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Medicament for preventing and treating senile dementia

A technology for senile dementia and drugs, applied in the field of medicine, can solve the problems of long treatment application cycle and high cost, achieve good curative effect and improve the effect of dysfunction

Inactive Publication Date: 2015-12-30
PHARMA FACTORY GUANGXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the treatment of its early memory impairment is a difficult clinical problem. Currently, the main drugs used are cholinergic preparations and non-cholinergic preparations. Huperzine A is widely used, but its treatment period is too long, the cost is expensive, and many side effects make its clinical application effect little, especially for severe dementia that is not detected in time

Method used

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  • Medicament for preventing and treating senile dementia
  • Medicament for preventing and treating senile dementia

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Experimental program
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Effect test

Embodiment 1

[0014] The effects of the present invention will be described below in conjunction with experiments.

[0015] 1. The results of the present invention’s influence on the learning and memory ability of senile dementia model rats showed that the rats in the low, middle and high dose groups had a shorter time to find the platform than the rats in the model group (P<0.05), suggesting that it can improve the learning and memory ability of rats .

[0016] Comparison of Morris water maze of rats in each group (x±s, unit: second)

[0017]

[0018] Note: *P<0.05 compared with the model group; ΔP<0.05 compared with the Tianbaoning group; P<0.05 compared with the normal group.

[0019] The low dose group of the present invention is 2ml / kg, the medium dose group of the present invention is 5ml / kg, the high dose group of the present invention is 10ml / kg, and the Tianbaoning group is 24mg / kg.

[0020] 2. The influence of the present invention on the activity of SOD in brain tissue o...

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Abstract

The invention discloses a medicament for preventing and treating senile dementia. Components of the medicament comprise prepared fleeceflower root, caulis spatholobi, caulis polygoni multiflori, matsuba, uncaria tomentosa, rehmannia glutinosa and stephania sinica diels. The medicament has a remarkable therapeutic effect on senile dementia.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new application of a compound preparation. Background technique [0002] Alzheimer's disease is a neurodegenerative disease with insidious onset and progressive development. Clinically, it is characterized by comprehensive dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality and behavior changes. The etiology is still unknown. The general symptoms continue to progress, and the course of the disease is usually 5-10 years, so it should be treated early. However, the treatment of its early memory impairment is a difficult clinical problem. Currently, the main drugs used are cholinergic preparations and non-cholinergic preparations. Huperzine A is widely used, but its treatment period is too long, the cost is expensive, and many side effects make its clinical application effect little, especially...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P25/28
Inventor 焦爱军蒋伟哲王捷李如敏黎明陈荣胡玉兰巫玲玲付书婕许立拔
Owner PHARMA FACTORY GUANGXI MEDICAL UNIV
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