401, which is very convenient for disassembly or installation.

[0045] A positioning plate 406 is fixed to the outer side wall of the second lap plate 405, a positioning groove 105 is formed on the inner side wall of the annular groove, and the positioning plate 406 is embedded in the positioning groove 105. This can prevent the upper cylinder 402 from rotating in the second window 102.

[0046] The waste liquid recovery bottle 404 is matched with the lower cylinder 401 , so that the waste liquid recovery bottle 404 can be prevented from shaking in the lower cylinder 401 .

[0047] Example 4

[0048] Please refer again Figure 1 On the basis of Example 1, a third window 103 is provided on the panel 1, and a recycling box is provided below the third window 103, and the recycling box is used for recycling the TIP head. The recycling box can directly use the box that comes with the TIP head when it is purchased, and no other consumables are used, which is energy-saving and environmentally friendly.

[0049] The mechanisms, components and parts not specifically described in the present invention are all existing structures in the prior art and can be directly purchased from the market.

[0050] In the description of the present utility model, it should be understood that the terms "upper", "lower", "left", "right", etc. indicating directions or positional relationships are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, and a specific direction structure and operation, and therefore, cannot be understood as a limitation on the present utility model. In addition, "first" and "second" are only for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present utility model, unless otherwise specified, "multiple" means two or more.

[0051] The above is only a preferred embodiment of the utility model, and is not intended to limit the protection scope of the utility model. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A consumables placement structure for a fully automatic immunofluorescence staining instrument, characterized in that: It comprises a panel (1) and a TIP frame (2); The TIP frame (2) comprises a mounting plate (201), a plurality of through holes (202) are provided on the mounting plate (201), the through holes (202) are used to clamp the TIP head, a first lap plate (203) is fixed on the side wall of the mounting plate (201), the first lap plate (203) is parallel to the mounting plate (201), the first lap plate (203) is arranged along the circumference of the mounting plate (201), a limiting plate (204) is fixed at the bottom end of the first lap plate (203), and the limiting plate (204) is perpendicular to the mounting plate (201); The panel (1) is provided with a first window (101) adapted to the mounting plate (201) and a limiting hole (104) adapted to the limiting plate (204); the mounting plate (201) is embedded in the first window (101); the first overlapping plate (203) is overlapped on the panel (1); the limiting plate (204) is embedded in the limiting hole (104); and a support plate (5) is installed at the bottom of the panel (1).

2. The consumables placement structure for a fully automatic immunofluorescence staining instrument according to claim 1, characterized in that: The plurality of through holes (202) are distributed in a matrix.

3. The consumables placement structure for a fully automatic immunofluorescence staining instrument according to claim 1, characterized in that: The limiting plate (204) has chamfered structures at both ends.

4. The consumables placement structure for a fully automatic immunofluorescence staining instrument according to claim 1, characterized in that: A guard plate (205) is fixed to the top end of the first lap plate (203).

5. The consumables placement structure for a fully automatic immunofluorescence staining instrument according to claim 1, characterized in that: A reagent bottle rack (3) is detachably mounted on the panel (1), and the reagent bottle rack (3) is used to place reagent bottles.

6. The consumables placement structure for a fully automatic immunofluorescence staining instrument according to claim 1, characterized in that: A waste liquid recovery unit (4) is installed on the panel (1), and the waste liquid recovery unit (4) is used for recovering waste liquid.

7. The consumables placement structure for a fully automatic immunofluorescence staining instrument according to claim 6, characterized in that: The waste liquid recovery unit (4) comprises a lower cylinder (401), an upper cylinder (402), an annular connecting plate (403), and a waste liquid recovery bottle (404); the upper end of the lower cylinder (401) is open, and the upper and lower ends of the upper cylinder (402) are open; the diameter of the upper cylinder (402) is larger than that of the lower cylinder (401); the upper cylinder (402) and the lower cylinder (401) are sealed and connected via the annular connecting plate (403); and the waste liquid recovery bottle (404) is embedded in the lower cylinder (401). 401), a second window (102) is opened on the panel (1), the upper tube (402) is matched with the second window (102), the upper tube (402) is clamped in the second window (102), a second lap plate (405) is fixed along the circumferential direction on the top of the outer wall of the upper tube (402), an annular groove matched with the second lap plate (405) is opened on the panel (1), and the second lap plate (405) is embedded in the annular groove.

8. The consumables placement structure for a fully automatic immunofluorescence staining instrument according to claim 7, characterized in that: A positioning plate (406) is fixed on the outer side wall of the second lap plate (405), a positioning groove (105) is opened on the inner side wall of the annular groove, and the positioning plate (406) is embedded in the positioning groove (105).

9. The consumables placement structure for a fully automatic immunofluorescence staining instrument according to claim 7, characterized in that: The waste liquid recovery bottle (404) is compatible with the lower cylinder (401).

10. The consumables placement structure for a fully automatic immunofluorescence staining instrument according to claim 1, characterized in that: A third window (103) is provided on the panel (1), and a recovery box is provided below the third window (103), wherein the recovery box is used for recovering the TIP head.