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Medicament coating applied to fixation screw in rachis, preparation method thereof and application thereof

A technology of drug coating and internal fixation, applied in the direction of internal fixator, coating, fixator, etc., to improve stability, improve anti-pullout force, and prevent osteoporosis

Inactive Publication Date: 2012-10-10
熊焱昊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to improve the pull-out resistance of pedicle screws or plate screws, the current research hotspots are changing the design of the screw, increasing the diameter of the screw, and injecting bone cement into the screw channel. All these researches have corresponding shortcomings. In the research and development of spinal internal fixation products, no company has focused on the research and development of drug screws

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Screw surface treatment

[0030] Ultrasonically treat the screw for 5 minutes, soak in 100% hydrofluoric acid for 20 minutes, then soak in a mixed solution of hydrogen peroxide and deionized water at 80°C for 10 minutes, and finally rinse with distilled water;

[0031] (2) Preparation of fibrinogen coating on screw surface

[0032] Soak the screws in protein at a concentration of 1 mg / ml, and dissolve them in phosphate-buffered saline PBS with a pH of 7.4 for 30 minutes, rinse the surface of the screws with PBS, and then soak them in 0.2 mol / L carbodiimide ethyl -Dimethyl-aminopropylcarbodiimide and 0.05mol / L of N-hydroxysuccinimide N-hydroxysuccinimide in PBS solution for 30 minutes, the pH value is 5.4;

[0033] (3) Preparation of drug-coated screws

[0034] 10 g of ibandronate and 40 g of raloxifene were dissolved in distilled water, and the screws were soaked in this solution for 24 hours to obtain drug-coated screws.

Embodiment 2

[0036] (1) Screw surface treatment

[0037] Ultrasonically treat the screw for 8 minutes, soak in 100% hydrofluoric acid for 20 minutes, then soak in a mixed solution of hydrogen peroxide and deionized water at 80°C for 10 minutes, and finally rinse with distilled water;

[0038] (2) Preparation of fibrinogen coating on screw surface

[0039] Soak the screws in protein with a concentration of 1 mg / ml, and dissolve them in phosphate-buffered saline PBS with a pH of 7.4 for 30 minutes.

[0040] In the PBS solution of ethyl-dimethyl-aminopropylcarbodiimide and 0.05mol / L N-hydroxysuccinimide for 30 minutes, the pH value was 5.5;

[0041] (3) Preparation of drug-coated screws

[0042] Dissolve 20 g of alendronate sodium and 30 g of micalic acid in distilled water, and soak the screws in this solution for 24 hours to obtain drug-coated screws.

Embodiment 3

[0044] (1) Screw surface treatment

[0045] Ultrasonically treat the screw for 8 minutes, soak in 100% hydrofluoric acid for 20 minutes, then soak in a mixed solution of hydrogen peroxide and deionized water at 80°C for 10 minutes, and finally rinse with distilled water;

[0046](2) Preparation of fibrinogen coating on screw surface

[0047] Soak the screws in protein with a concentration of 1 mg / ml, and dissolve them in phosphate-buffered saline PBS with a pH of 7.4 for 30 minutes.

[0048] In the PBS solution of ethyl-dimethyl-aminopropylcarbodiimide and 0.05mol / L N-hydroxysuccinimide for 30 minutes, the pH value was 5.5;

[0049] (3) Preparation of drug-coated screws

[0050] 50g of ibandronate and 50g of vitamin B12 were dissolved in distilled water, and the screws were soaked in this solution for 24 hours to obtain drug-coated screws.

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Abstract

The invention relates to a medicament coating applied to fixation screw in rachis, a preparation method thereof and application thereof. Thickness of the medicament coating is 30-300 microns and the coating is uniform inside and outside. After being treated by ultrasonic wave, the screw is sequentially soaked in hydrofluoric acid and hydrogen peroxide solution, and then soaked in protein having concentration of 1mg / ml; after surface of the screw is rinsed with PBS, the screw is soaked in PBS dissolved with 0.2mol / L of diimine and 0.05mol / L of N-hydroxysuccinimide for 30min; the screw is then soaked in solution of distilled water dissolved with bisphosphonates and other medicaments for 24 hours, thus the medicament coating is obtained. The medicament coating screw can be applied to fixationin rachis so as to improve bone quality, reduce danger of fracture, and reduce diameter of screw on condition of same withdrawal resistance, thus risk because of screw with big diameter is reduced; the medicament coating has simple technique, low cost, good economic benefit and good application prospect.

Description

technical field [0001] The invention belongs to the field of drug coating, preparation and application of clinical internal fixation screws, and in particular relates to a drug coating, preparation and application of screws for spinal internal fixation. Background technique [0002] There are many series of spinal internal fixation products on the market at present, no matter which product, screws are the basic components of each product. The biomechanical properties of the bone-screw contact surface: such as fatigue resistance, pull-out resistance, and torsion resistance, determine whether the stability of spinal internal fixation is good or bad. The biomechanical properties of the bone-screw interface are affected by: screw material, screw length, screw diameter, screw pitch, screw thread, shape of the screw shank, and bone density of the patient. [0003] Loosening or prolapse of spinal fixation is a common complication, especially in patients with poor bone quality. Ax...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/08A61L31/16A61B17/70A61M31/00
Inventor 熊焱昊
Owner 熊焱昊
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