Medicine for treating senile dementia and preparation method thereof

A senile, drug technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of small effect, long application period, uncertain curative effect, etc., to achieve the effect of improving dysfunction

Active Publication Date: 2011-06-01
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still many problems to be solved in order to be truly applied to the prevention and treatment of human senile dementia; as far as cell gene therapy is concerned, due to the lack of control over the persistence and stability of exogenous cells or gene expression, limitations its application in clinical practice
In addition, due to the long application cycle of current drug therapy, high cost, and many side effects, its clinical application has little effect, especially for severe dementia that is not discovered in time.
At present, in the treatment of Chinese patent medicines, the curative effect is mostly uncertain, and most of them are not specific, and there is no new traditional Chinese medicine drug with certain curative effect and specially for the treatment of this disease.

Method used

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  • Medicine for treating senile dementia and preparation method thereof
  • Medicine for treating senile dementia and preparation method thereof
  • Medicine for treating senile dementia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Weigh 1200g of Rehmannia glutinosa, 2000g of Salvia miltiorrhiza, 1000g of Shichangpu, 1200g of Yizhi, 800g of tortoise shell gum, 1000g of Fushen, and 300g of Ziheche, crush Ziheche, pass through a 100-mesh sieve for later use, distill Shichangpu with water, and steam out The liquid is set aside, the residue after the extraction of Shichangpu is decocted with rehmannia glutinosa, salvia miltiorrhiza, Yizhi, and Fushen for two times, adding 8 times of water for the first time, soaking for 30 minutes, extracting, filtering, and extracting the residue with 3 times of water , the secondary extraction time was 2 hours, all the filtrates were combined, concentrated into an extract, and when measuring its specific gravity at normal temperature to be 1.20-1.25, slowly add 6 times of 95% ethanol under stirring, separate the supernatant, reclaim the ethanol, and Concentrate under reduced pressure at ℃, add tortoise shell glue, continue to concentrate to form an extract, measure i...

Embodiment 2

[0059] Weigh 1500g of Rehmannia glutinosa, 3000g of Salvia miltiorrhiza, 1200g of Shichangpu, 1000g of Yizhi, 1000g of tortoise shell glue, 1500g of Fushen, 600g of Ziheche, crush Ziheche, pass through a 100-mesh sieve for later use, distill Shichangpu with water, and steam out The liquid is set aside, the residue after the extraction of Shichangpu is decocted with rehmannia glutinosa, salvia miltiorrhiza, Yizhi, and Fushen together with water for two times, adding 10 times of water for the first time, soaking for 30 minutes, extracting, filtering, and extracting the residue with 6 times of water , the secondary extraction time was 3 hours, all the filtrates were combined, concentrated into an extract, and when measuring its specific gravity at normal temperature to be 1.20-1.25, slowly add 5 times of 95% ethanol under stirring, separate the supernatant, reclaim the ethanol, and Concentrate under reduced pressure at ℃, add tortoise shell glue, continue to concentrate to form an...

Embodiment 3

[0061] Weigh 2000g Rehmannia glutinosa, 2000g Salvia miltiorrhiza, 1200g Shichangpu, 1500g Yizhi, 1000g tortoise shell glue, 1000g Fushen, 800g Ziheche, crush Ziheche, pass through a 100-mesh sieve for later use, distill Shichangpu with water, and steam out The liquid is set aside, the residue after the extraction of Shichangpu is decocted with rehmannia glutinosa, salvia miltiorrhiza, Yizhi, and Fushen for two times, adding 7 times of water for the first time, soaking for 30 minutes, extracting, filtering, and extracting the residue with 5 times of water , the secondary extraction time was 3 hours, all the filtrates were combined, concentrated into an extract, and when its specific gravity was measured at room temperature as 1.20-1.25, 2 times of 95% ethanol was slowly added under stirring, the supernatant was separated, and the ethanol was recovered at 70 Concentrate under reduced pressure at ℃, add tortoise shell glue, continue to concentrate to form an extract, measure its ...

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PUM

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Abstract

The invention discloses a medicine for treating senile dementia, which is prepared by the following raw materials by weight portion: 8-20 portions of prepared rehmannia root, 10-30 portions of red sage root, 5-15 portions of rhizoma acori graminei, 6-16 portions of fructus alpiniae oxyphyllae, 4-10 portions of tortoise-shell glue, 8-20 portions of poria preparata and 2-8 portions of placenta hominis. The invention provides the treatment medicine for senile dementia patients, and the treatment medicine has the functions for invigorating the kidney, tonifying marrow, promoting blood flow, eliminating sputum and waking up the brain. In addition, the invention also discloses a preparation method of granules of the medicine.

Description

technical field [0001] The invention relates to a medicine for treating senile dementia and a preparation method thereof. Background technique [0002] Alzheimer's disease is a degeneration of the nervous system, with three typical characteristics: senile plaques, neurofibrillary tangles, vacuolar degeneration of hippocampal pyramidal cells, and neuron loss. Clinical onset is insidious, progressive mental decline, often accompanied by personality changes. The general symptoms continue to progress, and the course of the disease is usually 5 to 10 years, so early treatment should be performed. However, the treatment of its early memory impairment is a difficult clinical problem. Currently, the main drugs used are cholinergic preparations and non-cholinergic preparations. The most widely used is huperzine A. However, in recent years, it has been recognized that the curative effect of cholinesterase inhibitors depends on the integrity of cholinergic neurons. As the disease pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9062A61K9/16A61P25/28A61K35/56A61K35/50A61K35/586
Inventor 安红梅胡兵顾明昌许丽雯
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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