Treatment with an oncolytic virus and an immunostimulant for in vivo enhancement of immune system recognition of neoplasms

An immunostimulatory, oncolytic virus technology, applied in the directions of viruses/phages, medical raw materials derived from viruses/phages, viruses, etc., can solve the problem that the therapeutic efficacy is not optimal

Inactive Publication Date: 2008-11-12
ONCOLYTICS BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the efficacy of oncolytic virotherapy has generally been demonstrated in preclinical studies, the therapeutic efficacy in clinical trials is still suboptimal

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0059] Two groups of female SCID mice were injected with 1x10 at two subcutaneous locations on the two rear flanks 6 Human breast cancer MDA-MB468 cells. Tumors were clearly palpable approximately 2-4 weeks after injection. Mix 20μl, 1.O×1O 7 Undiluted reovirus serotype 3 (Dearing strain) at PFU / ml concentration was injected into the right tumor mass. Together with the reovirus, animals of group 1 were also injected with 10 μg of the CpG-containing oligonucleotide ODN 1826 (TCC ATG ACG TTCCTGACGTT). Two weeks later, the animals were reinjected with an equal amount of ODN 1826. Animals in group 2 received saline injections in the same amount and frequency as CpG. The results showed that in both groups, the tumors on the left side of the animals were larger than those on the right side of the animals, suggesting that oncolytic virotherapy was effective in treating tumors. Furthermore, the left side tumors in group 1 animals were smaller than the left side tumors in group 2 ...

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Abstract

This invention provides novel methods of treating or alleviating neoplasms in a mammal and enhancing the efficacy of oncolytic viruses by using a combination of an oncolytic virus and an immunostimulant, comprising administering a reovirus to a host and enhancing an immune response by the addition of an immunostimulant such as a CpG oligodeoxynucleotide or at least one antigen of said virus that is delivered to a host by dendritic cells.

Description

field of invention [0001] The present invention relates to methods of treating proliferative disorders in mammals using oncolytic viruses and immunostimulants. Background of the invention [0002] More than one million people are diagnosed with cancer each year in the United States alone. Despite many advances in medical research, cancer remains the second leading cause of death in the United States. In industrialized countries, about 1 in 5 people die from cancer. In the search for new strategies, oncolytic virotherapy has recently emerged as a viable approach to specifically kill tumor cells. Unlike conventional gene therapy, this approach uses replication-competent viruses that can spread throughout tumor tissue due to viral replication and subsequent cytolysis, thereby providing an alternative cancer treatment approach. The virus is genetically engineered to selectively replicate and kill cancer cells. [0003] Oncolytic viruses can kill cancer cells using multiple m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61P35/00A61K31/00A61P37/04A61K31/7084C07H21/04A61K35/76C12N7/00
CPCA61K2039/55561A61K45/06A61K35/765A61K31/7084A61K31/00C12N2720/12032A61P35/00A61P35/04A61P37/04A61K2300/00
Inventor M·C·科菲B·G·汤普逊
Owner ONCOLYTICS BIOTECH
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