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Application of ilex pubescens total flavone in preparing medicament for preventing and controlling transient ischemic attack syndrome
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A technology of holly vulgaris and total flavonoids, applied in the field of medicine, can solve problems such as slowness
Inactive Publication Date: 2011-05-11
HENAN UNIV OF CHINESE MEDICINE
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[0002] Ilex pubescens is the root of Ilex chinensis, which contains a variety of flavonoids, phenolic components, sterols, amino acids, sugars, tannins and triterpenes. Hot cold, lung heat, cough, laryngeal edema, tonsillitis, dysentery, coronary heart disease, hemiplegia caused by cerebrovascular accident, thromboangiitis obliterans, erysipelas, burns, central retinitis, uveitis, and acute skin Suppurative inflammation, modern medical research also shows that Mao Dongqing has an effect on cardiovascular, and it is clinically used to lower blood pressure, which is slow and long-lasting. With the deepening of medical research, the medical value of Mao Dongqing has a new beginning, but Mao Dongqing In the application of prevention and treatment of transient cerebral ischemic syndrome, there is no report, especially the total flavonoids of the active ingredient of Radix Ilex chinensis as a drug for the preparation of transient cerebral ischemic syndrome has no report
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[0004] The specific implementation of the present invention will be described in detail below in combination with specific situations.
[0005] When preparing the total flavonoids of Ilex pubescens, the present invention adopts an orthogonal experiment design method, selects main factors affecting the extraction effect such as ethanol concentration, alcohol addition amount, extraction time, and extraction times as investigation factors, and takes the content of total flavonoids and total saponins In order to measure the index, determine that the best extraction process is to get the coarse powder of Ilex pubescens, so get the Ilex pubescens medicinal material, pulverize, extract twice with 70% ethanol heating and reflux of 8 times the amount, combine the extracts, filter, reclaim the ethanol, and concentrate When measured at 50°C, the relative density is 1.10 to 1.20, and the concentrated solution is dispersed with water into a solution of medicinal liquid: medicinal material =...
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Abstract
The invention relates to an application of Pubescent Holly Root total flavone in preparing medicine for preventing and treating transient cerebral ischemia syndromes, which effectively solves the problem about the medicine for preventing and treating transient cerebral ischemia syndromes. The invention has the following technical proposal: a Pubescent Holly Root medicinal material is ground and extracted twice after heating reflux by use of ethanol; extract solutions are merged and filtered; the ethanol is reclaimed; the merged extract solutions are concentrated to the relative density between 1.10 and 1.20; a concentrated solution is dispersed by use of water and turned into a solution in which the proportion of liquid medicine and the medicinal material is 1:1; the solution is kept to stand and filtered; a filtrate is centrifuged; centrifugal liquid is ultrafiltered, passed through a polyamide column, eluted by use of water and then eluted by use of an ethanol solution after water liquid is discarded; eluent is collected on standby; the eluent in two steps is merged and then eluted by use of sodium carbonate aqueous solution; and the eluent is collected, has the pH regulated to be neutral by use of hydrochloric acid, decompressed, concentrated, dried and ground, so as to obtain the Pubescent Holly Root total flavone. The Pubescent Holly Root total flavone is effectively usedfor preparing the medicine for preventing and treating transient cerebral ischemia syndromes, realizes the treatment for cerebral ischemia syndromes, and benefits mankind.
Description
1. Technical field [0001] The invention relates to the field of medicine, in particular to the application of the total flavonoids of Ilex pubescens in the preparation of drugs for preventing and treating transient ischemic syndrome (TIA). 2. Background technology [0002] Ilex pubescens is the root of Ilex pubescens, which contains a variety of flavonoids, phenolic components, sterols, amino acids, sugars, tannins and triterpenes. Hot cold, lung heat, cough, laryngeal edema, tonsillitis, dysentery, coronary heart disease, hemiplegia caused by cerebrovascular accident, thromboangiitis obliterans, erysipelas, burns, central retinitis, uveitis, and acute skin Suppurative inflammation, modern medical research also shows that Mao Dongqing has an effect on the cardiovascular system, and it is clinically used to lower blood pressure, which is slow and long-lasting. With the deepening of medical research, the medical value of Mao Dongqing has a new beginning, but Mao Dongqing Ther...
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