Treatment with an oncolytic virus and an immunostimulant for in vivo enhancement of immune system recognition of neoplasms
An immunostimulatory, oncolytic virus technology, applied in the directions of viruses/phages, medical raw materials derived from viruses/phages, viruses, etc., can solve the problem that the therapeutic efficacy is not optimal
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[0059] Two groups of female SCID mice were injected with 1x10 at two subcutaneous locations on the two rear flanks 6 Human breast cancer MDA-MB468 cells. Tumors were clearly palpable approximately 2-4 weeks after injection. Mix 20μl, 1.O×1O 7 Undiluted reovirus serotype 3 (Dearing strain) at PFU / ml concentration was injected into the right tumor mass. Together with the reovirus, animals of group 1 were also injected with 10 μg of the CpG-containing oligonucleotide ODN 1826 (TCC ATG ACG TTCCTGACGTT). Two weeks later, the animals were reinjected with an equal amount of ODN 1826. Animals in group 2 received saline injections in the same amount and frequency as CpG. The results showed that in both groups, the tumors on the left side of the animals were larger than those on the right side of the animals, suggesting that oncolytic virotherapy was effective in treating tumors. Furthermore, the left side tumors in group 1 animals were smaller than the left side tumors in group 2 ...
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