Application of ilex pubescens total flavone in preparing medicament for preventing and controlling transient ischemic attack syndrome

Abstract

The invention relates to an application of Pubescent Holly Root total flavone in preparing medicine for preventing and treating transient cerebral ischemia syndromes, which effectively solves the problem about the medicine for preventing and treating transient cerebral ischemia syndromes. The invention has the following technical proposal: a Pubescent Holly Root medicinal material is ground and extracted twice after heating reflux by use of ethanol; extract solutions are merged and filtered; the ethanol is reclaimed; the merged extract solutions are concentrated to the relative density between 1.10 and 1.20; a concentrated solution is dispersed by use of water and turned into a solution in which the proportion of liquid medicine and the medicinal material is 1:1; the solution is kept to stand and filtered; a filtrate is centrifuged; centrifugal liquid is ultrafiltered, passed through a polyamide column, eluted by use of water and then eluted by use of an ethanol solution after water liquid is discarded; eluent is collected on standby; the eluent in two steps is merged and then eluted by use of sodium carbonate aqueous solution; and the eluent is collected, has the pH regulated to be neutral by use of hydrochloric acid, decompressed, concentrated, dried and ground, so as to obtain the Pubescent Holly Root total flavone. The Pubescent Holly Root total flavone is effectively used for preparing the medicine for preventing and treating transient cerebral ischemia syndromes, realizes the treatment for cerebral ischemia syndromes, and benefits mankind.

Description

1. Technical Field [0001] The invention relates to the field of medicine, in particular to the application of the total flavonoids of Ilex glabra in preparing medicines for preventing and treating transient cerebral ischemia syndrome (TIA). 2. Background technology [0002] Ilex holly is the root of Ilex holly. It contains a variety of flavonoids, phenolic components, sterols, amino acids, carbohydrates, tannins and triterpenes. It has the functions of clearing away heat, detoxifying, and promoting blood circulation. It is mainly used to treat wind Fever cold, lung-heat cough, throat edema, tonsillitis, dysentery, coronary heart disease, hemiplegia caused by cerebrovascular accident, thromboangiitis obliterans, erysipelas, scalds, central retinitis, uveitis, and acute skin For purulent inflammation, modern medical research has also shown that Mao Dongqing has an effect on the cardiovascular system. It has been clinically used to lower blood pressure, which is slow and long-lastin...

AI Technical Summary

Problems solved by technology

[0002] Ilex pubescens is the root of Ilex chinensis, which contains a variety of flavonoids, phenolic components, sterols, amino acids, sugars, tannins and triterpenes. Hot cold, lung heat, cough, laryngeal edema, tonsillitis, dysentery, coronary heart disease, hemiplegia caused by cerebrovascular accident, thromboangiitis obliterans, erysipelas, burns, central retinitis, uveitis, and acute skin Suppurative inflammation, modern medical research also shows that Mao Dongqing has an effect on cardiovascular, and it is clinically used to lower blood pressure, which is slow and long-lasting. With the deepening of medical research, the medical value of Mao Dongqing has a new beginning, but Mao Dongqing In the application of prevention and treatment of transient cerebral ischemic syndrome, there is no report, especially the total flavonoids of the active ingredient of Radix Ilex chinensis as a drug for the preparation of transient cerebral ischemic syndrome has no report

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