5 results about "Bradykinin receptor" patented technology

The invention is applicable to the technical field of biological medicine, and provides a self-assembled drug molecule and a preparation method and application thereof, and the preparation method comprises the following steps: synthesizing a compound Py-S-S-COOH; the method comprises the following steps: synthesizing a compound Py-S-S-B1RA; synthesizing a compound A; synthesizing a compound B; synthesizing a compound C; synthesizing a compound D; synthesizing a compound E; synthesizing a compound F; and the compound CBT-Gem-B1RA is synthesized through the synthesis of A chemotherapeutic drug gemcitabine and a targeted peptide bradykinin B1 receptor stimulant are coupled with a peptide fragment with self-assembly performance, so that the molecule has the capabilities of penetrating a blood brain barrier and targeting brain glioma, can smoothly enter a brain glioma part and can be self-assembled into nano particles in brain glioma cells, and the nano particles can be used for preparing a drug for treating brain glioma. The residence time of the drug in tumor cells is prolonged, the drug enrichment concentration is increased, and finally the glioma specific targeted therapy is realized.

To provide antibodies that specifically bind to Kallidin or des-Arg10-Kallidin.SOLUTION: The invention provides an isolated monoclonal antibody or antigen binding fragment thereof configured to: a) bind specifically to Kallidin or des-Arg10-Kallidin but not specifically to Bradykinin or des-Arg9-Bradykinin; b) specifically bind to Kallidin or des-Arg10-Kallidin with a KD of less than 1×10-10 M; c) specifically bind to Kallidin or des-Arg10-Kallidin with a Koff of less than 1×104 s-1; and / or d) specifically bind to Kallidin or des-Arg10-Kallidin and inhibit binding to the bradykinin B1 receptor.SELECTED DRAWING: None

The present invention relates to antibodies to bradykinin B1 receptor ligands, and specifically provides antibodies that can specifically bind to bradykinin or des-Arg10-bradykinin. The present disclosure also provides pharmaceutical compositions, and nucleic acids encoding anti-bradykinin or des-Arg10-bradykinin antibodies, and recombinant vectors and host cells for preparing such antibodies or fragments thereof. The present invention also provides methods for regulating bradykinin or des-Arg10-bradykinin activity in vivo or in vitro, or detecting bradykinin or des-Arg10-bradykinin using the disclosed antibodies. The present disclosure further provides methods for preparing antibodies that can specifically bind to des-Argg-bradykinin and des-Arg10-bradykinin-like polypeptides.

Provided are a bradykinin receptor active peptide and a use thereof in promoting hair regeneration. Further provided are a composition comprising the bradykinin receptor active peptide, a pharmaceutical preparation, a kit, and a preparation method for the bradykinin receptor active peptide. The bradykinin receptor active peptide has a good hair regeneration effect and safety, and has clinical application prospects.

The present invention relates to antibodies to bradykinin B1 receptor ligands, and specifically provides antibodies that can specifically bind to pancreatic kinin or de-Arg10-pancreatic kinin. The disclosure also provides pharmaceutical compositions, as well as nucleic acids encoding anti-pancreatic kinin or de-Arg10-pancreatic kinin antibodies, recombinant vectors and host cells for making such antibodies or fragments thereof. The invention also provides methods of modulating pancreatic kinin or anti-Arg10-pancreatic kinin activity in vivo or in vitro, or detecting pancreatic kinin or anti-Arg10-pancreatic kinin using the disclosed antibodies. The present disclosure further provides methods of making antibodies that can specifically bind to de-Arg-bradykinin and de-Arg10-pancreatic kinin-like polypeptides.