Medicament for preventing and treating alzheimer disease
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An aging and drug-based technology, applied in the field of medicine, can solve problems such as no curative effect, long application cycle, and uncertain curative effect
Inactive Publication Date: 2014-04-23
张亚萍
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Problems solved by technology
However, there are still many problems to be solved in order to be truly applied to the prevention and treatment of human senile dementia; as far as cell gene therapy is concerned, due to the lack of control over the persistence and stability of exogenous cells or gene expression, limitations its application in clinical practice
In addition, due to the long application cycle of current drug therapy, high cost, and many side effects, its clinical application has little effect, especially for severe dementia that is not discovered in time.
At present, in the treatment of Chinese patent medicines, the curative effects are mostly uncertain, and most of them are not specific, and there are no new Chinese medicines with certain curative effects that specifically treat this disease.
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Embodiment 1
[0011] 8 parts of acai berry, 3 parts of hirudin, 1 part of salvia miltiorrhiza, 1 part of yam, 1 part of orange peel, 1 part of paeonol, 1 part of Yizhi kernel, 1 part of schisandra, 1 part of Panax notoginseng, 1 part of safflower, 1 part of orange 1 part of golden fruit olive, 1 part of American ginseng, 0.5 part of licorice.
Embodiment 2
[0013] 10 parts of acai berry, 5 parts of hirudin, 2 parts of salvia miltiorrhiza, 2 parts of yam, 2 parts of orange peel, 2 parts of paeonol, 2 parts of Yizhi kernel, 2 parts of schisandra, 2 parts of Panax notoginseng, 2 parts of safflower, 2 parts of orange red 2 parts of golden fruit olive, 2 parts of American ginseng, 1 part of licorice.
Embodiment 3
[0015] 9 parts of acai berry, 4 parts of hirudin, 2 parts of salvia miltiorrhiza, 2 parts of yam, 1 part of orange peel, 1 part of paeonol, 2 parts of Yizhi kernel, 2 parts of schisandra, 2 parts of Panax notoginseng, 2 parts of safflower, 1 part of orange 1 part of golden fruit olive, 1 part of American ginseng, 0.5 part of licorice.
[0016] The effects of the present invention will be described below in conjunction with experiments.
[0017] 1. The results of the present invention on the learning and memory ability of senile dementia model rats show that the rats in the low, middle and high dose groups have shorter time to find the platform than the model group rats (P<0.05), suggesting that it can improve the learning and memory ability of rats .
[0018] Comparison of Morris water maze of rats in each group (x±s, unit: second)
[0019]
[0020] Note: *: P<0.05 compared with the model group, Δ: P<0.05 compared with the Tianbaoning group, :u P<0.05 compared with the n...
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Abstract
The invention discloses a medicament for preventing and treating alzheimer disease. The medicament is prepared from the following raw materials: acai berry, hirudin, red-rooted salvia root, Chinese yam, dried tangerine or orange peel, the root bark of the peony tree, fructus alpiniae oxyphyllae, Chinese magnoliavine fruit, pseudo-ginseng, safflower, orange, radix tinosporae, American ginseng and liquorice. According to the medicament, key pathological links of brain insufficiency and phlegm stagnation and aperture blockage of the alzheimer disease are reasonably applied and hit, a pathological process of the alzheimer disease is possibly blocked, the dysfunction is improved, the theory of causing alzheimer disease by deficiency of the kidney and the theory of storing essence by the kidney in the traditional Chinese medicine are fully developed, the theory of growing marrow and dredging brain guides the function of clinical practice, and thus the purposes of treatment and protection are achieved.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a medicine for preventing and treating senile dementia. Background technique [0002] Senile dementia is a degeneration of the nervous system, characterized by senile plaques, neurofibrillary tangles, vacuolar degeneration of pyramidal cells in the hippocampus and neuron loss. Clinical onset is insidious, progressive mental decline, often accompanied by personality changes. The general symptoms continue to progress, and the course of the disease is usually 5-10 years, so it should be treated early. However, the treatment of its early memory impairment is a difficult clinical problem. Currently, the main drugs used are cholinergic preparations and non-cholinergic preparations. The most widely used is huperzine A. However, in recent years, it has been recognized that the efficacy of cholinesterase inhibitors depends on the integrity of cholinergic neurons. As the disease progre...
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