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Application of fugillin in treating immunity entiritis and related immunity disease

A technology of Aspergillus fumigatus C and autoimmunity, which can be used in allergic diseases, metabolic diseases, muscular system diseases, etc., and can solve problems such as side effects of drugs and lack of cure methods

Inactive Publication Date: 2008-01-30
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the disease process can be controlled clinically at present, there is still no effective cure, and the drugs used have strong side effects

Method used

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  • Application of fugillin in treating immunity entiritis and related immunity disease
  • Application of fugillin in treating immunity entiritis and related immunity disease
  • Application of fugillin in treating immunity entiritis and related immunity disease

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Embodiment Construction

[0038] Intraperitoneal injection of Aspergillus fumigatus can significantly improve the immune enteritis induced by TNBS in mice. Adopt BALB / c female mice, inject TNBS at first, then administer to mice on the 3rd day to the 8th day: daily intraperitoneal injection of Aspergillus fumigatus C (5, 10, 20 mg / kg) or cyclosporine A ( CsA, 10mg / kg), the control group was intraperitoneally injected with a corresponding volume of phosphate buffered saline (PBS). The results showed that: after enteritis was induced by administration of TNBS into the colon, the mice would have severe inflammatory symptoms, such as diarrhea, weight loss, etc., accompanied by a relatively high mortality rate. Compared with the control group, Aspergillus fumigatus C. fumigatus was able to restore body weight gain and improve the survival rate of mice when administered at doses of 10 and 20 mg / kg (Fig. 1). At the same time, the local inflammatory response and mucosal ulcer of the colon were significantly im...

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Abstract

An application of fumigaclavine C in treating Crohn's disease, ulcerative colitis, and T cell-related autoimmune diseases, such as delayed hypersensitivity, multiple sclerosis, insulin-dependent diabetes, etc, is disclosed.

Description

1. Technical field [0001] The invention belongs to the technical field of biopharmaceuticals. 2. Background technology [0002] Since Aspergillus fumigatus C (Fumigaclavine C) was discovered in 1977, there have been very few relevant studies on the compound, and reports on pharmacology are even rarer. Only one article shows that the compound has a good curative effect in the immune hepatitis model ( Zhao et al. J Pharm Pharmacol 2004, 56:775-84). On the other hand, autoimmune enteritis is a clinically frequent and intractable disease, including Crohn's disease and ulcerative colitis. Immune enteritis often occurs from adolescence, and the reported incidence is as high as 4 to 10 / 100,000 people per year. It is difficult to heal for life, and it will develop into various gastrointestinal diseases including intestinal cancer in the later stage, accompanied by a high mortality rate. Although the disease process can be controlled clinically at present, there is still no effect...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/48A61P1/00A61P1/04A61P3/10A61P9/00A61P21/04A61P37/02
Inventor 徐强谭仁祥吴雪丰
Owner NANJING UNIV
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